Abstract:
:The aim of the study was to characterize and to quantify peripheral and tissue. IL-35- and IL-37-producing cells in Inflammatory Bowel Disease (IBD) patients. We studied a total of 38 active UC, 31 inactive UC, 17 active CD, and 13 inactive CD and 50 non-inflamed tissues as control group. Gene expression was measured by real time polymerase chain reaction (RT-PCR) and protein expression was evaluated in tissue by immunohistochemistry and in peripheral blood mononuclear cells by flow cytometry. Higher levels of IL-35 was produced by intestinal regulatory B cells and circulating regulatory CD4(+) and CD8(+) T cells in active vs. inactive disease or healthy donors (P<0.05). The IL-37 was conspicuously synthesized by circulating B cells, active natural killer cells and monocytes. These results suggest that down-regulation of inflammation in active IBD patients might be based on the increased expression of IL-35 and IL-37.
journal_name
Cytokinejournal_title
Cytokineauthors
Fonseca-Camarillo G,Furuzawa-Carballeda J,Yamamoto-Furusho JKdoi
10.1016/j.cyto.2015.04.009subject
Has Abstractpub_date
2015-10-01 00:00:00pages
389-402issue
2eissn
1043-4666issn
1096-0023pii
S1043-4666(15)00160-Xjournal_volume
75pub_type
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