Relationship between interleukin-17A and isolated coronary ectasia.

Abstract:

:The aim of this study was to evaluate serum interleukin (IL)-17A levels in patients with coronary artery ectasia (CAE), the relationship between IL and 17A and CAE, and to determine the relationship between the severity of coronary ectasia and the level of IL-17A. In total, 41 patients (19 female and 22 male) with ischemic symptoms whose non-invasive cardiac tests were positive for myocardial ischemia, and in whom coronary artery ectasia were detected after coronary angiography, and 45 patients (32 female and 13 male) with normal coronary arteries were included in this study. Echocardiographic assessments were performed. Serum IL-17A levels of all patients were evaluated using an enzyme-linked immunosorbent assay. IL-17A levels of the group with isolated coronary artery ectasia were significantly higher compared with the control group (4.86 ± 3.24 and 1.37 ± 1.56 ng/ml, respectively; p < 0.001). There was no correlation between the levels of IL-17A and the extension of the CAE, but IL-17A levels were high in both groups. CAE patients have significantly increased levels of IL-17A, fibrinogen, and RDW compared to patients with normal coronary arteries. It was demonstrated that increased levels of IL-17A were associated with ectasia formation in CAE patients.

journal_name

Cytokine

journal_title

Cytokine

authors

Uygun T,Demir B,Tosun V,Ungan İ,Kural A,Çiftçi R,Fatullayev F

doi

10.1016/j.cyto.2018.11.015

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

84-88

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(18)30429-0

journal_volume

115

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Decreased CD4+CD8low T cells in early HIV infection are associated with rapid disease progression.

    abstract:BACKGROUND:HIV rapid progressors (RPs) present with a rapid decline of CD4+ T cells within a few years of infection. Determining the underlying mechanisms throughout this decline is important to identify prognostic biomarkers and intervention strategies. Determining the numbers of CD4+ and CD8+ T cells is essential for...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2019.154801

    authors: Ding ZD,Zheng JF,Song CB,Fu YJ,Xu JJ,Jiang YJ,Shang H,Zhang ZN

    更新日期:2020-01-01 00:00:00

  • Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy.

    abstract::Staphylococcus aureus is one of the versatile Gram positive bacteria causing a range of diseases. Upon challenge, host immune cells recognize S. aureus and mount diverse immune responses including production of pro-inflammatory cytokines such as IL-1β and TNF-α. These cytokines are important mediators of inflammation ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2016.03.007

    authors: Javed N,Xue G,Lu A,Xing Y,Iwakura Y,Xiao H,Lecoeur H,Späth GF,Meng G

    更新日期:2016-05-01 00:00:00

  • Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin.

    abstract::Although tumor necrosis factor (TNF) and interleukin 6 (IL 6) are purported to be important mediators of inflammatory responses following trauma, it is not known if the serum levels of these cytokines are altered by simple hemorrhage. The objective of this study therefore was to determine whether or not: 1) there is a...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/1043-4666(90)90012-i

    authors: Ayala A,Perrin MM,Meldrum DR,Ertel W,Chaudry IH

    更新日期:1990-05-01 00:00:00

  • Erythroid differentiation regulator (EDR), a novel, highly conserved factor I. Induction of haemoglobin synthesis in erythroleukaemic cells.

    abstract::In serum-free WEHI-3 supernatants an activity was detected inducing haemoglobin synthesis in human and murine erythroleukaemia cell lines. The absolute numbers of benzidine-positive cells induced with either DMSO or WEHI-3-conditioned medium were comparable. Terminal differentiation was not observed. An expression lib...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2004.02.005

    authors: Dörmer P,Spitzer E,Frankenberger M,Kremmer E

    更新日期:2004-06-21 00:00:00

  • Potential gingival crevicular fluid and serum biomarkers by stage of HIV infection.

    abstract:OBJECTIVE:This study evaluates the potential of gingival crevicular fluid and serum cytokines as HIV stage biomarkers. METHODS:Gingival crevicular fluid (GCF) and serum samples from 78 HIV-positive adult male subjects (cases) and 39 HIV-negative male subjects (controls) from Mexico were examined for 17 cytokines using...

    journal_title:Cytokine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.cyto.2016.12.019

    authors: Elizondo JE,Rocha-Pizaña MD,Treviño AC,Violant D,Álvarez MM,Rivas-Estilla AM

    更新日期:2017-03-01 00:00:00

  • Effects of selective H.E.L.P. LDL-apheresis on plasma inflammatory markers concentration in severe dyslipidemia: Implication for anti-inflammatory response.

    abstract::Therapeutic plasmapheresis is a recognized medical procedure in which various techniques are used to separate and remove undesirable or excessively elevated plasma elements from blood. The main purpose of the procedure is to remove the substances responsible for the disease (autoantibodies, circulating immune complexe...

    journal_title:Cytokine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cyto.2011.08.038

    authors: Zenti MG,Stefanutti C

    更新日期:2011-12-01 00:00:00

  • Interleukin-10 controls human peripheral PMN activation triggered by lipopolysaccharide.

    abstract::Large amounts of anti-inflammatory mediators, such as interleukin (IL)-10, are produced and found early in the course of sepsis. We explore the role of IL-10 on neutrophil (PMN) activation/function using an in vitro model. Isolated human PMN were pre-incubated with lipopolysaccharide (LPS) and/or IL-10 for 18h. Subseq...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2013.03.025

    authors: Martire-Greco D,Rodriguez-Rodrigues N,Landoni VI,Rearte B,Isturiz MA,Fernández GC

    更新日期:2013-06-01 00:00:00

  • Expression of biologically active recombinant equine interferon-gamma by two different baculovirus gene expression systems using insect cells and silkworm larvae.

    abstract::The full-length equine interferon-gamma (eIFN-gamma) cDNA, including the secretion signal peptide coding region, was recloned into baculovirus transfer vector pAcYM1. This vector was co-transfected with Autographa californica nuclear polyhedrosis virus DNA or hybrid nuclear polyhedrosis virus DNA into Spodoptera frugi...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.2002.1983

    authors: Wu D,Murakami K,Liu N,Inoshima Y,Yokoyama T,Kokuho T,Inumaru S,Matsumura T,Kondo T,Nakano K,Sentsui H

    更新日期:2002-10-21 00:00:00

  • Kidney and splanchnic handling of interleukin-6 in humans.

    abstract::Chronic elevation of circulating Interleukin-6 (IL-6) is observed in elderly individuals as well as in several illnesses, including chronic kidney diseases. A number of cells and tissues possess the ability to metabolize significant amounts of IL-6 in vitro. However, information on signals and mechanisms by which IL-6...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2007.02.015

    authors: Garibotto G,Sofia A,Balbi M,Procopio V,Villaggio B,Tarroni A,Di Martino M,Cappelli V,Gandolfo MT,Valli A,Verzola D

    更新日期:2007-01-01 00:00:00

  • Nutritional effects on NF-kappaB/IkappaB activity in weight-gaining and -losing rats.

    abstract:BACKGROUND:We had previously reported metabolic abnormalities in TNF-treated weight-gaining (WG) rats, associated with increased soluble and membrane TNF receptors. OBJECTIVE:On the basis of these findings, we hypothesized that stabilization of TNF in circulation in WG animals by these receptors augmented the action o...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/s1043-4666(03)00105-4

    authors: Raina N,Jeejeebhoy KN

    更新日期:2003-06-21 00:00:00

  • Dissimilar cytokine patterns in different human liver and colon cancer cell lines.

    abstract::An accurate and simultaneous estimate of cellular levels of a large cytokine number is very useful to obtain information about an organ dysfunction leading to cancer because through the understanding of the evolution of cytokine patterns we can recognize and predict the disease progression. Cancer cell lines are commo...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2013.09.002

    authors: Guerriero E,Capone F,Rusolo F,Colonna G,Castello G,Costantini S

    更新日期:2013-11-01 00:00:00

  • Marked cell-type-specific differences in glycosylation of human interleukin-6.

    abstract::Human interleukin-6 (IL-6) secreted by cytokine- or endotoxin-induced fibroblasts, monocytes, keratinocytes, endometrial stromal cells, and endothelial cells, when analyzed under denaturing and reducing conditions, consists of a set of differentially modified phosphoglycoproteins of molecular mass in the range from 23...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/1043-4666(91)90018-9

    authors: May LT,Shaw JE,Khanna AK,Zabriskie JB,Sehgal PB

    更新日期:1991-05-01 00:00:00

  • Elevated circulating osteoprotegerin and reduced matrix-metalloprotease-9 in post-menopausal women with chronic Hepatitis C virus infection.

    abstract::The failure of the immune response to clear the Hepatitis C virus (HCV) results in chronic inflammation that leads to liver cirrhosis. In general, women have a better prognosis than men and this may be associated with increased levels of anti-inflammatory mediators that are positively regulated by female sex hormones....

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2012.07.006

    authors: Nanda KS,Brady JJ,Murray BF,Sullivan O,Fearon U,McKenna MJ,Hegarty JE,O'Farrelly C,Ryan EJ

    更新日期:2012-11-01 00:00:00

  • Glutathione depletion inhibits IL-1 beta-stimulated nitric oxide production by reducing inducible nitric oxide synthase gene expression.

    abstract::L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. The thiol depletor diethyl maleate (DEM) and an inhibi...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.2000.0712

    authors: Nikulina MA,Andersen HU,Karlsen AE,Darville MI,Eizirik DL,Mandrup-Poulsen T

    更新日期:2000-09-01 00:00:00

  • IL-4, but not IL-13, modulates TARC (thymus and activation-regulated chemokine)/CCL17 and IP-10 (interferon-induced protein of 10kDA)/CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line.

    abstract::It is known that both interleukin-4 (IL-4) and IL-13 are produced by Th2-type cells and share similar biological functions with each other. However, recently accumulated evidences have revealed that IL-4 may be involved in the Th1-type response. Both thymus and activation-regulated chemokine (TARC/CCL17), a ligand for...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.2002.1965

    authors: Kakinuma T,Nakamura K,Wakugawa M,Yano S,Saeki H,Torii H,Komine M,Asahina A,Tamaki K

    更新日期:2002-10-07 00:00:00

  • Neutrophil microparticles modulate cytokine production by natural killer cells.

    abstract::Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α bu...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2013.11.010

    authors: Pliyev BK,Kalintseva MV,Abdulaeva SV,Yarygin KN,Savchenko VG

    更新日期:2014-02-01 00:00:00

  • Palmitate-induced IL6 expression ameliorated by chicoric acid through AMPK and SIRT1-mediated pathway in the PBMCs of newly diagnosed type 2 diabetes patients and healthy subjects.

    abstract::Inhibition of inflammation is one of the possible therapeutic approaches for Insulin resistance (IR) during type 2 diabetes mellitus (T2DM). In the current study we investigated the effects of palmitate and chicoric acid (CA) on inflammation in peripheral blood mononuclear cells (PBMCs) of newly diagnosed T2DM patient...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2018.12.012

    authors: Sadeghabadi ZA,Ziamajidi N,Abbasalipourkabir R,Mohseni R,Borzouei S

    更新日期:2019-04-01 00:00:00

  • Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs).

    abstract::The Toll like receptors (TLRs) and the type I interferons have critical roles to play in innate immunity. In this review we will discuss new developments relating to the important area of TLR/IFN cross regulation. ...

    journal_title:Cytokine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cyto.2015.03.001

    authors: Perkins DJ,Vogel SN

    更新日期:2015-08-01 00:00:00

  • Retinal pigment epithelium-secretome: A diabetic retinopathy perspective.

    abstract::Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE i...

    journal_title:Cytokine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cyto.2017.02.013

    authors: Ponnalagu M,Subramani M,Jayadev C,Shetty R,Das D

    更新日期:2017-07-01 00:00:00

  • Increased fibrinogen synthesis in mice during the acute phase response: co-operative interaction of interleukin 1, interleukin 6, and interleukin 1 receptor antagonist.

    abstract::Interleukin 6 (IL-6) stimulates fibrinogen (Fg) gene expression both in vivo and in vitro; while interleukin 1 (IL-1) paradoxically stimulates in vivo, yet inhibits in vitro, Fg synthesis. The naturally occurring interleukin 1 receptor antagonist (IL-1ra) and passive immunization with anti-IL-6 antiserum were used to ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/1043-4666(93)90035-4

    authors: Rokita H,Neta R,Sipe JD

    更新日期:1993-09-01 00:00:00

  • Molecular cloning and functional characterization of Cynomolgus monkey (Macaca fascicularis) CC chemokine receptor, CCR3.

    abstract::We have cloned and performed the first functional characterization of the chemokine receptor, CCR3, of Cynomolgus monkey (Macaca fascicularis). The deduced amino acid sequence of the cloned Cynomolgus CCR3 was found to be more similar to that of a previously-reported Rhesus (Macaca mulatta) CCR3 (99.4%) than that of a...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.2002.1971

    authors: Iino T,Sugimoto H,Watanabe A,Encinas JA,Liu N,Floeckner J,Bacon KB

    更新日期:2002-09-21 00:00:00

  • Longitudinal analysis of serum interleukin-18 in patients with familial Mediterranean fever carrying MEFV mutations in exon 10.

    abstract:BACKGROUND:Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene. Mutations in exon 10 are associated with typical FMF phenotypes, and patients with exon 10 mutations have higher serum levels of interleukin (IL)-18 both during attacks and afebrile phases, compared to tho...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2017.10.007

    authors: Wada T,Toma T,Miyazawa H,Koizumi E,Shirahashi T,Matsuda Y,Yachie A

    更新日期:2018-04-01 00:00:00

  • Urine epidermal growth factor, monocyte chemoattractant protein-1 or their ratio as predictors of complete remission in primary glomerulonephritis.

    abstract:BACKGROUND:The balance of several cytokines likely influences the resolution of glomerulonephritis. Monocyte chemoattractant protein-1(MCP-1) is a chemokine that promotes renal inflammation whereas epidermal growth factor (EGF) stimulates protective responses. Previously, high urine MCP-1(MCP-1) and low urine EGF (EGF)...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2018.01.015

    authors: Chanrat E,Worawichawong S,Radinahamed P,Sathirapongsasuti N,Nongnuch A,Assanatham M,Udomsubpayakul U,Kitiyakara C

    更新日期:2018-04-01 00:00:00

  • A human cell line isolated from fetal kidney produces an apparently erythroid-specific stimulating activity.

    abstract::The burst formation from human and murine burst forming unit-erythroid (BFU-E) requires the presence of erythropoietin (Epo) in semi-solid cultures of bone marrow cells. A number of haematopoietic factors are described that increase the burst number: interleukin 3 (IL-3), stem cell factor (SCF), granulocyte-macrophage...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1998.0335

    authors: Rodriguez MH,Arnaud S,Geay T,Mouchiroud G,Grasset MF,Blanchet JP

    更新日期:1998-08-01 00:00:00

  • Cytokines modulate endothelial cell intracellular signal transduction required for VCAM-1-dependent lymphocyte transendothelial migration.

    abstract::Vascular cell adhesion molecule-1 (VCAM-1) activates endothelial cell NADPH oxidase which catalyzes production of reactive oxygen species (ROS). This activity is required for VCAM-1-dependent lymphocyte migration. The focus of our study was to determine whether these VCAM-1-dependent functions are modulated by cytokin...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.2001.0922

    authors: Tudor KS,Hess KL,Cook-Mills JM

    更新日期:2001-08-21 00:00:00

  • Impaired production of IL-12 in systemic lupus erythematosus. III: deficient IL-12 p40 gene expression and cross-regulation of IL-12, IL-10 and IFN-gamma gene expression.

    abstract::Interleukin 12 (IL-12) is a heterodimer comprising p35 and p40 subunits which are encoded and regulated separately. The authors previously demonstrated deficient IL-12 production in SLE which correlates negatively with disease activity. The present study was designed to determine whether deficiency of IL-12 and excess...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1999.0512

    authors: Liu TF,Jones BM,Wong RW,Srivastava G

    更新日期:1999-10-01 00:00:00

  • Interferon alpha induces generation of semi-mature dendritic cells with high pro-inflammatory and cytotoxic potential.

    abstract::Dendritic cell-based vaccines are considered as a new and promising immunotherapeutic approach for cancer treatment. However, the choice of optimal protocol of dendritic cell generation in vitro represents the major challenge. Here, we compared phenotype and functional characteristics of human monocyte-derived dendrit...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2014.07.258

    authors: Leplina OY,Tyrinova TV,Tikhonova MA,Ostanin AA,Chernykh ER

    更新日期:2015-01-01 00:00:00

  • Disruption of thrombo-inflammatory response and activation of a distinct cytokine cluster after subarachnoid hemorrhage.

    abstract:BACKGROUND:Unregulated inflammatory and thrombotic responses have been proposed to be important causes of early brain injury and worse clinical outcomes after subarachnoid hemorrhage (SAH). OBJECTIVE:We hypothesize that SAH is characterized by an increased inflammatory and thrombotic state and disruption of associatio...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2018.09.003

    authors: Savarraj JP,McGuire MF,Parsha K,Hergenroeder G,Bajgur S,Ahn S,Zhu L,Espino E,Chang T,Blackburn S,Kim DH,Dash P,Choi HA

    更新日期:2018-11-01 00:00:00

  • Cytokine dependent and independent iNKT cell activation.

    abstract::Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold. iNKT cells have the ability to respond as innate immune cel...

    journal_title:Cytokine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cyto.2010.04.016

    authors: Reilly EC,Wands JR,Brossay L

    更新日期:2010-09-01 00:00:00

  • Quercetin 3-O-beta-(2''-galloyl)-glucopyranoside inhibits endotoxin LPS-induced IL-6 expression and NF-kappa B activation in macrophages.

    abstract::We previously isolated quercetin 3-O-beta-(2''-galloyl)-glucopyranoside (QG-32) from Persicaria lapathifolia (Polygonacease) as an inhibitor of superoxide production. In the present study, QG-32 was found to inhibit interleukin (IL)-6 production in endotoxin lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. T...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2007.08.002

    authors: Kim BH,Lee IJ,Lee HY,Han SB,Hong JT,Ahn B,Lee CK,Kim Y

    更新日期:2007-09-01 00:00:00