Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations.

abstract：:Acute respiratory distress syndrome following an acute lung injury (ALI) is a life threatening inflammatory condition predominantly characterized by vascular protein leakage, neutrophil recruitment and overexpression of proinflammatory cytokines. Pulmonary and systemic bacterial infections are the major cause of ALI w...

journal_title：Cytokine

authors： Trivedi J,Shaikh J,Chavan N,Thorve D,Chaudhary B,Karade A,Gupta S,Patel A,Bhagwat S

更新日期：2020-05-01 00:00:00

abstract：CONTEXT:CTLA-4 is engaged on effector cells that may alter signal transduction and subsequently cytokine production. The transmission of longer repeats of (AT)(n) alleles of CTLA-4 is also associated with women undergoing recurrent miscarriage. The TNF-α known as an embryo-toxic cytokine is reported to be greater in pl...

journal_title：Cytokine

authors： Gupta R,Prakash S,Parveen F,Agrawal S

更新日期：2012-11-01 00:00:00

abstract：:Numerous proteins are cleaved or "shed" from their membrane-bound form. One such protein, tumour necrosis factor alpha (TNF-alpha), is synthesized as a type 2 transmembrane protein. Recently, a human protease responsible for this shedding, the TNF-alpha converting enzyme (TACE/ADAM17), was isolated. TACE/ADAM17 is a m...

journal_title：Cytokine

authors： Cerretti DP,Poindexter K,Castner BJ,Means G,Copeland NG,Gilbert DJ,Jenkins NA,Black RA,Nelson N

更新日期：1999-08-01 00:00:00

abstract：:Inflammatory processes are implicated in gastric cancer development. In contrast, the role of inflammation and proinflammatory cytokines in established cancer remains to be clarified. We investigated the contribution of IL-17A versus IL-17F-mediated intracellular signalling pathways in human gastric adenocarcinoma AGS...

journal_title：Cytokine

authors： Zhou Y,Toh ML,Zrioual S,Miossec P

更新日期：2007-06-01 00:00:00

abstract：:We have demonstrated that ingested murine interferon alpha (IFN-alpha) suppressed clinical relapse in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), decreased inflammation and suppressed the adoptive transfer of EAE, and is a biological response modifier in patients with multiple sclerosis. We e...

journal_title：Cytokine

authors： Brod SA,Nelson L,Jin R,Wolinsky JS

更新日期：1999-07-01 00:00:00

abstract：:Toll-like receptors induce a complex inflammatory response that can function to alert the body to infection, neutralize pathogens and repair damaged tissues. Toll-like receptors are expressed on kupffer, endothelial, dendritic, biliary epithelial, hepatic stellate cells, and hepatocytes in the liver. The endoplasmic r...

journal_title：Cytokine

authors： Lawless MW,Greene CM

更新日期：2012-08-01 00:00:00

abstract：:Fifty-five adult patients with primary bone tumour, 27 benign and 28 malignant tumours, were assayed for leukaemia inhibitory factor (LIF) in urine and serum samples. Supernatant was obtained from primary tumour tissue cultures in 24 cases (14 benign, 10 malignant tumours). LIF was found in 11 urine samples (16.7%, 1 ...

journal_title：Cytokine

authors： Gouin F,Heymann D,Raher S,De Groote D,Passuti N,Daculsi G,Godard A

更新日期：1998-02-01 00:00:00

abstract：:The production of nitric oxide (NO) is increased in experimental nephritis, with NO thought to be an important mediator of cell damage. The cytokines interleukin 1 beta (IL-1 beta), IL-6, IL-8, monocyte chemotactic protein-1 (MCP-1) and transforming growth factor-beta (TGF-beta) are released from mesangial cells in vi...

journal_title：Cytokine

authors： Ikeda M,Ikeda U,Ohkawa F,Shimada K,Kano S

更新日期：1994-11-01 00:00:00

abstract：:The proper balance between IL-12p40-related cytokines controls the appearance of normal and pathological Th1 immune responses. In this study, we examined the inducible IL-12p40, IL-12p35 and IL-23p19 mRNA expression and protein production in human peripheral blood mononuclear cells (PBMC) and purified monocytes, isola...

journal_title：Cytokine

authors： Dobreva ZG,Stanilova SA,Miteva LD

更新日期：2008-07-01 00:00:00

abstract：:Obesity, a chronic low-grade inflammation metabolic abnormality, is related to high proinflammatory cytokines concentrations. Epstein-Barr virus-induced gene 3 (EBI3) encodes for the EBI3 beta subunit that constitutes interleukin (IL) 27 and 35. Our objective was to assess the association of three EBI3 single nucleoti...

journal_title：Cytokine

authors： Posadas-Sánchez R,Del Carmen González-Salazar M,Cardoso-Saldaña G,Andrés Criales-Vera S,Reyes-Barrera J,Pérez-Hernández N,Manuel Fragoso J,Vargas-Alarcón G

更新日期：2020-11-01 00:00:00

abstract：:Interleukin (IL)-7 is a potent proliferation, activation, and survival cytokine for CD8+ T cells to improve viral and tumor specific CD8+ T cell responses. However, the role of IL-7 in regulation of dysfunctional hepatitis C virus (HCV)-specific CD8+ T cells was not fully elucidated. Thus, a total of 53 patients with ...

journal_title：Cytokine

authors： Hou H,Kang Y,Zeng Y,Li Y,Shang J

更新日期：2018-02-01 00:00:00

abstract：:Purpose suppressor of cytokine signaling 1 (SOCS-1) is inducible feedback inhibitors of cytokine signaling and involved in viral infection through regulation of both innate and adaptive immunity. In this study, we firstly cloned SOCS-1 (goSOCS-1) from duck Tembusu virus (DTMUV) infected goose. The full-length sequence...

journal_title：Cytokine

authors： Zhang W,Chen S,Zhang J,Wu Z,Wang M,Jia R,Zhu D,Liu M,Sun K,Yang Q,Wu Y,Chen X,Cheng A

更新日期：2017-05-01 00:00:00

abstract：:L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. The thiol depletor diethyl maleate (DEM) and an inhibi...

journal_title：Cytokine

authors： Nikulina MA,Andersen HU,Karlsen AE,Darville MI,Eizirik DL,Mandrup-Poulsen T

更新日期：2000-09-01 00:00:00

abstract：:KYM-1D4 cells are a subline derived from a human rhabdomyosarcoma which are highly sensitive to TNF-mediated cytotoxicity. They were selected for this study because they express human TNF-R and are therefore a more relevant target for comparing the potential therapeutic value of human TNF-inhibitory agents than the us...

journal_title：Cytokine

authors： Butler DM,Scallon B,Meager A,Kissonerghis M,Corcoran A,Chernajovsky Y,Feldmann M,Ghrayeb J,Brennan FM

更新日期：1994-11-01 00:00:00

abstract：:Bone tissue is continually being remodelled according to physiological circumstances. Two main cell populations (osteoblasts and osteoclasts) are involved in this process, and cellular activities (including cell differentiation) are modulated by hormones, cytokines and growth factors. Within the last 20 years, many fa...

journal_title：Cytokine

authors： Heymann D,Rousselle AV

更新日期：2000-10-01 00:00:00

abstract：:CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...

journal_title：Cytokine

authors： Huang L,Cao RB,Wang N,Liu K,Wei JC,Isahg H,Song LJ,Zuo WY,Zhou B,Wang WW,Mao X,Chen PY

更新日期：2012-01-01 00:00:00

abstract：:Interleukin-21 (IL-21) is overproduced in human intestines affected by inflammatory bowel disease (IBD) and in the gut of mice with DSS-induced colitis. IL-21-deficient mice are largely protected against DSS-induced colitis, indicating that IL-21 plays a key role in the development of IBD. We previously identified a n...

journal_title：Cytokine

authors： Araki A,Nara H,Rahman M,Onoda T,Li J,Juliana FM,Jin L,Murata K,Takeda Y,Asao H

更新日期：2013-05-01 00:00:00

abstract：:IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-...

journal_title：Cytokine

authors： Scott LM,Bryant AH,Rees A,Down B,Jones RH,Thornton CA

更新日期：2017-11-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGFbeta1) induces plasminogen activator inhibitor-1 (PAI-1) as a major target protein. PAI-1 is associated with fibrosis, thrombosis, and metabolic disorders. TGFbeta1 induces PAI-1 via phosphorylation and nuclear translocation of Smads. Oltipraz inhibits TGFbeta1 expression and also ...

journal_title：Cytokine

authors： Cho IJ,Kim SH,Kim SG

更新日期：2006-09-01 00:00:00

abstract：:This study was conducted to compare the secretion of TGF-beta isoforms by human ovarian carcinoma (OVCA) cell lines (n=12) and human peritoneal mesothelial cells (HPMC;n=6) and to examine the regulation of their production by inflammatory cytokines. TGF-beta isoforms were furthermore analysed in OVCA-associated asciti...

journal_title：Cytokine

authors： Abendstein B,Stadlmann S,Knabbe C,Buck M,Müller-Holzner E,Zeimet AG,Marth C,Obrist P,Krugmann J,Offner FA

更新日期：2000-07-01 00:00:00

abstract：:Among myriads of distinct chemical modification in RNAs, the dynamic, reversible and fine-tuned methylation of N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic mRNAs. This RNA mark is generated by proteins that act as m6A writers and can be reversed by proteins that act as m6A erasers. The RNA...

journal_title：Cytokine

authors： Chang G,Leu JS,Ma L,Xie K,Huang S

更新日期：2019-06-01 00:00:00

abstract：:Tumour necrosis factor alpha(TNF-alpha) is one of the most important pro-inflammatory cytokines, which plays an important role in host defense and acute inflammation related to tissue injury. The major source of TNF-alpha has been shown to be immune cells such as macrophages and neutrophils. In the present study, we d...

journal_title：Cytokine

authors： McRitchie DI,Isowa N,Edelson JD,Xavier AM,Cai L,Man HY,Wang YT,Keshavjee SH,Slutsky AS,Liu M

更新日期：2000-06-01 00:00:00

abstract：AIM:How irreversible electroporation (IRE) affect immune status is still kept unknown. This preclinical study is to investigate its local and systemic immune reaction both on tumor-bearing and tumor free animals. METHODS:Liver ablation was performed by a standard IRE instrument and proposal. Altogether 57 tumor bearin...

journal_title：Cytokine

authors： Chen X,Ren Z,Yin S,Xu Y,Guo D,Xie H,Zhou L,Wu L,Jiang J,Li H,Sun J,Zheng S

更新日期：2017-05-01 00:00:00

abstract：:Castration-refractory prostate cancer (CRPC) is treated with taxane-based chemotherapy, but eventually becomes drug resistant. It is thus essential to identify novel therapeutic targets for taxane resistance in CRPC patients. We investigated the role of the chemokine (C-C motif) receptor 1 (CCR1) and its ligand, chemo...

journal_title：Cytokine

authors： Kato T,Fujita Y,Nakane K,Mizutani K,Terazawa R,Ehara H,Kanimoto Y,Kojima T,Nozawa Y,Deguchi T,Ito M

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Among all cytokines involved in the pathogenesis and in the progression of psoriasis, Tumor Necrosis Factor (TNF)-alpha and interleukin (IL)-17 play a pivotal role. OBJECTIVE:The aim of the present study was to mimic a psoriatic microenvironment and to investigate the early effects of TNF-alpha and IL-17 in...

journal_title：Cytokine

authors： Donetti E,Cornaghi L,Gualerzi A,Baruffaldi Preis FW,Prignano F

更新日期：2014-07-01 00:00:00

abstract：:Stem cell therapy is a promising strategy for recovering of injured cardiac tissue after acute myocardial infarction. The effects promoted by preventive physical training, beneficial for regeneration, are not yet understood on stem cell homing. In the present study, we evaluated the effect of preventive physical train...

journal_title：Cytokine

authors： Schaun MI,Kristochek M,Dias LD,Peres TR,Lehnen AM,Irigoyen MC,Markoski MM

更新日期：2020-02-01 00:00:00

abstract：UNLABELLED:Burn is associated with profound inflammation and activation of the innate immune system in multiple organ beds, including the lung. Similarly, toll-like receptors (TLR) are associated with innate immune activation. Nonetheless, it is unclear what impact burn has on TLR-induced inflammatory responses in the ...

journal_title：Cytokine

authors： Oppeltz RF,Rani M,Zhang Q,Schwacha MG

更新日期：2011-09-01 00:00:00

abstract：:Leukaemia inhibitory factor (LIF), a pleiotropic cytokine detected in various inflammatory body fluids, plays a poorly defined role in the pathogenesis of human disease. This study was conducted to correlate the LIF concentrations in pleural effusions with the type of pathology and to compare its levels with those of ...

journal_title：Cytokine

authors： Heymann D,L'Her E,NGuyen JM,Raher S,Canfrère I,Coupey L,Fixe P,Chailleux E,De Groote D,Praloran V,Godard A

更新日期：1996-05-01 00:00:00

abstract：:LIGHT (lymphotoxin-like inducible protein that competes with glycoprotein D for binding herpesvirus entry mediator on T cells) is a recently identified of the tumor necrosis factor alpha (TNF-alpha) ligand superfamily. We wanted to establish whether the presence of chronic viral hepatitis could be implicated in enhanc...

journal_title：Cytokine

authors： Pawlak K,Mysliwiec M,Pawlak D

更新日期：2007-09-01 00:00:00

abstract：:The genetic producibilities of T helper type 1 (Th1) and T helper type 2 (Th2) cytokines are associated with the prognosis of autoimmune thyroid diseases (AITDs). Interleukin (IL)-10 is considered to be a Th2 cytokine that can exhibit an anti-inflammatory role. Furthermore, IL-10 may be associated with the development...

journal_title：Cytokine

authors： Inoue N,Watanabe M,Wada M,Morita M,Hidaka Y,Iwatani Y

更新日期：2013-10-01 00:00:00