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Developmental changes in circulating IL-8/CXCL8 isoforms in neonates.

Abstract：

:Interleukin-8 (IL-8/CXCL8) is widely expressed in fetal tissues although inflammatory changes are not seen. Circulating IL-8 is comprised of an endothelial-derived [ala-IL-8](77) isoform and another, more potent [ser-IL-8](72) secreted by most other cells; [ala-IL-8](77) can be converted into [ser-IL-8](72) by proteolytic removal of an N-terminal pentapeptide from [ala-IL-8](77). In this study, we show [ala-IL-8](77) is the predominant circulating isoform of IL-8 in premature neonates but not in term neonates/adults, who have [ser-IL-8](72) as the major isoform. This isoform switch from the less potent [ala-IL-8](77) to [ser-IL-8](72) correlates with a maturational increase in the neutrophil chemotactic potency of plasma IL-8. The emergence of [ser-IL-8](72) as the major isoform is likely due to increased plasma [ala-IL-8](77)-convertase activity and/or changes in the cellular sources of IL-8. Developmental changes in IL-8 isoforms may serve to minimize its inflammatory effects in the fetus and also provide a mechanism to restore its full activity after birth.

journal_name

Cytokine

journal_title

Cytokine

authors

Maheshwari A,Voitenok NN,Akalovich S,Shaik SS,Randolph DA,Sims B,Patel RP,Killingsworth CR,Fallon MB,Ohls RK

doi

10.1016/j.cyto.2008.12.022

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

12-6

issue

1

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(09)00023-4

journal_volume

46

pub_type

杂志文章

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