Human CC chemokine CCL23, a ligand for CCR1, induces endothelial cell migration and promotes angiogenesis.

Abstract:

:A number of chemokines induce angiogenesis and endothelial cells express several chemokine receptors. To date, only a limited number of CC chemokines for CCR1 have been reported to induce angiogenic responses. We investigated the ability of CCL23 (also known as MPIF-1, MIP-3, or CKbeta8) to promote angiogenesis, which induces chemotaxis of immune cells through CCR1. CCL23 promoted the chemotactic migration and differentiation of endothelial cells, and neovascularization in the chick chorioallantoic membrane. An N-terminal truncated form of CCL23 was at least 100-fold more potent than its intact form and was comparable to that of FGF in the angiogenic activities. Treatment with either pertussis toxin or anti-CCR1 antibody completely inhibited the CCL23-induced endothelial cell migration, indicating that endothelial cell migration was mediated through CCR1. CCL23 didn't promote the migration of HT1080 human fibrosarcoma cells that did not express CCR1. Our results suggest a role of CCL23 in angiogenesis in vitro as well as in vivo.

journal_name

Cytokine

journal_title

Cytokine

authors

Hwang J,Son KN,Kim CW,Ko J,Na DS,Kwon BS,Gho YS,Kim J

doi

10.1016/j.cyto.2005.01.018

keywords:

subject

Has Abstract

pub_date

2005-06-07 00:00:00

pages

254-63

issue

5

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(05)00061-X

journal_volume

30

pub_type

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