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Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis.

Abstract：

:The clinical phenotype in sepsis that is observed as LPS tolerance is determined by silencing of pro-inflammatory genes like IL-1 beta (IL-1β). This study shows that facultative heterochromatin (fHC) silences IL-1β expression during sepsis, where we find dephosphorylated histone H3 serine 10 and increased binding of heterochromatin protein-1 (HP-1) to the promoter. In both human sepsis blood leukocytes and an LPS tolerant human THP-1 cell model, we show that IκBα and v-rel reticuloendotheliosis viral oncogene homolog B (RelB) function as dominant labile mediators of fHC formation at the IL-1β promoter. Protein synthesis inhibition decreases levels of IκBα and RelB, converts silent fHC to euchromatin, and restores IL-1β transcription. We further show TLR dependent NFκB p65 and histone H3 serine 10 phosphorylation binding at the promoter. We conclude that the resolution phase of sepsis, which correlates with survival in humans, may depend on the plasticity of chromatin structure as found in fHC.

journal_name

Cytokine

journal_title

Cytokine

authors

Yoza BK,McCall CE

doi

10.1016/j.cyto.2010.10.007

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

145-52

issue

2

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(10)00702-7

journal_volume

53

pub_type

杂志文章

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