当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > In vivo effects of cardiotrophin-1.

In vivo effects of cardiotrophin-1.

Abstract：

:Cardiotrophin-1 (CT-1) is a recently discovered cytokine that was isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. In this study, the effects of chronic administration of CT-1 to mice (0.5 or 2 microg by intraperitoneal injection, twice a day for 14 days) were determined. A dose-dependent increase in both the heart weight and ventricular weight to body ratios was observed in the treated groups. The body weights of the animals were unaffected. These results indicate that CT-1 can induce cardiac hypertrophy in vivo. CT-1 was not specific for the heart, however. It stimulated the growth of the liver, kidney, and spleen, and caused atrophy of the thymus. CT-1 administration also increased the platelet counts by 70%, with no change in mean platelet volume. Red blood cell counts were increased in the treated animals, and there was a concomitant increase in haemoglobin concentration. Thus, CT-1 has a broad spectrum of biological activities in vivo. This observation is consistent with previous in-vitro findings showing that the mRNA for CT-1 is expressed in several tissues, and that CT-1 can function through binding to the leukaemia inhibitory factor (LIF) receptor and signalling through the gp130 pathway.

journal_name

Cytokine

journal_title

Cytokine

authors

Jin H,Yang R,Keller GA,Ryan A,Ko A,Finkle D,Swanson TA,Li W,Pennica D,Wood WI,Paoni NF

doi

10.1006/cyto.1996.0123

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

920-6

issue

12

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(96)90123-4

journal_volume

8

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Serum factors potentiate hypoxia-induced hepatotoxicity in vitro through increasing transforming growth factor-beta1 activation and release.

    abstract：BACKGROUND:Although transforming growth factor-beta (TGF-beta), a growth regulator of hepatocytes, induces cell death under pathological conditions, responsiveness of hepatocytes to hypoxic stimulus has not been fully defined. This study aimed at investigating the role of TGF-beta1 in hypoxia-induced hepatotoxicity usi...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.03.004

    authors： Kao YH,Jawan B,Goto S,Pan MC,Lin YC,Sun CK,Hsu LW,Tai MH,Cheng YF,Nakano T,Wang CS,Huang CJ,Chen CL

    更新日期：2009-07-01 00:00:00

  • Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1.

    abstract：:Interleukin 1 (IL-1) activates p42/p44 and p38 mitogen-activated protein kinases (MAP kinases) in target cells. Here we have used two specific inhibitors, PD98059 which inhibits MAP kinase kinase (MEK), and SB203580 which inhibits p38 MAP kinase to explore the involvement of these kinases in the induction of IL-2 by I...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1998.0478

    authors： Matthews JS,O'Neill LA

    更新日期：1999-09-01 00:00:00

  • Co-culture of human monocytes and thyrocytes in bicameral chamber: monocyte-derived IL-1alpha impairs the thyroid epithelial barrier.

    abstract：:Pro-inflammatory cytokines are important mediators in tissue responses to a wide range of endogenous (e.g. autoantigens) and exogenous (e.g. infections, wounds, biomaterials) stimuli. The complex interactions taking place between different cell types in such processes are difficult to examine in vivo. Here we studied ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0523

    authors： Gretzer C,Thomsen P,Jansson S,Nilsson M

    更新日期：2000-01-01 00:00:00

  • TIMP-3 induces cell death by stabilizing TNF-alpha receptors on the surface of human colon carcinoma cells.

    abstract：:Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) regulate the structural integrity of the extracellular matrix (ECM). Constitutive expression of human TIMP-3 in human DLD colon carcinoma cells renewed serum-responses and inhibited tumour formation in nude mice. To elucidate the mecha...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0233

    authors： Smith MR,Kung H,Durum SK,Colburn NH,Sun Y

    更新日期：1997-10-01 00:00:00

  • Association between polymorphisms of cytokine genes and brucellosis: A comprehensive systematic review and meta-analysis.

    abstract：OBJECTIVE:Owing to involvement of host genetic factors in susceptibility to brucellosis infection and its outcome, this study aimed to carry out a comprehensive systematic review and meta-analysis to derive a precise evaluation of the association between the risk of brucellosis and its focal complication and all cytoki...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2019.154949

    authors： Zafari P,Zarifian A,Alizadeh-Navaei R,Taghadosi M,Rafiei A

    更新日期：2020-03-01 00:00:00

  • TNF-alpha and IL-8: serum levels and gene polymorphisms (-308G>A and -251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia.

    abstract：:Sickle cell anemia (SCA) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-alpha) -308G>A and Interleukin 8 (IL-8) -251A>T gene polymorphisms, medical history and classical biomarkers in children with steady-...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.07.002

    authors： Cajado C,Cerqueira BA,Couto FD,Moura-Neto JP,Vilas-Boas W,Dorea MJ,Lyra IM,Barbosa CG,Reis MG,Goncalves MS

    更新日期：2011-11-01 00:00:00

  • Expression of TNF-alpha mRNA by peripheral blood mononuclear cells of multiple sclerosis patients treated with IFN-beta 1A.

    abstract：:The aim of the present study was to verify the expression of tumour necrosis factor (TNF)-alpha mRNA by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) in unstimulated peripheral blood mononuclear cells (MNCs) of 15 relapsing-remitting multiple sclerosis (MS) patients who underwent treatment ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0881

    authors： Sarchielli P,Critelli A,Greco L,Sokola E,Floridi A,Gallai V

    更新日期：2001-06-07 00:00:00

  • Interleukin-1beta can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells.

    abstract：:Interleukin-1beta (IL-1beta) is a pleiotropic cytokine that can induce several cellular signal transduction pathways. Here, we show that IL-1beta can induce cell cycle arrest and differentiation in the human medullary thyroid carcinoma (MTC) cell line, TT. IL-1beta induces cell cycle arrest accompanied by morphologica...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.10.005

    authors： Park JI,Strock CJ,Ball DW,Nelkin BD

    更新日期：2005-02-07 00:00:00

  • Wheat gliadin promotes the interleukin-4-induced IgE production by normal human peripheral mononuclear cells through a redox-dependent mechanism.

    abstract：:Increased levels of serum IgE have been described in gliadin-intolerant patients; however, biological mechanisms implicated in this immunoglobulin production remained unknown. In this study, we demonstrated that in vitro crude gliadins and gliadin lysates (Glilys) promoted the IL-4-induced IgE production by human peri...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00100-5

    authors： Dugas B,Dugas N,Conti M,Calenda A,Pino P,Thomas Y,Mazier D,Vouldoukis I

    更新日期：2003-03-21 00:00:00

  • Evidence that cervical cancer cells secrete IL-2, which becomes an autocrine growth factor.

    abstract：:We present evidence that cervical cancer cells express a functional IL-2 receptor (IL-2R). In fact, by RT-PCR we obtained that the IL-2R is present in CALO, and INBL cells, and that it consisted of the alphaIL-2R, betaIL-2R, and gammaIL-2R chains. We also found that IL-2 is a growth factor for these cell lines, and un...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.02.013

    authors： Rangel-Corona R,Corona-Ortega T,Soto-Cruz I,López-Labra A,Pablo-Arcos T,Torres-Guarneros CF,Weiss-Steider B

    更新日期：2010-06-01 00:00:00

  • IL-17 reduces TNF-induced Rantes and VCAM-1 expression.

    abstract：:Functional diversity of the memory T-cell-derived cytokine IL-17 was explored at the receptor level. IL-17 inhibited TNF-induced chemokine Rantes expression in human synovial fibroblasts and mouse lung fibroblasts. This inhibitory activity of IL-17 (IC50=0.2 ng/ml) was 6-fold more potent than its stimulatory activity ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2005.02.012

    authors： Schnyder B,Schnyder-Candrian S,Pansky A,Schmitz ML,Heim M,Ryffel B,Moser R

    更新日期：2005-08-07 00:00:00

  • Cytokine gene polymorphisms involved in chronicity and complications of anterior uveitis.

    abstract：:The aim of this study was to identify key cytokine polymorphisms associated with disease susceptibility, clinical phenotype, and outcome in patients with chronic anterior uveitis (CAU) as compared to those with recurrent self-limiting anterior uveitis (RAU). One hundred fifty seven British Caucasian patients with ante...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.08.003

    authors： Menezo V,Bond SK,Towler HM,Kuo NW,Baharlo B,Wilson AG,Lightman S

    更新日期：2006-08-01 00:00:00

  • IL-4, but not IL-13, modulates TARC (thymus and activation-regulated chemokine)/CCL17 and IP-10 (interferon-induced protein of 10kDA)/CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line.

    abstract：:It is known that both interleukin-4 (IL-4) and IL-13 are produced by Th2-type cells and share similar biological functions with each other. However, recently accumulated evidences have revealed that IL-4 may be involved in the Th1-type response. Both thymus and activation-regulated chemokine (TARC/CCL17), a ligand for...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.1965

    authors： Kakinuma T,Nakamura K,Wakugawa M,Yano S,Saeki H,Torii H,Komine M,Asahina A,Tamaki K

    更新日期：2002-10-07 00:00:00

  • The chemokine C10: immunological and functional analysis of the sequence encoded by the novel second exon.

    abstract：:The gene for C10, a member of the beta-chemokine family of cytokines, contains a novel second exon encoding a 16 amino acid sequence which is inserted into the amino-terminal region of the protein. We propose a model of C10 structure in which the sequence encoded by the second exon is located on the surface of the pro...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0060

    authors： Berger MS,Taub DD,Orlofsky A,Kleyman TR,Coupaye-Gerard B,Eisner D,Cohen SA

    更新日期：1996-06-01 00:00:00

  • Pattern of cytokine expression by rat liver epithelial cells supporting long-term culture of human CD34(+)umbilical cord blood cells.

    abstract：:Fetal liver is the main site of haematopoiesis during mid-gestation. The adult liver still provides a favourable environment for extramedullary haematopoiesis. Nevertheless, regulation of liver haematopoiesis by cell-cell contacts or by cytokines remains poorly understood. Recently, we have shown that rat liver epithe...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0639

    authors： Rialland M,Corlu A,Ilyin G,Cabillic F,Lamy I,Guguen-Guillouzo C

    更新日期：2000-07-01 00:00:00

  • Interleukin-10 controls human peripheral PMN activation triggered by lipopolysaccharide.

    abstract：:Large amounts of anti-inflammatory mediators, such as interleukin (IL)-10, are produced and found early in the course of sepsis. We explore the role of IL-10 on neutrophil (PMN) activation/function using an in vitro model. Isolated human PMN were pre-incubated with lipopolysaccharide (LPS) and/or IL-10 for 18h. Subseq...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.03.025

    authors： Martire-Greco D,Rodriguez-Rodrigues N,Landoni VI,Rearte B,Isturiz MA,Fernández GC

    更新日期：2013-06-01 00:00:00

  • Leishmania major strains isolated from distinct endemic areas show diverse cytokine mRNA expression levels in C57BL/6 mice: Toward selecting an ideal strain for the vaccine studies.

    abstract：:Leishmania major, the causative agent of zoonotic cutaneous leishmaniasis shows heterogeneity and diverse clinical manifestations in different areas of infection and experimental models. Such polymorphism may cause difficulties in selection of reliable strains for development of prophylaxes. Hence, the aim of this stu...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.05.022

    authors： Darabi S,Khaze V,Riazi-Rad F,Darabi H,Bahrami F,Ajdary S,Alimohammadian MH

    更新日期：2015-12-01 00:00:00

  • Effects of long-term estrogen treatment on IFN-gamma, IL-2 and IL-4 gene expression and protein synthesis in spleen and thymus of normal C57BL/6 mice.

    abstract：:Estrogens have been shown to markedly modulate the immune system. One mechanism by which estrogens could modulate the immune system is by regulating cytokines, an aspect not well-studied thus far. To address this issue, normal C57BL/6 orchiectomized mice were given estrogen and its effects on selected cytokines, inter...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0876

    authors： Karpuzoglu-Sahin E,Zhi-Jun Y,Lengi A,Sriranganathan N,Ansar Ahmed S

    更新日期：2001-05-21 00:00:00

  • Effects of repeated injections of interleukin 1beta or lipopolysaccharide on the HPA axis in the newborn rat.

    abstract：:The hypothalamic-pituitary-adrenal (HPA) axis is stimulated during immune and inflammatory processes. Interleukin 1beta (IL-1beta) and lipopolysaccharide (LPS) are known to be potent stimulators of this axis. During postnatal development, the rat seems to be hyporesponsive to many stimuli. The effects of repeated syst...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0423

    authors： Bumiller A,Götz F,Rohde W,Dörner G

    更新日期：1999-03-01 00:00:00

  • IL17 and IFNgamma production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis.

    abstract：:We evaluated the spontaneous IL17, IFNgamma and IL10 production by peripheral blood mononuclear cells from patients affected by clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) both in acute phase and in remission, relapsing remitting MS (RRMS) both in relapse and in remission, not-relapsing s...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.08.007

    authors： Frisullo G,Nociti V,Iorio R,Patanella AK,Marti A,Caggiula M,Mirabella M,Tonali PA,Batocchi AP

    更新日期：2008-10-01 00:00:00

  • Multiple cytokine secretion by IL-7-stimulated human T cells.

    abstract：:The induction of cytokine secretion by human peripheral blood (PB) T cells was examined. Highly purified T cells stimulated with interleukin 7 (IL-7), in the absence of co-mitogen, secreted IL-2, IL-4, IL-6 and interferon gamma (IFN-gamma) upon restimulation with phorbol ester and ionomycin. In contrast, induction of ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(92)90006-d

    authors： Armitage RJ,Macduff BM,Ziegler SF,Grabstein KH

    更新日期：1992-11-01 00:00:00

  • IL-10 induces gene expression in macrophages: partial overlap with IL-5 but not with IL-4 induced genes.

    abstract：:The hypothesis that IL-10, in addition to down-regulating pro-inflammatory activities of macrophages, induces an alternative state of macrophage reactivity was tested. We therefore conducted a systematic search for genes induced by IL-10 using the method of suppression subtractive hybridisation. Of an initial 1,300 ca...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00270-9

    authors： Stumpo R,Kauer M,Martin S,Kolb H

    更新日期：2003-10-01 00:00:00

  • Citrullination of TNF-α by peptidylarginine deiminases reduces its capacity to stimulate the production of inflammatory chemokines.

    abstract：:Citrullination, a posttranslational modification (PTM) recently discovered on inflammatory chemokines such as interleukin-8 (IL-8/CXCL8) and interferon-γ-inducible protein-10 (IP-10/CXCL10), seriously influences their biological activity. Citrullination or the deimination of arginine to citrulline is dependent on pept...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.09.011

    authors： Moelants EA,Mortier A,Grauwen K,Ronsse I,Van Damme J,Proost P

    更新日期：2013-01-01 00:00:00

  • Molecular identification and immunological characteristics of goose suppressor of cytokine signaling 1 (SOCS-1) in vitro and vivo following DTMUV challenge.

    abstract：:Purpose suppressor of cytokine signaling 1 (SOCS-1) is inducible feedback inhibitors of cytokine signaling and involved in viral infection through regulation of both innate and adaptive immunity. In this study, we firstly cloned SOCS-1 (goSOCS-1) from duck Tembusu virus (DTMUV) infected goose. The full-length sequence...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.03.015

    authors： Zhang W,Chen S,Zhang J,Wu Z,Wang M,Jia R,Zhu D,Liu M,Sun K,Yang Q,Wu Y,Chen X,Cheng A

    更新日期：2017-05-01 00:00:00

  • Molecular characterization of the bovine type II IL-1 receptor.

    abstract：:The purpose of this study was to clone and characterize the bovine IL-1rII. Using a human IL-1rII probe, three putative exons of the bovine IL-1rII were identified from a bovine genomic library. The full length cDNA for bovine IL-1rII was cloned from a bovine endometrial cDNA library using oligonucleotides designed fr...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0129

    authors： Yu PW,Chen HT,Czuprynski CJ,Schuler LA

    更新日期：1997-01-01 00:00:00

  • Modulation by colony stimulating factors of human epithelial colon cancer cell apoptosis.

    abstract：:Colony stimulating factors (CSF) promote leukocyte survival by reducing apoptotic cell death. However, their effects on non-leukocyte cell types are unclear. Reduced apoptosis in colon epithelial cells is thought to contribute to the initiation of cancer. Here, we report diminished spontaneous apoptosis of human colon...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.1999

    authors： Calatayud S,Warner TD,Breese EJ,Mitchell JA

    更新日期：2002-11-24 00:00:00

  • The TNF cytokine family: one track in a road paved by many.

    abstract：:During the quarter of a century since TNF was isolated, much knowledge has been gained of the identity of other ligands besides TNF in the TNF cytokine family, and of the proximal signaling molecules that these ligands activate. The numerous laboratories contributing to this advance have approached TNF research from v...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2013.05.027

    authors： Wallach D

    更新日期：2013-09-01 00:00:00

  • IL-27 is elevated in sepsis with acute hepatic injury and promotes hepatic damage and inflammation in the CLP model.

    abstract：BACKGROUND:Immuno-inflammation plays an important role in the pathophysiological process of sepsis-associated acute hepatic injury (AHI). Interleukin 27 (IL-27) is an important inflammatory regulator; however, its role in this condition is not clear. METHODS:The clinical data and IL-27 serum levels in sepsis patients ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.154936

    authors： Fan J,Zhang YC,Zheng DF,Zhang M,Liu H,He M,Wu ZJ

    更新日期：2020-03-01 00:00:00

  • Upregulation of neuropilin-1 by basic fibroblast growth factor enhances vascular smooth muscle cell migration in response to VEGF.

    abstract：:Neuropilin-1 (NRP-1) is a co-receptor for vascular endothelial growth factor (VEGF). During neovascularization, vascular smooth muscle cells (VSMCs) and pericytes modulate the function of endothelial cells. Factors that mediate NRP-1 in human VSMCs (hVSMCs) remain to be elucidated. We studied various angiogenic cytoki...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2005.09.009

    authors： Liu W,Parikh AA,Stoeltzing O,Fan F,McCarty MF,Wey J,Hicklin DJ,Ellis LM

    更新日期：2005-12-07 00:00:00

  • Expression of tumour necrosis factor-alpha, -beta and interferon-gamma genes within human neuroglial tumour cells and brain specimens.

    abstract：:Expression of cytokine genes, TNF-alpha, TNF-beta and IFN-gamma, in human astroglial cell lines and in fresh brain specimens was studied by PCR. mRNA transcripts of TNF-alpha could be detected in three out of five astrocytomas and neuroblastoma cell lines, and after stimulation with IL-1 beta/IFN-gamma or LPS/IFN-gamm...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(94)90039-6

    authors： Nitta T,Ebato M,Sato K,Okumura K

    更新日期：1994-03-01 00:00:00