Constitutive expression of IL-6-LIKE cytokines in normal bone marrow: implications for pathophysiology of myeloma.

abstract：:The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m(2); serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randoml...

journal_title：Cytokine

authors： Barker T,Rogers VE,Levy M,Templeton J,Goldfine H,Schneider ED,Dixon BM,Henriksen VT,Weaver LK

更新日期：2015-02-01 00:00:00

abstract：:Interleukin(IL)-2 and IL-7 are cytokines with important functions related to CD4(+) lymphocyte proliferation, differentiation and survival. Depending on doses, they theoretically activate regulatory (Treg) and/or effector T cells (Teff) and thus may be indicated with different therapeutic objectives. In this study we ...

journal_title：Cytokine

authors： Dupont G,Demaret J,Venet F,Malergue F,Malcus C,Poitevin-Later F,Morel J,Monneret G

更新日期：2014-09-01 00:00:00

abstract：:Effector CD4+ T cells can be classified by the cytokines they secrete, with T helper 1 (Th1) cells generating interferon (IFN)γ and Th17 cells secreting interleukin (IL)-17. Both Th1 and Th17 cells are strongly implicated in the initiation and chronicity of autoimmune diseases such as multiple sclerosis. The endoplasm...

journal_title：Cytokine

authors： Pradeep Yeola A,Akbar I,Baillargeon J,Mercy Ignatius Arokia Doss P,Paavilainen VO,Rangachari M

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Among all cytokines involved in the pathogenesis and in the progression of psoriasis, Tumor Necrosis Factor (TNF)-alpha and interleukin (IL)-17 play a pivotal role. OBJECTIVE:The aim of the present study was to mimic a psoriatic microenvironment and to investigate the early effects of TNF-alpha and IL-17 in...

journal_title：Cytokine

authors： Donetti E,Cornaghi L,Gualerzi A,Baruffaldi Preis FW,Prignano F

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Estrogen is thought to aid maintenance of insulin sensitivity potentially through modulation of a counter-regulatory mechanism that interferes with the contribution of adaptive and innate immune systems to visceral fat deposition. We evaluated the impact of estrogen on long-term high fat diet (HFD) intake in...

journal_title：Cytokine

authors： Wintrob ZA,Oppong EK,Foster M,Martorana M,Tse YC,Zhong L,Welt JM,Boateng HR,Drumea IM,Irlam J,Levea CM,Faitar SL,Ceacareanu AC

更新日期：2014-06-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a molecule with plethora of functions such as regulation of immune response, hormone-like, enzymatic and chaperone-like activity. Further, MIF is a major participant in glucose homeostasis since it is an autocrine stimulator of insulin secretion. MIF absence in male knoc...

journal_title：Cytokine

authors： Vujicic M,Senerovic L,Nikolic I,Saksida T,Stosic-Grujicic S,Stojanovic I

更新日期：2014-09-01 00:00:00

abstract：:During the quarter of a century since TNF was isolated, much knowledge has been gained of the identity of other ligands besides TNF in the TNF cytokine family, and of the proximal signaling molecules that these ligands activate. The numerous laboratories contributing to this advance have approached TNF research from v...

journal_title：Cytokine

authors： Wallach D

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Tumor necrosis factor (TNFα) is a proinflammatory cytokine and has been a target for intervention in human sepsis. However, inhibition of TNF-α with a high dose of a TNF-receptor fusion protein in patients with septic shock worsened patient survival. This study was designed to investigate whether blocking TNF-α...

journal_title：Cytokine

authors： Tsay TB,Yang MC,Chen PH,Lai KH,Huang HT,Hsu CM,Chen LW

更新日期：2013-07-01 00:00:00

abstract：:Intestinal immunity differs from systemic immunity in several aspects and is frequently studied separately. In this work we have analysed the frequency of mononuclear cells spontaneously secreting the cytokines IL-2, IL-4, IL-5, IL-6, IL-10, interferon gamma (IFN-gamma) and tumour necrosis factor (TNF-alpha), in Peyer...

journal_title：Cytokine

authors： Vázquez E,Gil A,García-Olivares E,Rueda R

更新日期：2000-08-01 00:00:00

abstract：:Recent studies have implicated leptin as a "stress" hormone and highlighted its association with increases in inflammatory cytokines, C-reactive protein and cortisol. In order to investigate the exact temporal leptin response to stress we undertook a detailed longitudinal study of circulating leptin concentrations dur...

journal_title：Cytokine

authors： Wallace AM,Sattar N,Mcmillan DC

更新日期：2000-07-01 00:00:00

abstract：:Interleukin-6 (IL-6) is an important pro-inflammatory cytokine of relevance to cardiovascular diseases. The aim of this case-control study was to evaluate the association between the G(-174)C functional polymorphism in the IL-6 gene and risk of cardiovascular disease (CVD) in type 2 diabetes patients. We examined 1090...

journal_title：Cytokine

authors： Buraczynska M,Zukowski P,Drop B,Baranowicz-Gaszczyk I,Ksiazek A

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Cardiac surgery is associated with inflammatory responses that are known to affect its outcome. The present study was designed to define whether post-operative release of interleukin (IL)-6, 8 and tumor necrosis factor-alpha (TNF-alpha) is related to the presence of a certain allele in functional polymorphis...

journal_title：Cytokine

authors： Wang Z,Shao J,Zhou Q,Liu J,Zhu Y,Yang J,Wei M

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Immuno-inflammation plays an important role in the pathophysiological process of sepsis-associated acute hepatic injury (AHI). Interleukin 27 (IL-27) is an important inflammatory regulator; however, its role in this condition is not clear. METHODS:The clinical data and IL-27 serum levels in sepsis patients ...

journal_title：Cytokine

authors： Fan J,Zhang YC,Zheng DF,Zhang M,Liu H,He M,Wu ZJ

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Pneumonia is the leading cause of death in children under 5, with the highest burden in resource-limited countries. Endothelial activation occurs in pneumonia and can be assessed using quantitative levels of biomarkers angiopoietin (Ang)-1 and Ang-2. We examined admission levels of Ang-1 and Ang-2 in pediatri...

journal_title：Cytokine

authors： Zhang R,Rai U,Ibrahim NBM,Amazouz Y,Soo J,Conroy AL,Namasopo S,Opoka RO,Bhargava R,Hawkes MT

更新日期：2020-09-01 00:00:00

abstract：:The production of nitric oxide (NO) is increased in experimental nephritis, with NO thought to be an important mediator of cell damage. The cytokines interleukin 1 beta (IL-1 beta), IL-6, IL-8, monocyte chemotactic protein-1 (MCP-1) and transforming growth factor-beta (TGF-beta) are released from mesangial cells in vi...

journal_title：Cytokine

authors： Ikeda M,Ikeda U,Ohkawa F,Shimada K,Kano S

更新日期：1994-11-01 00:00:00

abstract：:Measuring T-cell production of intracellular cytokines by flow cytometry enables specific monitoring of airway inflammation and response to therapies in chronic lung diseases including chronic obstructive pulmonary disease (COPD). We have previously shown that T cells in the airways of ex- and current- smoker COPD pat...

journal_title：Cytokine

authors： Hodge G,Reynolds PN,Holmes M,Hodge S

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid ...

journal_title：Cytokine

authors： Thorat Manojkumar S,Pradeep AR,Garg G,Raju A

更新日期：2010-06-01 00:00:00

abstract：:We present evidence that cervical cancer cells express a functional IL-2 receptor (IL-2R). In fact, by RT-PCR we obtained that the IL-2R is present in CALO, and INBL cells, and that it consisted of the alphaIL-2R, betaIL-2R, and gammaIL-2R chains. We also found that IL-2 is a growth factor for these cell lines, and un...

journal_title：Cytokine

authors： Rangel-Corona R,Corona-Ortega T,Soto-Cruz I,López-Labra A,Pablo-Arcos T,Torres-Guarneros CF,Weiss-Steider B

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Resveratrol has been reported to alleviate inflammatory responses and oxidative stress in mesangial cells and in several types of renal injury in animal models. Previously, the active resveratrol derivatives from the roots of Vitis thunbergii Sieb. & Zucc. (Vitaceae) were shown to have significant anti-pla...

journal_title：Cytokine

authors： Lee IT,Lin CF,Huang YL,Chong KY,Hsieh MF,Huang TH,Cheng CY

更新日期：2019-01-01 00:00:00

abstract：:Gangliosides have been extensively described to be involved in the proliferation and differentiation of various cell types, such including hematopoietic cells. Our previous studies on murine models of stroma-mediated myelopoiesis have shown that gangliosides are required for optimal capacity of stromal cells to suppor...

journal_title：Cytokine

authors： Santos AX,Maia JE,Crespo PM,Pettenuzzo LF,Daniotti JL,Barbé-Tuana FM,Martins LM,Trindade VM,Borojevic R,Guma FC

更新日期：2011-12-01 00:00:00

abstract：:Chronic liver injury causes liver regeneration, resulting in fibrosis. The proinflammatory cytokine tumor necrosis factor (TNF) is involved in the pathogenesis of many acute and chronic liver diseases. TNF has pleiotropic functions, but its role in liver fibrosis has not been clarified. Chronic repeated injection of C...

journal_title：Cytokine

authors： Sudo K,Yamada Y,Moriwaki H,Saito K,Seishima M

更新日期：2005-03-07 00:00:00

abstract：:The authors describe the design and validation of a competitive RT-PCR method for the efficient and reproducible quantitation of mRNA molecules of IFN-gamma, TNF-alpha, IL-4 and IL-10 in mouse spleen RNA extracts. Before being subjected to RT-PCR, the RNA extracts were supplemented with internal control RNAs (IC-RNAs)...

journal_title：Cytokine

authors： Zhou NM,Matthys P,Polacek C,Fiten P,Sato A,Billiau A,Froyen G

更新日期：1997-03-01 00:00:00

abstract：:Malignant ascites of epithelial ovarian cancer patients contains high levels of interleukin 6 (IL-6). The present study was conducted to compare the secretion of IL-6 by seven different human ovarian cancer cell lines (OVCA) and cultured human peritoneal mesothelial cells (HPMC) and to examine the regulation of its pr...

journal_title：Cytokine

authors： Offner FA,Obrist P,Stadlmann S,Feichtinger H,Klingler P,Herold M,Zwierzina H,Hittmair A,Mikuz G,Abendstein B

更新日期：1995-08-01 00:00:00

abstract：:In order to understand the cellular disease mechanisms of osteoarthritic cartilage degeneration it is of primary importance to understand both the anabolic and the catabolic processes going on in parallel in the diseased tissue. In this study, we have applied cDNA-array technology (Clontech) to study gene expression p...

journal_title：Cytokine

authors： Aigner T,McKenna L,Zien A,Fan Z,Gebhard PM,Zimmer R

更新日期：2005-08-07 00:00:00

abstract：:The proinflammatory cytokines TNFalpha and IL-1beta are thought to play a role in the mechanism of septic vasodilatory shock. Most evidence indicate that the vascular effects these cytokines are mediated through increased expression of inducible nitric oxide synthase, whereas several animal studies report a more rapid...

journal_title：Cytokine

authors： Pickkers P,Netea MG,van der Meer JW,Smits P

更新日期：2002-12-07 00:00:00

abstract：CONTEXT:CTLA-4 is engaged on effector cells that may alter signal transduction and subsequently cytokine production. The transmission of longer repeats of (AT)(n) alleles of CTLA-4 is also associated with women undergoing recurrent miscarriage. The TNF-α known as an embryo-toxic cytokine is reported to be greater in pl...

journal_title：Cytokine

authors： Gupta R,Prakash S,Parveen F,Agrawal S

更新日期：2012-11-01 00:00:00

abstract：:Interferon (IFN)-alpha and -beta are important antiviral mediators. IFN-alpha is widely used for the treatment of chronic hepatitis B. In our previous studies, a subtype of woodchuck IFN-alpha (wIFN-alpha) was characterized and has been shown to be active in suppressing the replication of woodchuck hepatitis virus (WH...

journal_title：Cytokine

authors： Lu Y,Xu Y,Yang D,Kemper T,Roggendorf M,Lu M

更新日期：2008-02-01 00:00:00

abstract：:This study was aimed to assess whether ex vivo treatment with granulocyte-colony stimulating factor (G-CSF) modifies biological properties of bone marrow stromal cells (BMSC) and enhances functional recovery by BMSC transplantation into infarct brain. Immunohistochemistry was conducted to characterize the cultured BMS...

journal_title：Cytokine

authors： Hokari M,Kuroda S,Chiba Y,Maruichi K,Iwasaki Y

更新日期：2009-05-01 00:00:00

abstract：:A number of chemokines induce angiogenesis and endothelial cells express several chemokine receptors. To date, only a limited number of CC chemokines for CCR1 have been reported to induce angiogenic responses. We investigated the ability of CCL23 (also known as MPIF-1, MIP-3, or CKbeta8) to promote angiogenesis, which...

journal_title：Cytokine

authors： Hwang J,Son KN,Kim CW,Ko J,Na DS,Kwon BS,Gho YS,Kim J

更新日期：2005-06-07 00:00:00

abstract：:Interleukin (IL)-7 is a potent proliferation, activation, and survival cytokine for CD8+ T cells to improve viral and tumor specific CD8+ T cell responses. However, the role of IL-7 in regulation of dysfunctional hepatitis C virus (HCV)-specific CD8+ T cells was not fully elucidated. Thus, a total of 53 patients with ...

journal_title：Cytokine

authors： Hou H,Kang Y,Zeng Y,Li Y,Shang J

更新日期：2018-02-01 00:00:00