Abstract:
:A number of chemokines induce angiogenesis and endothelial cells express several chemokine receptors. To date, only a limited number of CC chemokines for CCR1 have been reported to induce angiogenic responses. We investigated the ability of CCL23 (also known as MPIF-1, MIP-3, or CKbeta8) to promote angiogenesis, which induces chemotaxis of immune cells through CCR1. CCL23 promoted the chemotactic migration and differentiation of endothelial cells, and neovascularization in the chick chorioallantoic membrane. An N-terminal truncated form of CCL23 was at least 100-fold more potent than its intact form and was comparable to that of FGF in the angiogenic activities. Treatment with either pertussis toxin or anti-CCR1 antibody completely inhibited the CCL23-induced endothelial cell migration, indicating that endothelial cell migration was mediated through CCR1. CCL23 didn't promote the migration of HT1080 human fibrosarcoma cells that did not express CCR1. Our results suggest a role of CCL23 in angiogenesis in vitro as well as in vivo.
journal_name
Cytokinejournal_title
Cytokineauthors
Hwang J,Son KN,Kim CW,Ko J,Na DS,Kwon BS,Gho YS,Kim Jdoi
10.1016/j.cyto.2005.01.018keywords:
subject
Has Abstractpub_date
2005-06-07 00:00:00pages
254-63issue
5eissn
1043-4666issn
1096-0023pii
S1043-4666(05)00061-Xjournal_volume
30pub_type
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