Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1.

abstract：:Cell death and innate immunity are ancient evolutionary conserved processes that utilize a dazzling number of related molecular effectors and parallel signal transduction mechanisms. The investigation of the molecular mechanisms linking the sensing of a danger signal (pathogens or tissue damage) to the induction of an...

journal_title：Cytokine

authors： Yeretssian G,Labbé K,Saleh M

更新日期：2008-09-01 00:00:00

abstract：:The Toll like receptors (TLRs) and the type I interferons have critical roles to play in innate immunity. In this review we will discuss new developments relating to the important area of TLR/IFN cross regulation. ...

journal_title：Cytokine

authors： Perkins DJ,Vogel SN

更新日期：2015-08-01 00:00:00

abstract：:We have recently reported the identification of four novel members of the interleukin-1 (IL-1) family which we designated as IL-1 homologue 1-4 (IL-1H1-4). These proteins exhibit significant sequence homology to other members of the IL-1 family. Of these homologues, only IL-1H4 (renamed IL-1F7b) was predicted to conta...

journal_title：Cytokine

authors： Kumar S,Hanning CR,Brigham-Burke MR,Rieman DJ,Lehr R,Khandekar S,Kirkpatrick RB,Scott GF,Lee JC,Lynch FJ,Gao W,Gambotto A,Lotze MT

更新日期：2002-04-21 00:00:00

abstract：PURPOSE:Tumor necrosis factor (TNFα) is a proinflammatory cytokine and has been a target for intervention in human sepsis. However, inhibition of TNF-α with a high dose of a TNF-receptor fusion protein in patients with septic shock worsened patient survival. This study was designed to investigate whether blocking TNF-α...

journal_title：Cytokine

authors： Tsay TB,Yang MC,Chen PH,Lai KH,Huang HT,Hsu CM,Chen LW

更新日期：2013-07-01 00:00:00

abstract：:We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 su...

journal_title：Cytokine

authors： Nibali L,D'Aiuto F,Donos N,Griffiths GS,Parkar M,Tonetti MS,Humphries SE,Brett PM

更新日期：2009-01-01 00:00:00

abstract：:Since its first description in 1966, macrophage migration inhibitory factor (MIF) was found to play a critical role in inflammatory and immune responses as well as in disease pathogenesis especially in tumor pathogenesis and cancer progression. MIF is expressed in different cell types and is associated with many disea...

journal_title：Cytokine

authors： Adzavon YM,Zhao P,Lv B,Liu M,Zhang X,Xie F,Yang L,Shang L,Zhang M,Li Q,Ma X

更新日期：2017-09-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a molecule with plethora of functions such as regulation of immune response, hormone-like, enzymatic and chaperone-like activity. Further, MIF is a major participant in glucose homeostasis since it is an autocrine stimulator of insulin secretion. MIF absence in male knoc...

journal_title：Cytokine

authors： Vujicic M,Senerovic L,Nikolic I,Saksida T,Stosic-Grujicic S,Stojanovic I

更新日期：2014-09-01 00:00:00

abstract：:The pathogenesis of sickle cell disease (HbSS), which has numerous complications including stroke, involves inflammation resulting in alteration of plasma inflammatory protein concentration. We investigated HbSS children with abnormal cerebral blood flow detected by trans-cranial Doppler ultrasound (TCD) who participa...

journal_title：Cytokine

authors： Asare K,Gee BE,Stiles JK,Wilson NO,Driss A,Quarshie A,Adams RJ,Kutlar A,Hibbert JM

更新日期：2010-01-01 00:00:00

abstract：:Tenidap is a novel anti-inflammatory and anti-arthritic agent that lowers intracellular pH and suppresses anion transport when applied to cells in vitro. Both of these parameters are known to influence pro-inflammatory cell function. To investigate whether tenidap can modulate cellular responses to cytokine stimulatio...

journal_title：Cytokine

authors： McNiff PA,Laliberte RE,Svensson L,Pazoles CJ,Gabel CA

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Hypertension is one of the most prominent risk factors for coronary artery disease (CAD). Treatment of hypertension is therefore important for reducing cardiovascular events and the progression of atherosclerosis. Several treatment strategies are common in clinical practice for example the use of ACE-blocker...

journal_title：Cytokine

authors： Klinghammer L,Urschel K,Cicha I,Lewczuk P,Raaz-Schrauder D,Achenbach S,Garlichs CD

更新日期：2013-05-01 00:00:00

abstract：:Although immune responses following soft-tissue trauma-hemorrhage are markedly different in young (6-8 weeks) and aged (18-20 months) mice, it remains unknown if there are any differences in immune responses in middle-aged and young mice following bone fracture, soft-tissue trauma-hemorrhage (Fx-TH). To study this, yo...

journal_title：Cytokine

authors： Kang SC,Matsutani T,Choudhry MA,Schwacha MG,Rue LW,Bland KI,Chaudry IH

更新日期：2004-06-07 00:00:00

abstract：:The effects of interleukin 1beta administration on the thymus of adult and old rats were studied in order to study the interactions between the nervous and immune systems and to confirm the important role played by catecholaminergic nerve fibres (CNF) in the regulation of thymic functions. Moreover, chemical sympathec...

journal_title：Cytokine

authors： Artico M,Cavallotti C,Cameroni M,Cavallotti D

更新日期：2001-09-07 00:00:00

abstract：:In order to study structure-function relationships of the M(r) 55,000 subunit of the murine IL-2R (p55 IL-2R) by epitope mapping, we have expressed the p55 IL-2R molecule in a cell-free translation system. Under these in vitro conditions, we detected the expected p55 IL-2R polypeptide initiated at Met 1 and, in additi...

journal_title：Cytokine

authors： Lorenzo F,Jaulin C,Jankovic DL,Theze J

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Interleukin (IL)-17A is proinflammatory cytokine produced by Th17 cells, which play key, but sometimes inconsistent role in autoimmunity and cancer. Polymorphic variants in IL-17A gene were differentially associated with susceptibility to cancer, including colorectal cancer (CRC). AIM:We investigated the as...

journal_title：Cytokine

authors： Bedoui SA,Barbirou M,Stayoussef M,Dallel M,Mokrani A,Makni L,Mezlini A,Bouhaouala B,Yacoubi-Loueslati B,Almawi WY

更新日期：2018-10-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a fast-growing cancer characterized by high occurrences of nodal and distant metastases and poor prognosis. It is therefore important to identify new serum biomarkers for the early diagnosis and prognostic prediction of this disease. The present study identifies biomarkers in NPC pati...

journal_title：Cytokine

authors： Gong D,Li Z,Ding R,Cheng M,Huang H,Liu A,Kang M,He H,Xu Y,Shao J,Wang Y,Duan C

更新日期：2019-06-01 00:00:00

abstract：RATIONALE:Sarcoidosis is an idiopathic granulomatous disorder with heterogeneous clinical manifestations and variable prognosis. Monitoring disease activity is important to identify patients requiring treatment. Several cytokines have previously been shown to be elevated in the serum of patients with sarcoidosis and ma...

journal_title：Cytokine

authors： Geyer AI,Kraus T,Roberts M,Wisnivesky J,Eber CD,Hiensch R,Moran TM

更新日期：2013-10-01 00:00:00

abstract：:Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE i...

journal_title：Cytokine

authors： Ponnalagu M,Subramani M,Jayadev C,Shetty R,Das D

更新日期：2017-07-01 00:00:00

abstract：INTRODUCTION:Transfersomes (TF) are new, ultradeformable carriers with characteristics that enable them to penetrate the skin spontaneously. TFs are able to transport noninvasively both low- and high-molecular-weight molecules into the body. MATERIALS AND METHODS:TFs contain phosphatidylcholine and sodium cholate. Rec...

journal_title：Cytokine

authors： Hofer C,van Randenborgh H,Lehmer A,Hartung R,Breul J

更新日期：2004-02-21 00:00:00

abstract：:Natural terrestrial ionizing radiations emerge from uranium deposits and can impact human tissues by affecting DNA bases which constitute genes. Human interferon alpha-2b (hIFNα-2b) gene synthesizes a protein which exhibits anticancerous, immunomodulatory, anti-proliferative and antiviral properties. This research aim...

journal_title：Cytokine

authors： Shahid S,Mahmood N,Chaudhry MN,Ahmad N

更新日期：2015-12-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1) is a recently discovered cytokine that was isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. In this study, the effects of chronic administration of CT-1 to mice (0.5 or 2 microg by intraperitoneal injection, twice a day for 14 days) were determined. A dose-dependent ...

journal_title：Cytokine

authors： Jin H,Yang R,Keller GA,Ryan A,Ko A,Finkle D,Swanson TA,Li W,Pennica D,Wood WI,Paoni NF

更新日期：1996-12-01 00:00:00

abstract：:Interactions between interleukin 8 (IL-8) and endothelial cells play an important role in the emigration of mononuclear cells from the blood into areas of inflammation. We examined the ability of specific second-line antirheumatic drugs to regulate (IL-8) gene expression and protein secretion in interleukin 1 (IL-1) s...

journal_title：Cytokine

authors： Deleuran B,Kristensen M,Paludan K,Zachariae C,Larsen CG,Zachariae E,Thestrup-Pedersen K

更新日期：1992-09-01 00:00:00

abstract：:Toll-like receptors induce a complex inflammatory response that can function to alert the body to infection, neutralize pathogens and repair damaged tissues. Toll-like receptors are expressed on kupffer, endothelial, dendritic, biliary epithelial, hepatic stellate cells, and hepatocytes in the liver. The endoplasmic r...

journal_title：Cytokine

authors： Lawless MW,Greene CM

更新日期：2012-08-01 00:00:00

abstract：:We investigated inflammatory cytokine response in chronic depressed patients during abdominal surgery. Twenty-five major depressed patients (Group D) and twenty-five patients (Group C) as the control were studied. Plasma interleukin 6 (IL-6), interleukin 8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) concentrat...

journal_title：Cytokine

authors： Kudoh A,Katagai H,Takazawa T

更新日期：2001-01-21 00:00:00

abstract：:Imbalance in the production of cytokines and their inhibitors plays a part in inflammation in chronic destructive diseases. Direct cell-cell contact with stimulated T cells markedly induces the production of pro-inflammatory cytokines and matrix metalloproteinases in monocytes. This study demonstrates that direct cont...

journal_title：Cytokine

authors： Vey E,Dayer JM,Burger D

更新日期：1997-07-01 00:00:00

abstract：:Literature studies suggest important protective effects of low-frequency, low-energy pulsed electromagnetic fields (PEMFs) on inflammatory pathways affecting joint and cerebral diseases. However, it is not clear on which bases they affect neuroprotection and the mechanism responsible is yet unknown. Therefore the aim ...

journal_title：Cytokine

authors： Merighi S,Gessi S,Bencivenni S,Battistello E,Vincenzi F,Setti S,Cadossi M,Borea PA,Cadossi R,Varani K

更新日期：2020-01-01 00:00:00

abstract：:Measuring T-cell production of intracellular cytokines by flow cytometry enables specific monitoring of airway inflammation and response to therapies in chronic lung diseases including chronic obstructive pulmonary disease (COPD). We have previously shown that T cells in the airways of ex- and current- smoker COPD pat...

journal_title：Cytokine

authors： Hodge G,Reynolds PN,Holmes M,Hodge S

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...

journal_title：Cytokine

authors： Sabry A,Sheashaa H,El-Husseini A,Mahmoud K,Eldahshan KF,George SK,Abdel-Khalek E,El-Shafey EM,Abo-Zenah H

更新日期：2006-08-01 00:00:00

abstract：:Although much research has been done related to biomarker discovery for tuberculosis infection, a set of biomarkers that can discriminate between active and latent TB diseases remains elusive. In the current study we correlate clinical aspects of TB disease with changes in the immune response as determined by biomarke...

journal_title：Cytokine

authors： Zambuzi FA,Cardoso-Silva PM,Espindola MS,Soares LS,Galvão-Lima LJ,Brauer VS,Gomes MS,Amaral LR,Schaller M,Bollela VR,Frantz FG

更新日期：2016-12-01 00:00:00

abstract：:Effector CD4+ T cells can be classified by the cytokines they secrete, with T helper 1 (Th1) cells generating interferon (IFN)γ and Th17 cells secreting interleukin (IL)-17. Both Th1 and Th17 cells are strongly implicated in the initiation and chronicity of autoimmune diseases such as multiple sclerosis. The endoplasm...

journal_title：Cytokine

authors： Pradeep Yeola A,Akbar I,Baillargeon J,Mercy Ignatius Arokia Doss P,Paavilainen VO,Rangachari M

更新日期：2020-05-01 00:00:00

abstract：:Interleukin (IL)-4, IL-10, and IL-13 are T-helper2 cell derived cytokines, which are known to suppress pro-inflammatory cytokine production. The biologically related IL-4 and IL-13 have an impact on the development of atopic inflammation, whereas IL-10 is mostly supposed to be involved in fibrotic disorders or inflamm...

journal_title：Cytokine

authors： Hocke AC,Ermert M,Althoff A,Brell B,N'Guessan PD,Suttorp N,Ermert L

更新日期：2006-02-21 00:00:00