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Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines.

Abstract：

:Chemokines are small chemoattractant cytokines involved in normal and pathological immune processes. Although extensive nucleotide sequence data are available for human and murine chemokine cDNA sequences, very few data are currently available regarding rhesus macaque sequences. To increase our understanding of immune function in nonhuman primates, we have used reverse-transcription polymerase chain reaction (RT-PCR) to clone and sequence rhesus macaque cDNAs from each of the C, CC, CXC, and CX3C groups of chemokines. Relative to the respective human chemokines, these 25 chemokine cDNA sequences were from 77% to 98% identical. Of the amino acid differences between the rhesus macaque and human chemokines, 51% were species-specific when compared together with the respective murine chemokine sequences. These studies of rhesus macaque chemokine sequences demonstrate that chemokine genes are highly conserved across species, and provide a large foundation for the study of chemokine biology and genetics in nonhuman primates.

journal_name

Cytokine

journal_title

Cytokine

authors

Basu S,Schaefer TM,Ghosh M,Fuller CL,Reinhart TA

doi

10.1006/cyto.2002.0875

keywords:

subject

Has Abstract

pub_date

2002-05-07 00:00:00

pages

140-8

issue

3

eissn

1043-4666

issn

1096-0023

pii

S1043466602908756

journal_volume

18

pub_type

杂志文章

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