Abstract：
:Previous studies identified the variant IFNG +874A/T (rs2430561) in the first intron of the gene in association with mycobacterial infection, especially tuberculosis and leprosy. The aim of this investigation was to analyze the protective role of the T allele in relation to leprosy using a meta-analysis evaluation. Thus, 1573 patients and 1914 controls were included and analyzed in fixed effects model. The T allele is associated with a protective effect for leprosy under the dominant model (pooled OR=0.83, 95% CI=0.72-0.96, p=0.011) suggesting that carriers of the IFNG +874T allele may be protected from developing leprosy. The T allele has been suggested to correlate with high interferon-γ levels. A phenotype with high IFN-γ producing and an increased inflammatory profile may account for these findings. This meta-analysis suggests that IFNG +874T allele is associated with leprosy resistance.
journal_name
Cytokinejournal_title
Cytokineauthors
Silva GA,Naveca FG,Ramasawmy R,Boechat ALdoi
10.1016/j.cyto.2013.12.002subject
Has Abstractpub_date
2014-02-01 00:00:00pages
130-3issue
2eissn
1043-4666issn
1096-0023pii
S1043-4666(13)00764-3journal_volume
65pub_type
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