The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro

abstract：OBJECTIVES:To measure the serum and synovial fluid (SF) levels of interleukin (IL)-37 in patients with rheumatoid arthritis (RA) and to investigate the effect of recombinant human (rh)IL-37 on inflammatory cytokine production (tumor necrosis factor [TNF]-α, IL-6, IL-17 and IL-10) by peripheral blood mononuclear cells (...

journal_title：Cytokine

authors： Xia L,Shen H,Lu J

更新日期：2015-12-01 00:00:00

abstract：:In serum-free WEHI-3 supernatants an activity was detected inducing haemoglobin synthesis in human and murine erythroleukaemia cell lines. The absolute numbers of benzidine-positive cells induced with either DMSO or WEHI-3-conditioned medium were comparable. Terminal differentiation was not observed. An expression lib...

journal_title：Cytokine

authors： Dörmer P,Spitzer E,Frankenberger M,Kremmer E

更新日期：2004-06-21 00:00:00

abstract：:A large body of evidence supports the involvement of the immune system in the pathogenesis of multiple sclerosis (MS). Nevertheless, how the peripheral T-cells phenotypes are associated with factors such as the disability score, the effects of immunomodulatory treatments, or the activation period is poorly understood....

journal_title：Cytokine

authors： Sepulcre J,Sanchez-Ibarrola A,Moreno C,de Castro P

更新日期：2005-10-21 00:00:00

abstract：:Emerging evidence indicates that chemokine receptor expression patterns are critical in determining the spectrum of action of the chemokines. We have analysed the expression patterns of 17 chemokine receptors and two orphan chemokine receptor-like genes in various freshly prepared human peripheral blood leucocyte popu...

journal_title：Cytokine

authors： Patel L,Charlton SJ,Chambers JK,Macphee CH

更新日期：2001-04-07 00:00:00

abstract：PURPOSE:Tumor necrosis factor (TNFα) is a proinflammatory cytokine and has been a target for intervention in human sepsis. However, inhibition of TNF-α with a high dose of a TNF-receptor fusion protein in patients with septic shock worsened patient survival. This study was designed to investigate whether blocking TNF-α...

journal_title：Cytokine

authors： Tsay TB,Yang MC,Chen PH,Lai KH,Huang HT,Hsu CM,Chen LW

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:Vascular endothelial cell growth factor (VEGF) plays an important role in the biology of gynecological cancer, usually linked with aggressive tumour behaviour and a poor postoperative outcome. Yet, its role in benign breast/gynecological conditions is less clear. METHODS:Serum VEGF was analysed in a series ...

journal_title：Cytokine

authors： Koukourakis MI,Limberis V,Tentes I,Kontomanolis E,Kortsaris A,Sivridis E,Giatromanolaki A

更新日期：2011-03-01 00:00:00

abstract：:Cytokine induction following stimulation by endotoxin (LPS) was investigated in human peripheral whole blood. Blood cells were suspended in autologous plasma diluted in basal medium (BM-plasma) or Compound Sodium Lactate Solution (CSL-plasma), or in autologous serum diluted in CSL. Induction of interleukin 1 beta, int...

journal_title：Cytokine

authors： Yentis SM,Gooding RP,Riches PG

更新日期：1994-05-01 00:00:00

abstract：:The in vivo influence of recombinant human erythropoietin (rhEpo) and iron on human neutrophil (PMN) antimicrobial function was assessed. A total of 21 preterm infants were randomized to receive either 200 U/kg/other day of rHuEPO+12 mg/kg/day of iron (EPO+high Fe, seven infants) or 200 U/kg/other day of rhEPO+4 mg/kg...

journal_title：Cytokine

authors： Soubasi V,Roilides E,Tsantali C,Mussafiris K,Tsakiris D,Kremenopoulos G

更新日期：1999-01-01 00:00:00

abstract：:Cytokine mRNA expression was analyzed by reverse transcriptase (RT)/PCR in extensively purified normal peripheral CD4+CD45R T cell subsets. Both CD45RA+ and CD45 RO+ populations produced mRNAs for interleukin (IL)-2, IL-2 receptor (alpha chain), IL-6 receptor and tumour necrosis factor (TNF)-beta within 3-4 h of activ...

journal_title：Cytokine

authors： Beckman I,Shepherd K,Dimopoulos K,Ahern M,Firgaira F,Bradley J

更新日期：1994-03-01 00:00:00

abstract：:IFNγ is a potent activator and IL-10 a powerful inhibitor of macrophage functions. However, neither all cellular functions are enhanced by IFNγ nor IL-10 inhibits all cellular responses. Thus, FcγRs-mediated phagocytosis in monocyte-derived macrophages (MDM) increases after IL-10 treatment, and decreases after treatme...

journal_title：Cytokine

authors： Frausto-Del-Río D,Soto-Cruz I,Garay-Canales C,Ambriz X,Soldevila G,Carretero-Ortega J,Vázquez-Prado J,Ortega E

更新日期：2012-01-01 00:00:00

abstract：:Non-Hodgkin's lymphomas (NHL) constitute a heterogenous group of mainly B-cell lymphoproliferative diseases with different patterns of clinical behaviour. Biological mechanisms leading to development of NHL are not clearly understood. Transforming growth factor-beta1 (TGF-beta1) influences B cell growth and developmen...

journal_title：Cytokine

authors： Mazur G,Bogunia-Kubik K,Wrobel T,Kuliczkowski K,Lange A

更新日期：2006-02-07 00:00:00

abstract：:Periodontitis is the most prevalent infectious disease caused by periodontopathic bacteria and is also a chronic inflammatory disease. Gingival crevicular fluid (GCF) is an inflammatory exudate that seeps into the gingival crevices or periodontal pockets around teeth with inflamed gingiva, and contains various materia...

journal_title：Cytokine

authors： Yoshimoto T,Fujita T,Kajiya M,Matsuda S,Ouhara K,Shiba H,Kurihara H

更新日期：2015-09-01 00:00:00

abstract：:Monocytes/macrophages (Mphi) play a pivotal role in the persistence of chronic inflammation and local tissue destruction in diseases such as rheumatoid arthritis and atherosclerosis. The production by Mphi of cytokines, chemokines, metalloproteinases and their inhibitors is an essential component in this process, whic...

journal_title：Cytokine

authors： Meier CA,Chicheportiche R,Juge-Aubry CE,Dreyer MG,Dayer JM

更新日期：2002-06-21 00:00:00

abstract：BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...

journal_title：Cytokine

authors： Sabry A,Sheashaa H,El-Husseini A,Mahmoud K,Eldahshan KF,George SK,Abdel-Khalek E,El-Shafey EM,Abo-Zenah H

更新日期：2006-08-01 00:00:00

abstract：:Recently, we reported that extracellular ubiquitin functions as another agonist of CXC chemokine receptor (CXCR)4. Whereas the cognate CXCR4 ligand, stromal cell-derived factor (SDF)-1α, is also a CXCR7 agonist, ubiquitin does not bind to CXCR7. Because both ligands are present in the extracellular environment, co-act...

journal_title：Cytokine

authors： Tripathi A,Davis JD,Staren DM,Volkman BF,Majetschak M

更新日期：2014-02-01 00:00:00

abstract：:We examined seasonal differences in whole blood cytokine production after endotoxin (LPS) stimulation in 17 healthy individuals from an urban area having normal sleep/wakefulness pattern. We used 500 pg/ml of LPS for incubation period of 4 h to stimulate 100 microl of whole blood of the same subjects in June, Septembe...

journal_title：Cytokine

authors： Myrianthefs P,Karatzas S,Venetsanou K,Grouzi E,Evagelopoulou P,Boutzouka E,Fildissis G,Spiliotopoulou I,Baltopoulos G

更新日期：2003-12-21 00:00:00

abstract：BACKGROUND:HIV-1 and HIV-2 are two related viruses with distinct clinical outcomes, where HIV-1 is more pathogenic and transmissible than HIV-2. The pathogenesis of both infections is influenced by the dysregulation and deterioration of the adaptive immune system. However, their effects on the responsiveness of innate ...

journal_title：Cytokine

authors： Nowroozalizadeh S,Månsson F,da Silva Z,Repits J,Dabo B,Pereira C,Biague A,Albert J,Nielsen J,Aaby P,Fenyö EM,Norrgren H,Holmgren B,Jansson M

更新日期：2009-06-01 00:00:00

abstract：:Circulating interleukin (IL)-6 and IL-10 concentrations can be elevated following the surgically induced trauma of total knee arthroplasty (TKA). An exaggerated increase in IL-6 relative to IL-10 (i.e., IL-6/IL-10 ratio) associates with trauma severity and indicative of pro-inflammatory predominance. Although various ...

journal_title：Cytokine

authors： Barker T,Henriksen VT,Rogers VE,Trawick RH,Momberger NG,Lynn Rasmussen G

更新日期：2021-01-23 00:00:00

abstract：:The failure of the immune response to clear the Hepatitis C virus (HCV) results in chronic inflammation that leads to liver cirrhosis. In general, women have a better prognosis than men and this may be associated with increased levels of anti-inflammatory mediators that are positively regulated by female sex hormones....

journal_title：Cytokine

authors： Nanda KS,Brady JJ,Murray BF,Sullivan O,Fearon U,McKenna MJ,Hegarty JE,O'Farrelly C,Ryan EJ

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:HIV rapid progressors (RPs) present with a rapid decline of CD4+ T cells within a few years of infection. Determining the underlying mechanisms throughout this decline is important to identify prognostic biomarkers and intervention strategies. Determining the numbers of CD4+ and CD8+ T cells is essential for...

journal_title：Cytokine

authors： Ding ZD,Zheng JF,Song CB,Fu YJ,Xu JJ,Jiang YJ,Shang H,Zhang ZN

更新日期：2020-01-01 00:00:00

abstract：:It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely ...

journal_title：Cytokine

authors： Palumbo ML,Di Rosso ME,Simon EH,Gonzalez Murano MR,Genaro AM

更新日期：2018-07-01 00:00:00

abstract：:Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies w...

journal_title：Cytokine

authors： de Lemos Rieper C,Galle P,Pedersen BK,Hansen MB

更新日期：2010-09-01 00:00:00

abstract：:Following recent attention focused on IL-32 as an important component involved in the inflammatory cytokine network, we speculated that IL-32's action on IFN-γ and IFN-γ secreting T cell subsets may help sustain the immune activation and dysregulation found in patients with HIV-1 achieving viral suppression. To explor...

journal_title：Cytokine

authors： Santinelli L,Statzu M,Pierangeli A,Frasca F,Bressan A,Pinacchio C,Nonne C,Turriziani O,Antonelli G,d'Ettorre G,Scagnolari C

更新日期：2019-08-01 00:00:00

abstract：:IL-12p70 is a proinflammatory cytokine secreted by dendritic cells, monocytes and macrophages. It plays a crucial role in cell-mediated immunity by inducing proliferation of T cell and natural killer cells, and enhancing their cytotoxic activity. In adaptive immune response, it acts on naive T cells to differentiate i...

journal_title：Cytokine

authors： Chen IF,Khan J,Noma N,Hadlaq E,Teich S,Benoliel R,Eliav E

更新日期：2013-06-01 00:00:00

abstract：:In order to understand the cellular disease mechanisms of osteoarthritic cartilage degeneration it is of primary importance to understand both the anabolic and the catabolic processes going on in parallel in the diseased tissue. In this study, we have applied cDNA-array technology (Clontech) to study gene expression p...

journal_title：Cytokine

authors： Aigner T,McKenna L,Zien A,Fan Z,Gebhard PM,Zimmer R

更新日期：2005-08-07 00:00:00

abstract：:The present study aimed to assess the kinetics of cytokine release and compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) associated with Kawasaki disease (KD). Serum neopterin, interleukin (IL)-18, IL-6 and soluble tumour necrosis factor receptor type I (sTNFR-I) and sT...

journal_title：Cytokine

authors： Jinkawa A,Shimizu M,Nishida K,Kaneko S,Usami M,Sakumura N,Irabu H,Takakuwa M,Inoue N,Mizuta M,Ikawa Y,Fujita S,Yachie A

更新日期：2019-07-01 00:00:00

abstract：:Thrombopoietin (TPO) plays a pivotal role in megakaryopoiesis. TPO initiates its biological effects by binding to its receptor Mpl. A recombinant protein consisting of a carrier Fc domain linked to multiple Mpl-binding domains was constructed, and is called AMG531. To define the biological activity of AMG531, we exami...

journal_title：Cytokine

authors： Broudy VC,Lin NL

更新日期：2004-01-21 00:00:00

abstract：PURPOSE:Three tear supplements were compared for their effects on the signs, symptoms and inflammatory status of subjects with dry eye disease. Assessments were made before and after both 2 and 4 weeks of treatment. METHODS:In this masked, randomized, 3-way crossover trial, eighteen dry eye subjects were recruited. At...

journal_title：Cytokine

authors： Martin E,Oliver KM,Pearce EI,Tomlinson A,Simmons P,Hagan S

更新日期：2018-05-01 00:00:00

abstract：:Asthma and type I diabetes are major causes of chronic illness in childhood which, according to the current paradigm, have mutually antagonistic immunopathologies. Nonetheless, the disorders appear to preferably coexist both on population and individual levels. To assess whether children with asthma and type I diabete...

journal_title：Cytokine

authors： Kainonen E,Rautava S,Korkeamäki M,Isolauri E

更新日期：2006-05-01 00:00:00

abstract：:Interleukin 5 (IL-5) is a T-cell derived cytokine that induces eosinophil growth and differentiation in both mouse and human bone marrow cultures. Elevated levels of IL-5 as well as eosinophils have been detected in the sputum and Bronchoalveolar lavage (BAL) fluids of asthmatics. Since the recruitment of inflammatory...

journal_title：Cytokine

authors： Fattah D,Page KR,Bezbaruah S,Priest RC,Horgan CM,Solari R

更新日期：1996-03-01 00:00:00