当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > Effects of hypothermia and re-warming on the inflammatory response in a murine multiple hit model of trauma.

Effects of hypothermia and re-warming on the inflammatory response in a murine multiple hit model of trauma.

Abstract：

INTRODUCTION:Although, hypothermia is a frequent event after trauma, it is unclear whether its beneficial or detrimental effects are more important. This study aims to quantify the effects of hypothermia and re-warming on the inflammatory response after fracture/hemorrhage and subsequent fracture stabilization with resuscitation. MATERIALS AND METHODS:Eighty-one male C57Bl/6 mice (aged 8-10 weeks, weighing 22.0+/-3.0 g) underwent femoral fracture and hemorrhage followed by resuscitation and splint fixation of the fracture. Animals were sacrificed 3h after induction of hemorrhage and fracture. Besides a sham group (n=6), four experimental groups were created: A: normothermia (n=12), B: hypothermia after trauma (n=21), C: re-warming after resuscitation and before stabilization (n=21), and D: hypothermia before trauma (n=21). Groups B-D were further subdivided into three subgroups according to the degree of hypothermia (subgroup 1: 35-33 degrees C, subgroup 2: 32.9-30.0 degrees C, and subgroup 3: 29.9-27.0 degrees C). Plasma cytokine (TNF-alpha, IL-6, and IL-10) and chemokine (MCP-1) concentrations were determined by ELISA, pulmonary permeability changes were quantified, and histological analysis of lung and liver tissues was performed. RESULTS:Normothermia resulted in a significantly increased early mortality rate. A significantly increased pro-inflammatory and decreased anti-inflammatory responses were also observed in normothermia as compared to hypothermia. The extent of these changes was most pronounced in the severe hypothermic group. Re-warming after mild hypothermia resulted in a pro-inflammatory response comparable to normothermia. CONCLUSION:Hypothermia has a beneficial effect on early survival after trauma, which appears to be independent of the level of hypothermia and re-warming. Re-warming, however, enhanced the pro-inflammatory response. Further studies with a longer posttraumatic observation period are required to investigate the long term effects of the hypothermia and re-warming-induced changes on the pro- and anti-inflammatory responses.

journal_name

Cytokine

journal_title

Cytokine

authors

Hildebrand F,van Griensven M,Giannoudis P,Luerig A,Harwood P,Harms O,Fehr M,Krettek C,Pape HC

doi

10.1016/j.cyto.2005.06.008

keywords:

subject

Has Abstract

pub_date

2005-09-07 00:00:00

pages

382-93

issue

5

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(05)00198-5

journal_volume

31

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Comparative moleculo-immunological analysis of swamp- and riverine-type water buffaloes responses.

    abstract：:This moleculo-epidemiological and immunological study through cytokine response assessment was done to know the dynamics of cytokines in the initiation, persistence and association to physiological changes of a particular pathogen in water buffaloes. This is important to understand the magnitude and behavior of diseas...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.02.006

    authors： Mingala CN,Konnai S,Cruz LC,Onuma M,Ohashi K

    更新日期：2009-05-01 00:00:00

  • The tertiary structure of γc cytokines dictates receptor sharing.

    abstract：:The γc family of cytokines comprising interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-2 is an important group of 4-helix bundle cytokines that signals through receptors incorporating the common gamma chain (γc). These cytokines are involved in lymphocyte biology and their specific functions are contingent on bind...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.01.007

    authors： Reche PA

    更新日期：2019-04-01 00:00:00

  • Mechanism of regulation of autoimmunity by iNKT cells.

    abstract：:iNKT cells, CD1d dependent natural killer T cells are a unique population of T cells. The capacity of iNKT cells to produce regulatory cytokines first provided an indication of their regulatory potential. Later on, in experimental models as well as in patients afflicted with an auto-immune disease, such as Type 1 diab...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2010.11.001

    authors： Novak J,Lehuen A

    更新日期：2011-03-01 00:00:00

  • Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers.

    abstract：:Typically, ovarian cancer remains restricted to the peritoneal cavity. Because of this unique localization, the study of ovarian cancer is particularly suitable for immune analysis and for the development of immunotherapy. Here we report that peritoneal fluid from patients with ovarian or other intra-abdominal cancers...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(92)90082-3

    authors： Gotlieb WH,Abrams JS,Watson JM,Velu TJ,Berek JS,Martínez-Maza O

    更新日期：1992-09-01 00:00:00

  • Upregulation of osteopontin expression via the interaction of macrophages and fibroblasts under IL-1b stimulation.

    abstract：BACKGROUND:Fibrosis is attributed to dysregulation of tissue-remodeling. In remodeling areas, fibroblasts and macrophages actively make contact with each other. Osteopontin (OPN) is a pro-fibrotic molecule, whose expression is upregulated by interleukin (IL)-1β via secretion of its downstream cytokines, such as IL-6. H...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.04.025

    authors： Shimodaira T,Matsuda K,Uchibori T,Sugano M,Uehara T,Honda T

    更新日期：2018-10-01 00:00:00

  • Visfatin protein may be responsible for suppression of proliferation and apoptosis in the infantile mice ovary.

    abstract：:Visfatin is an important adipokines, which are expressed in different tissues including ovary of mammals. The postnatal ovary in rodents undergoes dramatic changes of intra-ovarian factors in relation to proliferation and apoptosis. There are studies which showed that gonadal visfatin changes in postnatal life. Howeve...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2021.155422

    authors： Annie L,Gurusubramanian G,Kumar Roy V

    更新日期：2021-01-18 00:00:00

  • Low concentrations of recombinant granulocyte macrophage-colony stimulating factor derived from Chinese hamster ovary cells augments long-term bioactivity with delayed clearance in vitro.

    abstract：:To date, the biological activity of granulocyte macrophage-colony stimulating factor (GM-CSF) has been investigated by using mostly Escherichia coli- or yeast cell-derived recombinant human GM-CSF (erhGM-CSF and yrhGM-CSF, respectively). However, Chinese hamster ovary cell-derived recombinant human GM-CSF (crhGM-CSF),...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.03.009

    authors： Hashimoto A,Tanaka T,Itoh Y,Yamagata A,Kitamura N,Tazawa R,Nakagaki K,Nakata K

    更新日期：2014-08-01 00:00:00

  • Cytokine gene expression in splenic macrophages and Kupffer cells following haemorrhage.

    abstract：:TNF-alpha, IL-1, IL-6 and TGF-beta are important macrophage-derived mediators which play the pleiotropic role in inflammatory, metabolic, hematopoietic and immunologic processes. Studies have shown that haemorrhagic shock without significant tissue trauma induces profound immunosuppression which is associated with ele...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1995.1002

    authors： Zhu XL,Zellweger R,Zhu XH,Ayala A,Chaudry IH

    更新日期：1995-01-01 00:00:00

  • Distinct functions of erythropoietin and stem cell factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors.

    abstract：:Erythropoietin (EPO) and Stem Cell Factor (SCF) have partially distinct functions in erythroid cell development. The primary functions of EPO are to prevent apoptosis and promote differentiation, with a minor role as a mitogen. On the other hand SCF acts primarily as a mitogenic factor promoting erythroid cell prolife...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.10.017

    authors： Geslain R,Uddin S,Liu H,Jiang H,van Besien K,Pan T,Wickrema A

    更新日期：2013-01-01 00:00:00

  • Mitochondrial STAT3: Powering up a potent factor.

    abstract：:The JAK-STAT3 signaling pathway is engaged by many cytokines and growth factor stimuli to control diverse biological processes including proliferation, angiogenesis, survival, immune modulation, and metabolism. For over two decades it has been accepted that STAT3-dependent biology is due to its potency as a transcript...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2016.05.019

    authors： Garama DJ,White CL,Balic JJ,Gough DJ

    更新日期：2016-11-01 00:00:00

  • The G to A polymorphism at -597 of the interleukin-6 gene is extremely rare in southern Han Chinese.

    abstract：:Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH pati...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.03.006

    authors： Gao SP,Pan M,Chen C,Ge LJ,Jiang MH,Luan H,Zheng JG,Deng XT,Pan HY,Zhu JH

    更新日期：2011-07-01 00:00:00

  • Altered plasma levels of βC and γC chain cytokines and post-treatment modulation in tuberculous lymphadenitis.

    abstract：BACKGROUND:Alterations in β common (βC) and γ common (γC) chain cytokines have been described in pulmonary tuberculosis. However, their role in tuberculous lymphadenitis (TBL) disease has not been assessed. METHODS:Thus, in the present study, we have examined the systemic levels of βC and γC chain cytokines in TBL, la...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155405

    authors： Kathamuthu GR,Moideen K,Sridhar R,Baskaran D,Babu S

    更新日期：2021-02-01 00:00:00

  • D-dopachrome tautomerase (D-DT or MIF-2): doubling the MIF cytokine family.

    abstract：:D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily. MIF is a broadly expressed pro-inflammatory cytokine that regulates both the innate and the adaptive immune response. MIF activates the MAP kinase cascade, modulates cell ...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2012.03.014

    authors： Merk M,Mitchell RA,Endres S,Bucala R

    更新日期：2012-07-01 00:00:00

  • Constitutive expression of IL-6-LIKE cytokines in normal bone marrow: implications for pathophysiology of myeloma.

    abstract：:Myeloma is a neoplasm thought to "home" to bone marrow. However, evidence for bone-marrow-specific receptors or adhesion molecules expressed on myeloma cells is scanty. Initial myeloma expansion is thought to be due to IL-6 and/or related cytokines. Previous determinations of cytokine expression in bone marrow were pe...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0748

    authors： Barton BE,Murphy TF

    更新日期：2000-10-01 00:00:00

  • Shark cartilage extract induces cytokines expression and release in endothelial cells and induces E-selectin, plasminogen and t-PA genes expression through an antioxidant-sensitive mechanism.

    abstract：:Neovastat® is a standardized extract of marine cartilage, an avascular tissue, which contains many biologically active molecules and has multiple antiangiogenic properties. In addition to VEGFR2 and MMPs inhibition, shark cartilage extract (SCE) has recently been shown to induce tissue plasminogen activator gene (PLAT...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.08.035

    authors： Simard B,Ratel D,Dupré I,Pautre V,Berger F

    更新日期：2013-01-01 00:00:00

  • Quantification of Interleukin-6 in cell culture medium using surface plasmon resonance biosensors.

    abstract：:Interleukin (IL)-6, a multifunctional cytokine, is widely used as an index for illnesses such as inflammatory and autoimmune disorders, coronary artery disease, neurological disease, and gestational problems. It is thus very important to be able to precisely quantify the level of IL-6 for disease diagnosis and any sub...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.04.004

    authors： Chou TH,Chuang CY,Wu CM

    更新日期：2010-07-01 00:00:00

  • Association of interleukin (IL)-4 variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms with susceptibility to pediatric autoimmune hepatitis type 1.

    abstract：OBJECTIVE:Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease mediated by an autoimmune reaction to hepatocytes, the present study aimed to assess the possible associations between interleukin-4 (IL-4) variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms and susceptibility to aut...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.01.009

    authors： Mansour AI,Behairy OG,Abd Almonaem ER,Abd-Rabuh RM,Ahmed IAE

    更新日期：2018-10-01 00:00:00

  • Association of TNF-α but not IL-1β levels with the presence of Helicobacter pylori infection increased the risk of peptic ulcer development.

    abstract：:Peptic ulcer is a lesion in the mucosa of the digestive tract affecting many people all around the world. Recent investigations have indicated that produced inflammatory cytokines such as TNF-α and IL-1β in response to gastric infection by Helicobacter pylori play an important role in the development of peptic ulcer. ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.01.003

    authors： Tourani M,Habibzadeh M,Karkhah A,Shokri-Shirvani J,Barari L,Nouri HR

    更新日期：2018-10-01 00:00:00

  • A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion.

    abstract：:Organ failure is associated with increased mortality and morbidity in patients with systemic inflammatory response syndrome. Previously, we showed that a short course of infusion of a hydrogen sulfide (H(2)S) donor reduced metabolism with concurrent reduction of lung injury. Here, we hypothesize that prolonged H(2)S i...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.11.018

    authors： Aslami H,Beurskens CJ,de Beer FM,Kuipers MT,Roelofs JJ,Hegeman MA,Van der Sluijs KF,Schultz MJ,Juffermans NP

    更新日期：2013-02-01 00:00:00

  • CK2 induced RIG-I drives metabolic adaptations in IFNγ-treated glioma cells.

    abstract：:Given the known anti-tumorigenic properties of IFNγ, its effect on glioma cell survival was investigated. Though IFNγ had no effect on glioma cell viability, it induced cell cycle arrest. This was accompanied by increased expression of p53 and retinoic acid inducible gene (RIG-I). While RIG-I had no effect on glioma c...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.10.009

    authors： Ghildiyal R,Sen E

    更新日期：2017-01-01 00:00:00

  • Mechanisms of mRNA translation of interferon stimulated genes.

    abstract：:Over the last two decades, a lot of research work has been focused on the interferon (IFN)-regulated JAK-STAT pathway and understanding the mechanisms governing the transcription of interferon stimulated genes (ISGs). Evidence suggests that the JAK-STAT pathway alone does not account in its entirety for mediating cell...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2010.03.019

    authors： Joshi S,Kaur S,Kroczynska B,Platanias LC

    更新日期：2010-10-01 00:00:00

  • IL-9 receptor: Regulatory role on FLS and pannus formation.

    abstract：OBJECTIVE:Functions of the Th9 cells and its signature cytokine IL-9 in human autoimmune diseases is currently under extensive research. Here we are reporting new functions of IL-9-receptor (IL-9R); its regulatory role on (i) FLS (fibroblast like synoviocyte) biology and (ii) pannus formation in rheumatoid arthritis (R...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.08.001

    authors： Raychaudhuri SK,Abria C,Maverakis EM,Raychaudhuri SP

    更新日期：2018-11-01 00:00:00

  • Stages versus subsets: Invariant Natural Killer T cell lineage differentiation.

    abstract：:Invariant Natural Killer T (iNKT) cells represent a population of innate T lymphocytes which act as 'first-responders' to infection. While they have long been considered a versatile cell, capable of secretion of multiple cytokines upon activation, recent evidence now indicates that distinct lineages of iNKT cells with...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2014.12.005

    authors： Buechel HM,Stradner MH,D'Cruz LM

    更新日期：2015-04-01 00:00:00

  • Gingival crevicular fluid levels of oncostatin M in periodontal conditions.

    abstract：OBJECTIVE:The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.02.002

    authors： Thorat Manojkumar S,Pradeep AR,Garg G,Raju A

    更新日期：2010-06-01 00:00:00

  • IL-1 acts on T cells to enhance the magnitude of in vivo immune responses.

    abstract：:IL-1 strikingly enhances antigen-driven responses of CD4 and CD8 T cells. It is substantially more effective than LPS and when added to a priming regime of antigen plus LPS, it strikingly enhances cell expansion. The effect is mediated by direct action on CD4 and CD8 T cells; the response occurs when OT-I or OT-II cel...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2011.07.006

    authors： Ben-Sasson SZ,Caucheteux S,Crank M,Hu-Li J,Paul WE

    更新日期：2011-10-01 00:00:00

  • Cytokines modulate endothelial cell intracellular signal transduction required for VCAM-1-dependent lymphocyte transendothelial migration.

    abstract：:Vascular cell adhesion molecule-1 (VCAM-1) activates endothelial cell NADPH oxidase which catalyzes production of reactive oxygen species (ROS). This activity is required for VCAM-1-dependent lymphocyte migration. The focus of our study was to determine whether these VCAM-1-dependent functions are modulated by cytokin...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0922

    authors： Tudor KS,Hess KL,Cook-Mills JM

    更新日期：2001-08-21 00:00:00

  • IFN-gamma priming of monocytes enhances LPS-induced TNF production by augmenting both transcription and MRNA stability.

    abstract：:The induction of cytokine expression in monocytes/macrophages by bacterial endotoxin or lipopolysaccharide is a critical, highly regulated host defence response. The augmentation of LPS responses by interferon gamma (IFN-gamma), referred to as priming, is well established. However, the mechanism(s) by which priming oc...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1995.0058

    authors： Hayes MP,Freeman SL,Donnelly RP

    更新日期：1995-07-01 00:00:00

  • Burn-induced alterations in toll-like receptor-mediated responses by bronchoalveolar lavage cells.

    abstract：UNLABELLED:Burn is associated with profound inflammation and activation of the innate immune system in multiple organ beds, including the lung. Similarly, toll-like receptors (TLR) are associated with innate immune activation. Nonetheless, it is unclear what impact burn has on TLR-induced inflammatory responses in the ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.05.004

    authors： Oppeltz RF,Rani M,Zhang Q,Schwacha MG

    更新日期：2011-09-01 00:00:00

  • Antagonism between interleukin 3 and erythropoietin in mice with azidothymidine-induced anemia and in bone marrow endothelial cells.

    abstract：:Azidothymidine (AZT)-induced anemia in mice can be reversed by the administration of IGF-IL-3 (fusion protein of insulin-like growth factor II (IGF II) and interleukin 3). Although interleukin 3 (IL-3) and erythropoietin (EPO) are known to act synergistically on hematopoietic cell proliferation in vitro, injection of ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.1029

    authors： DiFalco MR,Congote LF

    更新日期：2002-04-07 00:00:00

  • Differential serum cytokine responses to inactivated and live attenuated seasonal influenza vaccines.

    abstract：:Despite vaccine efforts, influenza outbreaks pose a significant threat to global public health. There are two commercially available seasonal influenza vaccines in the United States: the trivalent inactivated vaccine (TIV), delivered parenterally, and the live attenuated influenza vaccine (LAIV), delivered intranasall...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.08.004

    authors： Ramakrishnan A,Althoff KN,Lopez JA,Coles CL,Bream JH

    更新日期：2012-12-01 00:00:00