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Mitochondrial STAT3: Powering up a potent factor.

Abstract：

:The JAK-STAT3 signaling pathway is engaged by many cytokines and growth factor stimuli to control diverse biological processes including proliferation, angiogenesis, survival, immune modulation, and metabolism. For over two decades it has been accepted that STAT3-dependent biology is due to its potency as a transcription factor capable of regulating the expression of many hundreds of genes. However, recent evidence of non-canonical and non-genomic activities of STAT3 has emerged. The most exciting of these activities is its capacity to translocate into the mitochondria where it regulates the activity of the electron transport chain and the opening of the mitochondrial permeability transition pore. These have broad consequences including cell survival and the production of reactive oxygen species and ATP in both normal tissue and under pathological conditions. Despite these fascinating observations there are many key unanswered questions about the mechanism of STAT mitochondrial activity.

journal_name

Cytokine

journal_title

Cytokine

authors

Garama DJ,White CL,Balic JJ,Gough DJ

doi

10.1016/j.cyto.2016.05.019

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

20-5

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(16)30112-0

journal_volume

87

pub_type

杂志文章,评审

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