Cross-talk between SUMOylation and ISGylation in response to interferon.

abstract：:Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE i...

journal_title：Cytokine

authors： Ponnalagu M,Subramani M,Jayadev C,Shetty R,Das D

更新日期：2017-07-01 00:00:00

abstract：:The aim of this study is to investigate the relationship between chemokines and the inflammation in Familial Mediterranean Fever (FMF). Forty-nine patients with FMF (41 in remission and 8 in acute attack period) and 20 healthy controls were included in the study. Serum levels of macrophage inflammatory protein-1alpha ...

journal_title：Cytokine

authors： Dizdar O,Kalyoncu U,Karadag O,Akdogan A,Kiraz S,Ertenli I,Barista I,Calguneri M

更新日期：2007-01-01 00:00:00

abstract：:The transforming growth factor-beta 1 (TGFβ1) and NFκB pathways are important regulators of epidermal homeostasis, inflammatory responses and carcinogenesis. Previous studies have shown extensive crosstalk between these pathways that is cell type and context dependent, but this has not been well-characterized in epide...

journal_title：Cytokine

authors： Hogan KA,Ravindran A,Podolsky MA,Glick AB

更新日期：2013-12-01 00:00:00

abstract：:Thymic vulnerability, a leading cause of defective immunity, was discovered decades ago. To date, several strategies have been investigated to unveil any immunorestorative capacities they might confer. Studies exploiting castration, transplantation, adoptive cell therapies, hormones/growth factors, and cytokines have ...

journal_title：Cytokine

authors： El-Kadiry AE,Rafei M

更新日期：2019-08-01 00:00:00

abstract：:A number of chemokines induce angiogenesis and endothelial cells express several chemokine receptors. To date, only a limited number of CC chemokines for CCR1 have been reported to induce angiogenic responses. We investigated the ability of CCL23 (also known as MPIF-1, MIP-3, or CKbeta8) to promote angiogenesis, which...

journal_title：Cytokine

authors： Hwang J,Son KN,Kim CW,Ko J,Na DS,Kwon BS,Gho YS,Kim J

更新日期：2005-06-07 00:00:00

abstract：OBJECTIVES:The fact that ovarian cancer remains confined to the peritoneal cavity even in advanced stages has allowed us to surmise that local immunosuppressive factors could be involved in the tumor biology of ovarian cancer. In this context, IL-10 can be one of the key factors. By studying the kinetics of IL-10 conce...

journal_title：Cytokine

authors： Mustea A,Braicu EI,Koensgen D,Yuan S,Sun PM,Stamatian F,Lichtenegger W,Chen FC,Chekerov R,Sehouli J

更新日期：2009-01-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis is stimulated during immune and inflammatory processes. Interleukin 1beta (IL-1beta) and lipopolysaccharide (LPS) are known to be potent stimulators of this axis. During postnatal development, the rat seems to be hyporesponsive to many stimuli. The effects of repeated syst...

journal_title：Cytokine

authors： Bumiller A,Götz F,Rohde W,Dörner G

更新日期：1999-03-01 00:00:00

abstract：:Thalidomide has antiangiogenic and immunomodulatory effects, mediated by several cytokines such as vascular endothelial growth factor (VEGF), fibroblastic growth factor (FGF-2), hepatocyte growth factor (HGF), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Although extramedullary plasmacytomas (EMP)...

journal_title：Cytokine

authors： Rosiñol L,Cibeira MT,Segarra M,Cid MC,Filella X,Aymerich M,Rozman M,Arenillas L,Esteve J,Bladé J,Montserrat E

更新日期：2004-05-21 00:00:00

abstract：:Chronic liver injury causes liver regeneration, resulting in fibrosis. The proinflammatory cytokine tumor necrosis factor (TNF) is involved in the pathogenesis of many acute and chronic liver diseases. TNF has pleiotropic functions, but its role in liver fibrosis has not been clarified. Chronic repeated injection of C...

journal_title：Cytokine

authors： Sudo K,Yamada Y,Moriwaki H,Saito K,Seishima M

更新日期：2005-03-07 00:00:00

abstract：BACKGROUND:HIV-1 and HIV-2 are two related viruses with distinct clinical outcomes, where HIV-1 is more pathogenic and transmissible than HIV-2. The pathogenesis of both infections is influenced by the dysregulation and deterioration of the adaptive immune system. However, their effects on the responsiveness of innate ...

journal_title：Cytokine

authors： Nowroozalizadeh S,Månsson F,da Silva Z,Repits J,Dabo B,Pereira C,Biague A,Albert J,Nielsen J,Aaby P,Fenyö EM,Norrgren H,Holmgren B,Jansson M

更新日期：2009-06-01 00:00:00

abstract：:Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Although the pathogenesis of AD is not fully understood, we and others have shown that IL-4 plays a key role. In this study we aimed to identify keratinocyte genes regulated by IL-4 that may play important roles in the pathophysiology of AD. HaCat c...

journal_title：Cytokine

authors： Bao L,Shi VY,Chan LS

更新日期：2013-02-01 00:00:00

abstract：:Interleukin 15 (IL-15) is a cytokine with many functional characteristics that are similar to IL-2. Most of the functional activities that IL-2 and IL-15 support have been evaluated in short-term assays. It was our intention, then, to determine the long-term effects of IL-15 in comparison to IL-2. These studies were p...

journal_title：Cytokine

authors： Farner NL,Gan J,de Jong JL,Leary TP,Fenske TS,Buckley P,Dunlap S,Sondel PM

更新日期：1997-05-01 00:00:00

abstract：:Propofol anesthesia and sedation are known to downregulate the functions of many hematopoietic cells, such as macrophages and neutrophils, in vivo. However, the effects of propofol on secretion of the regulatory cytokine transforming growth factor β1 (TGF-β1) in vivo are unknown. In this study, the effects of propofol...

journal_title：Cytokine

authors： Li CH,Lee RP,Lin YL,Lin CS,Hsu BG,Tseng FJ,Chen YC,Liao KW,Yang FL

更新日期：2010-12-01 00:00:00

abstract：:The authors studied plasma cytokine activity using cross reactive polyclonal antibodies to human cytokines in young and old female monkeys to determine if age had any effect on cytokine secretion, and compared hormonal effects as well. While interleukin 1 (IL-1) was not higher in aged cycling monkeys, it was after men...

journal_title：Cytokine

authors： Kaack MB,Harrison RM,Roberts JA

更新日期：1998-03-01 00:00:00

abstract：:We previously isolated quercetin 3-O-beta-(2''-galloyl)-glucopyranoside (QG-32) from Persicaria lapathifolia (Polygonacease) as an inhibitor of superoxide production. In the present study, QG-32 was found to inhibit interleukin (IL)-6 production in endotoxin lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. T...

journal_title：Cytokine

authors： Kim BH,Lee IJ,Lee HY,Han SB,Hong JT,Ahn B,Lee CK,Kim Y

更新日期：2007-09-01 00:00:00

abstract：:Endothelial barrier dysfunction leads to increased endothelial permeability and is an early step in the development of vascular inflammatory diseases such as atherosclerosis. Interferon-γ (IFN-γ), a proinflammatory cytokine, is known to cause increased endothelial permeability. However, the mechanisms by which IFN-γ d...

journal_title：Cytokine

authors： Ng CT,Fong LY,Yong YK,Hakim MN,Ahmad Z

更新日期：2018-11-01 00:00:00

abstract：:Candida albicans is an opportunistic fungal pathogen that colonizes human gastro-intestinal mucosal tissues. Its effect on the immune response in intestinal epithelial cells and on the intestinal mucosal barrier are not yet fully understood. In this study, we investigated Caco-2 cells, a monolayer model of intestinal ...

journal_title：Cytokine

authors： Mao X,Qiu X,Jiao C,Lu M,Zhao X,Li X,Li J,Ma J,Zhang H

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Adipocytokines represent a molecular link between metabolic factors and vascular function. The purpose of our study was to investigate the relationship between adiponectin, leptin and renal function parameters in patients with glomerular filtration rate (GFR) above 90 ml/min/m(2) and type 2 diabetes. MATE...

journal_title：Cytokine

authors： Barlovic DP,Zaletel J,Prezelj J

更新日期：2009-04-01 00:00:00

abstract：:Interleukin 6 (IL-6) and related gp130-signalling cytokines rapidly activate latent cytoplasmic Stat transcription factors and these are believed to play pivotal roles in the expression of downstream cytokine-responsive genes. We have previously shown in IL-6-deficient (-/-) mice that IL-6 is absolutely required for t...

journal_title：Cytokine

authors： Alonzi T,Fattori E,Cappelletti M,Ciliberto G,Poli V

更新日期：1998-01-01 00:00:00

abstract：:Cartilage-specific extracellular matrix synthesis is the prerequisite for chondrocyte survival and cartilage function, but is affected by the pro-inflammatory cytokine TNF-alpha in arthritis. The aim of the present study was to characterize whether the immunoregulatory cytokine IL-10 might modulate cartilage matrix an...

journal_title：Cytokine

authors： Müller RD,John T,Kohl B,Oberholzer A,Gust T,Hostmann A,Hellmuth M,Laface D,Hutchins B,Laube G,Veh RW,Tschoeke SK,Ertel W,Schulze-Tanzil G

更新日期：2008-12-01 00:00:00

abstract：:The regulation of local L-tryptophan concentrations by tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO) induced by various stimuli such as interferon-γ (IFN-γ) is one of the key mechanisms in antimicrobial effect. Recently, IDO is also focused on an immunosuppressive mechanism shared by several different...

journal_title：Cytokine

authors： Murakami Y,Hoshi M,Hara A,Takemura M,Arioka Y,Yamamoto Y,Matsunami H,Funato T,Seishima M,Saito K

更新日期：2012-08-01 00:00:00

abstract：:Three representative cytokines interleukin (IL-8), RANTES and tumour necrosis factor alpha (TNF-alpha) have a concentration-dependent chemotactic effect on the unicellular Tetrahymena. Maximal effective concentrations of IL-8 (1 ng/ml) and RANTES (75 ng/ml) are in the same range as in mammals, which indicates an evolu...

journal_title：Cytokine

authors： Köhidai L,Csaba G

更新日期：1998-07-01 00:00:00

abstract：:Pregnancy in sickle cell disease is a problem due to the adverse outcomes related to the disease. Research into the role of chemokines in sickle cell disease is available, but studies investigating the disease in pregnancy are scarce. Our data show the chemokine profiles of pregnant women with sickle cell disease comp...

journal_title：Cytokine

authors： Hazin-Costa MF,da Silva Aráujo A,Guerra GL,da Matta MC,Torres LC,Souza AI

更新日期：2019-01-01 00:00:00

abstract：:The immunomodulatory functions of prolactin (PRL) are well recognized. Augmented PRL plasma levels were observed in patients with advanced tuberculosis (TB). Recently, we have reported that LPS and Mycobacterium bovis (M. bovis) induced differential expression of PRL receptor (PRLR) isoforms in THP-1 cells and bovine ...

journal_title：Cytokine

authors： Martínez-Neri PA,López-Rincón G,Mancilla-Jiménez R,del Toro-Arreola S,Muñoz-Valle JF,Fafutis-Morris M,Bueno-Topete MR,Estrada-Chávez C,Pereira-Suárez AL

更新日期：2015-01-01 00:00:00

abstract：:Natural terrestrial ionizing radiations emerge from uranium deposits and can impact human tissues by affecting DNA bases which constitute genes. Human interferon alpha-2b (hIFNα-2b) gene synthesizes a protein which exhibits anticancerous, immunomodulatory, anti-proliferative and antiviral properties. This research aim...

journal_title：Cytokine

authors： Shahid S,Mahmood N,Chaudhry MN,Ahmad N

更新日期：2015-12-01 00:00:00

abstract：:To date, the biological activity of granulocyte macrophage-colony stimulating factor (GM-CSF) has been investigated by using mostly Escherichia coli- or yeast cell-derived recombinant human GM-CSF (erhGM-CSF and yrhGM-CSF, respectively). However, Chinese hamster ovary cell-derived recombinant human GM-CSF (crhGM-CSF),...

journal_title：Cytokine

authors： Hashimoto A,Tanaka T,Itoh Y,Yamagata A,Kitamura N,Tazawa R,Nakagaki K,Nakata K

更新日期：2014-08-01 00:00:00

abstract：:IL-1 strikingly enhances antigen-driven responses of CD4 and CD8 T cells. It is substantially more effective than LPS and when added to a priming regime of antigen plus LPS, it strikingly enhances cell expansion. The effect is mediated by direct action on CD4 and CD8 T cells; the response occurs when OT-I or OT-II cel...

journal_title：Cytokine

authors： Ben-Sasson SZ,Caucheteux S,Crank M,Hu-Li J,Paul WE

更新日期：2011-10-01 00:00:00

abstract：:IL-4 and IL-13 are pleiotropic Th2 cytokines produced by a wide variety of different cell types and responsible for a broad range of biology and functions. Physiologically, Th2 cytokines are known to mediate host defense against parasites but they can also trigger disease if their activities are dysregulated. In this ...

journal_title：Cytokine

authors： May RD,Fung M

更新日期：2015-09-01 00:00:00

abstract：:Measuring T-cell production of intracellular cytokines by flow cytometry enables specific monitoring of airway inflammation and response to therapies in chronic lung diseases including chronic obstructive pulmonary disease (COPD). We have previously shown that T cells in the airways of ex- and current- smoker COPD pat...

journal_title：Cytokine

authors： Hodge G,Reynolds PN,Holmes M,Hodge S

更新日期：2012-12-01 00:00:00

abstract：:It has been reported that rapamycin (rap), cyclosporin A (CsA) and FK506 have immunosuppressive effect during the activation process of murine T cells. These drugs were investigated for their suppressive effect on a murine T cell line expressing intermediate (TS1 beta) or high (TS1 alpha beta) affinity IL-2R. Rap and ...

journal_title：Cytokine

authors： Rebollo A,Mérida I,Gómez J,Pitton C,Silva A,Martínez C,García A

更新日期：1995-04-01 00:00:00