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Association of CTLA-4 and TNF-α polymorphism with recurrent miscarriage among North Indian women.

Abstract：

CONTEXT:CTLA-4 is engaged on effector cells that may alter signal transduction and subsequently cytokine production. The transmission of longer repeats of (AT)(n) alleles of CTLA-4 is also associated with women undergoing recurrent miscarriage. The TNF-α known as an embryo-toxic cytokine is reported to be greater in placentas of abortion prone pregnancies. OBJECTIVES:The present study investigated the role of CTLA-4+49 A/G, CTLA-4 (AT)(n) 3'UTR, TNF-α-308G/A and TNF-α-238G/A polymorphisms as a susceptibility marker for recurrent miscarriage (RM). PARTICIPANTS AND METHODS:We genotyped CTLA4+49 A/G, TNF-α-308 and TNF-α-238 gene polymorphisms in 300 patients with RM and 500 age and ethnically matched negative controls using PCR-RFLP method. While gene sequencing method was adopted for studying the CTLA-4 (AT)(n) 3'UTR polymorphism. RESULTS:The mutant homozygous genotype GG of CTLA4+49A/G, AA genotype and A allele of TNF-α-308, G allele of TNF-α-238 were observed to be predisposing among RM cases along with the 104 bp, 106 bp, 110 bp and 116 bp alleles of CTLA-4 (AT)(n) microsatellite repeat. GA and AG haplotypes of TNF-α were low risk associated haplotypes among recurrent miscarriage women. CONCLUSIONS:Roles of CTLA-4 A49G, CTLA-4 (AT)(n) 3'UTR, TNF-α-308 and TNF-α-238 polymorphisms in RM cases from North India is reflected through this study.

journal_name

Cytokine

journal_title

Cytokine

authors

Gupta R,Prakash S,Parveen F,Agrawal S

doi

10.1016/j.cyto.2012.05.018

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

456-62

issue

2

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(12)00214-1

journal_volume

60

pub_type

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