Abstract:
:Nerve growth factor (NGF), which is a neurotrophic factor, is involved in autoimmune and inflammatory processes. Serum NGF levels were investigated in 131 patients with autoimmune (95 with Graves' disease, of whom 57 had ophthalmopathy, 19 with Hashimoto's thyroiditis) and nonimmune thyroid diseases (17 with toxic nodular goitre), and 20 controls. NGF levels were measured via enzyme-linked immunosorbent assay. Twenty-nine positive cases for NGF were detected: 21 cases in Graves' disease, 7 cases in Hashimoto's thyroiditis, no case in toxic nodular goitre and one case in controls. NGF levels were higher in patients with Graves' disease and particularly with Hashimoto's thyroiditis compared with controls (1786.47+/-34.79 pg/ml and 1996.27+/-77.71pg/ml vs 1579.16+/-57.45pg/ml, P<0.049 and P<0.0001, respectively). Increased NGF levels associated with Graves' hyperthyroidism and correlated with FT(3) (P<0.01). Patients with the presence of antibodies against TSH receptor showed higher NGF levels than those with no antibodies (1938.61+/-56.44pg/ml vs 1712.12+/-54.22pg/ml, P<0.009). Decreased NGF levels were demonstrated in hyperthyroid Graves' ophthalmopathy compared with those without eye symptoms (1746.65+/-51.98pg/ml vs 1910.47+/-55.62pg/ml, P<0.036). NGF may be involved in the pathomechanism of autoimmune thyroid diseases. Decreased NGF levels in hyperthyroid Graves' ophthalmopathy highlight the importance of NGF in the neuroprotection of orbital tissues.
journal_name
Cytokinejournal_title
Cytokineauthors
Molnár I,Bokk Adoi
10.1016/j.cyto.2006.08.002subject
Has Abstractpub_date
2006-08-01 00:00:00pages
109-14issue
3-4eissn
1043-4666issn
1096-0023pii
S1043-4666(06)00246-8journal_volume
35pub_type
杂志文章,评审相关文献
CYTOKINE文献大全abstract::Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig....
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2009.07.007
更新日期:2009-10-01 00:00:00
abstract::The failure of the immune response to clear the Hepatitis C virus (HCV) results in chronic inflammation that leads to liver cirrhosis. In general, women have a better prognosis than men and this may be associated with increased levels of anti-inflammatory mediators that are positively regulated by female sex hormones....
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.07.006
更新日期:2012-11-01 00:00:00
abstract::Encephalitic listeriosis in sheep is a life-threatening disease. However, little is known about the cytokine response and their predictive value in this disease. The aim of present study was to assess the prognostic significance of Tumor Necrosis Factor-α (TNF-α), Interleukin-12(p40) (IL-12 p40), Interleukin-6 (IL-6),...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.03.004
更新日期:2015-06-01 00:00:00
abstract::An accurate and simultaneous estimate of cellular levels of a large cytokine number is very useful to obtain information about an organ dysfunction leading to cancer because through the understanding of the evolution of cytokine patterns we can recognize and predict the disease progression. Cancer cell lines are commo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.09.002
更新日期:2013-11-01 00:00:00
abstract::T cells and T cell derived cytokines are involved in the complex pathogenesis of asthma. The role of the cytokine IL-18 however, is not clearly defined so far. On the one hand side IL-18 induces Th1-type cytokines and thereby might counter-regulate Th2-mediated allergic asthma. On the other hand IL-18 also bears pro-i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.02.012
更新日期:2008-06-01 00:00:00
abstract::Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies w...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.06.009
更新日期:2010-09-01 00:00:00
abstract::In the present study, we investigated the effect of CdCl2 on the inflammatory cytokines in human intestinal Caco-2 cells. The secretion of IL-8 from Caco-2 cells was significantly increased in a dose- and time-dependent manner, whereas the secretion of such other inflammatory cytokines as TNF-alpha and IFN-gamma was n...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.02.011
更新日期:2007-01-01 00:00:00
abstract::The aim of this study was to investigate the clinical relevance of lymphocyte-related serum miRNAs to the pathogenesis of acute graft-versus-host disease (aGVHD) and evaluate the predictive and prognosis value of miRNAs. Consecutive patients who received allogeneic peripheral blood stem cell transplantation (allo-PBSC...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2016.05.021
更新日期:2016-09-01 00:00:00
abstract::Long-term exposure to biomass-burning smoke (BS) is associated with chronic obstructive pulmonary disease (COPD), asthma, and other chronic inflammatory lung diseases. BS results from such processes as the burning of wood for indoor cooking and heating, with women and children having the highest exposure rate. This st...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155089
更新日期:2020-07-01 00:00:00
abstract::Thymic vulnerability, a leading cause of defective immunity, was discovered decades ago. To date, several strategies have been investigated to unveil any immunorestorative capacities they might confer. Studies exploiting castration, transplantation, adoptive cell therapies, hormones/growth factors, and cytokines have ...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2019.05.009
更新日期:2019-08-01 00:00:00
abstract::TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1h (time 1) and 2-3 days (time 2) after delivery in a group of healthy women (n=17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3 pg/ml median; 41.2 ± 15.9 mean ± SD) to time 2 (...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.05.005
更新日期:2013-10-01 00:00:00
abstract::This study was conducted to compare the secretion of TGF-beta isoforms by human ovarian carcinoma (OVCA) cell lines (n=12) and human peritoneal mesothelial cells (HPMC;n=6) and to examine the regulation of their production by inflammatory cytokines. TGF-beta isoforms were furthermore analysed in OVCA-associated asciti...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0632
更新日期:2000-07-01 00:00:00
abstract::Interleukin 12 (IL-12) is a heterodimer comprising p35 and p40 subunits which are encoded and regulated separately. The authors previously demonstrated deficient IL-12 production in SLE which correlates negatively with disease activity. The present study was designed to determine whether deficiency of IL-12 and excess...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0512
更新日期:1999-10-01 00:00:00
abstract::Cytokine mRNA expression was analyzed by reverse transcriptase (RT)/PCR in extensively purified normal peripheral CD4+CD45R T cell subsets. Both CD45RA+ and CD45 RO+ populations produced mRNAs for interleukin (IL)-2, IL-2 receptor (alpha chain), IL-6 receptor and tumour necrosis factor (TNF)-beta within 3-4 h of activ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90032-9
更新日期:1994-03-01 00:00:00
abstract::ICAM-1-mediated cell-cell adhesion is essential for different immunologic functions including non-MHC-restricted cytotoxicity. The shedding of a soluble form of ICAM-1 from melanoma impairs immune recognition and leads to tumour escape. Pretreatment of the Foss human melanoma cell line with HILDA/LIF or OSM, two cytok...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.1015
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVE:The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.002
更新日期:2010-06-01 00:00:00
abstract::Erythropoietin (EPO) and Stem Cell Factor (SCF) have partially distinct functions in erythroid cell development. The primary functions of EPO are to prevent apoptosis and promote differentiation, with a minor role as a mitogen. On the other hand SCF acts primarily as a mitogenic factor promoting erythroid cell prolife...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.10.017
更新日期:2013-01-01 00:00:00
abstract::Overweight and obesity are associated with chronic and subclinical inflammation due to an imbalance of inflammatory mediators. However, the association with gene polymorphism has been rarely studied in children. The aim of this study was to determine if serum concentrations of C-reactive protein (CRP) and interleukin-...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1016/j.cyto.2016.09.007
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Published studies on association between IL12B (G/A) rs10045431, (T/C)rs6887695 polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian population have yielded conflicting results. The aim of this study was to potentially provide more reliable conclusions by conducting a meta-analysis. METHODS:...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155296
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:The clinical symptoms of the patients with intracellular bacterial bloodstream infections (Intra-bac BSIs) are atypical, and no early and accurate diagnostic biomarkers exist, which can easily lead to misdiagnosis, inappropriate and delayed treatment. Therefore, it is imperative to find novel biomarkers to h...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155238
更新日期:2020-12-01 00:00:00
abstract::The production of nitric oxide (NO) is increased in experimental nephritis, with NO thought to be an important mediator of cell damage. The cytokines interleukin 1 beta (IL-1 beta), IL-6, IL-8, monocyte chemotactic protein-1 (MCP-1) and transforming growth factor-beta (TGF-beta) are released from mesangial cells in vi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90047-7
更新日期:1994-11-01 00:00:00
abstract:PURPOSE:This case-control study aimed to evaluate the ability to use a panel of IL-31, IL-1ß and NLRP3 to differentiate sepsis from systemic inflammatory response syndrome (SIRS) and to predict septic shock. METHODS:Serum levels of IL-31, IL-1ß and NLRP3 were measured by ELISA in 149 participants; 38 with sepsis, 51 w...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155102
更新日期:2020-07-01 00:00:00
abstract::In serum-free WEHI-3 supernatants an activity was detected inducing haemoglobin synthesis in human and murine erythroleukaemia cell lines. The absolute numbers of benzidine-positive cells induced with either DMSO or WEHI-3-conditioned medium were comparable. Terminal differentiation was not observed. An expression lib...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2004.02.005
更新日期:2004-06-21 00:00:00
abstract::These experiments were designed to investigate the effects of IL-17 upon the phenotype and function of human Natural Killer (NK) cells. Peripheral blood mononuclear cells from healthy subjects were cultured in the presence or absence of different combinations of IL-17s and changes in relative numbers and cell surface ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.02.005
更新日期:2013-04-01 00:00:00
abstract::Large amounts of anti-inflammatory mediators, such as interleukin (IL)-10, are produced and found early in the course of sepsis. We explore the role of IL-10 on neutrophil (PMN) activation/function using an in vitro model. Isolated human PMN were pre-incubated with lipopolysaccharide (LPS) and/or IL-10 for 18h. Subseq...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.03.025
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:In pregnancy, the placental contribution of cytokines to maternal immunosuppression has been established, however their role in normal maternal blood pressure regulation has not been identified. We investigate the contribution of interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha) to the vasod...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2004.10.011
更新日期:2005-02-21 00:00:00
abstract::IFNγ is a potent activator and IL-10 a powerful inhibitor of macrophage functions. However, neither all cellular functions are enhanced by IFNγ nor IL-10 inhibits all cellular responses. Thus, FcγRs-mediated phagocytosis in monocyte-derived macrophages (MDM) increases after IL-10 treatment, and decreases after treatme...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.11.008
更新日期:2012-01-01 00:00:00
abstract::In the family of cytokines and cytokine receptors, alternative splicing of pre-mRNA is a frequently observed process that generates different protein isoforms from a single genetic locus. The splicing-derived cytokine receptor protein isoforms are mostly soluble receptors or show alterations in their cytoplasmic domai...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0777
更新日期:2000-11-01 00:00:00
abstract::Asthma and type I diabetes are major causes of chronic illness in childhood which, according to the current paradigm, have mutually antagonistic immunopathologies. Nonetheless, the disorders appear to preferably coexist both on population and individual levels. To assess whether children with asthma and type I diabete...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.04.015
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:Tumor necrosis factor (TNFα) is a proinflammatory cytokine and has been a target for intervention in human sepsis. However, inhibition of TNF-α with a high dose of a TNF-receptor fusion protein in patients with septic shock worsened patient survival. This study was designed to investigate whether blocking TNF-α...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.04.002
更新日期:2013-07-01 00:00:00