Mutations of the human interferon alpha-2b (hIFNα-2b) gene in low-dose natural terrestrial ionizing radiation exposed dwellers.

abstract：:The interleukin (IL)-7 receptor (IL-7R) is expressed on human pre-B but not mature B-cells. We hypothesised that aberrant expression of IL-7R contributes to B-cell oncogenesis. Surface expression of IL-7R components CD127 and CD132, and intracellular Ki-67 and Bcl-2 were examined by flow cytometry on peripheral blood ...

journal_title：Cytokine

authors： Sasson SC,Smith S,Seddiki N,Zaunders JJ,Bryant A,Koelsch KK,Weatherall C,Munier ML,McGinley C,Yeung J,Mulligan SP,Moore J,Cooper DA,Milliken S,Kelleher AD

更新日期：2010-04-01 00:00:00

abstract：:This study was aimed to evaluate the effects on some inflammatory markers of two dialytic treatments [bicarbonate dialysis (BHD) and hemodiafiltration (HDF)] in patients with severe chronic kidney disease. We evaluated: blood glucose, homeostasis model assessment insulin resistance index, homocistein (Hcs), high sensi...

journal_title：Cytokine

authors： Derosa G,Libetta C,Esposito P,Borettaz I,Tinelli C,D'angelo A,Maffioli P

更新日期：2017-04-01 00:00:00

abstract：:Imbalance in the production of cytokines and their inhibitors plays a part in inflammation in chronic destructive diseases. Direct cell-cell contact with stimulated T cells markedly induces the production of pro-inflammatory cytokines and matrix metalloproteinases in monocytes. This study demonstrates that direct cont...

journal_title：Cytokine

authors： Vey E,Dayer JM,Burger D

更新日期：1997-07-01 00:00:00

abstract：:Asthma and type I diabetes are major causes of chronic illness in childhood which, according to the current paradigm, have mutually antagonistic immunopathologies. Nonetheless, the disorders appear to preferably coexist both on population and individual levels. To assess whether children with asthma and type I diabete...

journal_title：Cytokine

authors： Kainonen E,Rautava S,Korkeamäki M,Isolauri E

更新日期：2006-05-01 00:00:00

abstract：:Metabolic syndrome poses a major threat on human health affecting the quality of life. Adipose tissue is an important organ which plays a crucial role in the pathogenesis of metabolic syndrome. Adipocytokines secreted by the adipose tissue plays a critical role in storage, food intake, energy expenditure, lipid and gl...

journal_title：Cytokine

authors： Ghadge AA,Khaire AA

更新日期：2019-09-01 00:00:00

abstract：:Obesity, a chronic low-grade inflammation metabolic abnormality, is related to high proinflammatory cytokines concentrations. Epstein-Barr virus-induced gene 3 (EBI3) encodes for the EBI3 beta subunit that constitutes interleukin (IL) 27 and 35. Our objective was to assess the association of three EBI3 single nucleoti...

journal_title：Cytokine

authors： Posadas-Sánchez R,Del Carmen González-Salazar M,Cardoso-Saldaña G,Andrés Criales-Vera S,Reyes-Barrera J,Pérez-Hernández N,Manuel Fragoso J,Vargas-Alarcón G

更新日期：2020-11-01 00:00:00

abstract：:Neutrophil-activating peptide 1/interleukin 8 (NAP-1/IL-8) is a recently described cytokine with potent chemotactic activity for human neutrophil granulocytes (PMN) and T cells. In psoriasis, a chronic hyperproliferative and inflammatory skin disorder, PMN and T cells are found as prominent cells in the inflammatory i...

journal_title：Cytokine

authors： Mrowietz U,Sticherling M,Mielke V,Schröder JM,Christophers E

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Immune and inflammatory responses, mediated by cytokines, play important roles in the pathophysiology of asthma. These responses are associated with over expression of T helper (Th)-2 cytokine, particularly interleukin (IL)-4 and IL-5, and decreased expression of Th-1 cytokine, IL-2 and IFN-γ. We...

journal_title：Cytokine

authors： Lama M,Chatterjee M,Nayak CR,Chaudhuri TK

更新日期：2011-09-01 00:00:00

abstract：:Atherosclerosis is an inflammatory disease of the vasculature regulated by cytokines. Macrophages play a crucial role at all stages of this disease, including regulation of foam cell formation, the inflammatory response and stability of atherosclerotic plaques. For example, matrix metalloproteinases produced by macrop...

journal_title：Cytokine

authors： Ashlin TG,Kwan AP,Ramji DP

更新日期：2013-10-01 00:00:00

abstract：:The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m(2); serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randoml...

journal_title：Cytokine

authors： Barker T,Rogers VE,Levy M,Templeton J,Goldfine H,Schneider ED,Dixon BM,Henriksen VT,Weaver LK

更新日期：2015-02-01 00:00:00

abstract：:The effect of epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and insulin-like growth factor-1 (IGF-1) on the cytostatic activity of tumour necrosis factor-alpha (TNF-alpha) was studied on the breast cancer cell line, T47D. TNF-alpha completely blocked the potent growth-promoting activity of all t...

journal_title：Cytokine

authors： Pusztai L,Lewis CE,McGee JO

更新日期：1993-03-01 00:00:00

abstract：:Propofol anesthesia and sedation are known to downregulate the functions of many hematopoietic cells, such as macrophages and neutrophils, in vivo. However, the effects of propofol on secretion of the regulatory cytokine transforming growth factor β1 (TGF-β1) in vivo are unknown. In this study, the effects of propofol...

journal_title：Cytokine

authors： Li CH,Lee RP,Lin YL,Lin CS,Hsu BG,Tseng FJ,Chen YC,Liao KW,Yang FL

更新日期：2010-12-01 00:00:00

abstract：:Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC), but specific genetic variants remain unknown. Genome-wide association studies have identified rs4444235 at BMP4 as a new colorectal cancer (CRC) and colorectal adenoma (CRA) susceptibility locus in populations of European descent. Afte...

journal_title：Cytokine

authors： Zhou L,Xie J,Gu EL,Huang Y,Qu Y,Xu AP,Zhu Y,Wang H

更新日期：2015-04-01 00:00:00

abstract：:Sickle cell anemia (SCA) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-alpha) -308G>A and Interleukin 8 (IL-8) -251A>T gene polymorphisms, medical history and classical biomarkers in children with steady-...

journal_title：Cytokine

authors： Cajado C,Cerqueira BA,Couto FD,Moura-Neto JP,Vilas-Boas W,Dorea MJ,Lyra IM,Barbosa CG,Reis MG,Goncalves MS

更新日期：2011-11-01 00:00:00

abstract：CONTEXT:CTLA-4 is engaged on effector cells that may alter signal transduction and subsequently cytokine production. The transmission of longer repeats of (AT)(n) alleles of CTLA-4 is also associated with women undergoing recurrent miscarriage. The TNF-α known as an embryo-toxic cytokine is reported to be greater in pl...

journal_title：Cytokine

authors： Gupta R,Prakash S,Parveen F,Agrawal S

更新日期：2012-11-01 00:00:00

abstract：:Recently, we reported that extracellular ubiquitin functions as another agonist of CXC chemokine receptor (CXCR)4. Whereas the cognate CXCR4 ligand, stromal cell-derived factor (SDF)-1α, is also a CXCR7 agonist, ubiquitin does not bind to CXCR7. Because both ligands are present in the extracellular environment, co-act...

journal_title：Cytokine

authors： Tripathi A,Davis JD,Staren DM,Volkman BF,Majetschak M

更新日期：2014-02-01 00:00:00

abstract：:Paraquat (PQ) is a herbicide which is highly pneumotoxic by generating reactive oxygen intermediates (ROI). Pro-inflammatory cytokines, particularly IL-1 and TNF, have been implicated in some ROI-mediated pathologies, including bleomycin toxicity and ischaemia/reperfusion injury. We have studied the effect of PQ on th...

journal_title：Cytokine

authors： Bianchi M,Fantuzzi G,Bertini R,Perin L,Salmona M,Ghezzi P

更新日期：1993-09-01 00:00:00

abstract：:It has been reported that rapamycin (rap), cyclosporin A (CsA) and FK506 have immunosuppressive effect during the activation process of murine T cells. These drugs were investigated for their suppressive effect on a murine T cell line expressing intermediate (TS1 beta) or high (TS1 alpha beta) affinity IL-2R. Rap and ...

journal_title：Cytokine

authors： Rebollo A,Mérida I,Gómez J,Pitton C,Silva A,Martínez C,García A

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Endothelial injury is recognized to trigger organ failures during the first 48h of septic shock. We evaluate endothelial biomarkers at ICU admission in their ability to predict severity, outcome, and organ failures in septic shock patients. METHODS:This prospective observational pilot study was conducted in...

journal_title：Cytokine

authors： Palud A,Parmentier-Decrucq E,Pastre J,De Freitas Caires N,Lassalle P,Mathieu D

更新日期：2015-06-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1) can induce expression of the protective heat shock proteins (hsps) in cardiac cells. We show here that, unlike the stress induced accumulation of hsps, the effect of CT-1 is not accompanied by increased hsp mRNA levels and is insensitive to the RNA synthesis inhibitor actinomycin D, suggesting t...

journal_title：Cytokine

authors： Railson J,Lawrence K,Stephanou A,Brar B,Pennica D,Latchman D

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:The effects of LDL-apheresis (LDLa) with dextran sulphate on plasma cytokines in 6 homozygous familial hypercholesterolemic (HozFH) patients, were evaluated. METHODS:Plasma IL-1α; IL-1ra; IL-4; IL-6; IL-10; IL-12(p40); IL-12(p70); TNF-α, sTNF-R, VEGF, VEGF-R1, E-Selectin (ESEL), and P-Selectin (PSEL) concent...

journal_title：Cytokine

authors： Stefanutti C,Vivenzio A,Di Giacomo S,Ferraro PM

更新日期：2011-08-01 00:00:00

abstract：:Data exist linking elevated epithelial neutrophil activating peptide (ENA-78) concentrations with myriad inflammatory conditions. ENA-78 is encoded by the CXCL5 gene which has recently been shown to be polymorphic in nature (rs352046 and rs425535). No functional data on these polymorphisms exist. We investigated wheth...

journal_title：Cytokine

authors： Zineh I,Aquilante CL,Langaee TY,Beitelshees AL,Arant CB,Wessel TR,Schofield RS

更新日期：2006-03-07 00:00:00

abstract：OBJECTIVE:This study evaluates the potential of gingival crevicular fluid and serum cytokines as HIV stage biomarkers. METHODS:Gingival crevicular fluid (GCF) and serum samples from 78 HIV-positive adult male subjects (cases) and 39 HIV-negative male subjects (controls) from Mexico were examined for 17 cytokines using...

journal_title：Cytokine

authors： Elizondo JE,Rocha-Pizaña MD,Treviño AC,Violant D,Álvarez MM,Rivas-Estilla AM

更新日期：2017-03-01 00:00:00

abstract：:Fifty-five adult patients with primary bone tumour, 27 benign and 28 malignant tumours, were assayed for leukaemia inhibitory factor (LIF) in urine and serum samples. Supernatant was obtained from primary tumour tissue cultures in 24 cases (14 benign, 10 malignant tumours). LIF was found in 11 urine samples (16.7%, 1 ...

journal_title：Cytokine

authors： Gouin F,Heymann D,Raher S,De Groote D,Passuti N,Daculsi G,Godard A

更新日期：1998-02-01 00:00:00

abstract：:Although physical therapy has been shown to be an effective method for treatment of rheumatoid arthritis, a thorough investigation on the impact of mechanical signals upon the complex cytokine network associated with pathogenesis has not yet been conducted. In the current study, our research group investigated the eff...

journal_title：Cytokine

authors： Bader RA,Wagoner KL

更新日期：2010-07-01 00:00:00

abstract：:The TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) superfamily that has been recognized for its specific pro-apoptotic effect on cancer cells and has been therefore proposed as a treatment in cancer. Studies on animal models have shown that TRAIL could also have a benefici...

journal_title：Cytokine

authors： Audo R,Combe B,Hahne M,Morel J

更新日期：2013-08-01 00:00:00

abstract：:Candida albicans is an opportunistic fungal pathogen that colonizes human gastro-intestinal mucosal tissues. Its effect on the immune response in intestinal epithelial cells and on the intestinal mucosal barrier are not yet fully understood. In this study, we investigated Caco-2 cells, a monolayer model of intestinal ...

journal_title：Cytokine

authors： Mao X,Qiu X,Jiao C,Lu M,Zhao X,Li X,Li J,Ma J,Zhang H

更新日期：2020-02-01 00:00:00

abstract：:MERS-CoV, a highly pathogenic virus in humans, is associated with high morbidity and case fatality. Inflammatory responses have a significant impact on MERS-CoV pathogenesis and disease outcome. However, CD4+ T-cell induced immune responses during acute MERS-CoV infection are barely detectable, with potent inhibition ...

journal_title：Cytokine

authors： Alosaimi B,Hamed ME,Naeem A,Alsharef AA,AlQahtani SY,AlDosari KM,Alamri AA,Al-Eisa K,Khojah T,Assiri AM,Enani MA

更新日期：2020-02-01 00:00:00

abstract：:Angiopoietin-like proteins (ANGPTL) are responsible for inhibiting lipoprotein lipase activity, and ANGPTL3 and ANGPTL4 deficiencies have been shown to lower lipoprotein levels in animal models and in humans carrying loss-of-function mutations. Sickle cell anemia (SCA) is a hereditary hemolytic anemia characterized by...

journal_title：Cytokine

authors： Vendrame F,Olops L,Saad STO,Costa FF,Fertrin KY

更新日期：2019-08-01 00:00:00

abstract：:The N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP), a unique cytokine present in human granulocytes, was determined to be: Pyroglu-Leu-Lys-X-Tyr-Thr-X-Lys-Glu-Pro-Met-Thr-Ser(Thr)-Ala-Ala... This sequence showed no significant homology with any other protein when used in database searches...

journal_title：Cytokine

authors： Ridge RJ,Sloane NH

更新日期：1996-01-01 00:00:00