IL-6 secretion by human peritoneal mesothelial and ovarian cancer cells.

abstract：:Interleukin-21 (IL-21) is an important immune cytokine that was well characterized in human and mammals, but little is known in fish. In present study, an IL-21 homologue was cloned and well characterized from Tetraodon nigroviridis. The full-length Tetraodon IL-21 cDNA was 849bp in size, containing an open reading fr...

journal_title：Cytokine

authors： Wang HJ,Xiang LX,Shao JZ,Jia S

更新日期：2006-08-01 00:00:00

abstract：:Given the known anti-tumorigenic properties of IFNγ, its effect on glioma cell survival was investigated. Though IFNγ had no effect on glioma cell viability, it induced cell cycle arrest. This was accompanied by increased expression of p53 and retinoic acid inducible gene (RIG-I). While RIG-I had no effect on glioma c...

journal_title：Cytokine

authors： Ghildiyal R,Sen E

更新日期：2017-01-01 00:00:00

abstract：:Since liver regeneration after partial hepatectomy (PHx) is known to improve by pretreatment with recombinant human G-CSF (rhG-CSF), we investigated the mechanism by evaluating the distribution and activity of sinusoidal NK cells. F344 rats were treated with rhG-CSF (250 microg/kg/day) for 5 days before PHx. Pretreatm...

journal_title：Cytokine

authors： Oishi K,Hayamizu K,Aihaiti X,Itamoto T,Arihiro K,Asahara T

更新日期：2006-04-01 00:00:00

abstract：:Patients admitted to a medical intensive care unit (ICU) are characterized by an activated immune system and exhibit a high mortality rate irrespective of the underlying cause of admission. Interleukin (IL)-33 has been shown to be protective in experimental sepsis models and it has been demonstrated that circulating l...

journal_title：Cytokine

authors： Krychtiuk KA,Stojkovic S,Lenz M,Brekalo M,Huber K,Wojta J,Heinz G,Demyanets S,Speidl WS

更新日期：2018-03-01 00:00:00

abstract：:Suspect field cases of BSE infection (displaying clinical signs) were examined for possible alterations of cytokine/autacoid plasma levels and were compared to control cases (not displaying clinical signs of BSE infection). Interferon gamma (IFN-gamma) plasma levels were demonstrated as being elevated in all suspected...

journal_title：Cytokine

authors： Murphy C,Breen C,Rogers M,Giese M

更新日期：2001-02-07 00:00:00

abstract：BACKGROUND:Interleukin 17 (IL-17) is induced during the early stages of tuberculosis infection, playing an important role in the defense against mycobacterial infection. To date, only one study performed in Chinese Han population has found an association between IL-17F sequence variants and susceptibility to tuberculos...

journal_title：Cytokine

authors： Ocejo-Vinyals JG,de Mateo EP,Hoz MÁ,Arroyo JL,Agüero R,Ausín F,Fariñas MC

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease mediated by an autoimmune reaction to hepatocytes, the present study aimed to assess the possible associations between interleukin-4 (IL-4) variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms and susceptibility to aut...

journal_title：Cytokine

authors： Mansour AI,Behairy OG,Abd Almonaem ER,Abd-Rabuh RM,Ahmed IAE

更新日期：2018-10-01 00:00:00

abstract：:This study was conducted to compare the secretion of TGF-beta isoforms by human ovarian carcinoma (OVCA) cell lines (n=12) and human peritoneal mesothelial cells (HPMC;n=6) and to examine the regulation of their production by inflammatory cytokines. TGF-beta isoforms were furthermore analysed in OVCA-associated asciti...

journal_title：Cytokine

authors： Abendstein B,Stadlmann S,Knabbe C,Buck M,Müller-Holzner E,Zeimet AG,Marth C,Obrist P,Krugmann J,Offner FA

更新日期：2000-07-01 00:00:00

abstract：:Dermal wounding is accompanied by inflammation and the resulting proinflammatory cytokines, including interleukin (IL)-6, are thought to play an important role in the repair process. IL-6 is produced by normal human keratinocytes to various dermatological diseases and we have recently shown it is also required for nor...

journal_title：Cytokine

authors： Sugawara T,Gallucci RM,Simeonova PP,Luster MI

更新日期：2001-09-21 00:00:00

abstract：:Angiopoietin-like proteins (ANGPTL) are responsible for inhibiting lipoprotein lipase activity, and ANGPTL3 and ANGPTL4 deficiencies have been shown to lower lipoprotein levels in animal models and in humans carrying loss-of-function mutations. Sickle cell anemia (SCA) is a hereditary hemolytic anemia characterized by...

journal_title：Cytokine

authors： Vendrame F,Olops L,Saad STO,Costa FF,Fertrin KY

更新日期：2019-08-01 00:00:00

abstract：:Imbalance in the production of cytokines and their inhibitors plays a part in inflammation in chronic destructive diseases. Direct cell-cell contact with stimulated T cells markedly induces the production of pro-inflammatory cytokines and matrix metalloproteinases in monocytes. This study demonstrates that direct cont...

journal_title：Cytokine

authors： Vey E,Dayer JM,Burger D

更新日期：1997-07-01 00:00:00

abstract：:Studies have shown that following bacterial infection or endotoxin administration, immune functions are regulated differently in mice of different genetic background. Since the susceptibility to sepsis following trauma-hemorrhage is dependant on the severity of injury, it is important to determine whether genetic back...

journal_title：Cytokine

authors： Matsutani T,Anantha Samy TS,Kang SC,Bland KI,Chaudry IH

更新日期：2005-05-21 00:00:00

abstract：:To date, the biological activity of granulocyte macrophage-colony stimulating factor (GM-CSF) has been investigated by using mostly Escherichia coli- or yeast cell-derived recombinant human GM-CSF (erhGM-CSF and yrhGM-CSF, respectively). However, Chinese hamster ovary cell-derived recombinant human GM-CSF (crhGM-CSF),...

journal_title：Cytokine

authors： Hashimoto A,Tanaka T,Itoh Y,Yamagata A,Kitamura N,Tazawa R,Nakagaki K,Nakata K

更新日期：2014-08-01 00:00:00

abstract：:In a previous work we demonstrated that monoclonal antibody (mAb) 8C2 recognized a human granulocyte-colony stimulating factor (hG-CSF) region left unmasked after binding to placenta receptors, whereas mAb 6E3 defined a receptor-buried epitope. Herein we examined the role of these antigenic regions on the proliferativ...

journal_title：Cytokine

authors： Marino VJ,Sterin-Prync AE,Roguin LP

更新日期：2003-04-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) is a potent immunomodulatory cytokine whose physiological roles are modulated by the extracellular matrix. Here, circular dichroism and fluorescence spectroscopic techniques are used to demonstrate that low molecular weight heparin and chondroitin sulfate cause significant changes in secon...

journal_title：Cytokine

authors： Balasubramanian V,Ramanathan M

更新日期：2000-05-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) demonstrating pro-angiogenic activity promote new blood vessel formation in psoriatic lesions. The aim of this study was to evaluate the serum concentrations of VEGF, its soluble receptors (sVEGF R1 and R2) and VEGF content in scales of patients with psoriasis. To analyze poss...

journal_title：Cytokine

authors： Flisiak I,Zaniewski P,Rogalska M,Myśliwiec H,Jaroszewicz J,Chodynicka B

更新日期：2010-12-01 00:00:00

abstract：:Tenidap is a novel anti-inflammatory and anti-arthritic agent that lowers intracellular pH and suppresses anion transport when applied to cells in vitro. Both of these parameters are known to influence pro-inflammatory cell function. To investigate whether tenidap can modulate cellular responses to cytokine stimulatio...

journal_title：Cytokine

authors： McNiff PA,Laliberte RE,Svensson L,Pazoles CJ,Gabel CA

更新日期：1995-02-01 00:00:00

abstract：:Interleukin-4 (IL-4) is a pleiotropic cytokine with broad spectrum of biological effects on target cells. This study deals with the mammalian expression of canine IL-4 (cIL-4) in canine articular chondrocytes (CAC) and its ability to down-regulate pro-inflammatory cytokines, enzyme mediators and their catabolites. We ...

journal_title：Cytokine

authors： Rachakonda PS,Rai MF,Manning K,Schmidt MF

更新日期：2008-10-01 00:00:00

abstract：:The proper balance between IL-12p40-related cytokines controls the appearance of normal and pathological Th1 immune responses. In this study, we examined the inducible IL-12p40, IL-12p35 and IL-23p19 mRNA expression and protein production in human peripheral blood mononuclear cells (PBMC) and purified monocytes, isola...

journal_title：Cytokine

authors： Dobreva ZG,Stanilova SA,Miteva LD

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:The effects of LDL-apheresis (LDLa) with dextran sulphate on plasma cytokines in 6 homozygous familial hypercholesterolemic (HozFH) patients, were evaluated. METHODS:Plasma IL-1α; IL-1ra; IL-4; IL-6; IL-10; IL-12(p40); IL-12(p70); TNF-α, sTNF-R, VEGF, VEGF-R1, E-Selectin (ESEL), and P-Selectin (PSEL) concent...

journal_title：Cytokine

authors： Stefanutti C,Vivenzio A,Di Giacomo S,Ferraro PM

更新日期：2011-08-01 00:00:00

abstract：:The history of the discovery and the development of our knowledge of IL-4 exemplifies the path of progress in biomedical science. There are unanticipated twists and turns although progress is made, sometimes quickly, other times far too slowly. Illustrative is the extended time from the first report of IL-4 in 1982 to...

journal_title：Cytokine

authors： Paul WE

更新日期：2015-09-01 00:00:00

abstract：:Tumour necrosis factor alpha(TNF-alpha) is one of the most important pro-inflammatory cytokines, which plays an important role in host defense and acute inflammation related to tissue injury. The major source of TNF-alpha has been shown to be immune cells such as macrophages and neutrophils. In the present study, we d...

journal_title：Cytokine

authors： McRitchie DI,Isowa N,Edelson JD,Xavier AM,Cai L,Man HY,Wang YT,Keshavjee SH,Slutsky AS,Liu M

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Cutaneous melanoma displays high morbidity and mortality rates. Isolated limb perfusion with melphalan (Mel) is used for the treatment of non-resectable, locally advanced extremity melanomas. When combined with tumor necrosis factor alpha (TNF-alpha) treatment, the complete response varies between 70% and 90...

journal_title：Cytokine

authors： de Lima VC,de Carvalho AF,Morato-Marques M,Hashimoto VL,Spilborghs GM,Marques SM,Landman G,Torres C,Braga Ribeiro K,Brentani H,Reis LF,Dias AA

更新日期：2013-05-01 00:00:00

abstract：:Recently, we reported that extracellular ubiquitin functions as another agonist of CXC chemokine receptor (CXCR)4. Whereas the cognate CXCR4 ligand, stromal cell-derived factor (SDF)-1α, is also a CXCR7 agonist, ubiquitin does not bind to CXCR7. Because both ligands are present in the extracellular environment, co-act...

journal_title：Cytokine

authors： Tripathi A,Davis JD,Staren DM,Volkman BF,Majetschak M

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Brain abscess develops in response to a parenchymal infection with pyogenic bacteria. Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are the most crucial pro-inflammatory cytokines with both beneficial and destructive properties for the central nervous system. The present study evaluated the assoc...

journal_title：Cytokine

authors： Mishra P,Prasad KN,Singh K,Bajpai A,Sahu RN,Ojha BK

更新日期：2015-09-01 00:00:00

abstract：:The authors evaluated the relationship between hormonal and cytokine responses after surgery. Patients who underwent thoracic oesophagectomy (O group; n = 7), pulmonary lobectomy (P group; n = 5), modified mastectomy (M group; n = 5) and laparoscopic cholecystectomy (LC group; n = 7), were randomly selected. Circulati...

journal_title：Cytokine

authors： Yamauchi H,Kobayashi E,Yoshida T,Kiyozaki H,Hozumi Y,Kohiyama R,Suminaga Y,Sakurabayashi I,Fujimura A,Miyata M

更新日期：1998-07-01 00:00:00

abstract：:The aim of this study was to characterize the association between adipocyte enlargement and circulating levels of serum amyloid A (SAA). Furthermore, we wanted to search for possible associations with measures of glycemic control and levels of circulating adipokines and/or inflammatory markers in men and women with a ...

journal_title：Cytokine

authors： Sjöholm K,Lundgren M,Olsson M,Eriksson JW

更新日期：2009-12-01 00:00:00

abstract：:Peptic ulcer is a lesion in the mucosa of the digestive tract affecting many people all around the world. Recent investigations have indicated that produced inflammatory cytokines such as TNF-α and IL-1β in response to gastric infection by Helicobacter pylori play an important role in the development of peptic ulcer. ...

journal_title：Cytokine

authors： Tourani M,Habibzadeh M,Karkhah A,Shokri-Shirvani J,Barari L,Nouri HR

更新日期：2018-10-01 00:00:00

abstract：:Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against var...

journal_title：Cytokine

authors： Metzger DW

更新日期：2010-10-01 00:00:00

abstract：:Asthma and type I diabetes are major causes of chronic illness in childhood which, according to the current paradigm, have mutually antagonistic immunopathologies. Nonetheless, the disorders appear to preferably coexist both on population and individual levels. To assess whether children with asthma and type I diabete...

journal_title：Cytokine

authors： Kainonen E,Rautava S,Korkeamäki M,Isolauri E

更新日期：2006-05-01 00:00:00