Abstract:
:The self-renewal capacity of germline derived stem cells (GSCs) makes them an ideal source for research and use in clinics. Despite the presence of active gene network similarities between embryonic stem cells (ESCs) and GSCs, there are unanswered questions regarding the roles of evolutionary conserved genes in GSCs. To determine the reprogramming potential of germ cell- specific genes, we designed a polycistronic gene cassette expressing Stella, Oct4 and Nanos2 in a lentiviral-based vector. Deep transcriptome analysis showed the activation of a set of pluripotency and germ-cell-specific markers and the downregulation of innate immune system. The global shut down of antiviral genes included MHC class I, interferon response genes and dsRNA 2'-5'-oligoadenylate synthetase are critical pathways that has been affected . Individual expression of each factor highlighted suppressive effect of Nanos2 on genes such as Isg15 and Oasl2. Collectively, to our knowledge this is the first report showing that Nanos2 could be considered as an immunosuppressive factor. Furthermore, our results demonstrate suppression of endogenous retrotransposons that harbor immune response but further analysis require to uncover the correlation between transposon suppression and immune response in germ cell development.
journal_name
Cytokinejournal_title
Cytokineauthors
Farshchian M,Matin MM,Armant O,Geerts D,Dastpak M,Nakhaei-Rad S,Tajeran M,Jebelli A,Shahriyari M,Bahrami M,Fallah A,Yaghoobi V,Mirahmadi M,Abbaszadegan MR,Bahrami ARdoi
10.1016/j.cyto.2018.02.021subject
Has Abstractpub_date
2018-06-01 00:00:00pages
1-11eissn
1043-4666issn
1096-0023pii
S1043-4666(18)30069-3journal_volume
106pub_type
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