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The G to A polymorphism at -597 of the interleukin-6 gene is extremely rare in southern Han Chinese.

Abstract：

:Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH patients and 194 healthy controls from Jiangsu area (south of China). Individuals all carried the GG wild genotype, no GA or AA genotypes were found. Our results suggest that IL-6-597G/A polymorphism is extremely rare and unlikely to be contributing significantly to disease susceptibility in southern Han Chinese.

journal_name

Cytokine

journal_title

Cytokine

authors

Gao SP,Pan M,Chen C,Ge LJ,Jiang MH,Luan H,Zheng JG,Deng XT,Pan HY,Zhu JH

doi

10.1016/j.cyto.2011.03.006

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

1-3

issue

1

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(11)00070-6

journal_volume

55

pub_type

杂志文章

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