当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > Increased expression of IL-32 correlates with IFN-γ, Th1 and Tc1 in virologically suppressed HIV-1-infected patients.

Increased expression of IL-32 correlates with IFN-γ, Th1 and Tc1 in virologically suppressed HIV-1-infected patients.

Abstract：

:Following recent attention focused on IL-32 as an important component involved in the inflammatory cytokine network, we speculated that IL-32's action on IFN-γ and IFN-γ secreting T cell subsets may help sustain the immune activation and dysregulation found in patients with HIV-1 achieving viral suppression. To explore this hypothesis, transcript levels of IL-32 and IFN-γ were evaluated in PBMC from 139 virologically suppressed HIV-1-infected patients and from 63 healthy individuals by Real Time RT-PCR assays. IL-32 and IFN-γ mRNA levels were also analyzed in CD4+ T cells, CD14+ monocytes and lamina propria lymphocytes (LPL) of the gut district in a subgroup of HIV-1-infected subjects. IFN-γ secreting CD4+ (Th1) and CD8+ (Tc1) T cell subset frequencies were evaluated in LPL by multiparametric flow cytometry. Gene expression results revealed that IL-32 and IFN-γ levels in PBMC from HIV-1-positive patients were significantly elevated compared to those from healthy donors, correlated with each other and increased with patient age. Both IL-32 and IFN-γ genes were also more strongly expressed in CD4+ T cells than in CD14+ monocytes. By contrast, IL-32 levels in LPL were comparable to those measured in PBMC, while IFN-γ levels were higher in PBMC than those in LPL. Negative correlations were found between IL-32 levels and the frequencies of Th1 and Tc1 subsets in gut mucosa. Collectively, our results provide the first evidence that IL-32 levels remain elevated in treated HIV-1-infected patients and correlate with IFN-γ, Th1 and Tc1 subsets.

journal_name

Cytokine

journal_title

Cytokine

authors

Santinelli L,Statzu M,Pierangeli A,Frasca F,Bressan A,Pinacchio C,Nonne C,Turriziani O,Antonelli G,d'Ettorre G,Scagnolari C

doi

10.1016/j.cyto.2019.01.012

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

273-281

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(19)30036-5

journal_volume

120

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines.

    abstract：:Chemokines are small chemoattractant cytokines involved in normal and pathological immune processes. Although extensive nucleotide sequence data are available for human and murine chemokine cDNA sequences, very few data are currently available regarding rhesus macaque sequences. To increase our understanding of immune...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.0875

    authors： Basu S,Schaefer TM,Ghosh M,Fuller CL,Reinhart TA

    更新日期：2002-05-07 00:00:00

  • Identification of promising plasma immune biomarkers to differentiate active pulmonary tuberculosis.

    abstract：:Although much research has been done related to biomarker discovery for tuberculosis infection, a set of biomarkers that can discriminate between active and latent TB diseases remains elusive. In the current study we correlate clinical aspects of TB disease with changes in the immune response as determined by biomarke...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.cyto.2016.08.030

    authors： Zambuzi FA,Cardoso-Silva PM,Espindola MS,Soares LS,Galvão-Lima LJ,Brauer VS,Gomes MS,Amaral LR,Schaller M,Bollela VR,Frantz FG

    更新日期：2016-12-01 00:00:00

  • Bullous pemphigoid: interaction of interleukin 5, anti-basement membrane zone antibodies and eosinophils. A preliminary observation. .

    abstract：:Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the presence of autoantibodies to normal components of the hemidesmosome (BPAg1 and BPAg2). Histology of skin lesions demonstrate a subepidermal vesicle and a predominantly eosinophilic dermal cellular infiltrate. Interleukin 5 (IL-5) pl...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0791

    authors： Engineer L,Bhol K,Kumari S,Razzaque Ahmed A

    更新日期：2001-01-07 00:00:00

  • Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue.

    abstract：:CC Chemokine ligand 22 (Ccl22) is a selective, high affinity ligand at the CC chemokine receptor 4 (Ccr4). We have identified cDNAs encoding both ligand and receptor of the Ccl22-Ccr4 pair in cDNA libraries of the anterior hypothalamus/pre-optic area (AH/POA) by PCR. The AH/POA is the key brain region where endogenous...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.11.017

    authors： Osborn O,Sanchez-Alavez M,Dubins JS,Gonzalez AS,Morrison B,Hadcock JR,Bartfai T

    更新日期：2011-03-01 00:00:00

  • Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls.

    abstract：OBJECTIVES:Little is known about the role of adipokines in the pathogenesis of coronary artery disease in young patients. The aims of this study were to compare serum levels of adipokines and expression of adipokines in peripheral blood leukocytes in patients with premature coronary artery disease (CAD), metabolic synd...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.03.016

    authors： Smékal A,Václavík J,Stejskal D,Benešová K,Jarkovský J,Svobodová G,Richterová R,Švesták M,Táborský M

    更新日期：2019-10-01 00:00:00

  • Association between the IFNG +874A/T gene polymorphism and leprosy resistance: a meta-analysis.

    abstract：:Previous studies identified the variant IFNG +874A/T (rs2430561) in the first intron of the gene in association with mycobacterial infection, especially tuberculosis and leprosy. The aim of this investigation was to analyze the protective role of the T allele in relation to leprosy using a meta-analysis evaluation. Th...

    journal_title：Cytokine

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.cyto.2013.12.002

    authors： Silva GA,Naveca FG,Ramasawmy R,Boechat AL

    更新日期：2014-02-01 00:00:00

  • Transcutaneous IL-2 uptake mediated by Transfersomes depends on concentration and fractionated application.

    abstract：INTRODUCTION:Transfersomes (TF) are new, ultradeformable carriers with characteristics that enable them to penetrate the skin spontaneously. TFs are able to transport noninvasively both low- and high-molecular-weight molecules into the body. MATERIALS AND METHODS:TFs contain phosphatidylcholine and sodium cholate. Rec...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2003.10.010

    authors： Hofer C,van Randenborgh H,Lehmer A,Hartung R,Breul J

    更新日期：2004-02-21 00:00:00

  • Enhanced production of tumour necrosis factor alpha (TNF-alpha) by its precursor on the cell surface of primed THP-1 cells.

    abstract：:To clarify the biological significance of tumour necrosis factor alpha (TNF-alpha) precursor, we analysed its expression at the primed and triggered stages using human monocyte-like cell line THP-1. To prime them, THP-1 cells were treated with either recombinant human interferon gamma (rIFN-gamma) or recombinant human...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(94)90056-6

    authors： Tanabe Y,Kitahara-Tanabe N,Mizuno D,Soma GI

    更新日期：1994-07-01 00:00:00

  • PAR-2 activation in intestinal epithelial cells potentiates interleukin-1beta-induced chemokine secretion via MAP kinase signaling pathways.

    abstract：:Intestinal epithelial cells can be induced to secrete the chemokine interleukin (IL)-8 during inflammation. The PAR-2 receptor is believed to play a proinflammatory role and is expressed in gut epithelial cells. The aim was to investigate PAR-2 signaling in Caco-2 intestinal epithelial cells, with respect to chemokine...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2005.06.004

    authors： Fyfe M,Bergström M,Aspengren S,Peterson A

    更新日期：2005-09-07 00:00:00

  • The interferon-induced gene ISG12 is regulated by various cytokines as the gene 6-16 in human cell lines.

    abstract：:The gene for ISG12 (originally designated p27) was isolated as an oestrogen-induced gene. The authors undertook a comprehensive study using quantitative RT-PCR, in which we delineate the regulation of ISG12 by seven different cytokines including interferons and poly(I). poly(C) in seven human cell lines of different o...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0549

    authors： Gjermandsen IM,Justesen J,Martensen PM

    更新日期：2000-03-01 00:00:00

  • Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency.

    abstract：:X-linked lymphoproliferative syndrome (XLP) is a rare primary immunodeficiency characterized by increased vulnerability to Epstein-Barr virus infection. XLP type 1 is caused by mutations in SH2D1A, whereas X-linked inhibitor of apoptosis (XIAP) encoded by XIAP/BIRC4 is mutated in XLP type 2. In XIAP deficiency, hemoph...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.09.007

    authors： Wada T,Kanegane H,Ohta K,Katoh F,Imamura T,Nakazawa Y,Miyashita R,Hara J,Hamamoto K,Yang X,Filipovich AH,Marsh RA,Yachie A

    更新日期：2014-01-01 00:00:00

  • Leishmania major strains isolated from distinct endemic areas show diverse cytokine mRNA expression levels in C57BL/6 mice: Toward selecting an ideal strain for the vaccine studies.

    abstract：:Leishmania major, the causative agent of zoonotic cutaneous leishmaniasis shows heterogeneity and diverse clinical manifestations in different areas of infection and experimental models. Such polymorphism may cause difficulties in selection of reliable strains for development of prophylaxes. Hence, the aim of this stu...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.05.022

    authors： Darabi S,Khaze V,Riazi-Rad F,Darabi H,Bahrami F,Ajdary S,Alimohammadian MH

    更新日期：2015-12-01 00:00:00

  • Autocrine IL-6 regulates GRO-alpha production in thymic epithelial cells.

    abstract：:Thymic interleukin-6 (IL-6), which is produced primarily by thymic epithelial cells, is an important cytokine for T cell growth and differentiation in the thymus. In the present study, we investigated the effects of autocrine IL-6 on the cytokines in primary cultures of human thymic epithelial cells. Using an antibody...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.05.002

    authors： Tseng YL,Wu MH,Yang HC,Wang CY,Lin CF

    更新日期：2010-08-01 00:00:00

  • Expression of cytokines and their receptors by psoriatic fibroblasts. II. decreased TNF receptor expression.

    abstract：:Psoriatic fibroblasts produce enhanced amounts of IL-6 in vitro. This state of activation may reflect an altered expression of cytokine receptors, involved in auto/paracrine induction of IL-6. Cultures of dermal fibroblasts derived from lesional psoriatic (PP) and normal control (NN) skin were therefore analysed for t...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0011

    authors： Debets R,Hegmans JP,Buurman WA,Benner R,Prens EP

    更新日期：1996-01-01 00:00:00

  • Differences in biomarkers of inflammation and immune responses in chronic smokers and moist snuff users.

    abstract：BACKGROUND:Cigarette smoking is a major risk factor for cancer and other diseases. While smoking induces chronic inflammation and aberrant immune responses, the effects of smokeless tobacco products (STPs) on immune responses is less clear. Here we evaluated markers related to immune regulation in smokers (SMK), moist ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155299

    authors： Tran QT,Arimilli S,Scott E,Chen P,Prasad GL

    更新日期：2021-01-01 00:00:00

  • Glutathione depletion inhibits IL-1 beta-stimulated nitric oxide production by reducing inducible nitric oxide synthase gene expression.

    abstract：:L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. The thiol depletor diethyl maleate (DEM) and an inhibi...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0712

    authors： Nikulina MA,Andersen HU,Karlsen AE,Darville MI,Eizirik DL,Mandrup-Poulsen T

    更新日期：2000-09-01 00:00:00

  • TNF-α polymorphisms and coronary artery disease: association study in the Korean population.

    abstract：:Coronary artery disease (CAD) results from atherosclerosis, a chronic inflammatory disease mediated in part by proinflammatory cytokines, particularly tumor necrosis factor-α (TNF-α), which is expressed by atherosclerotic plaques. In this study, we investigated whether TNF-α gene promoter polymorphisms affect the inci...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.02.008

    authors： Cho HC,Yu G,Lee MY,Kim HS,Shin DH,Kim YN

    更新日期：2013-04-01 00:00:00

  • Response to thalidomide in multiple myeloma: impact of angiogenic factors.

    abstract：:Thalidomide has antiangiogenic and immunomodulatory effects, mediated by several cytokines such as vascular endothelial growth factor (VEGF), fibroblastic growth factor (FGF-2), hepatocyte growth factor (HGF), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Although extramedullary plasmacytomas (EMP)...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.02.002

    authors： Rosiñol L,Cibeira MT,Segarra M,Cid MC,Filella X,Aymerich M,Rozman M,Arenillas L,Esteve J,Bladé J,Montserrat E

    更新日期：2004-05-21 00:00:00

  • Cytokine mRNA expression in inflammatory multiple sclerosis lesions: detection by non-radioactive in situ hybridization.

    abstract：:The predominant pathological features in the central nervous system (CNS) in multiple sclerosis (MS) are perivascular inflammation and demyelination. The cells in the inflammatory cuff consist mainly of T lymphocytes and macrophages. Cytokines produced by inflammatory cells within the CNS have the potential to enhance...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(05)80008-0

    authors： Woodroofe MN,Cuzner ML

    更新日期：1993-11-01 00:00:00

  • Association of CTLA-4 and TNF-α polymorphism with recurrent miscarriage among North Indian women.

    abstract：CONTEXT:CTLA-4 is engaged on effector cells that may alter signal transduction and subsequently cytokine production. The transmission of longer repeats of (AT)(n) alleles of CTLA-4 is also associated with women undergoing recurrent miscarriage. The TNF-α known as an embryo-toxic cytokine is reported to be greater in pl...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.05.018

    authors： Gupta R,Prakash S,Parveen F,Agrawal S

    更新日期：2012-11-01 00:00:00

  • Interferon gamma induces actin polymerization, Rac1 activation and down regulates phagocytosis in human monocytic cells.

    abstract：:IFNγ is a potent activator and IL-10 a powerful inhibitor of macrophage functions. However, neither all cellular functions are enhanced by IFNγ nor IL-10 inhibits all cellular responses. Thus, FcγRs-mediated phagocytosis in monocyte-derived macrophages (MDM) increases after IL-10 treatment, and decreases after treatme...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.11.008

    authors： Frausto-Del-Río D,Soto-Cruz I,Garay-Canales C,Ambriz X,Soldevila G,Carretero-Ortega J,Vázquez-Prado J,Ortega E

    更新日期：2012-01-01 00:00:00

  • Influence of acute alcohol intake and alcohol withdrawal on circulating levels of IL-6, IL-8, IL-10 and IL-12.

    abstract：:Cytokine balance alterations are responsible for some of the systemic and hepatic manifestations of alcoholism. The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Serum cytok...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0715

    authors： González-Quintela A,Dominguez-Santalla MJ,Pérez LF,Vidal C,Lojo S,Barrio E

    更新日期：2000-09-01 00:00:00

  • Ingested interferon alpha induces Mx mRNA.

    abstract：:We have demonstrated that ingested murine interferon alpha (IFN-alpha) suppressed clinical relapse in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), decreased inflammation and suppressed the adoptive transfer of EAE, and is a biological response modifier in patients with multiple sclerosis. We e...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1998.0450

    authors： Brod SA,Nelson L,Jin R,Wolinsky JS

    更新日期：1999-07-01 00:00:00

  • IL-10 and IFN-γ gene expression in chronic Chagas disease patients after in vitro stimulation with recombinant antigens of Trypanosoma cruzi.

    abstract：:Along with several other aspects of Chagas disease, the mechanisms responsible for the different clinical outcomes observed in chronic infected individuals have not yet been clarified. It is believed that the host immune response to the parasite plays an important role in the development of the pathology. Therefore, t...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.01.008

    authors： de Melo AS,de Lorena VM,de Moura Braz SC,Docena C,de Miranda Gomes Y

    更新日期：2012-05-01 00:00:00

  • Seasonal variation in whole blood cytokine production after LPS stimulation in normal individuals.

    abstract：:We examined seasonal differences in whole blood cytokine production after endotoxin (LPS) stimulation in 17 healthy individuals from an urban area having normal sleep/wakefulness pattern. We used 500 pg/ml of LPS for incubation period of 4 h to stimulate 100 microl of whole blood of the same subjects in June, Septembe...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2003.08.005

    authors： Myrianthefs P,Karatzas S,Venetsanou K,Grouzi E,Evagelopoulou P,Boutzouka E,Fildissis G,Spiliotopoulou I,Baltopoulos G

    更新日期：2003-12-21 00:00:00

  • A rapid activation assay for human eosinophils based on adhesion to immobilized ICAM-1, VCAM-1 and IgG.

    abstract：:Interleukin 5 (IL-5) is a T-cell derived cytokine that induces eosinophil growth and differentiation in both mouse and human bone marrow cultures. Elevated levels of IL-5 as well as eosinophils have been detected in the sputum and Bronchoalveolar lavage (BAL) fluids of asthmatics. Since the recruitment of inflammatory...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0034

    authors： Fattah D,Page KR,Bezbaruah S,Priest RC,Horgan CM,Solari R

    更新日期：1996-03-01 00:00:00

  • Hypocholesterolemia and dysregulated production of angiopoietin-like proteins in sickle cell anemia patients.

    abstract：:Angiopoietin-like proteins (ANGPTL) are responsible for inhibiting lipoprotein lipase activity, and ANGPTL3 and ANGPTL4 deficiencies have been shown to lower lipoprotein levels in animal models and in humans carrying loss-of-function mutations. Sickle cell anemia (SCA) is a hereditary hemolytic anemia characterized by...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.04.014

    authors： Vendrame F,Olops L,Saad STO,Costa FF,Fertrin KY

    更新日期：2019-08-01 00:00:00

  • IL-12 induction of resistance to pulmonary blastomycosis.

    abstract：BACKGROUND:Why severity varies in blastomycosis outbreaks remains unresolved. In experimental pulmonary blastomycosis, susceptibility varied in mouse strains. In susceptible BALB/c the response is Th-2, in immunized, resistance is associated with Th-1. Can susceptibility be redirected by IL-12? Methods, results: BALB/c...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.08.004

    authors： Brummer E,Vinoda V,Stevens DA

    更新日期：2006-09-01 00:00:00

  • Change in the accessibility of an epitope of the human granulocyte-colony stimulating factor after binding to receptors.

    abstract：:In a previous work we demonstrated that monoclonal antibody (mAb) 8C2 recognized a human granulocyte-colony stimulating factor (hG-CSF) region left unmasked after binding to placenta receptors, whereas mAb 6E3 defined a receptor-buried epitope. Herein we examined the role of these antigenic regions on the proliferativ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00099-1

    authors： Marino VJ,Sterin-Prync AE,Roguin LP

    更新日期：2003-04-01 00:00:00

  • Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25.

    abstract：:Numerous proteins are cleaved or "shed" from their membrane-bound form. One such protein, tumour necrosis factor alpha (TNF-alpha), is synthesized as a type 2 transmembrane protein. Recently, a human protease responsible for this shedding, the TNF-alpha converting enzyme (TACE/ADAM17), was isolated. TACE/ADAM17 is a m...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1998.0466

    authors： Cerretti DP,Poindexter K,Castner BJ,Means G,Copeland NG,Gilbert DJ,Jenkins NA,Black RA,Nelson N

    更新日期：1999-08-01 00:00:00