当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > Potentiation of Fas- and TRAIL-mediated apoptosis by IFN-gamma in A549 lung epithelial cells: enhancement of caspase-8 expression through IFN-response element.

Potentiation of Fas- and TRAIL-mediated apoptosis by IFN-gamma in A549 lung epithelial cells: enhancement of caspase-8 expression through IFN-response element.

Abstract：

:Epithelial cell apoptosis triggered cooperatively by multiple cytokines contributes to the injury induced by inflammatory responses in the lung and elsewhere. Here we show that interferon-gamma (IFN-gamma) sensitizes A549 cells, human lung epithelial cells, to cytokine-mediated apoptosis by upregulating caspase-8 expression. Pretreating the cells with IFN-gamma potentiated Fas- and TNF-related apoptosis inducing ligand (TRAIL)-induced cell death, but other forms of apoptosis, not mediated via receptors, were unaffected. Western blotting and inhibitor assays showed that IFN-gamma selectively increased expression of caspases-7 and -8, but not caspases-2, -3, -9, or -10, as a necessary step leading to apoptosis. Assaying promoter activity using a luciferase reporter gene indicated that an IFN-gamma response element was located in the 5'-flanking region of the caspase-8 gene, spanning positions -227 to -219. Taken together, these findings suggest that IFN-gamma potentiates Fas- and TRAIL-mediated apoptosis by increasing caspase-8 expression via an IFN-gamma response element in A549 cells.

journal_name

Cytokine

journal_title

Cytokine

authors

Kim KB,Choi YH,Kim IK,Chung CW,Kim BJ,Park YM,Jung YK

doi

10.1006/cyto.2003.2008

keywords:

subject

Has Abstract

pub_date

2002-12-21 00:00:00

pages

283-8

issue

6

eissn

1043-4666

issn

1096-0023

pii

S1043466603920084

journal_volume

20

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Coexpression of oncostatin M and its receptors and evidence for STAT3 activation in human ovarian carcinomas.

    abstract：:The expression of oncostatin M and leukemia inhibitory factor (LIF), JAK-STAT activators and members of the interleukin-6 family of cytokines, were examined in a series of primary ovarian carcinomas using immunohistochemistry. The malignant epithelial cells of all 29 ovarian carcinomas examined expressed oncostatin M;...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.1022

    authors： Savarese TM,Campbell CL,McQuain C,Mitchell K,Guardiani R,Quesenberry PJ,Nelson BE

    更新日期：2002-03-21 00:00:00

  • TNF receptor fusion proteins are effective inhibitors of TNF-mediated cytotoxicity on human KYM-1D4 rhabdomyosarcoma cells.

    abstract：:KYM-1D4 cells are a subline derived from a human rhabdomyosarcoma which are highly sensitive to TNF-mediated cytotoxicity. They were selected for this study because they express human TNF-R and are therefore a more relevant target for comparing the potential therapeutic value of human TNF-inhibitory agents than the us...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(94)90049-3

    authors： Butler DM,Scallon B,Meager A,Kissonerghis M,Corcoran A,Chernajovsky Y,Feldmann M,Ghrayeb J,Brennan FM

    更新日期：1994-11-01 00:00:00

  • A novel cytokine profile associated with cancer metastasis to mediastinal and hilar lymph nodes identified using fine needle aspiration biopsy - A pilot study.

    abstract：:Cancer metastasis to the lymph nodes is indicative of a poor prognosis. An endobronchial ultrasound-guided fine needle aspiration (EBUS-FNA) biopsy is increasingly being used to sample paratracheal lymph nodes for simultaneous cancer diagnosis and staging. In this prospective, single-center study, we collected dedicat...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.cyto.2016.08.011

    authors： Saeed AI,Qeadan F,Sood A,VanderJagt DJ,Mishra SI,Hill DA,Peikert T,Sopori ML

    更新日期：2017-01-01 00:00:00

  • Up-regulation of cell surface Toll-like receptors on circulating gammadelta T-cells following burn injury.

    abstract：:Burn injury is associated with profound inflammation and activation of the innate immune system involving gammadelta T-cells. Similarly, Toll-like receptors (TLR) are associated with activation of the innate immune response; however, it is unclear whether TLR expression is altered in gammadelta T-cells after major bur...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.09.001

    authors： Schwacha MG,Daniel T

    更新日期：2008-12-01 00:00:00

  • Galectin-3 is a sensor-regulator of toll-like receptor pathways in synovial fibroblasts.

    abstract：:Galectin-3 is a β-galactoside-binding lectin that plays an important role in the modulation of immune responses. It has been shown to aggravate joint inflammation and destruction in experimental arthritis. We investigated the role of galectin-3 in TLR-induced cell activation in human synovial fibroblasts (SF) in order...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.01.016

    authors： Arad U,Madar-Balakirski N,Angel-Korman A,Amir S,Tzadok S,Segal O,Menachem A,Gold A,Elkayam O,Caspi D

    更新日期：2015-05-01 00:00:00

  • Interleukin 35 (IL-35) and IL-37: Intestinal and peripheral expression by T and B regulatory cells in patients with Inflammatory Bowel Disease.

    abstract：:The aim of the study was to characterize and to quantify peripheral and tissue. IL-35- and IL-37-producing cells in Inflammatory Bowel Disease (IBD) patients. We studied a total of 38 active UC, 31 inactive UC, 17 active CD, and 13 inactive CD and 50 non-inflamed tissues as control group. Gene expression was measured ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.04.009

    authors： Fonseca-Camarillo G,Furuzawa-Carballeda J,Yamamoto-Furusho JK

    更新日期：2015-10-01 00:00:00

  • CCR1/CCL5 interaction promotes invasion of taxane-resistant PC3 prostate cancer cells by increasing secretion of MMPs 2/9 and by activating ERK and Rac signaling.

    abstract：:Castration-refractory prostate cancer (CRPC) is treated with taxane-based chemotherapy, but eventually becomes drug resistant. It is thus essential to identify novel therapeutic targets for taxane resistance in CRPC patients. We investigated the role of the chemokine (C-C motif) receptor 1 (CCR1) and its ligand, chemo...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.06.313

    authors： Kato T,Fujita Y,Nakane K,Mizutani K,Terazawa R,Ehara H,Kanimoto Y,Kojima T,Nozawa Y,Deguchi T,Ito M

    更新日期：2013-10-01 00:00:00

  • IL-12 induction of resistance to pulmonary blastomycosis.

    abstract：BACKGROUND:Why severity varies in blastomycosis outbreaks remains unresolved. In experimental pulmonary blastomycosis, susceptibility varied in mouse strains. In susceptible BALB/c the response is Th-2, in immunized, resistance is associated with Th-1. Can susceptibility be redirected by IL-12? Methods, results: BALB/c...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.08.004

    authors： Brummer E,Vinoda V,Stevens DA

    更新日期：2006-09-01 00:00:00

  • Interleukin-6 induced activation of a non-selective outward cation conductance in human cardiac fibroblasts.

    abstract：BACKGROUND:It has been demonstrated that cardiac fibroblasts of the human heart have several myocyte-like features, induced by inflammation. OBJECTIVES:This study analyzed the changes of the expressed currents in the basal condition and in the presence of interleukin-6 in cultured human cardiac fibroblasts. METHODS:H...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.06.004

    authors： Mitrokhin V,Kazanski V,Kalsin V,Mladenov M,Kamkin A

    更新日期：2017-09-01 00:00:00

  • The mediating role of the visceral fat area in the correlation between the serum osteocalcin levels and a prolonged QTc interval.

    abstract：AIMS:Osteocalcin, a bone-derived factor, could be a feasible marker for metabolic disorders and adverse cardiovascular outcomes. This study aimed to explore the correlation between serum osteocalcin levels and correct QT interval (QTc) interval prolongation, a risk factor of cardiac morbidity and mortality. METHODS:We...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155261

    authors： Xu Y,Wang Y,Ma X,Xiao Y,Wang Y,Bao Y

    更新日期：2020-12-01 00:00:00

  • Implication of STAT1 and STAT3 transcription factors in the response to superantigens.

    abstract：:The activation of STAT1 and STAT3 in response to SEB was analyzed in spleen of Balb/c mice. The intraperitoneal injection of the superantigen SEB activated STAT1 and STAT3 in spleen. Activated STAT1 almost completely disappeared in 24 h even though activated STAT3 was present for more than 48 h after SEB injection. Cy...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2003.09.006

    authors： Plaza R,Vidal S,Rodriguez-Sanchez JL,Juarez C

    更新日期：2004-01-07 00:00:00

  • Human skeletal muscle releases leptin in vivo.

    abstract：:Leptin is considered an adipokine, however, cultured myocytes have also been found to release leptin. Therefore, as proof-of-concept we investigated if human skeletal muscle synthesized leptin by measuring leptin in skeletal muscle biopsies. Following this, we quantified human skeletal muscle and adipose tissue leptin...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.08.021

    authors： Wolsk E,Mygind H,Grøndahl TS,Pedersen BK,van Hall G

    更新日期：2012-12-01 00:00:00

  • Cytokine dependent and independent iNKT cell activation.

    abstract：:Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold. iNKT cells have the ability to respond as innate immune cel...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2010.04.016

    authors： Reilly EC,Wands JR,Brossay L

    更新日期：2010-09-01 00:00:00

  • Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo.

    abstract：:Three molecules, interleukin 1 (IL-1) receptor I (IL-1RI), IL-1 receptor II (IL-1RII or decoy) and IL-1 receptor accessory protein (IL-1R AcP or IL-1RIII), are involved in IL-1 binding and signal transduction. In addition, three homologous genes (T1/ST2, MyD88 and rsc786) have been identified. Expression of the signal...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1998.0359

    authors： Saccani S,Polentarutti N,Penton-Rol G,Sims JE,Mantovani A

    更新日期：1998-10-01 00:00:00

  • Physiological effects of CNTF-induced wasting.

    abstract：:The authors have shown previously that in addition to its survival effects on neurons and glia, ciliary neurotrophic factor (CNTF) induced potent cachectic effects and acute phase proteins when present in the peripheral circulation at concentrations of < or = 10 ng/ml. These effects did not depend upon the induction o...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0104

    authors： Henderson JT,Mullen BJ,Roder JC

    更新日期：1996-10-01 00:00:00

  • The local liver ablation with pulsed electric field stimulate systemic immune reaction against hepatocellular carcinoma (HCC) with time-dependent cytokine profile.

    abstract：AIM:How irreversible electroporation (IRE) affect immune status is still kept unknown. This preclinical study is to investigate its local and systemic immune reaction both on tumor-bearing and tumor free animals. METHODS:Liver ablation was performed by a standard IRE instrument and proposal. Altogether 57 tumor bearin...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.05.003

    authors： Chen X,Ren Z,Yin S,Xu Y,Guo D,Xie H,Zhou L,Wu L,Jiang J,Li H,Sun J,Zheng S

    更新日期：2017-05-01 00:00:00

  • Tumor necrosis factor-α and interleukin-1β gene polymorphisms and risk of brain abscess in North Indian population.

    abstract：OBJECTIVE:Brain abscess develops in response to a parenchymal infection with pyogenic bacteria. Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are the most crucial pro-inflammatory cytokines with both beneficial and destructive properties for the central nervous system. The present study evaluated the assoc...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.07.009

    authors： Mishra P,Prasad KN,Singh K,Bajpai A,Sahu RN,Ojha BK

    更新日期：2015-09-01 00:00:00

  • Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit.

    abstract：:It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.11.010

    authors： Palumbo ML,Di Rosso ME,Simon EH,Gonzalez Murano MR,Genaro AM

    更新日期：2018-07-01 00:00:00

  • Meta-analysis of -308G > A polymorphism in TNFα gene and susceptibility to leishmaniasis.

    abstract：:The clinical spectrum of leishmaniasis depends on several factors, including Leishmania species and immunogenetic factors. Tumor necrosis factor α (TNFα) plays a central role in immunity against intracellular infections. Many studies have reported that TNFα-308G > A polymorphism is associated with susceptibility to in...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2021.155437

    authors： Ejghal R,Charoute H,Talimi H,Rhazlane S,Lemrani M

    更新日期：2021-01-24 00:00:00

  • Citrullination of TNF-α by peptidylarginine deiminases reduces its capacity to stimulate the production of inflammatory chemokines.

    abstract：:Citrullination, a posttranslational modification (PTM) recently discovered on inflammatory chemokines such as interleukin-8 (IL-8/CXCL8) and interferon-γ-inducible protein-10 (IP-10/CXCL10), seriously influences their biological activity. Citrullination or the deimination of arginine to citrulline is dependent on pept...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.09.011

    authors： Moelants EA,Mortier A,Grauwen K,Ronsse I,Van Damme J,Proost P

    更新日期：2013-01-01 00:00:00

  • Identification of two U937 cell sublines exhibiting different patterns of response to tumour necrosis factor.

    abstract：:The monocytic cell line U937 is a frequently used model in studies on the cytotoxic effect of tumour necrosis factor (TNF). Two sublines of this cell line, termed U937(G) and U937(M), revealing different patterns of response to this cytokine, have been identified. The U937(G) cells, similarly to the cells obtained fro...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0844

    authors： Kaszubowska L,Engelmann H,Gotartowska M,Iliszko M,Bigda J

    更新日期：2001-03-21 00:00:00

  • IL-10 overexpression differentially affects cartilage matrix gene expression in response to TNF-alpha in human articular chondrocytes in vitro.

    abstract：:Cartilage-specific extracellular matrix synthesis is the prerequisite for chondrocyte survival and cartilage function, but is affected by the pro-inflammatory cytokine TNF-alpha in arthritis. The aim of the present study was to characterize whether the immunoregulatory cytokine IL-10 might modulate cartilage matrix an...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.10.012

    authors： Müller RD,John T,Kohl B,Oberholzer A,Gust T,Hostmann A,Hellmuth M,Laface D,Hutchins B,Laube G,Veh RW,Tschoeke SK,Ertel W,Schulze-Tanzil G

    更新日期：2008-12-01 00:00:00

  • Preferential production of IL-12 by peritoneal macrophages activated by liposomes prepared from neoglycolipids containing oligomannose residues.

    abstract：:The present study demonstrates that liposomes coated with synthesized neoglycolipids constructed from mannotriose and dipalmitoylphosphatidylethanolamine (Man3-DPPE) activate peritoneal macrophages (PEMs) to up-regulate expression of co-stimulatory molecules and preferentially secrete IL-12. Injection of Man3-DPPE-coa...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2007.10.005

    authors： Takagi H,Furuya N,Kojima N

    更新日期：2007-12-01 00:00:00

  • Low serum interleukin-6 levels as a predictive marker of recurrence in patients with hepatitis B virus related hepatocellular carcinoma who underwent curative treatment.

    abstract：BACKGROUND:We aimed to investigate the use of novel serum biomarkers for predicting the recurrence and survival of patients with hepatitis B virus (HBV)-related early hepatocellular carcinoma (HCC) after hepatic resection or radiofrequency ablation (RFA). METHODS:One hundred and five patients with HBV-related HCC, who...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.02.027

    authors： Cho HJ,Kim SS,Ahn SJ,Park SY,Park JH,Kim JK,Wang HJ,Cheong JY,Cho SW

    更新日期：2015-06-01 00:00:00

  • Differential serum cytokine responses to inactivated and live attenuated seasonal influenza vaccines.

    abstract：:Despite vaccine efforts, influenza outbreaks pose a significant threat to global public health. There are two commercially available seasonal influenza vaccines in the United States: the trivalent inactivated vaccine (TIV), delivered parenterally, and the live attenuated influenza vaccine (LAIV), delivered intranasall...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.08.004

    authors： Ramakrishnan A,Althoff KN,Lopez JA,Coles CL,Bream JH

    更新日期：2012-12-01 00:00:00

  • Effect of age and hormonal state on cytokine synthesis in the monkey.

    abstract：:The authors studied plasma cytokine activity using cross reactive polyclonal antibodies to human cytokines in young and old female monkeys to determine if age had any effect on cytokine secretion, and compared hormonal effects as well. While interleukin 1 (IL-1) was not higher in aged cycling monkeys, it was after men...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0281

    authors： Kaack MB,Harrison RM,Roberts JA

    更新日期：1998-03-01 00:00:00

  • CCR7 signaling in pediatric opsoclonus-myoclonus: upregulated serum CCL21 expression is steroid-responsive.

    abstract：:Identifying and blocking chemokine inflammatory mediators in pediatric opsoclonus-myoclonus syndrome (OMS) is critical to the treatment of this autoimmune, paraneoplastic, neurological disorder. In a prospective, case-control, clinico-scientific study of children with OMS compared to non-inflammatory neurological cont...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.05.020

    authors： Pranzatelli MR,Tate ED,McGee NR,Ransohoff RM

    更新日期：2013-10-01 00:00:00

  • Common genetic variant on BMP4 contributes to colorectal adenoma and cancer: A meta-analysis based on 15 studies.

    abstract：:Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC), but specific genetic variants remain unknown. Genome-wide association studies have identified rs4444235 at BMP4 as a new colorectal cancer (CRC) and colorectal adenoma (CRA) susceptibility locus in populations of European descent. Afte...

    journal_title：Cytokine

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.cyto.2014.12.021

    authors： Zhou L,Xie J,Gu EL,Huang Y,Qu Y,Xu AP,Zhu Y,Wang H

    更新日期：2015-04-01 00:00:00

  • Influence of acute alcohol intake and alcohol withdrawal on circulating levels of IL-6, IL-8, IL-10 and IL-12.

    abstract：:Cytokine balance alterations are responsible for some of the systemic and hepatic manifestations of alcoholism. The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Serum cytok...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0715

    authors： González-Quintela A,Dominguez-Santalla MJ,Pérez LF,Vidal C,Lojo S,Barrio E

    更新日期：2000-09-01 00:00:00

  • Influence of recombinant human erythropoietin on neutrophil function in premature neonates.

    abstract：:The in vivo influence of recombinant human erythropoietin (rhEpo) and iron on human neutrophil (PMN) antimicrobial function was assessed. A total of 21 preterm infants were randomized to receive either 200 U/kg/other day of rHuEPO+12 mg/kg/day of iron (EPO+high Fe, seven infants) or 200 U/kg/other day of rhEPO+4 mg/kg...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1006/cyto.1998.0393

    authors： Soubasi V,Roilides E,Tsantali C,Mussafiris K,Tsakiris D,Kremenopoulos G

    更新日期：1999-01-01 00:00:00