VEGF gene therapy cooperatively recruits molecules from the immune system and stimulates cell homing and angiogenesis in refractory angina.

abstract：:The authors evaluated the relationship between hormonal and cytokine responses after surgery. Patients who underwent thoracic oesophagectomy (O group; n = 7), pulmonary lobectomy (P group; n = 5), modified mastectomy (M group; n = 5) and laparoscopic cholecystectomy (LC group; n = 7), were randomly selected. Circulati...

journal_title：Cytokine

authors： Yamauchi H,Kobayashi E,Yoshida T,Kiyozaki H,Hozumi Y,Kohiyama R,Suminaga Y,Sakurabayashi I,Fujimura A,Miyata M

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Cutaneous melanoma displays high morbidity and mortality rates. Isolated limb perfusion with melphalan (Mel) is used for the treatment of non-resectable, locally advanced extremity melanomas. When combined with tumor necrosis factor alpha (TNF-alpha) treatment, the complete response varies between 70% and 90...

journal_title：Cytokine

authors： de Lima VC,de Carvalho AF,Morato-Marques M,Hashimoto VL,Spilborghs GM,Marques SM,Landman G,Torres C,Braga Ribeiro K,Brentani H,Reis LF,Dias AA

更新日期：2013-05-01 00:00:00

abstract：:We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 su...

journal_title：Cytokine

authors： Nibali L,D'Aiuto F,Donos N,Griffiths GS,Parkar M,Tonetti MS,Humphries SE,Brett PM

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:Vascular endothelial cell growth factor (VEGF) plays an important role in the biology of gynecological cancer, usually linked with aggressive tumour behaviour and a poor postoperative outcome. Yet, its role in benign breast/gynecological conditions is less clear. METHODS:Serum VEGF was analysed in a series ...

journal_title：Cytokine

authors： Koukourakis MI,Limberis V,Tentes I,Kontomanolis E,Kortsaris A,Sivridis E,Giatromanolaki A

更新日期：2011-03-01 00:00:00

abstract：:This study was aimed to assess whether ex vivo treatment with granulocyte-colony stimulating factor (G-CSF) modifies biological properties of bone marrow stromal cells (BMSC) and enhances functional recovery by BMSC transplantation into infarct brain. Immunohistochemistry was conducted to characterize the cultured BMS...

journal_title：Cytokine

authors： Hokari M,Kuroda S,Chiba Y,Maruichi K,Iwasaki Y

更新日期：2009-05-01 00:00:00

abstract：:Pro-inflammatory cytokines are important mediators in tissue responses to a wide range of endogenous (e.g. autoantigens) and exogenous (e.g. infections, wounds, biomaterials) stimuli. The complex interactions taking place between different cell types in such processes are difficult to examine in vivo. Here we studied ...

journal_title：Cytokine

authors： Gretzer C,Thomsen P,Jansson S,Nilsson M

更新日期：2000-01-01 00:00:00

abstract：RATIONALE:Inflammation exacerbates a number of deleterious effects on the heart, most notable being left ventricular dysfunction (LVD). A promoter polymorphism of the NFKB1 gene (encodes p50 subunit) results in lower protein levels of NFkB p50 subunits, which in its dimmer (p50) form has anti-inflammatory effects. The ...

journal_title：Cytokine

authors： Mishra A,Srivastava A,Mittal T,Garg N,Mittal B

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Adiponectin is an anti-atherogenic insulin-sensitizer hormone whose plasma concentration is lower in patients with metabolic syndrome (MS). Visceral adiposity, including epicardial adipose tissue (EAT), is closely related to the development of MS and coronary artery disease (CAD). We sought to study whether ...

journal_title：Cytokine

authors： Teijeira-Fernandez E,Eiras S,Shamagian LG,Somoza AS,Delgado C,Gonzalez-Juanatey JR

更新日期：2011-05-01 00:00:00

abstract：:Azidothymidine (AZT)-induced anemia in mice can be reversed by the administration of IGF-IL-3 (fusion protein of insulin-like growth factor II (IGF II) and interleukin 3). Although interleukin 3 (IL-3) and erythropoietin (EPO) are known to act synergistically on hematopoietic cell proliferation in vitro, injection of ...

journal_title：Cytokine

authors： DiFalco MR,Congote LF

更新日期：2002-04-07 00:00:00

abstract：:The chemokine eotaxin (CCL11) is a key player in the trafficking of eosinophils to normal tissues and in the tissue eosinophilia associated with human allergic disease. We have recently cloned equine eotaxin and here we report the production of rEq eotaxin, with and without a C-terminal fusion peptide, in a novel expr...

journal_title：Cytokine

authors： Benarafa C,Collins ME,Hamblin AS,Sabroe I,Cunningham FM

更新日期：2002-07-07 00:00:00

abstract：:The development of acidic environments is a hallmark of inflammatory processes of different etiology. We have previously shown that transient exposure to acidic conditions, similar to those encountered in vivo, induces the activation of neutrophils and the phenotypic maturation of dendritic cells. We here report that ...

journal_title：Cytokine

authors： Jancic CC,Cabrini M,Gabelloni ML,Rodríguez Rodrigues C,Salamone G,Trevani AS,Geffner J

更新日期：2012-02-01 00:00:00

abstract：:A series of controlled clinical trials have shown that exogenous interferon-beta (IFN-β) benefits patients with relapsing-remitting multiple sclerosis (RRMS) by reducing relapse rate, disability progression, and the formation of new brain and spinal cord lesions on magnetic resonance imaging (MRI) scans. Unfortunately...

journal_title：Cytokine

authors： Huber AK,Duncker PC,Irani DN

更新日期：2015-08-01 00:00:00

abstract：:Preeclampsia is a complex disease of pregnancy with both feto-placental and maternal factors contributing to its pathogenesis. Although the cause of this disease is uncertain, imbalance between pro-and anti-inflammatory cytokines has been implicated in the pathogenesis of preeclampsia. Increased levels of the inflamma...

journal_title：Cytokine

authors： Xiao JP,Yin YX,Gao YF,Lau S,Shen F,Zhao M,Chen Q

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Pneumonia is the leading cause of death in children under 5, with the highest burden in resource-limited countries. Endothelial activation occurs in pneumonia and can be assessed using quantitative levels of biomarkers angiopoietin (Ang)-1 and Ang-2. We examined admission levels of Ang-1 and Ang-2 in pediatri...

journal_title：Cytokine

authors： Zhang R,Rai U,Ibrahim NBM,Amazouz Y,Soo J,Conroy AL,Namasopo S,Opoka RO,Bhargava R,Hawkes MT

更新日期：2020-09-01 00:00:00

abstract：:To verify the role of macrophage migration inhibitory factor (MIF) in tumourigenesis, we examined the effect of an anti-MIF antibody on tumour growth and angiogenesis. We inoculated murine colon adenocarcinoma cell line colon 26 cells subcutaneously into the flank in BALB/c mice. After nine days, we treated tumour-bea...

journal_title：Cytokine

authors： Ogawa H,Nishihira J,Sato Y,Kondo M,Takahashi N,Oshima T,Todo S

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Obesity is associated with endothelial dysfunction and increased inflammation as well as with expansion of the capillary bed in regional adipose deposits, and a balance between these factors is involved in angiogenesis. Osteopontin (OPN) is a proinflammatory cytokine involved in regulating immune processes a...

journal_title：Cytokine

authors： Komorowski J,Jankiewicz-Wika J,Kolomecki K,Cywinski J,Piestrzeniewicz K,Swiętoslawski J,Stepien H

更新日期：2011-07-01 00:00:00

abstract：INTRODUCTION:Transfersomes (TF) are new, ultradeformable carriers with characteristics that enable them to penetrate the skin spontaneously. TFs are able to transport noninvasively both low- and high-molecular-weight molecules into the body. MATERIALS AND METHODS:TFs contain phosphatidylcholine and sodium cholate. Rec...

journal_title：Cytokine

authors： Hofer C,van Randenborgh H,Lehmer A,Hartung R,Breul J

更新日期：2004-02-21 00:00:00

abstract：:The purpose of this study is to evaluate local levels of interleukin-1 beta (IL-1 beta), -4 (IL-4), -6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), in a model of murine osteomyelitis due to Staphylococcus aureus. Cytokine levels in supernatants derived from bone homogenates were determined by enzyme-linked im...

journal_title：Cytokine

authors： Yoshii T,Magara S,Miyai D,Nishimura H,Kuroki E,Furudoi S,Komori T,Ohbayashi C

更新日期：2002-07-21 00:00:00

abstract：:Endothelial barrier dysfunction leads to increased endothelial permeability and is an early step in the development of vascular inflammatory diseases such as atherosclerosis. Interferon-γ (IFN-γ), a proinflammatory cytokine, is known to cause increased endothelial permeability. However, the mechanisms by which IFN-γ d...

journal_title：Cytokine

authors： Ng CT,Fong LY,Yong YK,Hakim MN,Ahmad Z

更新日期：2018-11-01 00:00:00

abstract：:Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC), but specific genetic variants remain unknown. Genome-wide association studies have identified rs4444235 at BMP4 as a new colorectal cancer (CRC) and colorectal adenoma (CRA) susceptibility locus in populations of European descent. Afte...

journal_title：Cytokine

authors： Zhou L,Xie J,Gu EL,Huang Y,Qu Y,Xu AP,Zhu Y,Wang H

更新日期：2015-04-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) is the major cytokine involved in the control of neutrophil development. G-CSF activates the special receptor, the G-CSF receptor (GCSF-R), which subsequently triggers multiple signaling events. To obtain more interactive molecules with GCSF-R and to further understand the...

journal_title：Cytokine

authors： Yuan X,Shan Y,Zhao Z,Chen J,Cong Y

更新日期：2006-02-21 00:00:00

abstract：OBJECTIVE:Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease mediated by an autoimmune reaction to hepatocytes, the present study aimed to assess the possible associations between interleukin-4 (IL-4) variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms and susceptibility to aut...

journal_title：Cytokine

authors： Mansour AI,Behairy OG,Abd Almonaem ER,Abd-Rabuh RM,Ahmed IAE

更新日期：2018-10-01 00:00:00

abstract：:The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19. Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced cytokine storm and their predictive values have not been fully elu...

journal_title：Cytokine

authors： Liu Y,Chen D,Hou J,Li H,Cao D,Guo M,Ling Y,Gao M,Zhou Y,Wan Y,Zhu Z

更新日期：2021-02-01 00:00:00

abstract：:Colony stimulating factors (CSF) promote leukocyte survival by reducing apoptotic cell death. However, their effects on non-leukocyte cell types are unclear. Reduced apoptosis in colon epithelial cells is thought to contribute to the initiation of cancer. Here, we report diminished spontaneous apoptosis of human colon...

journal_title：Cytokine

authors： Calatayud S,Warner TD,Breese EJ,Mitchell JA

更新日期：2002-11-24 00:00:00

abstract：:CCR2, and its principle ligand MCP-1/CCL2, have been well documented for their ability to induce monocyte infiltration and promote the pathogenesis of rheumatoid arthritis and atherosclerosis. In order to assess additional roles for CCR2, we inserted allogeneic implants into CCR2-/- and MCP-1-/- mice and characterized...

journal_title：Cytokine

authors： Tylaska LA,Boring L,Weng W,Aiello R,Charo IF,Rollins BJ,Gladue RP

更新日期：2002-05-21 00:00:00

abstract：:Erythropoietin (EPO) and Stem Cell Factor (SCF) have partially distinct functions in erythroid cell development. The primary functions of EPO are to prevent apoptosis and promote differentiation, with a minor role as a mitogen. On the other hand SCF acts primarily as a mitogenic factor promoting erythroid cell prolife...

journal_title：Cytokine

authors： Geslain R,Uddin S,Liu H,Jiang H,van Besien K,Pan T,Wickrema A

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Vascular endothelial growth factor (VEGF) is a potent stimulus of angiogenesis that has an important role in many human malignancies including prostate carcinoma (PCa). We evaluated the role of the functional VEGF polymorphisms as genetic markers for PCa susceptibility and prognosis. METHODS:The study inclu...

journal_title：Cytokine

authors： Sfar S,Hassen E,Saad H,Mosbah F,Chouchane L

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:HIV rapid progressors (RPs) present with a rapid decline of CD4+ T cells within a few years of infection. Determining the underlying mechanisms throughout this decline is important to identify prognostic biomarkers and intervention strategies. Determining the numbers of CD4+ and CD8+ T cells is essential for...

journal_title：Cytokine

authors： Ding ZD,Zheng JF,Song CB,Fu YJ,Xu JJ,Jiang YJ,Shang H,Zhang ZN

更新日期：2020-01-01 00:00:00

abstract：:The regulation of local L-tryptophan concentrations by tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO) induced by various stimuli such as interferon-γ (IFN-γ) is one of the key mechanisms in antimicrobial effect. Recently, IDO is also focused on an immunosuppressive mechanism shared by several different...

journal_title：Cytokine

authors： Murakami Y,Hoshi M,Hara A,Takemura M,Arioka Y,Yamamoto Y,Matsunami H,Funato T,Seishima M,Saito K

更新日期：2012-08-01 00:00:00

abstract：:We have investigated phosphatidylinositol 3-kinase (PI3K)-dependent survival signalling pathways using several cytokines in three different hemopoietic cell lines, MC/9, FDC-P1, and TF-1. Cytokines caused PI3K- and PKB-dependent phosphorylation of FOXO3a (previously known as FKHRL1) at three distinct sites. Following ...

journal_title：Cytokine

authors： Behzad H,Jamil S,Denny TA,Duronio V

更新日期：2007-05-01 00:00:00