The interferon-induced gene ISG12 is regulated by various cytokines as the gene 6-16 in human cell lines.

abstract：:Growth related oncogene protein-alpha (GRO-alpha) is a member of C-X-C chemokine and plays an important role in inflammatory responses. Expression of GRO gene family is regulated by a number of factors at both transcriptional and posttranscriptional levels. In the present study, we have addressed the possible regulati...

journal_title：Cytokine

authors： Shibata T,Imaizumi T,Matsumiya T,Tamo W,Hatakeyama M,Yoshida H,Munakata H,Fukuda I,Satoh K

更新日期：2003-11-07 00:00:00

abstract：:The clinical phenotype in sepsis that is observed as LPS tolerance is determined by silencing of pro-inflammatory genes like IL-1 beta (IL-1β). This study shows that facultative heterochromatin (fHC) silences IL-1β expression during sepsis, where we find dephosphorylated histone H3 serine 10 and increased binding of h...

journal_title：Cytokine

authors： Yoza BK,McCall CE

更新日期：2011-02-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a fast-growing cancer characterized by high occurrences of nodal and distant metastases and poor prognosis. It is therefore important to identify new serum biomarkers for the early diagnosis and prognostic prediction of this disease. The present study identifies biomarkers in NPC pati...

journal_title：Cytokine

authors： Gong D,Li Z,Ding R,Cheng M,Huang H,Liu A,Kang M,He H,Xu Y,Shao J,Wang Y,Duan C

更新日期：2019-06-01 00:00:00

abstract：:In atherosclerotic plaques, macrophages (MAC) and smooth muscle cells (SMC) frequently reside in close proximity and resistin (Rs) and fractalkine (Fk) are present at increased levels, resistin being associated with CD68 macrophages and fractalkine predominantly associated with intimal SMC; however, their role in this...

journal_title：Cytokine

authors： Tucureanu MM,Butoi E,Gan AM,Stan D,Constantinescu CA,Calin M,Simionescu M,Manduteanu I

更新日期：2016-07-01 00:00:00

abstract：:We evaluated the changes of metallothionein induction and cellular zinc distribution in HepG2 cells by interferonbeta treatment. Immunohistochemical staining of metallothionein was observed in the cytoplasm and nuclei of hepatocytes; which was observed predominantly in the cells treated with interferon and zinc compar...

journal_title：Cytokine

authors： Nagamine T,Kusakabe T,Takada H,Nakazato K,Sakai T,Oikawa M,Satoh T,Arakawa K

更新日期：2006-06-01 00:00:00

abstract：AIMS:Interleukin-2 has a significant antitumor activity in some types of cancer, and has been associated with the development of atrial fibrillation (AF). In addition, IL-2 serum levels in recent onset AF have been related with pharmaceutical cardioversion outcomes. We evaluated the hypothesis that a relationship exist...

journal_title：Cytokine

authors： Cabrera-Bueno F,Medina-Palomo C,Ruiz-Salas A,Flores A,Rodríguez-Losada N,Barrera A,Jiménez-Navarro M,Alzueta J

更新日期：2015-05-01 00:00:00

abstract：:A number of chemokines induce angiogenesis and endothelial cells express several chemokine receptors. To date, only a limited number of CC chemokines for CCR1 have been reported to induce angiogenic responses. We investigated the ability of CCL23 (also known as MPIF-1, MIP-3, or CKbeta8) to promote angiogenesis, which...

journal_title：Cytokine

authors： Hwang J,Son KN,Kim CW,Ko J,Na DS,Kwon BS,Gho YS,Kim J

更新日期：2005-06-07 00:00:00

abstract：OBJECTIVE:The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid ...

journal_title：Cytokine

authors： Thorat Manojkumar S,Pradeep AR,Garg G,Raju A

更新日期：2010-06-01 00:00:00

abstract：:Interleukin-21 (IL-21) is overproduced in human intestines affected by inflammatory bowel disease (IBD) and in the gut of mice with DSS-induced colitis. IL-21-deficient mice are largely protected against DSS-induced colitis, indicating that IL-21 plays a key role in the development of IBD. We previously identified a n...

journal_title：Cytokine

authors： Araki A,Nara H,Rahman M,Onoda T,Li J,Juliana FM,Jin L,Murata K,Takeda Y,Asao H

更新日期：2013-05-01 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the presence of autoantibodies to normal components of the hemidesmosome (BPAg1 and BPAg2). Histology of skin lesions demonstrate a subepidermal vesicle and a predominantly eosinophilic dermal cellular infiltrate. Interleukin 5 (IL-5) pl...

journal_title：Cytokine

authors： Engineer L,Bhol K,Kumari S,Razzaque Ahmed A

更新日期：2001-01-07 00:00:00

abstract：:The pathogenesis of rheumatoid arthritis (RA) and psoriatic arthritis (PsA) involves an abnormal chemokine regulation. The chemokine receptor CCR4 is necessary for T cell migration to the skin. We, therefore, studied if CCR4 and its ligand macrophage-derived chemokine (MDC/CCL22) could participate in spreading the dis...

journal_title：Cytokine

authors： Flytlie HA,Hvid M,Lindgreen E,Kofod-Olsen E,Petersen EL,Jørgensen A,Deleuran M,Vestergaard C,Deleuran B

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Owing to involvement of host genetic factors in susceptibility to brucellosis infection and its outcome, this study aimed to carry out a comprehensive systematic review and meta-analysis to derive a precise evaluation of the association between the risk of brucellosis and its focal complication and all cytoki...

journal_title：Cytokine

authors： Zafari P,Zarifian A,Alizadeh-Navaei R,Taghadosi M,Rafiei A

更新日期：2020-03-01 00:00:00

abstract：:Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies w...

journal_title：Cytokine

authors： de Lemos Rieper C,Galle P,Pedersen BK,Hansen MB

更新日期：2010-09-01 00:00:00

abstract：:The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-beta1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade > or =1 RP, and 27 (22.3%) developed grade > or =2 RP. For the endpo...

journal_title：Cytokine

authors： Evans ES,Kocak Z,Zhou SM,Kahn DA,Huang H,Hollis DR,Light KL,Anscher MS,Marks LB

更新日期：2006-08-01 00:00:00

abstract：:The induction of cytokine expression in monocytes/macrophages by bacterial endotoxin or lipopolysaccharide is a critical, highly regulated host defence response. The augmentation of LPS responses by interferon gamma (IFN-gamma), referred to as priming, is well established. However, the mechanism(s) by which priming oc...

journal_title：Cytokine

authors： Hayes MP,Freeman SL,Donnelly RP

更新日期：1995-07-01 00:00:00

abstract：:Recent studies have implicated leptin as a "stress" hormone and highlighted its association with increases in inflammatory cytokines, C-reactive protein and cortisol. In order to investigate the exact temporal leptin response to stress we undertook a detailed longitudinal study of circulating leptin concentrations dur...

journal_title：Cytokine

authors： Wallace AM,Sattar N,Mcmillan DC

更新日期：2000-07-01 00:00:00

abstract：:Pregnancy in sickle cell disease is a problem due to the adverse outcomes related to the disease. Research into the role of chemokines in sickle cell disease is available, but studies investigating the disease in pregnancy are scarce. Our data show the chemokine profiles of pregnant women with sickle cell disease comp...

journal_title：Cytokine

authors： Hazin-Costa MF,da Silva Aráujo A,Guerra GL,da Matta MC,Torres LC,Souza AI

更新日期：2019-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) regulate the structural integrity of the extracellular matrix (ECM). Constitutive expression of human TIMP-3 in human DLD colon carcinoma cells renewed serum-responses and inhibited tumour formation in nude mice. To elucidate the mecha...

journal_title：Cytokine

authors： Smith MR,Kung H,Durum SK,Colburn NH,Sun Y

更新日期：1997-10-01 00:00:00

abstract：:To determine whether colony-stimulating factor (CSF) might participate to the inflammatory response after cardiac surgery, plasma concentrations of granulocyte-CSF (G-CSF), macrophage-CSF (M-CSF) and GM-CSF were measured in 31 patients undergoing coronary artery bypass graft (CABG) surgery with extracorporeal circulat...

journal_title：Cytokine

authors： Denizot Y,Karoutsos S,Nathan N

更新日期：2001-03-07 00:00:00

abstract：:Data exist linking elevated epithelial neutrophil activating peptide (ENA-78) concentrations with myriad inflammatory conditions. ENA-78 is encoded by the CXCL5 gene which has recently been shown to be polymorphic in nature (rs352046 and rs425535). No functional data on these polymorphisms exist. We investigated wheth...

journal_title：Cytokine

authors： Zineh I,Aquilante CL,Langaee TY,Beitelshees AL,Arant CB,Wessel TR,Schofield RS

更新日期：2006-03-07 00:00:00

abstract：:Recently, a novel technique for "real time" quantitative Reverse Transcriptase-PCR which measures PCR-product accumulation during the exponential phase of the PCR reaction using a dual-labelled fluorogenic probe, has been developed. This method allows direct detection of PCR-product formation by measuring the increase...

journal_title：Cytokine

authors： Overbergh L,Valckx D,Waer M,Mathieu C

更新日期：1999-04-01 00:00:00

abstract：:Increasing evidence shows that inflammation plays critical roles in the tumorigenesis of bladder cancer. Fibroblast growth factor 12 (FGF12), a kind of inflammatory cytokine, is located in the region of 3q28 that has been demonstrated to be a bladder cancer risk locus by genome wide association study (GWAS). In this s...

journal_title：Cytokine

authors： Wu J,Huang H,Huang Q,Qiu R,Huang M,Meng D

更新日期：2020-12-01 00:00:00

abstract：:Exercise training is known to induce a molecular adaptation process involving inflammatory responses. However any time-of-day effect of exercise on inflammatory responses remains unknown. The aim of the present study was to investigate whether acute bouts of intense exercise performed at different times of the day wou...

journal_title：Cytokine

authors： Pledge D,Grosset JF,Onambélé-Pearson GL

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Immuno-inflammation plays an important role in the pathophysiological process of sepsis-associated acute hepatic injury (AHI). Interleukin 27 (IL-27) is an important inflammatory regulator; however, its role in this condition is not clear. METHODS:The clinical data and IL-27 serum levels in sepsis patients ...

journal_title：Cytokine

authors： Fan J,Zhang YC,Zheng DF,Zhang M,Liu H,He M,Wu ZJ

更新日期：2020-03-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) are more frequently used as the cellular source in allogeneic hematopoietic stem cell transplantation (HSCT) than bone marrow stem cells (BMSCs) because they promote more rapid engraftment and immune reconstitution. However, th...

journal_title：Cytokine

authors： Joo YD,Lee WS,Won HJ,Lee SM,Choi JH,Lee SM,Han KH,Park SG,Choi IW,Seo SK

更新日期：2011-04-01 00:00:00

abstract：:In this study we have examined the effect of agents known to perturb certain signal transduction pathways on the biological responses of target cells to stimulation with interleukin-1 (IL-1). In the murine thymoma cell line EL4, IL-1 stimulation results in the secretion of interleukin-2 (IL-2), which was subsequently ...

journal_title：Cytokine

authors： Rollins P,Witham S,Ray K,Thompson N,Sadler H,Smithers N,Grenfell S,Solari R

更新日期：1991-01-01 00:00:00

abstract：:Neuropilin-1 (NRP-1) is a co-receptor for vascular endothelial growth factor (VEGF). During neovascularization, vascular smooth muscle cells (VSMCs) and pericytes modulate the function of endothelial cells. Factors that mediate NRP-1 in human VSMCs (hVSMCs) remain to be elucidated. We studied various angiogenic cytoki...

journal_title：Cytokine

authors： Liu W,Parikh AA,Stoeltzing O,Fan F,McCarty MF,Wey J,Hicklin DJ,Ellis LM

更新日期：2005-12-07 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is the key regulator of angiogenesis in the development of various cancers. Previous studies have examined the relationship between VEGF gene promoter polymorphisms such as -2578C/A and -460C/T and bladder cancer risk; however, these results are inconclusive. Therefo...

journal_title：Cytokine

authors： Chen CH,Ho CH,Kuan-Hua Huang S,Shen CH,Wu CC,Wang YH

更新日期：2020-07-01 00:00:00

abstract：:Platelet activation and platelet-derived cytokines contribute to the vascular inflammation and increased thrombotic activity known to occur in patients with sickle cell anemia (SCA). CD40 ligand (CD40L), a platelet-associated pro-inflammatory molecule that promotes endothelial cell activation, is elevated in the circu...

journal_title：Cytokine

authors： Garrido VT,Sonzogni L,Mtatiro SN,Costa FF,Conran N,Thein SL

更新日期：2017-09-01 00:00:00

abstract：:Among New Mexican Hispanic women, breast cancer is detected at a more advanced stage than compared to Non-Hispanic White women. One central factor that has been little studied is the role of critical cytokines. We genotyped incident breast cancer cases and their age-, gender- and smoking-matched controls (N=40 matched...

journal_title：Cytokine

authors： Erdei E,Kang H,Meisner A,White K,Pickett G,Baca C,Royce M,Berwick M

更新日期：2010-07-01 00:00:00