Role of IL-13 in systemic sclerosis.

abstract：:Thymic interleukin-6 (IL-6), which is produced primarily by thymic epithelial cells, is an important cytokine for T cell growth and differentiation in the thymus. In the present study, we investigated the effects of autocrine IL-6 on the cytokines in primary cultures of human thymic epithelial cells. Using an antibody...

journal_title：Cytokine

authors： Tseng YL,Wu MH,Yang HC,Wang CY,Lin CF

更新日期：2010-08-01 00:00:00

abstract：:We have investigated phosphatidylinositol 3-kinase (PI3K)-dependent survival signalling pathways using several cytokines in three different hemopoietic cell lines, MC/9, FDC-P1, and TF-1. Cytokines caused PI3K- and PKB-dependent phosphorylation of FOXO3a (previously known as FKHRL1) at three distinct sites. Following ...

journal_title：Cytokine

authors： Behzad H,Jamil S,Denny TA,Duronio V

更新日期：2007-05-01 00:00:00

abstract：:Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold. iNKT cells have the ability to respond as innate immune cel...

journal_title：Cytokine

authors： Reilly EC,Wands JR,Brossay L

更新日期：2010-09-01 00:00:00

abstract：INTRODUCTION:Adipocytokines represent a molecular link between metabolic factors and vascular function. The purpose of our study was to investigate the relationship between adiponectin, leptin and renal function parameters in patients with glomerular filtration rate (GFR) above 90 ml/min/m(2) and type 2 diabetes. MATE...

journal_title：Cytokine

authors： Barlovic DP,Zaletel J,Prezelj J

更新日期：2009-04-01 00:00:00

abstract：:The aim of this study was to investigate the clinical relevance of lymphocyte-related serum miRNAs to the pathogenesis of acute graft-versus-host disease (aGVHD) and evaluate the predictive and prognosis value of miRNAs. Consecutive patients who received allogeneic peripheral blood stem cell transplantation (allo-PBSC...

journal_title：Cytokine

authors： Xie L,Zhou F,Liu X,Fang Y,Yu Z,Song N,Kong F

更新日期：2016-09-01 00:00:00

abstract：:Ras expression has been suggested to be a marker for tumor aggressiveness of breast cancer. We previously showed that H-Ras, but not N-Ras, induced invasive/migratory phenotypes in MCF10A human breast epithelial cells. The present study aimed to determine the role of granulocyte colony-stimulating factor in H-Ras-indu...

journal_title：Cytokine

authors： Park S,Kim ES,Noh DY,Hwang KT,Moon A

更新日期：2011-07-01 00:00:00

abstract：:Non-Hodgkin's lymphomas (NHL) constitute a heterogenous group of mainly B-cell lymphoproliferative diseases with different patterns of clinical behaviour. Biological mechanisms leading to development of NHL are not clearly understood. Transforming growth factor-beta1 (TGF-beta1) influences B cell growth and developmen...

journal_title：Cytokine

authors： Mazur G,Bogunia-Kubik K,Wrobel T,Kuliczkowski K,Lange A

更新日期：2006-02-07 00:00:00

abstract：:IL-12p70 is a proinflammatory cytokine secreted by dendritic cells, monocytes and macrophages. It plays a crucial role in cell-mediated immunity by inducing proliferation of T cell and natural killer cells, and enhancing their cytotoxic activity. In adaptive immune response, it acts on naive T cells to differentiate i...

journal_title：Cytokine

authors： Chen IF,Khan J,Noma N,Hadlaq E,Teich S,Benoliel R,Eliav E

更新日期：2013-06-01 00:00:00

abstract：:Hepatitis C virus (HCV) chronic infection causes severe cellular immune dysfunction. Here, we investigated the production of Th17-associated cytokines by peripheral blood mononuclear cells (PBMCs) of untreated patients with HCV, patients presenting an early virologic response (EVR) after 12weeks of treatment with inte...

journal_title：Cytokine

authors： Cabral MS,Santos TPS,Santos PL,Schinoni MI,Oliveira IS,Pereira AB,Atta AM,Sousa-Atta MLB

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. Recently, CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets and have the opposite effects on autoimmunity. Clinical observation has revealed that the Th17/Treg imbala...

journal_title：Cytokine

authors： Xie JJ,Wang J,Tang TT,Chen J,Gao XL,Yuan J,Zhou ZH,Liao MY,Yao R,Yu X,Wang D,Cheng Y,Liao YH,Cheng X

更新日期：2010-02-01 00:00:00

abstract：:Cartilage-specific extracellular matrix synthesis is the prerequisite for chondrocyte survival and cartilage function, but is affected by the pro-inflammatory cytokine TNF-alpha in arthritis. The aim of the present study was to characterize whether the immunoregulatory cytokine IL-10 might modulate cartilage matrix an...

journal_title：Cytokine

authors： Müller RD,John T,Kohl B,Oberholzer A,Gust T,Hostmann A,Hellmuth M,Laface D,Hutchins B,Laube G,Veh RW,Tschoeke SK,Ertel W,Schulze-Tanzil G

更新日期：2008-12-01 00:00:00

abstract：:Interferon (IFN)-alpha and -beta are important antiviral mediators. IFN-alpha is widely used for the treatment of chronic hepatitis B. In our previous studies, a subtype of woodchuck IFN-alpha (wIFN-alpha) was characterized and has been shown to be active in suppressing the replication of woodchuck hepatitis virus (WH...

journal_title：Cytokine

authors： Lu Y,Xu Y,Yang D,Kemper T,Roggendorf M,Lu M

更新日期：2008-02-01 00:00:00

abstract：:Transforming Growth Factor-beta (TGFbeta) is known to be a negative regulator of G1 cyclin/cdk activity. It is not clear whether TGFbeta has any effect on G2 checkpoint kinases. We have found that TGFbeta downregulated the expression of several G2 checkpoint kinases including cdc2, cyclin B1, and cdc25c without causin...

journal_title：Cytokine

authors： Hu X,Cui D,Moscinski LC,Zhang X,Maccachero V,Zuckerman KS

更新日期：2007-02-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) are more frequently used as the cellular source in allogeneic hematopoietic stem cell transplantation (HSCT) than bone marrow stem cells (BMSCs) because they promote more rapid engraftment and immune reconstitution. However, th...

journal_title：Cytokine

authors： Joo YD,Lee WS,Won HJ,Lee SM,Choi JH,Lee SM,Han KH,Park SG,Choi IW,Seo SK

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is the key regulator of angiogenesis in the development of various cancers. Previous studies have examined the relationship between VEGF gene promoter polymorphisms such as -2578C/A and -460C/T and bladder cancer risk; however, these results are inconclusive. Therefo...

journal_title：Cytokine

authors： Chen CH,Ho CH,Kuan-Hua Huang S,Shen CH,Wu CC,Wang YH

更新日期：2020-07-01 00:00:00

abstract：:Psoriatic fibroblasts produce enhanced amounts of IL-6 in vitro. This state of activation may reflect an altered expression of cytokine receptors, involved in auto/paracrine induction of IL-6. Cultures of dermal fibroblasts derived from lesional psoriatic (PP) and normal control (NN) skin were therefore analysed for t...

journal_title：Cytokine

authors： Debets R,Hegmans JP,Buurman WA,Benner R,Prens EP

更新日期：1996-01-01 00:00:00

abstract：:M1 mouse leukemia cells differentiate to macrophages/monocytes by the stimulation of interleukin-6 (IL-6)/leukemia inhibitory factor (LIF). To identify new LIF-induced genes, we have performed representational difference analysis using M1 cells and cloned mouse interleukin-3 (IL-3) receptor beta subunit gene. The mRNA...

journal_title：Cytokine

authors： Iwamoto T,Senga T,Adachi K,Hamaguchi M

更新日期：2004-02-07 00:00:00

abstract：OBJECTIVES:Little is known about the role of adipokines in the pathogenesis of coronary artery disease in young patients. The aims of this study were to compare serum levels of adipokines and expression of adipokines in peripheral blood leukocytes in patients with premature coronary artery disease (CAD), metabolic synd...

journal_title：Cytokine

authors： Smékal A,Václavík J,Stejskal D,Benešová K,Jarkovský J,Svobodová G,Richterová R,Švesták M,Táborský M

更新日期：2019-10-01 00:00:00

abstract：:Air pollution causes increased cardiopulmonary morbidity and mortality. Airway inflammation plays a major role in the pathophysiology of many lung diseases. Proinflammatory cytokines, such as interleukin-8 (IL-8), are responsible in part for the initiation and maintenance of airway inflammation. Asbestos exposure and ...

journal_title：Cytokine

authors： Pei XH,Nakanishi Y,Inoue H,Takayama K,Bai F,Hara N

更新日期：2002-09-07 00:00:00

abstract：OBJECTIVE:The effects of LDL-apheresis (LDLa) with dextran sulphate on plasma cytokines in 6 homozygous familial hypercholesterolemic (HozFH) patients, were evaluated. METHODS:Plasma IL-1α; IL-1ra; IL-4; IL-6; IL-10; IL-12(p40); IL-12(p70); TNF-α, sTNF-R, VEGF, VEGF-R1, E-Selectin (ESEL), and P-Selectin (PSEL) concent...

journal_title：Cytokine

authors： Stefanutti C,Vivenzio A,Di Giacomo S,Ferraro PM

更新日期：2011-08-01 00:00:00

abstract：:Fifty-five adult patients with primary bone tumour, 27 benign and 28 malignant tumours, were assayed for leukaemia inhibitory factor (LIF) in urine and serum samples. Supernatant was obtained from primary tumour tissue cultures in 24 cases (14 benign, 10 malignant tumours). LIF was found in 11 urine samples (16.7%, 1 ...

journal_title：Cytokine

authors： Gouin F,Heymann D,Raher S,De Groote D,Passuti N,Daculsi G,Godard A

更新日期：1998-02-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1) can induce expression of the protective heat shock proteins (hsps) in cardiac cells. We show here that, unlike the stress induced accumulation of hsps, the effect of CT-1 is not accompanied by increased hsp mRNA levels and is insensitive to the RNA synthesis inhibitor actinomycin D, suggesting t...

journal_title：Cytokine

authors： Railson J,Lawrence K,Stephanou A,Brar B,Pennica D,Latchman D

更新日期：2000-11-01 00:00:00

abstract：:Inflammation may play a major role in the pathogenesis of preeclampsia (PE). In this meta-analysis, we determined whether maternal polymorphisms and serum concentrations of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) were associated with PE. All studies investigating the assoc...

journal_title：Cytokine

authors： Xie C,Yao MZ,Liu JB,Xiong LK

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) contributes to type 2 diabetes (T2DM) pathogenesis, and genetic variations in VEGFA gene were suggested to influence VEGF secretion and T2DM pathogenesis. AIM:To evaluate the association of specific VEGFA variants with altered VEGF levels, and with T2DM among Tunisi...

journal_title：Cytokine

authors： Sellami N,Lamine LB,Turki A,Sarray S,Jailani M,Al-Ansari AK,Ghorbel M,Mahjoub T,Almawi WY

更新日期：2018-06-01 00:00:00

abstract：:ALT-803 is a fusion protein complex consisting of an interleukin (IL)-15 superagonist and a dimeric IL-15 receptor alpha sushi domain IgG1 Fc fusion protein. When administered to mice, ALT-803 is capable of inducing natural killer (NK) and CD8+ T cell proliferation and activation, and effectively promoting potent anti...

journal_title：Cytokine

authors： Liu B,Jones M,Kong L,Noel T,Jeng EK,Shi S,England CG,Alter S,Miller JS,Cai W,Rhode PR,Wong HC

更新日期：2018-07-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) regulate the structural integrity of the extracellular matrix (ECM). Constitutive expression of human TIMP-3 in human DLD colon carcinoma cells renewed serum-responses and inhibited tumour formation in nude mice. To elucidate the mecha...

journal_title：Cytokine

authors： Smith MR,Kung H,Durum SK,Colburn NH,Sun Y

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVES:To investigate the distribution of multiple cytokines in gastroschisis and reveal its association with clinical outcomes, including gastrointestinal disorders and fetal brain damage caused by chronic inflammation in gastroschisis. METHODS:We obtained amniotic fluid and arterial cord blood from 10 patients w...

journal_title：Cytokine

authors： Owaki T,Imai K,Miki R,Niwa Y,Kotani T,Nakano-Kobayashi T,Ushida T,Kajiyama H

更新日期：2021-02-01 00:00:00

abstract：:Although tumor necrosis factor (TNF) and interleukin 6 (IL 6) are purported to be important mediators of inflammatory responses following trauma, it is not known if the serum levels of these cytokines are altered by simple hemorrhage. The objective of this study therefore was to determine whether or not: 1) there is a...

journal_title：Cytokine

authors： Ayala A,Perrin MM,Meldrum DR,Ertel W,Chaudry IH

更新日期：1990-05-01 00:00:00

abstract：:Epithelial cell apoptosis triggered cooperatively by multiple cytokines contributes to the injury induced by inflammatory responses in the lung and elsewhere. Here we show that interferon-gamma (IFN-gamma) sensitizes A549 cells, human lung epithelial cells, to cytokine-mediated apoptosis by upregulating caspase-8 expr...

journal_title：Cytokine

authors： Kim KB,Choi YH,Kim IK,Chung CW,Kim BJ,Park YM,Jung YK

更新日期：2002-12-21 00:00:00

abstract：:CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...

journal_title：Cytokine

authors： Huang L,Cao RB,Wang N,Liu K,Wei JC,Isahg H,Song LJ,Zuo WY,Zhou B,Wang WW,Mao X,Chen PY

更新日期：2012-01-01 00:00:00