Variations in transforming growth factor beta in human milk are not related to levels in plasma.

abstract：:The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19. Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced cytokine storm and their predictive values have not been fully elu...

journal_title：Cytokine

authors： Liu Y,Chen D,Hou J,Li H,Cao D,Guo M,Ling Y,Gao M,Zhou Y,Wan Y,Zhu Z

更新日期：2021-02-01 00:00:00

abstract：:Increased cerebrospinal fluid (CSF) IL-6 has been reported in patients with Behçet's disease (BD) and neurological involvement. To elucidate the value of IL-6 as a marker of disease activity, serum and CSF IL-6 levels of 68 BD patients with acute (26) or chronic progressive (14) parenchymal involvement (pNB), dural si...

journal_title：Cytokine

authors： Akman-Demir G,Tüzün E,Içöz S,Yeşilot N,Yentür SP,Kürtüncü M,Mutlu M,Saruhan-Direskeneli G

更新日期：2008-12-01 00:00:00

abstract：:Interleukin-1beta (IL-1beta) is a pleiotropic cytokine that can induce several cellular signal transduction pathways. Here, we show that IL-1beta can induce cell cycle arrest and differentiation in the human medullary thyroid carcinoma (MTC) cell line, TT. IL-1beta induces cell cycle arrest accompanied by morphologica...

journal_title：Cytokine

authors： Park JI,Strock CJ,Ball DW,Nelkin BD

更新日期：2005-02-07 00:00:00

abstract：:Tumour necrosis factor (TNF) is a key regulator of inflammation and immunity. The cellular effects exerted by TNF depend, apart from NF-kappaB-directed gene transcription, largely on its ability to activate phospholipase A2(PLA2), yielding the release of arachidonic acid (AA) and its metabolites. AA metabolites, espec...

journal_title：Cytokine

authors： van Puijenbroek AA,Wissink S,van der Saag PT,Peppelenbosch MP

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND AND AIM:Interleukin-22 (IL-22), plays a vital role in the mucosal repair of inflammatory bowel disease (IBD). Serum levels of IL-22 and IL-22 binding protein (IL-22BP), a soluble inhibitory IL-22 receptor, were measured in patients with IBD to investigate the profile of IL-22 in the systemic circulation. ME...

journal_title：Cytokine

authors： Sakemi R,Mitsuyama K,Morita M,Yoshioka S,Kuwaki K,Tokuyasu H,Fukunaga S,Mori A,Araki T,Yoshimura T,Yamasaki H,Tsuruta K,Morita T,Yamasaki S,Mizoguchi A,Sou S,Torimura T

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...

journal_title：Cytokine

authors： Sabry A,Sheashaa H,El-Husseini A,Mahmoud K,Eldahshan KF,George SK,Abdel-Khalek E,El-Shafey EM,Abo-Zenah H

更新日期：2006-08-01 00:00:00

abstract：:TNF-alpha, IL-1, IL-6 and TGF-beta are important macrophage-derived mediators which play the pleiotropic role in inflammatory, metabolic, hematopoietic and immunologic processes. Studies have shown that haemorrhagic shock without significant tissue trauma induces profound immunosuppression which is associated with ele...

journal_title：Cytokine

authors： Zhu XL,Zellweger R,Zhu XH,Ayala A,Chaudry IH

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:The effectual immune response is crucial to defeat viral infections. However, exuberant immune response with features of macrophage activation syndrome (MAS) lead detrimental consequences in COVID-19 patients. Interleukin (IL)-18 is one of the leading cytokines in MAS which has not been studied in COVID-19. ...

journal_title：Cytokine

authors： Satış H,Özger HS,Aysert Yıldız P,Hızel K,Gulbahar Ö,Erbaş G,Aygencel G,Guzel Tunccan O,Öztürk MA,Dizbay M,Tufan A

更新日期：2021-01-01 00:00:00

abstract：:Obesity, a chronic low-grade inflammation metabolic abnormality, is related to high proinflammatory cytokines concentrations. Epstein-Barr virus-induced gene 3 (EBI3) encodes for the EBI3 beta subunit that constitutes interleukin (IL) 27 and 35. Our objective was to assess the association of three EBI3 single nucleoti...

journal_title：Cytokine

authors： Posadas-Sánchez R,Del Carmen González-Salazar M,Cardoso-Saldaña G,Andrés Criales-Vera S,Reyes-Barrera J,Pérez-Hernández N,Manuel Fragoso J,Vargas-Alarcón G

更新日期：2020-11-01 00:00:00

abstract：:We investigated the effects of two low doses of interferon-alpha (IFN-alpha) on nocturnal sleep in 18 healthy men by means of polysomnographic sleep recordings. At 1900h, human recombinant IFN-alpha (1000 or 10000 U/kg body weight) or placebo was administered subcutaneously. Between 2300h and 0700h subjects were allow...

journal_title：Cytokine

authors： Späth-Schwalbe E,Lange T,Perras B,Fehm HL,Born J

更新日期：2000-05-01 00:00:00

abstract：INTRODUCTION:A growing body of evidence indicates that brain cytokines are involved in the control of the cardiovascular system. Tumour necrosis factor (TNF) is an archetypal cytokine, which exerts its proinflammatory actions via type 1 receptor (TNFR1). Interleukin 10 (IL-10) plays a critical anti-inflammatory role by...

journal_title：Cytokine

authors： Segiet A,Smykiewicz P,Kwiatkowski P,Żera T

更新日期：2019-01-01 00:00:00

abstract：:Sickle cell anemia (SCA) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-alpha) -308G>A and Interleukin 8 (IL-8) -251A>T gene polymorphisms, medical history and classical biomarkers in children with steady-...

journal_title：Cytokine

authors： Cajado C,Cerqueira BA,Couto FD,Moura-Neto JP,Vilas-Boas W,Dorea MJ,Lyra IM,Barbosa CG,Reis MG,Goncalves MS

更新日期：2011-11-01 00:00:00

abstract：:Propofol anesthesia and sedation are known to downregulate the functions of many hematopoietic cells, such as macrophages and neutrophils, in vivo. However, the effects of propofol on secretion of the regulatory cytokine transforming growth factor β1 (TGF-β1) in vivo are unknown. In this study, the effects of propofol...

journal_title：Cytokine

authors： Li CH,Lee RP,Lin YL,Lin CS,Hsu BG,Tseng FJ,Chen YC,Liao KW,Yang FL

更新日期：2010-12-01 00:00:00

abstract：:High-fat-fed C57Bl/6J FABP4/aP2 null mice develop obesity but not the related hyperglycemia or hyperinsulinemia characteristic of type II diabetes. FABP4/aP2 protein's function to bind fatty acids in the adipocytes may promote total body energy homeostasis by linking energy depots to the ability to express signaling m...

journal_title：Cytokine

authors： Witthuhn BA,Bernlohr DA

更新日期：2001-05-07 00:00:00

abstract：:Tumour necrosis factor alpha(TNF-alpha) is one of the most important pro-inflammatory cytokines, which plays an important role in host defense and acute inflammation related to tissue injury. The major source of TNF-alpha has been shown to be immune cells such as macrophages and neutrophils. In the present study, we d...

journal_title：Cytokine

authors： McRitchie DI,Isowa N,Edelson JD,Xavier AM,Cai L,Man HY,Wang YT,Keshavjee SH,Slutsky AS,Liu M

更新日期：2000-06-01 00:00:00

abstract：:Tenidap is a novel anti-inflammatory and anti-arthritic agent that lowers intracellular pH and suppresses anion transport when applied to cells in vitro. Both of these parameters are known to influence pro-inflammatory cell function. To investigate whether tenidap can modulate cellular responses to cytokine stimulatio...

journal_title：Cytokine

authors： McNiff PA,Laliberte RE,Svensson L,Pazoles CJ,Gabel CA

更新日期：1995-02-01 00:00:00

abstract：:The present study was aimed at defining the activity of human and mouse monocyte chemotactic protein-1 (MCP-1) on homologous and heterologous mononuclear phagocytes. Human natural and recombinant MCP-1 and mouse natural MCP-1/JE were tested as chemoattractants on human blood monocytes and mouse peritoneal macrophages....

journal_title：Cytokine

authors： Luini W,Sozzani S,Van Damme J,Mantovani A

更新日期：1994-01-01 00:00:00

abstract：:In serum-free WEHI-3 supernatants an activity was detected inducing haemoglobin synthesis in human and murine erythroleukaemia cell lines. The absolute numbers of benzidine-positive cells induced with either DMSO or WEHI-3-conditioned medium were comparable. Terminal differentiation was not observed. An expression lib...

journal_title：Cytokine

authors： Dörmer P,Spitzer E,Frankenberger M,Kremmer E

更新日期：2004-06-21 00:00:00

abstract：BACKGROUND:Among all cytokines involved in the pathogenesis and in the progression of psoriasis, Tumor Necrosis Factor (TNF)-alpha and interleukin (IL)-17 play a pivotal role. OBJECTIVE:The aim of the present study was to mimic a psoriatic microenvironment and to investigate the early effects of TNF-alpha and IL-17 in...

journal_title：Cytokine

authors： Donetti E,Cornaghi L,Gualerzi A,Baruffaldi Preis FW,Prignano F

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:In Ethiopia, visceral leishmaniasis (VL) is a growing public health threat. Among the key challenges in VL control in Ethiopia is lack of an effective test of cure. The recommended test of cure is parasite detection. As sterile cure is not expected with the current widely used drugs, the value of parasite de...

journal_title：Cytokine

authors： Gadisa E,Tasew G,Abera A,Gelaye W,Chanyalew M,Abebe M,Laskay T,Aseffa A

更新日期：2017-03-01 00:00:00

abstract：:Intestinal epithelial cells can be induced to secrete the chemokine interleukin (IL)-8 during inflammation. The PAR-2 receptor is believed to play a proinflammatory role and is expressed in gut epithelial cells. The aim was to investigate PAR-2 signaling in Caco-2 intestinal epithelial cells, with respect to chemokine...

journal_title：Cytokine

authors： Fyfe M,Bergström M,Aspengren S,Peterson A

更新日期：2005-09-07 00:00:00

abstract：BACKGROUND:Cardiac surgery is associated with inflammatory responses that are known to affect its outcome. The present study was designed to define whether post-operative release of interleukin (IL)-6, 8 and tumor necrosis factor-alpha (TNF-alpha) is related to the presence of a certain allele in functional polymorphis...

journal_title：Cytokine

authors： Wang Z,Shao J,Zhou Q,Liu J,Zhu Y,Yang J,Wei M

更新日期：2010-06-01 00:00:00

abstract：:The gene for ISG12 (originally designated p27) was isolated as an oestrogen-induced gene. The authors undertook a comprehensive study using quantitative RT-PCR, in which we delineate the regulation of ISG12 by seven different cytokines including interferons and poly(I). poly(C) in seven human cell lines of different o...

journal_title：Cytokine

authors： Gjermandsen IM,Justesen J,Martensen PM

更新日期：2000-03-01 00:00:00

abstract：:Interleukin 12 (IL-12) is a heterodimer comprising p35 and p40 subunits which are encoded and regulated separately. The authors previously demonstrated deficient IL-12 production in SLE which correlates negatively with disease activity. The present study was designed to determine whether deficiency of IL-12 and excess...

journal_title：Cytokine

authors： Liu TF,Jones BM,Wong RW,Srivastava G

更新日期：1999-10-01 00:00:00

abstract：:Interleukin 6 (IL-6) and related gp130-signalling cytokines rapidly activate latent cytoplasmic Stat transcription factors and these are believed to play pivotal roles in the expression of downstream cytokine-responsive genes. We have previously shown in IL-6-deficient (-/-) mice that IL-6 is absolutely required for t...

journal_title：Cytokine

authors： Alonzi T,Fattori E,Cappelletti M,Ciliberto G,Poli V

更新日期：1998-01-01 00:00:00

abstract：:Previous studies identified the variant IFNG +874A/T (rs2430561) in the first intron of the gene in association with mycobacterial infection, especially tuberculosis and leprosy. The aim of this investigation was to analyze the protective role of the T allele in relation to leprosy using a meta-analysis evaluation. Th...

journal_title：Cytokine

authors： Silva GA,Naveca FG,Ramasawmy R,Boechat AL

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The genetic basis of complex diseases like ischemic stroke probably consists of several predisposing risk factors, such as genes involved in inflammation and thrombotic pathways. On this basis the aim of our study was to evaluate the role of SNPs (single nucleotide polymorphisms) of some pro-inflammatory/ant...

journal_title：Cytokine

authors： Tuttolomondo A,Di Raimondo D,Forte GI,Casuccio A,Vaccarino L,Scola L,Pecoraro R,Serio A,Clemente G,Arnao V,Palmeri M,Misiano G,Lio D,Pinto A,Licata G

更新日期：2012-06-01 00:00:00

abstract：:Neutrophil-activating peptide 1/interleukin 8 (NAP-1/IL-8) is a recently described cytokine with potent chemotactic activity for human neutrophil granulocytes (PMN) and T cells. In psoriasis, a chronic hyperproliferative and inflammatory skin disorder, PMN and T cells are found as prominent cells in the inflammatory i...

journal_title：Cytokine

authors： Mrowietz U,Sticherling M,Mielke V,Schröder JM,Christophers E

更新日期：1991-07-01 00:00:00

abstract：:Following recent attention focused on IL-32 as an important component involved in the inflammatory cytokine network, we speculated that IL-32's action on IFN-γ and IFN-γ secreting T cell subsets may help sustain the immune activation and dysregulation found in patients with HIV-1 achieving viral suppression. To explor...

journal_title：Cytokine

authors： Santinelli L,Statzu M,Pierangeli A,Frasca F,Bressan A,Pinacchio C,Nonne C,Turriziani O,Antonelli G,d'Ettorre G,Scagnolari C

更新日期：2019-08-01 00:00:00

abstract：:Monocytes/macrophages (Mphi) play a pivotal role in the persistence of chronic inflammation and local tissue destruction in diseases such as rheumatoid arthritis and atherosclerosis. The production by Mphi of cytokines, chemokines, metalloproteinases and their inhibitors is an essential component in this process, whic...

journal_title：Cytokine

authors： Meier CA,Chicheportiche R,Juge-Aubry CE,Dreyer MG,Dayer JM

更新日期：2002-06-21 00:00:00