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Does transforming growth factor-beta1 predict for radiation-induced pneumonitis in patients treated for lung cancer?

Abstract：

:The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-beta1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade > or =1 RP, and 27 (22.3%) developed grade > or =2 RP. For the endpoint of grade > or =1 RP, those with V30>30% and an end-RT/baseline TGF-beta1 ratio> or =1 had a significantly higher incidence of RP than did those with V30>30% and an end-RT/baseline TGF-beta1 ratio<1. For most other patient groups, there were no clear associations between TGF-beta1 values and rates of RP. These findings suggest that TGF-beta1 is generally not predictive for RP except for the group of patients with a high V30.

journal_name

Cytokine

journal_title

Cytokine

authors

Evans ES,Kocak Z,Zhou SM,Kahn DA,Huang H,Hollis DR,Light KL,Anscher MS,Marks LB

doi

10.1016/j.cyto.2006.07.021

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

186-92

issue

3-4

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(06)00244-4

journal_volume

35

pub_type

杂志文章

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