The effect of second-line antirheumatic drugs on interleukin-8 mRNA synthesis and protein secretion in human endothelial cells.

abstract：OBJECTIVES:The fact that ovarian cancer remains confined to the peritoneal cavity even in advanced stages has allowed us to surmise that local immunosuppressive factors could be involved in the tumor biology of ovarian cancer. In this context, IL-10 can be one of the key factors. By studying the kinetics of IL-10 conce...

journal_title：Cytokine

authors： Mustea A,Braicu EI,Koensgen D,Yuan S,Sun PM,Stamatian F,Lichtenegger W,Chen FC,Chekerov R,Sehouli J

更新日期：2009-01-01 00:00:00

abstract：:We previously isolated quercetin 3-O-beta-(2''-galloyl)-glucopyranoside (QG-32) from Persicaria lapathifolia (Polygonacease) as an inhibitor of superoxide production. In the present study, QG-32 was found to inhibit interleukin (IL)-6 production in endotoxin lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. T...

journal_title：Cytokine

authors： Kim BH,Lee IJ,Lee HY,Han SB,Hong JT,Ahn B,Lee CK,Kim Y

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:Vascular endothelial cell growth factor (VEGF) plays an important role in the biology of gynecological cancer, usually linked with aggressive tumour behaviour and a poor postoperative outcome. Yet, its role in benign breast/gynecological conditions is less clear. METHODS:Serum VEGF was analysed in a series ...

journal_title：Cytokine

authors： Koukourakis MI,Limberis V,Tentes I,Kontomanolis E,Kortsaris A,Sivridis E,Giatromanolaki A

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Among all cytokines involved in the pathogenesis and in the progression of psoriasis, Tumor Necrosis Factor (TNF)-alpha and interleukin (IL)-17 play a pivotal role. OBJECTIVE:The aim of the present study was to mimic a psoriatic microenvironment and to investigate the early effects of TNF-alpha and IL-17 in...

journal_title：Cytokine

authors： Donetti E,Cornaghi L,Gualerzi A,Baruffaldi Preis FW,Prignano F

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...

journal_title：Cytokine

authors： Sabry A,Sheashaa H,El-Husseini A,Mahmoud K,Eldahshan KF,George SK,Abdel-Khalek E,El-Shafey EM,Abo-Zenah H

更新日期：2006-08-01 00:00:00

abstract：:The proper balance between IL-12p40-related cytokines controls the appearance of normal and pathological Th1 immune responses. In this study, we examined the inducible IL-12p40, IL-12p35 and IL-23p19 mRNA expression and protein production in human peripheral blood mononuclear cells (PBMC) and purified monocytes, isola...

journal_title：Cytokine

authors： Dobreva ZG,Stanilova SA,Miteva LD

更新日期：2008-07-01 00:00:00

abstract：:Specific high titre polyclonal antibodies rapidly obtained by intralymphnode immunization of rabbits with recombinant M-CSF and LIF (< 60 micrograms/animal) have been used to develop specific, accurate and sensitive EIAs. The same batch of purified anti-M-CSF or anti-LIF Igs has been used for the coating of 96-well pl...

journal_title：Cytokine

authors： Fixe P,Lorgeot V,Le Meur Y,Coupey L,Heymann D,Godard A,Praloran V

更新日期：1996-07-01 00:00:00

abstract：:In serum-free WEHI-3 supernatants an activity was detected inducing haemoglobin synthesis in human and murine erythroleukaemia cell lines. The absolute numbers of benzidine-positive cells induced with either DMSO or WEHI-3-conditioned medium were comparable. Terminal differentiation was not observed. An expression lib...

journal_title：Cytokine

authors： Dörmer P,Spitzer E,Frankenberger M,Kremmer E

更新日期：2004-06-21 00:00:00

abstract：:Three representative cytokines interleukin (IL-8), RANTES and tumour necrosis factor alpha (TNF-alpha) have a concentration-dependent chemotactic effect on the unicellular Tetrahymena. Maximal effective concentrations of IL-8 (1 ng/ml) and RANTES (75 ng/ml) are in the same range as in mammals, which indicates an evolu...

journal_title：Cytokine

authors： Köhidai L,Csaba G

更新日期：1998-07-01 00:00:00

abstract：:Tumor Necrosis Factor alpha (TNFα, TNF) is a key mediator and regulator of mammalian immune responses in healthy organisms and in diseased conditions. TNF governs development of the immune system, cell survival signaling pathways, proliferation and regulates metabolic processes. Whereas TNF-induced NF-κB and MAP pro-s...

journal_title：Cytokine

authors： Varfolomeev E,Vucic D

更新日期：2018-01-01 00:00:00

abstract：:Osteoclasts, the main protagonists involved in bone resorption mechanisms, are generally considered to be of haematopoietic origin, although the exact nature of the primary osteoclastic stem cells is still unknown. In vitro cellular models developed to study the different events of osteoclastic differentiation have re...

journal_title：Cytokine

authors： Heymann D,Guicheux J,Gouin F,Passuti N,Daculsi G

更新日期：1998-03-01 00:00:00

abstract：:Increased cerebrospinal fluid (CSF) IL-6 has been reported in patients with Behçet's disease (BD) and neurological involvement. To elucidate the value of IL-6 as a marker of disease activity, serum and CSF IL-6 levels of 68 BD patients with acute (26) or chronic progressive (14) parenchymal involvement (pNB), dural si...

journal_title：Cytokine

authors： Akman-Demir G,Tüzün E,Içöz S,Yeşilot N,Yentür SP,Kürtüncü M,Mutlu M,Saruhan-Direskeneli G

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Cutaneous melanoma displays high morbidity and mortality rates. Isolated limb perfusion with melphalan (Mel) is used for the treatment of non-resectable, locally advanced extremity melanomas. When combined with tumor necrosis factor alpha (TNF-alpha) treatment, the complete response varies between 70% and 90...

journal_title：Cytokine

authors： de Lima VC,de Carvalho AF,Morato-Marques M,Hashimoto VL,Spilborghs GM,Marques SM,Landman G,Torres C,Braga Ribeiro K,Brentani H,Reis LF,Dias AA

更新日期：2013-05-01 00:00:00

abstract：:We have cloned and performed the first functional characterization of the chemokine receptor, CCR3, of Cynomolgus monkey (Macaca fascicularis). The deduced amino acid sequence of the cloned Cynomolgus CCR3 was found to be more similar to that of a previously-reported Rhesus (Macaca mulatta) CCR3 (99.4%) than that of a...

journal_title：Cytokine

authors： Iino T,Sugimoto H,Watanabe A,Encinas JA,Liu N,Floeckner J,Bacon KB

更新日期：2002-09-21 00:00:00

abstract：:Expression of cytokine genes, TNF-alpha, TNF-beta and IFN-gamma, in human astroglial cell lines and in fresh brain specimens was studied by PCR. mRNA transcripts of TNF-alpha could be detected in three out of five astrocytomas and neuroblastoma cell lines, and after stimulation with IL-1 beta/IFN-gamma or LPS/IFN-gamm...

journal_title：Cytokine

authors： Nitta T,Ebato M,Sato K,Okumura K

更新日期：1994-03-01 00:00:00

abstract：:Human milk is a complex biological fluid. It contains many nutrients, anti-infectious and biologically active substance. Human milk also contains many angiogenic polypeptides. We have determined four of these: Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), insulin-like growth factor...

journal_title：Cytokine

authors： Ozgurtas T,Aydin I,Turan O,Koc E,Hirfanoglu IM,Acikel CH,Akyol M,Erbil MK

更新日期：2010-05-01 00:00:00

abstract：:We examined the possible alteration of circulating transforming growth factor-beta1 (TGF-beta1) concentrations in a time-dependent fashion in human plasma. Plasma TGF-beta1 was measured three times at 2 week-intervals from each of 12 healthy participants. Platelet factor 4 (PF4) was measured in parallel with TGF-beta1...

journal_title：Cytokine

authors： Jeon JH,Kim YS,Choi EJ,Cheon S,Kim S,Kim JS,Jang JS,Ha WS,Park ST,Park CS,Park K,Park BK

更新日期：2001-11-07 00:00:00

abstract：:Allogeneic bone marrow transplantation was performed in a 24-year-old woman with acute myelogenous leukemia in the first remission (FAB classification: M4). Graft-versus-host disease occurred from around day 150 after bone marrow transplantation. The levels of tumour necrosis factor-alpha, interleukin 12, and intercel...

journal_title：Cytokine

authors： Takatsuka H,Takemoto Y,Okada M,Sawada A,Katsuno T,Wada H,Kakishita E

更新日期：2000-08-01 00:00:00

abstract：:Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies w...

journal_title：Cytokine

authors： de Lemos Rieper C,Galle P,Pedersen BK,Hansen MB

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND/AIMS:Infliximab (Ifx) is effective in the treatment of Crohn's disease (CD) and rheumatoid arthritis (RA), etanercept (Eta) in RA but not in CD. The mechanisms underlying these clinical differences are not fully understood, but this knowledge could be valuable to identify responders and develop new treatment...

journal_title：Cytokine

authors： Agnholt J,Dahlerup JF,Kaltoft K

更新日期：2003-08-07 00:00:00

abstract：:Epidemiological studies suggest that chocolate increases the incidence and severity of acne. Here we demonstrate that chocolate consumption primes human blood mononuclear cells from volunteers to release more interleukin-1β (IL-1β) and IL-10 upon stimulation with Propionibacterium acne or Staphylcoccus aureus, the two...

journal_title：Cytokine

authors： Netea SA,Janssen SA,Jaeger M,Jansen T,Jacobs L,Miller-Tomaszewska G,Plantinga TS,Netea MG,Joosten LA

更新日期：2013-04-01 00:00:00

abstract：:A recombinant human GM-CSF-EPO hybrid protein named MEN 11300 was administered biweekly for a total of 6 weeks to rhesus monkeys in order to evaluate its pharmacokinetic behaviour, tolerability and immunogenicity. In this primate species a strong antibody response was induced which neutralized the in vitro biological ...

journal_title：Cytokine

authors： Coscarella A,Liddi R,Di Loreto M,Bach S,Faiella A,van der Meide PH,Mele A,De Santis R

更新日期：1998-12-01 00:00:00

abstract：:Antigen (Ag)-stimulated mast cells induce synthesis and production of cytokines including tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 with proinflammatory and immune regulatory properties. Expression of TNF-alpha and IL-6 was regulated by a transcription factor, nuclear factor (NF)-kappaB. The iridoid gly...

journal_title：Cytokine

authors： Jeong HJ,Koo HN,Na HJ,Kim MS,Hong SH,Eom JW,Kim KS,Shin TY,Kim HM

更新日期：2002-06-07 00:00:00

abstract：:Myeloma is a neoplasm thought to "home" to bone marrow. However, evidence for bone-marrow-specific receptors or adhesion molecules expressed on myeloma cells is scanty. Initial myeloma expansion is thought to be due to IL-6 and/or related cytokines. Previous determinations of cytokine expression in bone marrow were pe...

journal_title：Cytokine

authors： Barton BE,Murphy TF

更新日期：2000-10-01 00:00:00

abstract：:Galectin-3 is a β-galactoside-binding lectin that plays an important role in the modulation of immune responses. It has been shown to aggravate joint inflammation and destruction in experimental arthritis. We investigated the role of galectin-3 in TLR-induced cell activation in human synovial fibroblasts (SF) in order...

journal_title：Cytokine

authors： Arad U,Madar-Balakirski N,Angel-Korman A,Amir S,Tzadok S,Segal O,Menachem A,Gold A,Elkayam O,Caspi D

更新日期：2015-05-01 00:00:00

abstract：:Peptic ulcer is a lesion in the mucosa of the digestive tract affecting many people all around the world. Recent investigations have indicated that produced inflammatory cytokines such as TNF-α and IL-1β in response to gastric infection by Helicobacter pylori play an important role in the development of peptic ulcer. ...

journal_title：Cytokine

authors： Tourani M,Habibzadeh M,Karkhah A,Shokri-Shirvani J,Barari L,Nouri HR

更新日期：2018-10-01 00:00:00

abstract：:In the present study, we investigated the effect of CdCl2 on the inflammatory cytokines in human intestinal Caco-2 cells. The secretion of IL-8 from Caco-2 cells was significantly increased in a dose- and time-dependent manner, whereas the secretion of such other inflammatory cytokines as TNF-alpha and IFN-gamma was n...

journal_title：Cytokine

authors： Hyun JS,Satsu H,Shimizu M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Interleukin 17 (IL-17) is induced during the early stages of tuberculosis infection, playing an important role in the defense against mycobacterial infection. To date, only one study performed in Chinese Han population has found an association between IL-17F sequence variants and susceptibility to tuberculos...

journal_title：Cytokine

authors： Ocejo-Vinyals JG,de Mateo EP,Hoz MÁ,Arroyo JL,Agüero R,Ausín F,Fariñas MC

更新日期：2013-10-01 00:00:00

abstract：:Chronic liver injury causes liver regeneration, resulting in fibrosis. The proinflammatory cytokine tumor necrosis factor (TNF) is involved in the pathogenesis of many acute and chronic liver diseases. TNF has pleiotropic functions, but its role in liver fibrosis has not been clarified. Chronic repeated injection of C...

journal_title：Cytokine

authors： Sudo K,Yamada Y,Moriwaki H,Saito K,Seishima M

更新日期：2005-03-07 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF) is the standard-of-care therapy for chemotherapy-associated neutropenia in patients with malignancies. Recent case reports have implied that G-CSF treatment may be associated with the development of aortitis, but the precise nature of the relationship is unclear....

journal_title：Cytokine

authors： Oshima Y,Takahashi S,Tani K,Tojo A

更新日期：2019-07-01 00:00:00