Regulation of the production of pro-inflammatory cytokines and antagonists during chemotherapy-induced neutropenia in patients with haematological malignancies.

abstract：:Castration-refractory prostate cancer (CRPC) is treated with taxane-based chemotherapy, but eventually becomes drug resistant. It is thus essential to identify novel therapeutic targets for taxane resistance in CRPC patients. We investigated the role of the chemokine (C-C motif) receptor 1 (CCR1) and its ligand, chemo...

journal_title：Cytokine

authors： Kato T,Fujita Y,Nakane K,Mizutani K,Terazawa R,Ehara H,Kanimoto Y,Kojima T,Nozawa Y,Deguchi T,Ito M

更新日期：2013-10-01 00:00:00

abstract：:Kawasaki disease is a multi-system vasculitis and a primary cause of acquired heart disease among children. Genetic factors may increase susceptibility to Kawasaki disease. TBXA2R is a G-protein-coupled receptor that participates in tissue inflammation and is associated with susceptibility to several diseases, but its...

journal_title：Cytokine

authors： Che D,Pi L,Xu Y,Fu L,Zhou H,Wang Z,Huang P,Zhang L,Gu X

更新日期：2018-11-01 00:00:00

abstract：:Galectin-3 is a β-galactoside-binding lectin that plays an important role in the modulation of immune responses. It has been shown to aggravate joint inflammation and destruction in experimental arthritis. We investigated the role of galectin-3 in TLR-induced cell activation in human synovial fibroblasts (SF) in order...

journal_title：Cytokine

authors： Arad U,Madar-Balakirski N,Angel-Korman A,Amir S,Tzadok S,Segal O,Menachem A,Gold A,Elkayam O,Caspi D

更新日期：2015-05-01 00:00:00

abstract：:The aim of this study was to investigate the clinical relevance of lymphocyte-related serum miRNAs to the pathogenesis of acute graft-versus-host disease (aGVHD) and evaluate the predictive and prognosis value of miRNAs. Consecutive patients who received allogeneic peripheral blood stem cell transplantation (allo-PBSC...

journal_title：Cytokine

authors： Xie L,Zhou F,Liu X,Fang Y,Yu Z,Song N,Kong F

更新日期：2016-09-01 00:00:00

abstract：:We previously isolated quercetin 3-O-beta-(2''-galloyl)-glucopyranoside (QG-32) from Persicaria lapathifolia (Polygonacease) as an inhibitor of superoxide production. In the present study, QG-32 was found to inhibit interleukin (IL)-6 production in endotoxin lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. T...

journal_title：Cytokine

authors： Kim BH,Lee IJ,Lee HY,Han SB,Hong JT,Ahn B,Lee CK,Kim Y

更新日期：2007-09-01 00:00:00

abstract：:Cancer metastasis to the lymph nodes is indicative of a poor prognosis. An endobronchial ultrasound-guided fine needle aspiration (EBUS-FNA) biopsy is increasingly being used to sample paratracheal lymph nodes for simultaneous cancer diagnosis and staging. In this prospective, single-center study, we collected dedicat...

journal_title：Cytokine

authors： Saeed AI,Qeadan F,Sood A,VanderJagt DJ,Mishra SI,Hill DA,Peikert T,Sopori ML

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Tumor necrosis factor (TNFα) is a proinflammatory cytokine and has been a target for intervention in human sepsis. However, inhibition of TNF-α with a high dose of a TNF-receptor fusion protein in patients with septic shock worsened patient survival. This study was designed to investigate whether blocking TNF-α...

journal_title：Cytokine

authors： Tsay TB,Yang MC,Chen PH,Lai KH,Huang HT,Hsu CM,Chen LW

更新日期：2013-07-01 00:00:00

abstract：:Leprosy is an infectious disease caused by M. leprae. We analyzed 48 cytokine polymorphisms in 13 (pro as well as anti-inflammatory) cytokine genes using PCR-SSP assay in 102 leprosy patients and 120 healthy controls with intent to find out a link between cytokine polymorphisms and disease susceptibility. TNF-α (-308)...

journal_title：Cytokine

authors： Tarique M,Naqvi RA,Santosh KV,Kamal VK,Khanna N,Rao DN

更新日期：2015-05-01 00:00:00

abstract：:Although numerous studies have shown that visfatin is linked to several cancers, its prognostic value is still unclear. This first comprehensive meta-analysis was performed to evaluate the prognostic effect of visfatin in cancer patients. A systematic search was conducted for relevant studies in health-related electro...

journal_title：Cytokine

authors： Mohammadi M,Moradi A,Farhadi J,Akbari A,Pourmandi S,Mehrad-Majd H

更新日期：2020-03-01 00:00:00

abstract：:Recently, differences in the levels of various chemokines and cytokines were reported in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as compared with controls. Moreover, the analyte profile differed between chronic ME/CFS patients of long duration versus patients with disease of less than...

journal_title：Cytokine

authors： Landi A,Broadhurst D,Vernon SD,Tyrrell DL,Houghton M

更新日期：2016-02-01 00:00:00

abstract：:CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...

journal_title：Cytokine

authors： Huang L,Cao RB,Wang N,Liu K,Wei JC,Isahg H,Song LJ,Zuo WY,Zhou B,Wang WW,Mao X,Chen PY

更新日期：2012-01-01 00:00:00

abstract：:The pathogenesis of sickle cell disease (HbSS), which has numerous complications including stroke, involves inflammation resulting in alteration of plasma inflammatory protein concentration. We investigated HbSS children with abnormal cerebral blood flow detected by trans-cranial Doppler ultrasound (TCD) who participa...

journal_title：Cytokine

authors： Asare K,Gee BE,Stiles JK,Wilson NO,Driss A,Quarshie A,Adams RJ,Kutlar A,Hibbert JM

更新日期：2010-01-01 00:00:00

abstract：:Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE i...

journal_title：Cytokine

authors： Ponnalagu M,Subramani M,Jayadev C,Shetty R,Das D

更新日期：2017-07-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) regulate the structural integrity of the extracellular matrix (ECM). Constitutive expression of human TIMP-3 in human DLD colon carcinoma cells renewed serum-responses and inhibited tumour formation in nude mice. To elucidate the mecha...

journal_title：Cytokine

authors： Smith MR,Kung H,Durum SK,Colburn NH,Sun Y

更新日期：1997-10-01 00:00:00

abstract：:Pro-inflammatory cytokines are important mediators of cutaneous cellular activities during many skin diseases. In the present study, we investigated the production of tumor necrosis factor-alpha (TNF-alpha), IL-6 and IL-10 by UVB-irradiated human keratinocytes NCTC 2544 cell line in the presence of cAMP-elevating agen...

journal_title：Cytokine

authors： Grandjean-Laquerriere A,Le Naour R,Gangloff SC,Guenounou M

更新日期：2003-08-21 00:00:00

abstract：:Invariant natural killer T cells (iNKT cells) are innate-like non-conventional T cells restricted by the CD1d molecule that are unique in their ability to play a pivotal role in immune regulation. Deficient iNKT function has been reported in patients receiving umbilical cord blood (UCB) transplantation. We sought to d...

journal_title：Cytokine

authors： Lin SJ,Huang YC,Cheng PJ,Lee PT,Hsiao HS,Kuo ML

更新日期：2015-12-01 00:00:00

abstract：:There are limited and conflicting studies investigating the role of the angiopoietin family in human thyroid cancer development and progression. We have investigated cytokines angiopoietin-1, -2 and their receptor (Tie-2), known to be involved in angiogenesis, in the serum of 52 thyroid cancer patients (21 cases of pa...

journal_title：Cytokine

authors： Niedźwiecki S,Stepień T,Kopeć K,Kuzdak K,Komorowski J,Krupiński R,Stepień H

更新日期：2006-12-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is a key regulator of inflammation and immunity. The cellular effects exerted by TNF depend, apart from NF-kappaB-directed gene transcription, largely on its ability to activate phospholipase A2(PLA2), yielding the release of arachidonic acid (AA) and its metabolites. AA metabolites, espec...

journal_title：Cytokine

authors： van Puijenbroek AA,Wissink S,van der Saag PT,Peppelenbosch MP

更新日期：1999-02-01 00:00:00

abstract：:The activation of STAT1 and STAT3 in response to SEB was analyzed in spleen of Balb/c mice. The intraperitoneal injection of the superantigen SEB activated STAT1 and STAT3 in spleen. Activated STAT1 almost completely disappeared in 24 h even though activated STAT3 was present for more than 48 h after SEB injection. Cy...

journal_title：Cytokine

authors： Plaza R,Vidal S,Rodriguez-Sanchez JL,Juarez C

更新日期：2004-01-07 00:00:00

abstract：:Enteroviruses are associated with chronic inflammatory and autoimmune diseases in humans. In these conditions, the cytokine network is supposed to have an important role in inflammation and modulation of the (auto)immune response. In the present study, we demonstrate that coxsackie virus B4 and poliovirus type 1 induc...

journal_title：Cytokine

authors： Vreugdenhil GR,Wijnands PG,Netea MG,van der Meer JW,Melchers WJ,Galama JM

更新日期：2000-12-01 00:00:00

abstract：:Erythropoietin (EPO) and Stem Cell Factor (SCF) have partially distinct functions in erythroid cell development. The primary functions of EPO are to prevent apoptosis and promote differentiation, with a minor role as a mitogen. On the other hand SCF acts primarily as a mitogenic factor promoting erythroid cell prolife...

journal_title：Cytokine

authors： Geslain R,Uddin S,Liu H,Jiang H,van Besien K,Pan T,Wickrema A

更新日期：2013-01-01 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the presence of autoantibodies to normal components of the hemidesmosome (BPAg1 and BPAg2). Histology of skin lesions demonstrate a subepidermal vesicle and a predominantly eosinophilic dermal cellular infiltrate. Interleukin 5 (IL-5) pl...

journal_title：Cytokine

authors： Engineer L,Bhol K,Kumari S,Razzaque Ahmed A

更新日期：2001-01-07 00:00:00

abstract：:Rheumatoid arthritis (RA) is a common autoimmune disease that is marked by a systemic inflammatory reaction and joint erosions. Elevated levels of B cell activating factor (BAFF) have been detected in the serum and synovial fluid of RA patients. Moreover, the levels of BAFF increase in cases of autoimmune disease and ...

journal_title：Cytokine

authors： Wei F,Chang Y,Wei W

更新日期：2015-12-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1) is a recently discovered cytokine that was isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. In this study, the effects of chronic administration of CT-1 to mice (0.5 or 2 microg by intraperitoneal injection, twice a day for 14 days) were determined. A dose-dependent ...

journal_title：Cytokine

authors： Jin H,Yang R,Keller GA,Ryan A,Ko A,Finkle D,Swanson TA,Li W,Pennica D,Wood WI,Paoni NF

更新日期：1996-12-01 00:00:00

abstract：:Monocyte chemotactic protein-3 (MCP-3) is a C-C chemokine which interacts with the CCR1, CCR2 (MCP-1) and CCR3 receptors and has a distinct spectrum of action. The present study was designed to assess whether mycobacterial components were able to induce expression and production of MCP-3 in human monocytes. Mycobacter...

journal_title：Cytokine

authors： Vouret-Craviari V,Cenzuales S,Poli G,Mantovani A

更新日期：1997-12-01 00:00:00

abstract：:The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism. Indoleamine 2,3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting step in the pathway, as well as other enzymes in the pathway, have been shown to be highly regulated by cytokines. Hence, the KP has been i...

journal_title：Cytokine

authors： Baumgartner R,Forteza MJ,Ketelhuth DFJ

更新日期：2019-10-01 00:00:00

abstract：:Previous studies have suggested that heterotrimeric G(i) proteins, Src tyrosine kinase and phosphatidylinositol-3 kinase (PI3 Kinase) are involved in signaling events induced by lipopolysaccharide (LPS) leading to pro-inflammatory cytokines gene expression. To investigate the involvement of these mediators in Gram-pos...

journal_title：Cytokine

authors： Fan H,Teti G,Ashton S,Guyton K,Tempel GE,Halushka PV,Cook JA

更新日期：2003-06-07 00:00:00

abstract：:Peptic ulcer is a lesion in the mucosa of the digestive tract affecting many people all around the world. Recent investigations have indicated that produced inflammatory cytokines such as TNF-α and IL-1β in response to gastric infection by Helicobacter pylori play an important role in the development of peptic ulcer. ...

journal_title：Cytokine

authors： Tourani M,Habibzadeh M,Karkhah A,Shokri-Shirvani J,Barari L,Nouri HR

更新日期：2018-10-01 00:00:00

abstract：:Preeclampsia is a complex disease of pregnancy with both feto-placental and maternal factors contributing to its pathogenesis. Although the cause of this disease is uncertain, imbalance between pro-and anti-inflammatory cytokines has been implicated in the pathogenesis of preeclampsia. Increased levels of the inflamma...

journal_title：Cytokine

authors： Xiao JP,Yin YX,Gao YF,Lau S,Shen F,Zhao M,Chen Q

更新日期：2012-12-01 00:00:00

abstract：:The proinflammatory cytokines TNFalpha and IL-1beta are thought to play a role in the mechanism of septic vasodilatory shock. Most evidence indicate that the vascular effects these cytokines are mediated through increased expression of inducible nitric oxide synthase, whereas several animal studies report a more rapid...

journal_title：Cytokine

authors： Pickkers P,Netea MG,van der Meer JW,Smits P

更新日期：2002-12-07 00:00:00