Abstract:
:Although vaspin is regarded an insulin-sensitizing adipokine, its role in gestational diabetes mellitus (GDM) is currently unknown. We aimed to evaluate serum vaspin levels and their correlation with insulin resistance in women with and without GDM. Forty-four women with GDM [GDM Group - 20 managed with diet only (GDM-diet) and 24 with diet plus insulin (GDM-insulin)] and 44 age-matched pregnant women with normal glucose tolerance (Control Group) were studied. Serum glucose, lipids, uric acid, insulin and vaspin were measured at the 2nd and 3rd trimester of pregnancy and postpartum. The quantitative insulin sensitivity check index (QUICKI) and homeostasis model of assessment-insulin resistance (HOMA-IR) were calculated. Circulating vaspin levels decreased significantly postpartum in all groups (p<0.001), but did not differ between GDM or GDM Subgroups and Control Group in any time point. At the 3rd trimester of pregnancy vaspin was positively correlated to insulin (p=0.022), HOMA-IR (p=0.016) and triglycerides (p=0.033) and negatively correlated to QUICKI (p=0.016) in the GDM women, but not in the Controls. These correlations were not observed at the 2nd trimester or postpartum. Vaspin, in contrast to HOMA-IR, could not independently predict GDM in binary logistic regression. In patients with GDM, insulin treatment did not affect vaspin levels. In conclusion, our data suggest that vaspin levels gradually decrease from the 2nd trimester to postpartum; however, decreases are similar between women with or without GDM. Serum vaspin cannot independently predict GDM and it is not affected by the degree of glucose metabolism deregulation or the exogenous administration of insulin.
journal_name
Cytokinejournal_title
Cytokineauthors
Gkiomisi A,Makedou KG,Anastasilakis AD,Polyzos SA,Kourtis A,Gerou S,Gavana E,Dagklis T,Rousso D,Giannoulis Cdoi
10.1016/j.cyto.2012.09.006subject
Has Abstractpub_date
2013-01-01 00:00:00pages
127-32issue
1eissn
1043-4666issn
1096-0023pii
S1043-4666(12)00696-5journal_volume
61pub_type
杂志文章相关文献
CYTOKINE文献大全abstract::We investigated the effects of either intravenous (IV) or intrabronchial (IB) treatment with transforming growth factor beta1 (TGF-beta1) during bacterial pneumonia in rats. Immediately following IB Escherichia coli inoculation (T0), animals (n=270) were randomized to receive a single treatment with human recombinant ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2003.07.003
更新日期:2003-11-21 00:00:00
abstract::Obesity is closely associated with increased production of pro-inflammatory adipokines, including interleukin (IL)-6, plasminogen activator inhibitor (PAI)-1, and adipose-tissue-derived monocyte chemoattractant protein (MCP)-1, which contribute to chronic and low-grade inflammation in adipose tissue. Harpagoside, a ma...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.05.015
更新日期:2015-12-01 00:00:00
abstract::Published data on the association between CYP1A1 gene polymorphism and ovarian cancer risk are conflicting and heterogeneous. To derive a more precise estimation of the relationship, a meta-analysis was performed. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed for heterozygous, homozyg...
journal_title:Cytokine
pub_type: 杂志文章,meta分析
doi:10.1016/j.cyto.2011.12.025
更新日期:2012-04-01 00:00:00
abstract::The present study was aimed at defining the activity of human and mouse monocyte chemotactic protein-1 (MCP-1) on homologous and heterologous mononuclear phagocytes. Human natural and recombinant MCP-1 and mouse natural MCP-1/JE were tested as chemoattractants on human blood monocytes and mouse peritoneal macrophages....
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90004-3
更新日期:1994-01-01 00:00:00
abstract::Previously, two binding sites for interleukin 5 (IL-5) were identified on the IL-5 receptor alpha chain (IL-5Ralpha). They are located within the CD loop of the first fibronectin type III (FnIII)-like domain and the EF loop of the second FnIII-like domain. The first binding site was identified by exploiting the differ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0663
更新日期:2000-07-01 00:00:00
abstract::Our aim was to explore the putative beneficial effects of low-to-moderate intensity exercise training program in patients with irritable bowel syndrome (IBS). This study evaluated the changes in blood oxidative stress status, inflammatory biomarkers and IBS severity symptoms following 24 weeks of moderate aerobic exer...
journal_title:Cytokine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cyto.2017.12.016
更新日期:2018-02-01 00:00:00
abstract::The induction of cytokine expression in monocytes/macrophages by bacterial endotoxin or lipopolysaccharide is a critical, highly regulated host defence response. The augmentation of LPS responses by interferon gamma (IFN-gamma), referred to as priming, is well established. However, the mechanism(s) by which priming oc...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.0058
更新日期:1995-07-01 00:00:00
abstract::This study was aimed to assess whether ex vivo treatment with granulocyte-colony stimulating factor (G-CSF) modifies biological properties of bone marrow stromal cells (BMSC) and enhances functional recovery by BMSC transplantation into infarct brain. Immunohistochemistry was conducted to characterize the cultured BMS...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.02.008
更新日期:2009-05-01 00:00:00
abstract::Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α bu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.11.010
更新日期:2014-02-01 00:00:00
abstract::Organ failure is associated with increased mortality and morbidity in patients with systemic inflammatory response syndrome. Previously, we showed that a short course of infusion of a hydrogen sulfide (H(2)S) donor reduced metabolism with concurrent reduction of lung injury. Here, we hypothesize that prolonged H(2)S i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.11.018
更新日期:2013-02-01 00:00:00
abstract::Among New Mexican Hispanic women, breast cancer is detected at a more advanced stage than compared to Non-Hispanic White women. One central factor that has been little studied is the role of critical cytokines. We genotyped incident breast cancer cases and their age-, gender- and smoking-matched controls (N=40 matched...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.03.014
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Endothelial injury is recognized to trigger organ failures during the first 48h of septic shock. We evaluate endothelial biomarkers at ICU admission in their ability to predict severity, outcome, and organ failures in septic shock patients. METHODS:This prospective observational pilot study was conducted in...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.02.013
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Soy products contain several compounds with anti-inflammatory properties like genistein and daidzein which reported to act through different pathways. Present study conducted considering the inconsistent results and lack of any comprehensive review regarding randomized controlled trials which assess the effe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155282
更新日期:2020-12-01 00:00:00
abstract::Non-Hodgkin's lymphomas (NHL) constitute a heterogenous group of mainly B-cell lymphoproliferative diseases with different patterns of clinical behaviour. Biological mechanisms leading to development of NHL are not clearly understood. Transforming growth factor-beta1 (TGF-beta1) influences B cell growth and developmen...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.12.010
更新日期:2006-02-07 00:00:00
abstract::The specificity of leukocyte trafficking in inflammation is controlled by the interactions of chemokines with chemokine receptors. Reliable structure-function studies of chemokine-receptor interactions would benefit from cell lines that express consistent high levels of chemokine receptors. We describe herein two new ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2004.03.013
更新日期:2004-07-07 00:00:00
abstract::Myeloma is a neoplasm thought to "home" to bone marrow. However, evidence for bone-marrow-specific receptors or adhesion molecules expressed on myeloma cells is scanty. Initial myeloma expansion is thought to be due to IL-6 and/or related cytokines. Previous determinations of cytokine expression in bone marrow were pe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0748
更新日期:2000-10-01 00:00:00
abstract::Specific high titre polyclonal antibodies rapidly obtained by intralymphnode immunization of rabbits with recombinant M-CSF and LIF (< 60 micrograms/animal) have been used to develop specific, accurate and sensitive EIAs. The same batch of purified anti-M-CSF or anti-LIF Igs has been used for the coating of 96-well pl...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0078
更新日期:1996-07-01 00:00:00
abstract::The aim of this study was to evaluate serum interleukin (IL)-17A levels in patients with coronary artery ectasia (CAE), the relationship between IL and 17A and CAE, and to determine the relationship between the severity of coronary ectasia and the level of IL-17A. In total, 41 patients (19 female and 22 male) with isc...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.11.015
更新日期:2019-03-01 00:00:00
abstract::Elevated levels of the cytokine IL-13 has been found to be associated with autoimmune diseases, including Sjögren's Syndrome. However, whether IL-13 plays a causative role in disease development is not known and cannot be easily studied in humans. Our previous work has shown that levels of IL-13 are elevated in Id3 kn...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.06.009
更新日期:2014-10-01 00:00:00
abstract::Chemokines are small chemoattractant cytokines involved in normal and pathological immune processes. Although extensive nucleotide sequence data are available for human and murine chemokine cDNA sequences, very few data are currently available regarding rhesus macaque sequences. To increase our understanding of immune...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.0875
更新日期:2002-05-07 00:00:00
abstract::MERS-CoV, a highly pathogenic virus in humans, is associated with high morbidity and case fatality. Inflammatory responses have a significant impact on MERS-CoV pathogenesis and disease outcome. However, CD4+ T-cell induced immune responses during acute MERS-CoV infection are barely detectable, with potent inhibition ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.154895
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Alterations in β common (βC) and γ common (γC) chain cytokines have been described in pulmonary tuberculosis. However, their role in tuberculous lymphadenitis (TBL) disease has not been assessed. METHODS:Thus, in the present study, we have examined the systemic levels of βC and γC chain cytokines in TBL, la...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155405
更新日期:2021-02-01 00:00:00
abstract::Interleukin(IL)-2 and IL-7 are cytokines with important functions related to CD4(+) lymphocyte proliferation, differentiation and survival. Depending on doses, they theoretically activate regulatory (Treg) and/or effector T cells (Teff) and thus may be indicated with different therapeutic objectives. In this study we ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.05.021
更新日期:2014-09-01 00:00:00
abstract::Dermal wounding is accompanied by inflammation and the resulting proinflammatory cytokines, including interleukin (IL)-6, are thought to play an important role in the repair process. IL-6 is produced by normal human keratinocytes to various dermatological diseases and we have recently shown it is also required for nor...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2001.0946
更新日期:2001-09-21 00:00:00
abstract:BACKGROUND:Unregulated inflammatory and thrombotic responses have been proposed to be important causes of early brain injury and worse clinical outcomes after subarachnoid hemorrhage (SAH). OBJECTIVE:We hypothesize that SAH is characterized by an increased inflammatory and thrombotic state and disruption of associatio...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.09.003
更新日期:2018-11-01 00:00:00
abstract::It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.11.010
更新日期:2018-07-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) demonstrating pro-angiogenic activity promote new blood vessel formation in psoriatic lesions. The aim of this study was to evaluate the serum concentrations of VEGF, its soluble receptors (sVEGF R1 and R2) and VEGF content in scales of patients with psoriasis. To analyze poss...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.09.012
更新日期:2010-12-01 00:00:00
abstract::Macrophage migration inhibitory factor (MIF) is a molecule with plethora of functions such as regulation of immune response, hormone-like, enzymatic and chaperone-like activity. Further, MIF is a major participant in glucose homeostasis since it is an autocrine stimulator of insulin secretion. MIF absence in male knoc...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.05.013
更新日期:2014-09-01 00:00:00
abstract::Recently, a novel technique for "real time" quantitative Reverse Transcriptase-PCR which measures PCR-product accumulation during the exponential phase of the PCR reaction using a dual-labelled fluorogenic probe, has been developed. This method allows direct detection of PCR-product formation by measuring the increase...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0426
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:Interleukin (IL)-4 and IL-10 are viewed mainly as anti-inflammatory cytokines. Yet, high concentrations have also been associated with inflammation-related diseases in newborns. METHODS:We measured the concentrations of IL-4 and IL-10, as well as IL-8 and ICAM-1 in blood specimens collected on postnatal day...
journal_title:Cytokine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.cyto.2018.05.004
更新日期:2018-10-01 00:00:00