Weaning induces an increase in the number of specific cytokine-secreting intestinal lymphocytes in mice.

abstract：:The failure of the immune response to clear the Hepatitis C virus (HCV) results in chronic inflammation that leads to liver cirrhosis. In general, women have a better prognosis than men and this may be associated with increased levels of anti-inflammatory mediators that are positively regulated by female sex hormones....

journal_title：Cytokine

authors： Nanda KS,Brady JJ,Murray BF,Sullivan O,Fearon U,McKenna MJ,Hegarty JE,O'Farrelly C,Ryan EJ

更新日期：2012-11-01 00:00:00

abstract：:The pathogenesis of septic shock is mainly due to unregulated tumour necrosis factor-alpha (TNF-alpha) production. Procalcitonin (PCT) and calcitonin gene-related peptide (CGRP) are alternative transcription products of the calcitonin gene. Since high PCT levels have been described in human sepsis, and since CGRP inhi...

journal_title：Cytokine

authors： Monneret G,Pachot A,Laroche B,Picollet J,Bienvenu J

更新日期：2000-06-01 00:00:00

abstract：:Kawasaki disease is a multi-system vasculitis and a primary cause of acquired heart disease among children. Genetic factors may increase susceptibility to Kawasaki disease. TBXA2R is a G-protein-coupled receptor that participates in tissue inflammation and is associated with susceptibility to several diseases, but its...

journal_title：Cytokine

authors： Che D,Pi L,Xu Y,Fu L,Zhou H,Wang Z,Huang P,Zhang L,Gu X

更新日期：2018-11-01 00:00:00

abstract：:The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19. Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced cytokine storm and their predictive values have not been fully elu...

journal_title：Cytokine

authors： Liu Y,Chen D,Hou J,Li H,Cao D,Guo M,Ling Y,Gao M,Zhou Y,Wan Y,Zhu Z

更新日期：2021-02-01 00:00:00

abstract：:We investigated inflammatory cytokine response in chronic depressed patients during abdominal surgery. Twenty-five major depressed patients (Group D) and twenty-five patients (Group C) as the control were studied. Plasma interleukin 6 (IL-6), interleukin 8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) concentrat...

journal_title：Cytokine

authors： Kudoh A,Katagai H,Takazawa T

更新日期：2001-01-21 00:00:00

abstract：:Suspect field cases of BSE infection (displaying clinical signs) were examined for possible alterations of cytokine/autacoid plasma levels and were compared to control cases (not displaying clinical signs of BSE infection). Interferon gamma (IFN-gamma) plasma levels were demonstrated as being elevated in all suspected...

journal_title：Cytokine

authors： Murphy C,Breen C,Rogers M,Giese M

更新日期：2001-02-07 00:00:00

abstract：:Systemic sclerosis (SSc) has the highest fatality rate among connective tissue diseases and is characterized by vascular damage, inflammation and fibrosis. Currently, no therapy has proven effective in modifying the course of SSc, a reflection of its complex pathogenesis. T cell-derived cytokines have been implicated ...

journal_title：Cytokine

authors： Fuschiotti P

更新日期：2011-12-01 00:00:00

abstract：:Injection of tumour necrosis factor (TNF) in animals causes severe liver cell toxicity, especially when D-(+)-galactosamine (GalN) is co-administered. After challenge with TNF/GalN, serum complement activity (CH50 and APCH50) decreased dramatically, suggesting strong activation of both the classical and the alternativ...

journal_title：Cytokine

authors： Libert C,Wielockx B,Grijalba B,Van Molle W,Kremmer E,Colten HR,Fiers W,Brouckaert P

更新日期：1999-08-01 00:00:00

abstract：:There are indications that bone regulatory and immune systems are closely related. Of special interest in this context is the acute otitis media (AOM), which mainly affects immunologically immature patients and, when complicated, involves bone tissue. To explore host responses in bone tissue during Haemophilus influen...

journal_title：Cytokine

authors： Melhus A,Ryan AF

更新日期：2004-03-21 00:00:00

abstract：BACKGROUND:Among all cytokines involved in the pathogenesis and in the progression of psoriasis, Tumor Necrosis Factor (TNF)-alpha and interleukin (IL)-17 play a pivotal role. OBJECTIVE:The aim of the present study was to mimic a psoriatic microenvironment and to investigate the early effects of TNF-alpha and IL-17 in...

journal_title：Cytokine

authors： Donetti E,Cornaghi L,Gualerzi A,Baruffaldi Preis FW,Prignano F

更新日期：2014-07-01 00:00:00

abstract：:Large amounts of anti-inflammatory mediators, such as interleukin (IL)-10, are produced and found early in the course of sepsis. We explore the role of IL-10 on neutrophil (PMN) activation/function using an in vitro model. Isolated human PMN were pre-incubated with lipopolysaccharide (LPS) and/or IL-10 for 18h. Subseq...

journal_title：Cytokine

authors： Martire-Greco D,Rodriguez-Rodrigues N,Landoni VI,Rearte B,Isturiz MA,Fernández GC

更新日期：2013-06-01 00:00:00

abstract：:Malignant tumours are usually accompanied by an immune response. Chemokines such as MCP-1 have been claimed to be potent inducers of such tumour-associated reactions. In the present study MCP-1 mRNA was quantified by competitive reverse transcription polymerase reaction and localised by in situ hybridisation in renal ...

journal_title：Cytokine

authors： Hemmerlein B,Johanns U,Kugler A,Reffelmann M,Radzun HJ

更新日期：2001-02-21 00:00:00

abstract：:Interleukin-21 (IL-21) is an important immune cytokine that was well characterized in human and mammals, but little is known in fish. In present study, an IL-21 homologue was cloned and well characterized from Tetraodon nigroviridis. The full-length Tetraodon IL-21 cDNA was 849bp in size, containing an open reading fr...

journal_title：Cytokine

authors： Wang HJ,Xiang LX,Shao JZ,Jia S

更新日期：2006-08-01 00:00:00

abstract：:This study was designed to compare the effect of Aspirin (AS) and Nimesulide (NM) on renal failure and vascular disorder in streptozotocin (STZ)-induced diabetic rats. Rats were divided into four groups; control, diabetic rats, diabetic rats plus AS and diabetic rats plus NM, which are COX inhibitors. The renal and ao...

journal_title：Cytokine

authors： Yesilot S,Ozer MK,Bayram D,Oncu M,Karabacak HI,Cicek E

更新日期：2010-12-01 00:00:00

abstract：:The aim of this study was to characterize the association between adipocyte enlargement and circulating levels of serum amyloid A (SAA). Furthermore, we wanted to search for possible associations with measures of glycemic control and levels of circulating adipokines and/or inflammatory markers in men and women with a ...

journal_title：Cytokine

authors： Sjöholm K,Lundgren M,Olsson M,Eriksson JW

更新日期：2009-12-01 00:00:00

abstract：:Therapeutic plasmapheresis is a recognized medical procedure in which various techniques are used to separate and remove undesirable or excessively elevated plasma elements from blood. The main purpose of the procedure is to remove the substances responsible for the disease (autoantibodies, circulating immune complexe...

journal_title：Cytokine

authors： Zenti MG,Stefanutti C

更新日期：2011-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) chronic infection causes severe cellular immune dysfunction. Here, we investigated the production of Th17-associated cytokines by peripheral blood mononuclear cells (PBMCs) of untreated patients with HCV, patients presenting an early virologic response (EVR) after 12weeks of treatment with inte...

journal_title：Cytokine

authors： Cabral MS,Santos TPS,Santos PL,Schinoni MI,Oliveira IS,Pereira AB,Atta AM,Sousa-Atta MLB

更新日期：2018-02-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is a key regulator of inflammation and immunity. The cellular effects exerted by TNF depend, apart from NF-kappaB-directed gene transcription, largely on its ability to activate phospholipase A2(PLA2), yielding the release of arachidonic acid (AA) and its metabolites. AA metabolites, espec...

journal_title：Cytokine

authors： van Puijenbroek AA,Wissink S,van der Saag PT,Peppelenbosch MP

更新日期：1999-02-01 00:00:00

abstract：:Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis. Data from experimental arthritis indicate IL-17 receptor signaling as a critical pathway in turning an acute synovitis into a chronic destructive arthritis. The identification of six IL-17 family members (IL-17A-F) may extend the role of this novel...

journal_title：Cytokine

authors： Lubberts E

更新日期：2008-02-01 00:00:00

abstract：:IFN-gamma signalling involves the Jak-STAT pathway. However, several hypothesis have been proposed where the receptor and its ligand itself took an active role within the cell. Using a quantitative immunogold approach, we found that both IFN-gamma and its receptor are rapidly internalized and translocated in the nucle...

journal_title：Cytokine

authors： Sadir R,Lortat-Jacob H,Morel G

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. Recently, CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets and have the opposite effects on autoimmunity. Clinical observation has revealed that the Th17/Treg imbala...

journal_title：Cytokine

authors： Xie JJ,Wang J,Tang TT,Chen J,Gao XL,Yuan J,Zhou ZH,Liao MY,Yao R,Yu X,Wang D,Cheng Y,Liao YH,Cheng X

更新日期：2010-02-01 00:00:00

abstract：:The full-length equine interferon-gamma (eIFN-gamma) cDNA, including the secretion signal peptide coding region, was recloned into baculovirus transfer vector pAcYM1. This vector was co-transfected with Autographa californica nuclear polyhedrosis virus DNA or hybrid nuclear polyhedrosis virus DNA into Spodoptera frugi...

journal_title：Cytokine

authors： Wu D,Murakami K,Liu N,Inoshima Y,Yokoyama T,Kokuho T,Inumaru S,Matsumura T,Kondo T,Nakano K,Sentsui H

更新日期：2002-10-21 00:00:00

abstract：:In serum-free WEHI-3 supernatants an activity was detected inducing haemoglobin synthesis in human and murine erythroleukaemia cell lines. The absolute numbers of benzidine-positive cells induced with either DMSO or WEHI-3-conditioned medium were comparable. Terminal differentiation was not observed. An expression lib...

journal_title：Cytokine

authors： Dörmer P,Spitzer E,Frankenberger M,Kremmer E

更新日期：2004-06-21 00:00:00

abstract：:We have previously cloned the mouse platelet basic protein (mPBP), a homologue of human PBP, from mouse thymic stromal cells. Using EST alignment and RT-PCR, the rat homologue of human and mouse PBP was cloned from lung and named as rPBP. The complete open reading frame and part of the 3'- and 5'-non-coding regions we...

journal_title：Cytokine

authors： Fu WX,Zhu ML,Gong SY,Li Y,Chen WF

更新日期：2004-04-07 00:00:00

abstract：:Human co-infection by helminth species is frequent, but their consequences are mostly unknown. Here, we investigate the impact of Strongyloides venezuelensis co-infection on the immune response, schistosome burden, and the associated pathology of schistosomiasis in mice. Co-infection did not alter the schistosome para...

journal_title：Cytokine

authors： de Rezende MC,Moreira JMP,Fernandes LLM,Rodrigues VF,Negrão-Corrêa D

更新日期：2020-03-01 00:00:00

abstract：:Neutrophil-activating peptide 1/interleukin 8 (NAP-1/IL-8) is a recently described cytokine with potent chemotactic activity for human neutrophil granulocytes (PMN) and T cells. In psoriasis, a chronic hyperproliferative and inflammatory skin disorder, PMN and T cells are found as prominent cells in the inflammatory i...

journal_title：Cytokine

authors： Mrowietz U,Sticherling M,Mielke V,Schröder JM,Christophers E

更新日期：1991-07-01 00:00:00

abstract：:CC Chemokine ligand 22 (Ccl22) is a selective, high affinity ligand at the CC chemokine receptor 4 (Ccr4). We have identified cDNAs encoding both ligand and receptor of the Ccl22-Ccr4 pair in cDNA libraries of the anterior hypothalamus/pre-optic area (AH/POA) by PCR. The AH/POA is the key brain region where endogenous...

journal_title：Cytokine

authors： Osborn O,Sanchez-Alavez M,Dubins JS,Gonzalez AS,Morrison B,Hadcock JR,Bartfai T

更新日期：2011-03-01 00:00:00

abstract：:Our aim was to explore the putative beneficial effects of low-to-moderate intensity exercise training program in patients with irritable bowel syndrome (IBS). This study evaluated the changes in blood oxidative stress status, inflammatory biomarkers and IBS severity symptoms following 24 weeks of moderate aerobic exer...

journal_title：Cytokine

authors： Hajizadeh Maleki B,Tartibian B,Mooren FC,FitzGerald LZ,Krüger K,Chehrazi M,Malandish A

更新日期：2018-02-01 00:00:00

abstract：:Neovastat® is a standardized extract of marine cartilage, an avascular tissue, which contains many biologically active molecules and has multiple antiangiogenic properties. In addition to VEGFR2 and MMPs inhibition, shark cartilage extract (SCE) has recently been shown to induce tissue plasminogen activator gene (PLAT...

journal_title：Cytokine

authors： Simard B,Ratel D,Dupré I,Pautre V,Berger F

更新日期：2013-01-01 00:00:00

abstract：:Interleukin 12 (IL-12) is a heterodimer comprising p35 and p40 subunits which are encoded and regulated separately. The authors previously demonstrated deficient IL-12 production in SLE which correlates negatively with disease activity. The present study was designed to determine whether deficiency of IL-12 and excess...

journal_title：Cytokine

authors： Liu TF,Jones BM,Wong RW,Srivastava G

更新日期：1999-10-01 00:00:00