Monitoring of IL-10 in the serum of patients with advanced ovarian cancer: results from a prospective pilot-study.

abstract：:It has been reported that rapamycin (rap), cyclosporin A (CsA) and FK506 have immunosuppressive effect during the activation process of murine T cells. These drugs were investigated for their suppressive effect on a murine T cell line expressing intermediate (TS1 beta) or high (TS1 alpha beta) affinity IL-2R. Rap and ...

journal_title：Cytokine

authors： Rebollo A,Mérida I,Gómez J,Pitton C,Silva A,Martínez C,García A

更新日期：1995-04-01 00:00:00

abstract：:Interleukin-21 (IL-21) is an important immune cytokine that was well characterized in human and mammals, but little is known in fish. In present study, an IL-21 homologue was cloned and well characterized from Tetraodon nigroviridis. The full-length Tetraodon IL-21 cDNA was 849bp in size, containing an open reading fr...

journal_title：Cytokine

authors： Wang HJ,Xiang LX,Shao JZ,Jia S

更新日期：2006-08-01 00:00:00

abstract：:Interleukin 5 (IL-5) is a T-cell derived cytokine that induces eosinophil growth and differentiation in both mouse and human bone marrow cultures. Elevated levels of IL-5 as well as eosinophils have been detected in the sputum and Bronchoalveolar lavage (BAL) fluids of asthmatics. Since the recruitment of inflammatory...

journal_title：Cytokine

authors： Fattah D,Page KR,Bezbaruah S,Priest RC,Horgan CM,Solari R

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Published studies on association between IL12B (G/A) rs10045431, (T/C)rs6887695 polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian population have yielded conflicting results. The aim of this study was to potentially provide more reliable conclusions by conducting a meta-analysis. METHODS:...

journal_title：Cytokine

authors： Wu PB,Wu XM,Qian R,Hong C,Yitian G,Zhang G,Yu YJ

更新日期：2020-12-01 00:00:00

abstract：:IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-...

journal_title：Cytokine

authors： Scott LM,Bryant AH,Rees A,Down B,Jones RH,Thornton CA

更新日期：2017-11-01 00:00:00

abstract：:CCR2, and its principle ligand MCP-1/CCL2, have been well documented for their ability to induce monocyte infiltration and promote the pathogenesis of rheumatoid arthritis and atherosclerosis. In order to assess additional roles for CCR2, we inserted allogeneic implants into CCR2-/- and MCP-1-/- mice and characterized...

journal_title：Cytokine

authors： Tylaska LA,Boring L,Weng W,Aiello R,Charo IF,Rollins BJ,Gladue RP

更新日期：2002-05-21 00:00:00

abstract：:Obesity is closely associated with increased production of pro-inflammatory adipokines, including interleukin (IL)-6, plasminogen activator inhibitor (PAI)-1, and adipose-tissue-derived monocyte chemoattractant protein (MCP)-1, which contribute to chronic and low-grade inflammation in adipose tissue. Harpagoside, a ma...

journal_title：Cytokine

authors： Kim TK,Park KS

更新日期：2015-12-01 00:00:00

abstract：:Osteoclasts, the main protagonists involved in bone resorption mechanisms, are generally considered to be of haematopoietic origin, although the exact nature of the primary osteoclastic stem cells is still unknown. In vitro cellular models developed to study the different events of osteoclastic differentiation have re...

journal_title：Cytokine

authors： Heymann D,Guicheux J,Gouin F,Passuti N,Daculsi G

更新日期：1998-03-01 00:00:00

abstract：:The monocytic cell line U937 is a frequently used model in studies on the cytotoxic effect of tumour necrosis factor (TNF). Two sublines of this cell line, termed U937(G) and U937(M), revealing different patterns of response to this cytokine, have been identified. The U937(G) cells, similarly to the cells obtained fro...

journal_title：Cytokine

authors： Kaszubowska L,Engelmann H,Gotartowska M,Iliszko M,Bigda J

更新日期：2001-03-21 00:00:00

abstract：OBJECTIVES:In pregnancy, the placental contribution of cytokines to maternal immunosuppression has been established, however their role in normal maternal blood pressure regulation has not been identified. We investigate the contribution of interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha) to the vasod...

journal_title：Cytokine

authors： Orange S,Rasko JE,Thompson JF,Vaughan J,Olive E,Pedler M,Horvath JS,Hennessy A

更新日期：2005-02-21 00:00:00

abstract：OBJECTIVES:Vascular endothelial growth factor (VEGF) is a potent stimulus of angiogenesis that has an important role in many human malignancies including prostate carcinoma (PCa). We evaluated the role of the functional VEGF polymorphisms as genetic markers for PCa susceptibility and prognosis. METHODS:The study inclu...

journal_title：Cytokine

authors： Sfar S,Hassen E,Saad H,Mosbah F,Chouchane L

更新日期：2006-07-01 00:00:00

abstract：:The dental pulp space can become infected due to a breach in the surrounding hard tissues. This leads to inflammation of the pulp (pulpitis), soft tissue breakdown, and finally to bone loss around the root apex (apical periodontitis). The succession of the molecular events leading to apical periodontitis is currently ...

journal_title：Cytokine

authors： Rechenberg DK,Bostanci N,Zehnder M,Belibasakis GN

更新日期：2014-09-01 00:00:00

abstract：:IL-1 strikingly enhances antigen-driven responses of CD4 and CD8 T cells. It is substantially more effective than LPS and when added to a priming regime of antigen plus LPS, it strikingly enhances cell expansion. The effect is mediated by direct action on CD4 and CD8 T cells; the response occurs when OT-I or OT-II cel...

journal_title：Cytokine

authors： Ben-Sasson SZ,Caucheteux S,Crank M,Hu-Li J,Paul WE

更新日期：2011-10-01 00:00:00

abstract：:Prostaglandins (PGs), the arachidonic acid (AA) metabolites of the cyclooxygenase (COX) pathway, and the cytokine TNFalpha play major roles in inflammation and they are synthesised mainly by macrophages. Their syntheses have been shown to be regulated by several factors, including nitric oxide, a further important mac...

journal_title：Cytokine

authors： Guastadisegni C,Nicolini A,Balduzzi M,Ajmone-Cat MA,Minghetti L

更新日期：2002-08-21 00:00:00

abstract：BACKGROUND:Among all cytokines involved in the pathogenesis and in the progression of psoriasis, Tumor Necrosis Factor (TNF)-alpha and interleukin (IL)-17 play a pivotal role. OBJECTIVE:The aim of the present study was to mimic a psoriatic microenvironment and to investigate the early effects of TNF-alpha and IL-17 in...

journal_title：Cytokine

authors： Donetti E,Cornaghi L,Gualerzi A,Baruffaldi Preis FW,Prignano F

更新日期：2014-07-01 00:00:00

abstract：:Interleukin (IL-) 2 and IL-15 share the IL-2 receptor betagamma c subunits (IL-2Rbetagamma c) but have specific, unique alpha receptor subunits. We studied species specificity of human (hu), simian (si), and mouse (mu) IL-15 and found that hu and si IL-15 behaved similarly in all systems investigated. Hu and mu IL-15 ...

journal_title：Cytokine

authors： Eisenman J,Ahdieh M,Beers C,Brasel K,Kennedy MK,Le T,Bonnert TP,Paxton RJ,Park LS

更新日期：2002-11-07 00:00:00

abstract：:The evolution of malignant cells implies an increase in oncogenic fitness of cells which arises in active and reciprocal interaction with the tumor microenvironment. The mechanisms facilitating the adaptive evolution of cancer cells involve clonal selection of cancer cells, in a direction of increased adaptive potenti...

journal_title：Cytokine

authors： Todorović-Raković N

更新日期：2021-01-25 00:00:00

abstract：:Cisplatin is commonly prescribed for the treatment of various solid tumors but its use is limited due to certain side effects and renal injury is a true example. Oxidative stress and inflammation may contribute to the cisplatin induced nephrotoxicity. Accordingly, we evaluated the effect of oral vanillin intake (100mg...

journal_title：Cytokine

authors： Elseweidy MM,Askar ME,Elswefy SE,Shawky M

更新日期：2017-11-01 00:00:00

abstract：:There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CH...

journal_title：Cytokine

authors： Santos TPS,Pereira MM,Schinoni MI,Sampaio GP,Aras R Jr,Atta MLS,Atta AM

更新日期：2019-03-01 00:00:00

abstract：:T cells and T cell derived cytokines are involved in the complex pathogenesis of asthma. The role of the cytokine IL-18 however, is not clearly defined so far. On the one hand side IL-18 induces Th1-type cytokines and thereby might counter-regulate Th2-mediated allergic asthma. On the other hand IL-18 also bears pro-i...

journal_title：Cytokine

authors： Hartwig C,Tschernig T,Mazzega M,Braun A,Neumann D

更新日期：2008-06-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH pati...

journal_title：Cytokine

authors： Gao SP,Pan M,Chen C,Ge LJ,Jiang MH,Luan H,Zheng JG,Deng XT,Pan HY,Zhu JH

更新日期：2011-07-01 00:00:00

abstract：:The effects of scatter factor on the cytoskeleton of MDCK and PtK2 cells are described. During the first 6 h after the addition of scatter factor, MDCK cells were found to increase their projected areas twofold, as well as the number and size of their F-actin stress fibers. In contrast PtK2 cells showed no change in t...

journal_title：Cytokine

authors： Dowrick PG,Prescott AR,Warn RM

更新日期：1991-07-01 00:00:00

abstract：:iNKT cells, CD1d dependent natural killer T cells are a unique population of T cells. The capacity of iNKT cells to produce regulatory cytokines first provided an indication of their regulatory potential. Later on, in experimental models as well as in patients afflicted with an auto-immune disease, such as Type 1 diab...

journal_title：Cytokine

authors： Novak J,Lehuen A

更新日期：2011-03-01 00:00:00

abstract：:The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism. Indoleamine 2,3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting step in the pathway, as well as other enzymes in the pathway, have been shown to be highly regulated by cytokines. Hence, the KP has been i...

journal_title：Cytokine

authors： Baumgartner R,Forteza MJ,Ketelhuth DFJ

更新日期：2019-10-01 00:00:00

abstract：:In order to understand the cellular disease mechanisms of osteoarthritic cartilage degeneration it is of primary importance to understand both the anabolic and the catabolic processes going on in parallel in the diseased tissue. In this study, we have applied cDNA-array technology (Clontech) to study gene expression p...

journal_title：Cytokine

authors： Aigner T,McKenna L,Zien A,Fan Z,Gebhard PM,Zimmer R

更新日期：2005-08-07 00:00:00

abstract：:Ras expression has been suggested to be a marker for tumor aggressiveness of breast cancer. We previously showed that H-Ras, but not N-Ras, induced invasive/migratory phenotypes in MCF10A human breast epithelial cells. The present study aimed to determine the role of granulocyte colony-stimulating factor in H-Ras-indu...

journal_title：Cytokine

authors： Park S,Kim ES,Noh DY,Hwang KT,Moon A

更新日期：2011-07-01 00:00:00

abstract：:IL-12p70 is a proinflammatory cytokine secreted by dendritic cells, monocytes and macrophages. It plays a crucial role in cell-mediated immunity by inducing proliferation of T cell and natural killer cells, and enhancing their cytotoxic activity. In adaptive immune response, it acts on naive T cells to differentiate i...

journal_title：Cytokine

authors： Chen IF,Khan J,Noma N,Hadlaq E,Teich S,Benoliel R,Eliav E

更新日期：2013-06-01 00:00:00

abstract：:The proinflammatory cytokines TNFalpha and IL-1beta are thought to play a role in the mechanism of septic vasodilatory shock. Most evidence indicate that the vascular effects these cytokines are mediated through increased expression of inducible nitric oxide synthase, whereas several animal studies report a more rapid...

journal_title：Cytokine

authors： Pickkers P,Netea MG,van der Meer JW,Smits P

更新日期：2002-12-07 00:00:00

abstract：:We analyzed the gut immune stimulation induced by Gram-positive bacteria: non probiotic Lactobacillus acidophilus CRL 1462 and Lactobacillus acidophilus A9; two potentially probiotic strains: L. acidophilus CRL 924 and Lactobacillusdelbrueckii subsp. bulgaricus CRL 423; comparatively with a probiotic strain: Lactobaci...

journal_title：Cytokine

authors： Dogi CA,Galdeano CM,Perdigón G

更新日期：2008-03-01 00:00:00

abstract：:The purpose of these studies was to test whether pentoxifylline, a drug that can inhibit the production and action of cytokines hypothesized to be endogenous pyrogens (for example, interleukin 1 and tumor necrosis factor [TNF]), is antipyretic. We also tested the effects of pentoxifylline on plasma activities of inter...

journal_title：Cytokine

authors： LeMay LG,Vander AJ,Kluger MJ

更新日期：1990-07-01 00:00:00