Cardiotrophin-1 reduces stress-induced heat shock protein production in cardiac myocytes.

abstract：:Hetero-dimeric cytokines often require equi-molar expression of both subunits to achieve biological activity. Previously, we expressed ovine IL-12 p40 and p35 linked using a self-cleaving 2A peptide from foot-and-mouth disease virus (FMDV). We now generated a new improved vector for the expression of hetero-dimeric cy...

journal_title：Cytokine

authors： Yen HH,Scheerlinck JP

更新日期：2013-03-01 00:00:00

abstract：:Sickle cell anemia (SCA) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-alpha) -308G>A and Interleukin 8 (IL-8) -251A>T gene polymorphisms, medical history and classical biomarkers in children with steady-...

journal_title：Cytokine

authors： Cajado C,Cerqueira BA,Couto FD,Moura-Neto JP,Vilas-Boas W,Dorea MJ,Lyra IM,Barbosa CG,Reis MG,Goncalves MS

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Dysregulated production of TNF has been implicated in the pathogenesis and severity of inflammatory rheumatic diseases, many of which show age-related increased incidence. Ageing is also associated with changes in the immune system including higher systemic levels of pro-inflammatory cytokines. Methylation o...

journal_title：Cytokine

authors： Gowers IR,Walters K,Kiss-Toth E,Read RC,Duff GW,Wilson AG

更新日期：2011-12-01 00:00:00

abstract：:Leptin is considered an adipokine, however, cultured myocytes have also been found to release leptin. Therefore, as proof-of-concept we investigated if human skeletal muscle synthesized leptin by measuring leptin in skeletal muscle biopsies. Following this, we quantified human skeletal muscle and adipose tissue leptin...

journal_title：Cytokine

authors： Wolsk E,Mygind H,Grøndahl TS,Pedersen BK,van Hall G

更新日期：2012-12-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1) is a recently discovered cytokine that was isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. In this study, the effects of chronic administration of CT-1 to mice (0.5 or 2 microg by intraperitoneal injection, twice a day for 14 days) were determined. A dose-dependent ...

journal_title：Cytokine

authors： Jin H,Yang R,Keller GA,Ryan A,Ko A,Finkle D,Swanson TA,Li W,Pennica D,Wood WI,Paoni NF

更新日期：1996-12-01 00:00:00

abstract：:During the quarter of a century since TNF was isolated, much knowledge has been gained of the identity of other ligands besides TNF in the TNF cytokine family, and of the proximal signaling molecules that these ligands activate. The numerous laboratories contributing to this advance have approached TNF research from v...

journal_title：Cytokine

authors： Wallach D

更新日期：2013-09-01 00:00:00

abstract：:Transforming Growth Factor-beta (TGFbeta) is known to be a negative regulator of G1 cyclin/cdk activity. It is not clear whether TGFbeta has any effect on G2 checkpoint kinases. We have found that TGFbeta downregulated the expression of several G2 checkpoint kinases including cdc2, cyclin B1, and cdc25c without causin...

journal_title：Cytokine

authors： Hu X,Cui D,Moscinski LC,Zhang X,Maccachero V,Zuckerman KS

更新日期：2007-02-01 00:00:00

abstract：:Interleukin-6 (IL-6) is an important pro-inflammatory cytokine of relevance to cardiovascular diseases. The aim of this case-control study was to evaluate the association between the G(-174)C functional polymorphism in the IL-6 gene and risk of cardiovascular disease (CVD) in type 2 diabetes patients. We examined 1090...

journal_title：Cytokine

authors： Buraczynska M,Zukowski P,Drop B,Baranowicz-Gaszczyk I,Ksiazek A

更新日期：2016-03-01 00:00:00

abstract：:The effects of interleukin 1beta administration on the thymus of adult and old rats were studied in order to study the interactions between the nervous and immune systems and to confirm the important role played by catecholaminergic nerve fibres (CNF) in the regulation of thymic functions. Moreover, chemical sympathec...

journal_title：Cytokine

authors： Artico M,Cavallotti C,Cameroni M,Cavallotti D

更新日期：2001-09-07 00:00:00

abstract：INTRODUCTION:Adipocytokines represent a molecular link between metabolic factors and vascular function. The purpose of our study was to investigate the relationship between adiponectin, leptin and renal function parameters in patients with glomerular filtration rate (GFR) above 90 ml/min/m(2) and type 2 diabetes. MATE...

journal_title：Cytokine

authors： Barlovic DP,Zaletel J,Prezelj J

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Endothelial injury is recognized to trigger organ failures during the first 48h of septic shock. We evaluate endothelial biomarkers at ICU admission in their ability to predict severity, outcome, and organ failures in septic shock patients. METHODS:This prospective observational pilot study was conducted in...

journal_title：Cytokine

authors： Palud A,Parmentier-Decrucq E,Pastre J,De Freitas Caires N,Lassalle P,Mathieu D

更新日期：2015-06-01 00:00:00

abstract：:We have demonstrated that ingested murine interferon alpha (IFN-alpha) suppressed clinical relapse in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), decreased inflammation and suppressed the adoptive transfer of EAE, and is a biological response modifier in patients with multiple sclerosis. We e...

journal_title：Cytokine

authors： Brod SA,Nelson L,Jin R,Wolinsky JS

更新日期：1999-07-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is a pleiotropic cytokine which plays a central role in infection, inflammation and autoimmune diseases. Its functions are mediated through binding to high affinity cell surface receptors. An approach to modulate excessive levels of TNF-alpha in the serum is the use of soluble receptors. I...

journal_title：Cytokine

authors： Chirinos-Rojas CL,Steward MW,Partidos CD

更新日期：1997-04-01 00:00:00

abstract：INTRODUCTION:Patients with chronic kidney disease (CKD) have a high risk of death mainly due to cardiovascular diseases (CVD). Early risk identification may allow interventions and prevention of fatal events. OBJECTIVES:The study aim was to assess the usefulness of selected CVD biomarkers as predictors of 5-year morta...

journal_title：Cytokine

authors： Kamińska J,Stopiński M,Mucha K,Jędrzejczak A,Gołębiowski M,Niewczas MA,Pączek L,Foroncewicz B

更新日期：2019-08-01 00:00:00

abstract：:Burn injury is associated with profound inflammation and activation of the innate immune system involving gammadelta T-cells. Similarly, Toll-like receptors (TLR) are associated with activation of the innate immune response; however, it is unclear whether TLR expression is altered in gammadelta T-cells after major bur...

journal_title：Cytokine

authors： Schwacha MG,Daniel T

更新日期：2008-12-01 00:00:00

abstract：:Cytokine balance alterations are responsible for some of the systemic and hepatic manifestations of alcoholism. The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Serum cytok...

journal_title：Cytokine

authors： González-Quintela A,Dominguez-Santalla MJ,Pérez LF,Vidal C,Lojo S,Barrio E

更新日期：2000-09-01 00:00:00

abstract：:FK506 suppresses activation of T cells; however, it down-regulates E-selectin, ICAM-1 and VCAM-1 expression in inflamed tissues. In this study, we investigated the effect of FK506 on expression of those adhesion molecules on human vascular endothelial cells (HMVEC). Culture supernatant from peripheral blood mononuclea...

journal_title：Cytokine

authors： Sasakawa T,Sasakawa Y,Masunaga T,Fujitsu T,Hirayama Y,Ohkubo Y,Mutoh S

更新日期：2005-01-21 00:00:00

abstract：:Atherosclerosis is an inflammatory disease of the vasculature regulated by cytokines. Macrophages play a crucial role at all stages of this disease, including regulation of foam cell formation, the inflammatory response and stability of atherosclerotic plaques. For example, matrix metalloproteinases produced by macrop...

journal_title：Cytokine

authors： Ashlin TG,Kwan AP,Ramji DP

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:IL-10 family cytokines are associated with the host immune response to pulmonary tuberculosis (PTB), but their association with host response in tuberculous lymphadenitis (TBL) is not known. METHODS:Hence, we examined the circulating levels of the whole panel of IL-10 family cytokines in TBL (n = 44) and co...

journal_title：Cytokine

authors： Kathamuthu GR,Kumar NP,Moideen K,Baskaran D,Hissar S,Shrinivasa BM,Sridhar R,Babu S

更新日期：2018-11-01 00:00:00

abstract：:Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig....

journal_title：Cytokine

authors： Garrett WS,Glimcher LH

更新日期：2009-10-01 00:00:00

abstract：:Increased cerebrospinal fluid (CSF) IL-6 has been reported in patients with Behçet's disease (BD) and neurological involvement. To elucidate the value of IL-6 as a marker of disease activity, serum and CSF IL-6 levels of 68 BD patients with acute (26) or chronic progressive (14) parenchymal involvement (pNB), dural si...

journal_title：Cytokine

authors： Akman-Demir G,Tüzün E,Içöz S,Yeşilot N,Yentür SP,Kürtüncü M,Mutlu M,Saruhan-Direskeneli G

更新日期：2008-12-01 00:00:00

abstract：:CC Chemokine ligand 22 (Ccl22) is a selective, high affinity ligand at the CC chemokine receptor 4 (Ccr4). We have identified cDNAs encoding both ligand and receptor of the Ccl22-Ccr4 pair in cDNA libraries of the anterior hypothalamus/pre-optic area (AH/POA) by PCR. The AH/POA is the key brain region where endogenous...

journal_title：Cytokine

authors： Osborn O,Sanchez-Alavez M,Dubins JS,Gonzalez AS,Morrison B,Hadcock JR,Bartfai T

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND/AIMS:Infliximab (Ifx) is effective in the treatment of Crohn's disease (CD) and rheumatoid arthritis (RA), etanercept (Eta) in RA but not in CD. The mechanisms underlying these clinical differences are not fully understood, but this knowledge could be valuable to identify responders and develop new treatment...

journal_title：Cytokine

authors： Agnholt J,Dahlerup JF,Kaltoft K

更新日期：2003-08-07 00:00:00

abstract：:Flt3 ligand (FL) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are important growth factors for dendritic cells (DC). Substantial numbers of DC can be generated in vivo following the administration of either factor. We sought to extend our knowledge of the functional properties of these cells including...

journal_title：Cytokine

authors： Daro E,Butz E,Smith J,Teepe M,Maliszewski CR,McKenna HJ

更新日期：2002-02-07 00:00:00

abstract：AIM:High mobility group box 1 protein (HMGB1) has been identified as a late proinflammatory cytokine and plays a key role in immune regulation. However, it is not yet clear whether HMGB1 can induce the activation and differentiation of dendritic cell (DC) subsets and subsequently modulate immune function of T cells. Th...

journal_title：Cytokine

authors： Liu QY,Yao YM,Yan YH,Dong N,Sheng ZY

更新日期：2011-05-01 00:00:00

abstract：:The aim of this study was to evaluate serum interleukin (IL)-17A levels in patients with coronary artery ectasia (CAE), the relationship between IL and 17A and CAE, and to determine the relationship between the severity of coronary ectasia and the level of IL-17A. In total, 41 patients (19 female and 22 male) with isc...

journal_title：Cytokine

authors： Uygun T,Demir B,Tosun V,Ungan İ,Kural A,Çiftçi R,Fatullayev F

更新日期：2019-03-01 00:00:00

abstract：:IL-1 strikingly enhances antigen-driven responses of CD4 and CD8 T cells. It is substantially more effective than LPS and when added to a priming regime of antigen plus LPS, it strikingly enhances cell expansion. The effect is mediated by direct action on CD4 and CD8 T cells; the response occurs when OT-I or OT-II cel...

journal_title：Cytokine

authors： Ben-Sasson SZ,Caucheteux S,Crank M,Hu-Li J,Paul WE

更新日期：2011-10-01 00:00:00

abstract：AIM:How irreversible electroporation (IRE) affect immune status is still kept unknown. This preclinical study is to investigate its local and systemic immune reaction both on tumor-bearing and tumor free animals. METHODS:Liver ablation was performed by a standard IRE instrument and proposal. Altogether 57 tumor bearin...

journal_title：Cytokine

authors： Chen X,Ren Z,Yin S,Xu Y,Guo D,Xie H,Zhou L,Wu L,Jiang J,Li H,Sun J,Zheng S

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:HIV-1 and HIV-2 are two related viruses with distinct clinical outcomes, where HIV-1 is more pathogenic and transmissible than HIV-2. The pathogenesis of both infections is influenced by the dysregulation and deterioration of the adaptive immune system. However, their effects on the responsiveness of innate ...

journal_title：Cytokine

authors： Nowroozalizadeh S,Månsson F,da Silva Z,Repits J,Dabo B,Pereira C,Biague A,Albert J,Nielsen J,Aaby P,Fenyö EM,Norrgren H,Holmgren B,Jansson M

更新日期：2009-06-01 00:00:00

abstract：:Endothelial barrier dysfunction leads to increased endothelial permeability and is an early step in the development of vascular inflammatory diseases such as atherosclerosis. Interferon-γ (IFN-γ), a proinflammatory cytokine, is known to cause increased endothelial permeability. However, the mechanisms by which IFN-γ d...

journal_title：Cytokine

authors： Ng CT,Fong LY,Yong YK,Hakim MN,Ahmad Z

更新日期：2018-11-01 00:00:00