Abstract:
:Vascular smooth muscle cells (VSMC) may be programmed by nutrient deprivation. We found that after 2 and 12 h exposure to 75% reduced amino acids, the release of basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF beta 1) from VSMC was significantly greater than that from cells maintained in control medium [2572.0 (546.3) vs 602.1 (241.7), P=0.001 and 16 028.0 (2192. 4) vs 13 027.3 (1233.5) pg/10(6)cells, P=0.022 respectively]. These differences were magnified after two passages of exposure for both bFGF (P=0.0001) and TGF beta 1 (P=0.0001). The stimulated release of VEGF by hypoxia and bFGF was unaffected. Amino acid deprivation of human VSMC is associated with a patterned release of angiogenic cytokines which could be relevant to the programmed changes in VSMC phenotype.
journal_name
Cytokinejournal_title
Cytokineauthors
Pancholi S,Earle KAdoi
10.1006/cyto.2000.0710keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
1322-5issue
9eissn
1043-4666issn
1096-0023pii
S1043-4666(00)90710-5journal_volume
12pub_type
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