Abstract:
:The aim of this study was to identify key cytokine polymorphisms associated with disease susceptibility, clinical phenotype, and outcome in patients with chronic anterior uveitis (CAU) as compared to those with recurrent self-limiting anterior uveitis (RAU). One hundred fifty seven British Caucasian patients with anterior uveitis were identified and divided into those where the inflammatory process lasted less than 3 months (RAU=118) and those where the inflammation persisted longer than 3 months (CAU=39). Patients with CAU were further sub-divided into idiopathic CAU, CAU associated with systemic disease, CAU with and without complications (posterior synechiae, posterior subcapsular lens opacity, raised intraocular pressure, cystoid macular oedema, and poor response to treatment). Sixty-six healthy controls were ethnically matched. TaqMan PCR amplification was used to genotype five single nucleotide polymorphisms in cytokine genes; IL-1RN+2018, IL-6-174, IL-10-1082, TNF-238, TNF-308 and these were correlated with clinical phenotype.
journal_name
Cytokinejournal_title
Cytokineauthors
Menezo V,Bond SK,Towler HM,Kuo NW,Baharlo B,Wilson AG,Lightman Sdoi
10.1016/j.cyto.2006.08.003subject
Has Abstractpub_date
2006-08-01 00:00:00pages
200-6issue
3-4eissn
1043-4666issn
1096-0023pii
S1043-4666(06)00247-Xjournal_volume
35pub_type
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