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Mouse genetic background influences severity of immune responses following trauma-hemorrhage.

Abstract：

:Studies have shown that following bacterial infection or endotoxin administration, immune functions are regulated differently in mice of different genetic background. Since the susceptibility to sepsis following trauma-hemorrhage is dependant on the severity of injury, it is important to determine whether genetic background of the animal influence immune functions after trauma-hemorrhage. The aim of our studies, therefore, was to assess differences in the immune functions in genetically different strains of age-matched C3H/HeN and C57BL/6 male mice following trauma-hemorrhage. The analysis for immune functions included: proliferation of splenocyte and bone-marrow cells, IL-2 and IFN-gamma release by splenocytes, and TNF-alpha and IL-10 release by splenic, peritoneal, liver (Kupffer cell), and bone-marrow macrophages. The results show significant differences in splenocyte and bone-marrow functions, and in the release of the mediators of immune function by immune competent cells: (a) between the two genetic strains, and (b) in each mouse strain following trauma-hemorrhage. Thus, genetic background appears to significantly influence the severity of immune responses in males following trauma-hemorrhage.

journal_name

Cytokine

journal_title

Cytokine

authors

Matsutani T,Anantha Samy TS,Kang SC,Bland KI,Chaudry IH

doi

10.1016/j.cyto.2004.12.019

keywords:

subject

Has Abstract

pub_date

2005-05-21 00:00:00

pages

168-76

issue

4

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(05)00041-4

journal_volume

30

pub_type

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