Interleukin 10 suppresses phagocytic and antihyphal activities of human neutrophils.

abstract：:Inflammatory bowel diseases are characterized by dysregulated immune response to the normal microflora and structural and functional changes of the enteric nervous system which occur in inflamed as well as non-inflamed areas of the bowel. This study describes the changes in the expression of nerve growth factor (NGF) ...

journal_title：Cytokine

authors： Barada KA,Mourad FH,Sawah SI,Khoury C,Safieh-Garabedian B,Nassar CF,Tawil A,Jurjus A,Saadé NE

更新日期：2007-03-01 00:00:00

abstract：:Intraarticular injection of zymosan (1 mg) into the knee joints of male Wistar rats led to infiltration of neutrophils and monocytes, joint swelling and elevation of tumour necrosis factor (TNF-alpha) in joint lavage fluids. Neutrophil infiltration was maximal at 5 h after induction of arthritis but had declined by 24...

journal_title：Cytokine

authors： Pettipher ER,Salter ED

更新日期：1996-02-01 00:00:00

abstract：:Neuregulin-4 (Nrg4) is a novel adipokine associated with obesity, hyperglycemia, insulin resistance, dislipidemia, inflammation, and oxidative stress in mice and humans. However, no report has demonstrated the relationship of circulating Nrg4 with diabetic peripheral neuropathy (DPN). The objective of our study was to...

journal_title：Cytokine

authors： Yan P,Xu Y,Zhang Z,Gao C,Zhu J,Li H,Wan Q

更新日期：2019-01-01 00:00:00

abstract：:It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely ...

journal_title：Cytokine

authors： Palumbo ML,Di Rosso ME,Simon EH,Gonzalez Murano MR,Genaro AM

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:The clinical symptoms of the patients with intracellular bacterial bloodstream infections (Intra-bac BSIs) are atypical, and no early and accurate diagnostic biomarkers exist, which can easily lead to misdiagnosis, inappropriate and delayed treatment. Therefore, it is imperative to find novel biomarkers to h...

journal_title：Cytokine

authors： Lin MF,Sun B,Liu ZY,Tang P,Zhang LJ,Wang YY

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Although, hypothermia is a frequent event after trauma, it is unclear whether its beneficial or detrimental effects are more important. This study aims to quantify the effects of hypothermia and re-warming on the inflammatory response after fracture/hemorrhage and subsequent fracture stabilization with res...

journal_title：Cytokine

authors： Hildebrand F,van Griensven M,Giannoudis P,Luerig A,Harwood P,Harms O,Fehr M,Krettek C,Pape HC

更新日期：2005-09-07 00:00:00

abstract：:MicroRNAs (miRs) were only discovered little more than a decade ago, yet it has become rapidly clear that they are crucial posttranscriptional regulators of gene expression by decreasing the abundance or translational efficiency of mRNAs [Maroney PA, Yu Y, Nilsen TW. MicroRNAs, mRNAs, and translation. Cold Spring Harb...

journal_title：Cytokine

authors： Pedersen I,David M

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Cutaneous melanoma displays high morbidity and mortality rates. Isolated limb perfusion with melphalan (Mel) is used for the treatment of non-resectable, locally advanced extremity melanomas. When combined with tumor necrosis factor alpha (TNF-alpha) treatment, the complete response varies between 70% and 90...

journal_title：Cytokine

authors： de Lima VC,de Carvalho AF,Morato-Marques M,Hashimoto VL,Spilborghs GM,Marques SM,Landman G,Torres C,Braga Ribeiro K,Brentani H,Reis LF,Dias AA

更新日期：2013-05-01 00:00:00

abstract：:In serum-free WEHI-3 supernatants an activity was detected inducing haemoglobin synthesis in human and murine erythroleukaemia cell lines. The absolute numbers of benzidine-positive cells induced with either DMSO or WEHI-3-conditioned medium were comparable. Terminal differentiation was not observed. An expression lib...

journal_title：Cytokine

authors： Dörmer P,Spitzer E,Frankenberger M,Kremmer E

更新日期：2004-06-21 00:00:00

abstract：:Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α bu...

journal_title：Cytokine

authors： Pliyev BK,Kalintseva MV,Abdulaeva SV,Yarygin KN,Savchenko VG

更新日期：2014-02-01 00:00:00

abstract：:Overweight and obesity are associated with chronic and subclinical inflammation due to an imbalance of inflammatory mediators. However, the association with gene polymorphism has been rarely studied in children. The aim of this study was to determine if serum concentrations of C-reactive protein (CRP) and interleukin-...

journal_title：Cytokine

authors： Todendi PF,Possuelo LG,Klinger EI,Reuter CP,Burgos MS,Moura DJ,Fiegenbaum M,Valim AR

更新日期：2016-12-01 00:00:00

abstract：:The predominant pathological features in the central nervous system (CNS) in multiple sclerosis (MS) are perivascular inflammation and demyelination. The cells in the inflammatory cuff consist mainly of T lymphocytes and macrophages. Cytokines produced by inflammatory cells within the CNS have the potential to enhance...

journal_title：Cytokine

authors： Woodroofe MN,Cuzner ML

更新日期：1993-11-01 00:00:00

abstract：:The pathogenesis of septic shock is mainly due to unregulated tumour necrosis factor-alpha (TNF-alpha) production. Procalcitonin (PCT) and calcitonin gene-related peptide (CGRP) are alternative transcription products of the calcitonin gene. Since high PCT levels have been described in human sepsis, and since CGRP inhi...

journal_title：Cytokine

authors： Monneret G,Pachot A,Laroche B,Picollet J,Bienvenu J

更新日期：2000-06-01 00:00:00

abstract：:C-reactive protein (CRP) has been demonstrated to induce blood-brain barrier disruption (BBB) involving NAD(P)H-oxidase dependent oxidative stress. It is unclear why CRP affects the BBB and not other vascular beds following stroke. Therefore we examined CRP receptor and NAD(P)H-oxidase expression levels in bovine brai...

journal_title：Cytokine

authors： Closhen D,Bender B,Luhmann HJ,Kuhlmann CR

更新日期：2010-05-01 00:00:00

abstract：:The history of the discovery and the development of our knowledge of IL-4 exemplifies the path of progress in biomedical science. There are unanticipated twists and turns although progress is made, sometimes quickly, other times far too slowly. Illustrative is the extended time from the first report of IL-4 in 1982 to...

journal_title：Cytokine

authors： Paul WE

更新日期：2015-09-01 00:00:00

abstract：:Chronic elevation of circulating Interleukin-6 (IL-6) is observed in elderly individuals as well as in several illnesses, including chronic kidney diseases. A number of cells and tissues possess the ability to metabolize significant amounts of IL-6 in vitro. However, information on signals and mechanisms by which IL-6...

journal_title：Cytokine

authors： Garibotto G,Sofia A,Balbi M,Procopio V,Villaggio B,Tarroni A,Di Martino M,Cappelli V,Gandolfo MT,Valli A,Verzola D

更新日期：2007-01-01 00:00:00

abstract：:The effect of recombinant human granulocyte-macrophage colony stimulating factor (GM-CSF) on the expression of HLA-DR, and the production of the cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) by human peripheral blood monocyte-enriched populations was investigated. GM-CSF was shown to induc...

journal_title：Cytokine

authors： Chantry D,Turner M,Brennan F,Kingsbury A,Feldmann M

更新日期：1990-01-01 00:00:00

abstract：:The proinflammatory cytokines TNFalpha and IL-1beta are thought to play a role in the mechanism of septic vasodilatory shock. Most evidence indicate that the vascular effects these cytokines are mediated through increased expression of inducible nitric oxide synthase, whereas several animal studies report a more rapid...

journal_title：Cytokine

authors： Pickkers P,Netea MG,van der Meer JW,Smits P

更新日期：2002-12-07 00:00:00

abstract：:A recombinant human GM-CSF-EPO hybrid protein named MEN 11300 was administered biweekly for a total of 6 weeks to rhesus monkeys in order to evaluate its pharmacokinetic behaviour, tolerability and immunogenicity. In this primate species a strong antibody response was induced which neutralized the in vitro biological ...

journal_title：Cytokine

authors： Coscarella A,Liddi R,Di Loreto M,Bach S,Faiella A,van der Meide PH,Mele A,De Santis R

更新日期：1998-12-01 00:00:00

abstract：:In order to study structure-function relationships of the M(r) 55,000 subunit of the murine IL-2R (p55 IL-2R) by epitope mapping, we have expressed the p55 IL-2R molecule in a cell-free translation system. Under these in vitro conditions, we detected the expected p55 IL-2R polypeptide initiated at Met 1 and, in additi...

journal_title：Cytokine

authors： Lorenzo F,Jaulin C,Jankovic DL,Theze J

更新日期：1992-07-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is a major mediator in septic shock and several inflammatory diseases such as hepatitis. Galactosamine (GalN) sensitises experimental animals for TNF and the combination TNF/GalN leads to a lethal inflammatory hepatitis. We describe that a single injection of lipopolysaccharide (LPS), inte...

journal_title：Cytokine

authors： Wielockx B,Hochepied T,Staelens J,Van Molle W,Brouckaert P,Libert C

更新日期：2001-07-21 00:00:00

abstract：:Chemokines are small chemoattractant cytokines involved in normal and pathological immune processes. Although extensive nucleotide sequence data are available for human and murine chemokine cDNA sequences, very few data are currently available regarding rhesus macaque sequences. To increase our understanding of immune...

journal_title：Cytokine

authors： Basu S,Schaefer TM,Ghosh M,Fuller CL,Reinhart TA

更新日期：2002-05-07 00:00:00

abstract：:It has been reported that rapamycin (rap), cyclosporin A (CsA) and FK506 have immunosuppressive effect during the activation process of murine T cells. These drugs were investigated for their suppressive effect on a murine T cell line expressing intermediate (TS1 beta) or high (TS1 alpha beta) affinity IL-2R. Rap and ...

journal_title：Cytokine

authors： Rebollo A,Mérida I,Gómez J,Pitton C,Silva A,Martínez C,García A

更新日期：1995-04-01 00:00:00

abstract：:To verify the role of macrophage migration inhibitory factor (MIF) in tumourigenesis, we examined the effect of an anti-MIF antibody on tumour growth and angiogenesis. We inoculated murine colon adenocarcinoma cell line colon 26 cells subcutaneously into the flank in BALB/c mice. After nine days, we treated tumour-bea...

journal_title：Cytokine

authors： Ogawa H,Nishihira J,Sato Y,Kondo M,Takahashi N,Oshima T,Todo S

更新日期：2000-04-01 00:00:00

abstract：:There are indications that bone regulatory and immune systems are closely related. Of special interest in this context is the acute otitis media (AOM), which mainly affects immunologically immature patients and, when complicated, involves bone tissue. To explore host responses in bone tissue during Haemophilus influen...

journal_title：Cytokine

authors： Melhus A,Ryan AF

更新日期：2004-03-21 00:00:00

abstract：:Previously, two binding sites for interleukin 5 (IL-5) were identified on the IL-5 receptor alpha chain (IL-5Ralpha). They are located within the CD loop of the first fibronectin type III (FnIII)-like domain and the EF loop of the second FnIII-like domain. The first binding site was identified by exploiting the differ...

journal_title：Cytokine

authors： Czabotar PE,Holland J,Sanderson CJ

更新日期：2000-07-01 00:00:00

abstract：:Colony stimulating factors (CSF) promote leukocyte survival by reducing apoptotic cell death. However, their effects on non-leukocyte cell types are unclear. Reduced apoptosis in colon epithelial cells is thought to contribute to the initiation of cancer. Here, we report diminished spontaneous apoptosis of human colon...

journal_title：Cytokine

authors： Calatayud S,Warner TD,Breese EJ,Mitchell JA

更新日期：2002-11-24 00:00:00

abstract：:In the atopic allergic individual, challenge with allergen elicits manifestations of both the humoral (IgE-mediated or early-phase reaction) and the cell-mediated immune response (late-phase reaction). Detailed study of late-phase cell-mediated events is confounded by the effects of the earlier IgE-mediated response w...

journal_title：Cytokine

authors： Smith TR,Larché M

更新日期：2004-10-21 00:00:00

abstract：:The supernatant from normal liver cell (Clone 1469) culture enhanced polyclonal antibody production in mouse spleen cells but not in human peripheral blood lymphocytes. The supernatants from transforming growth factor beta (TGF-beta)-treated C3H/HeN spleen cells augmented greatly polyclonal antibody responses compared...

journal_title：Cytokine

authors： Ishizaka S,Saito S,Yoshikawa M,Kimoto M,Nishiyama T

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid ...

journal_title：Cytokine

authors： Thorat Manojkumar S,Pradeep AR,Garg G,Raju A

更新日期：2010-06-01 00:00:00