Homeopathic medicines cause Th1 predominance and induce spleen and megakaryocytes changes in BALB/c mice infected with Leishmania infantum.

abstract：:The objectives were to determine if blood IL-10 levels rise during the early stages of acute (wasting) pre-pubescent malnutrition in metabolically distinct murine models known to depress inflammatory immune competence and whether systemic IL-10 production is affected in these pathologies. Weanling C57BL/6J mice were a...

journal_title：Cytokine

authors： Monk JM,Woodward B

更新日期：2009-08-01 00:00:00

abstract：:Clara cell protein (CC16) is an endogenous anti-inflammatory agent. It is produced mainly in the respiratory and urogenital tracts. CC16 has been quantified in serum, but not in cerebrospinal fluid (CSF). The aim of this study was to examine CSF CC16 in relation to age, gender and serum CC16, and to examine CC16 level...

journal_title：Cytokine

authors： De Jongh R,Vranken J,Kenis G,Bosmans E,Maes M,Stans G,De Ley M,Heylen R

更新日期：1998-06-01 00:00:00

abstract：:We examined seasonal differences in whole blood cytokine production after endotoxin (LPS) stimulation in 17 healthy individuals from an urban area having normal sleep/wakefulness pattern. We used 500 pg/ml of LPS for incubation period of 4 h to stimulate 100 microl of whole blood of the same subjects in June, Septembe...

journal_title：Cytokine

authors： Myrianthefs P,Karatzas S,Venetsanou K,Grouzi E,Evagelopoulou P,Boutzouka E,Fildissis G,Spiliotopoulou I,Baltopoulos G

更新日期：2003-12-21 00:00:00

abstract：:Human interleukin-6 (IL-6) secreted by cytokine- or endotoxin-induced fibroblasts, monocytes, keratinocytes, endometrial stromal cells, and endothelial cells, when analyzed under denaturing and reducing conditions, consists of a set of differentially modified phosphoglycoproteins of molecular mass in the range from 23...

journal_title：Cytokine

authors： May LT,Shaw JE,Khanna AK,Zabriskie JB,Sehgal PB

更新日期：1991-05-01 00:00:00

abstract：:Within the human TNF promoter we have identified two sites at positions -189 and -101 that show C/EBP specific binding of nuclear proteins from cells of the human monocytic line Mono Mac 6. Supershift analysis with anti C/EBP antibodies revealed that the complexes formed consist of both C/EBP alpha and C/EBP beta. Whe...

journal_title：Cytokine

authors： Wedel A,Sulski G,Ziegler-Heitbrock HW

更新日期：1996-05-01 00:00:00

abstract：:Cytokine balance alterations are responsible for some of the systemic and hepatic manifestations of alcoholism. The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Serum cytok...

journal_title：Cytokine

authors： González-Quintela A,Dominguez-Santalla MJ,Pérez LF,Vidal C,Lojo S,Barrio E

更新日期：2000-09-01 00:00:00

abstract：:Inflammatory processes are implicated in gastric cancer development. In contrast, the role of inflammation and proinflammatory cytokines in established cancer remains to be clarified. We investigated the contribution of IL-17A versus IL-17F-mediated intracellular signalling pathways in human gastric adenocarcinoma AGS...

journal_title：Cytokine

authors： Zhou Y,Toh ML,Zrioual S,Miossec P

更新日期：2007-06-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) is a potent immunomodulatory cytokine whose physiological roles are modulated by the extracellular matrix. Here, circular dichroism and fluorescence spectroscopic techniques are used to demonstrate that low molecular weight heparin and chondroitin sulfate cause significant changes in secon...

journal_title：Cytokine

authors： Balasubramanian V,Ramanathan M

更新日期：2000-05-01 00:00:00

abstract：:Proteolytic activation of the IL-33 precursor, full-length interleukin-33 (FLIL33), at multiple sites within the sensor domain (aa 95-109) yields several functionally mature (MIL33) forms. Unlike nuclear FLIL33, intracellular MIL33 occurs in the cytoplasm, is secreted from source cells, and exerts biological effects b...

journal_title：Cytokine

authors： Luzina IG,Clerman A,Fishelevich R,Todd NW,Lockatell V,Atamas SP

更新日期：2019-07-01 00:00:00

abstract：:We investigated the effects of either intravenous (IV) or intrabronchial (IB) treatment with transforming growth factor beta1 (TGF-beta1) during bacterial pneumonia in rats. Immediately following IB Escherichia coli inoculation (T0), animals (n=270) were randomized to receive a single treatment with human recombinant ...

journal_title：Cytokine

authors： Cui X,Zeni F,Vodovitz Y,Correa-de-Araujo R,Quezado M,Roberts A,Wahl S,Danner RL,Banks SM,Gerstenberger E,Fitz Y,Natanson C,Eichacker PQ

更新日期：2003-11-21 00:00:00

abstract：BACKGROUND:Interleukin (IL)-17A is proinflammatory cytokine produced by Th17 cells, which play key, but sometimes inconsistent role in autoimmunity and cancer. Polymorphic variants in IL-17A gene were differentially associated with susceptibility to cancer, including colorectal cancer (CRC). AIM:We investigated the as...

journal_title：Cytokine

authors： Bedoui SA,Barbirou M,Stayoussef M,Dallel M,Mokrani A,Makni L,Mezlini A,Bouhaouala B,Yacoubi-Loueslati B,Almawi WY

更新日期：2018-10-01 00:00:00

abstract：:Vascular smooth muscle cells (VSMC) may be programmed by nutrient deprivation. We found that after 2 and 12 h exposure to 75% reduced amino acids, the release of basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF beta 1) from VSMC was significantly greater than that from cells maintained i...

journal_title：Cytokine

authors： Pancholi S,Earle KA

更新日期：2000-09-01 00:00:00

abstract：:Long-term exposure to biomass-burning smoke (BS) is associated with chronic obstructive pulmonary disease (COPD), asthma, and other chronic inflammatory lung diseases. BS results from such processes as the burning of wood for indoor cooking and heating, with women and children having the highest exposure rate. This st...

journal_title：Cytokine

authors： Falfán-Valencia R,Ramírez-Venegas A,Pérez Lara-Albisua JL,Ramírez-Rodriguez SL,Márquez-García JE,Buendía-Roldan I,Gayosso-Gómez LV,Pérez-Padilla R,Ortiz-Quintero B

更新日期：2020-07-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is a major mediator in septic shock and several inflammatory diseases such as hepatitis. Galactosamine (GalN) sensitises experimental animals for TNF and the combination TNF/GalN leads to a lethal inflammatory hepatitis. We describe that a single injection of lipopolysaccharide (LPS), inte...

journal_title：Cytokine

authors： Wielockx B,Hochepied T,Staelens J,Van Molle W,Brouckaert P,Libert C

更新日期：2001-07-21 00:00:00

abstract：:Propofol anesthesia and sedation are known to downregulate the functions of many hematopoietic cells, such as macrophages and neutrophils, in vivo. However, the effects of propofol on secretion of the regulatory cytokine transforming growth factor β1 (TGF-β1) in vivo are unknown. In this study, the effects of propofol...

journal_title：Cytokine

authors： Li CH,Lee RP,Lin YL,Lin CS,Hsu BG,Tseng FJ,Chen YC,Liao KW,Yang FL

更新日期：2010-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) chronic infection causes severe cellular immune dysfunction. Here, we investigated the production of Th17-associated cytokines by peripheral blood mononuclear cells (PBMCs) of untreated patients with HCV, patients presenting an early virologic response (EVR) after 12weeks of treatment with inte...

journal_title：Cytokine

authors： Cabral MS,Santos TPS,Santos PL,Schinoni MI,Oliveira IS,Pereira AB,Atta AM,Sousa-Atta MLB

更新日期：2018-02-01 00:00:00

abstract：:We have cloned and performed the first functional characterization of the chemokine receptor, CCR3, of Cynomolgus monkey (Macaca fascicularis). The deduced amino acid sequence of the cloned Cynomolgus CCR3 was found to be more similar to that of a previously-reported Rhesus (Macaca mulatta) CCR3 (99.4%) than that of a...

journal_title：Cytokine

authors： Iino T,Sugimoto H,Watanabe A,Encinas JA,Liu N,Floeckner J,Bacon KB

更新日期：2002-09-21 00:00:00

abstract：:Monocyte chemotactic protein-3 (MCP-3) is a C-C chemokine which interacts with the CCR1, CCR2 (MCP-1) and CCR3 receptors and has a distinct spectrum of action. The present study was designed to assess whether mycobacterial components were able to induce expression and production of MCP-3 in human monocytes. Mycobacter...

journal_title：Cytokine

authors： Vouret-Craviari V,Cenzuales S,Poli G,Mantovani A

更新日期：1997-12-01 00:00:00

abstract：PURPOSE:Tumor necrosis factor (TNFα) is a proinflammatory cytokine and has been a target for intervention in human sepsis. However, inhibition of TNF-α with a high dose of a TNF-receptor fusion protein in patients with septic shock worsened patient survival. This study was designed to investigate whether blocking TNF-α...

journal_title：Cytokine

authors： Tsay TB,Yang MC,Chen PH,Lai KH,Huang HT,Hsu CM,Chen LW

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Alterations in β common (βC) and γ common (γC) chain cytokines have been described in pulmonary tuberculosis. However, their role in tuberculous lymphadenitis (TBL) disease has not been assessed. METHODS:Thus, in the present study, we have examined the systemic levels of βC and γC chain cytokines in TBL, la...

journal_title：Cytokine

authors： Kathamuthu GR,Moideen K,Sridhar R,Baskaran D,Babu S

更新日期：2021-02-01 00:00:00

abstract：INTRODUCTION:Although, hypothermia is a frequent event after trauma, it is unclear whether its beneficial or detrimental effects are more important. This study aims to quantify the effects of hypothermia and re-warming on the inflammatory response after fracture/hemorrhage and subsequent fracture stabilization with res...

journal_title：Cytokine

authors： Hildebrand F,van Griensven M,Giannoudis P,Luerig A,Harwood P,Harms O,Fehr M,Krettek C,Pape HC

更新日期：2005-09-07 00:00:00

abstract：:The production of nitric oxide (NO) is increased in experimental nephritis, with NO thought to be an important mediator of cell damage. The cytokines interleukin 1 beta (IL-1 beta), IL-6, IL-8, monocyte chemotactic protein-1 (MCP-1) and transforming growth factor-beta (TGF-beta) are released from mesangial cells in vi...

journal_title：Cytokine

authors： Ikeda M,Ikeda U,Ohkawa F,Shimada K,Kano S

更新日期：1994-11-01 00:00:00

abstract：:Interleukin (IL)-4, IL-10, and IL-13 are T-helper2 cell derived cytokines, which are known to suppress pro-inflammatory cytokine production. The biologically related IL-4 and IL-13 have an impact on the development of atopic inflammation, whereas IL-10 is mostly supposed to be involved in fibrotic disorders or inflamm...

journal_title：Cytokine

authors： Hocke AC,Ermert M,Althoff A,Brell B,N'Guessan PD,Suttorp N,Ermert L

更新日期：2006-02-21 00:00:00

abstract：:The clinical phenotype in sepsis that is observed as LPS tolerance is determined by silencing of pro-inflammatory genes like IL-1 beta (IL-1β). This study shows that facultative heterochromatin (fHC) silences IL-1β expression during sepsis, where we find dephosphorylated histone H3 serine 10 and increased binding of h...

journal_title：Cytokine

authors： Yoza BK,McCall CE

更新日期：2011-02-01 00:00:00

abstract：:Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold. iNKT cells have the ability to respond as innate immune cel...

journal_title：Cytokine

authors： Reilly EC,Wands JR,Brossay L

更新日期：2010-09-01 00:00:00

abstract：:CCR2, and its principle ligand MCP-1/CCL2, have been well documented for their ability to induce monocyte infiltration and promote the pathogenesis of rheumatoid arthritis and atherosclerosis. In order to assess additional roles for CCR2, we inserted allogeneic implants into CCR2-/- and MCP-1-/- mice and characterized...

journal_title：Cytokine

authors： Tylaska LA,Boring L,Weng W,Aiello R,Charo IF,Rollins BJ,Gladue RP

更新日期：2002-05-21 00:00:00

abstract：:Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH pati...

journal_title：Cytokine

authors： Gao SP,Pan M,Chen C,Ge LJ,Jiang MH,Luan H,Zheng JG,Deng XT,Pan HY,Zhu JH

更新日期：2011-07-01 00:00:00

abstract：:Although physical therapy has been shown to be an effective method for treatment of rheumatoid arthritis, a thorough investigation on the impact of mechanical signals upon the complex cytokine network associated with pathogenesis has not yet been conducted. In the current study, our research group investigated the eff...

journal_title：Cytokine

authors： Bader RA,Wagoner KL

更新日期：2010-07-01 00:00:00

abstract：:Tumour necrosis factor alpha (TNF-alpha) plays an important role in orchestrating inflammatory responses with the vascular endothelium as main target cell type, and was found to promote migration of endothelial cells, as occurs in wound healing processes. Substantial evidence exists that endothelial cell migration in ...

journal_title：Cytokine

authors： van Rijen HV,van Kempen MJ,Postma S,Jongsma HJ

更新日期：1998-04-01 00:00:00

abstract：:ICAM-1-mediated cell-cell adhesion is essential for different immunologic functions including non-MHC-restricted cytotoxicity. The shedding of a soluble form of ICAM-1 from melanoma impairs immune recognition and leads to tumour escape. Pretreatment of the Foss human melanoma cell line with HILDA/LIF or OSM, two cytok...

journal_title：Cytokine

authors： Heymann D,Godard A,Raher S,Ringeard S,Lassort D,Blanchard F,Harb J

更新日期：1995-02-01 00:00:00