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Interleukin-12 as an adjuvant for induction of protective antibody responses.

Abstract：

:Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against various bacterial and viral pathogens, particularly in the lung. Studies examining the efficacy of IL-12-mediated effects on protective antibody response in the mouse model are summarized in this review.

journal_name

Cytokine

journal_title

Cytokine

authors

Metzger DW

doi

10.1016/j.cyto.2010.06.011

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

102-7

issue

1-2

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(10)00180-8

journal_volume

52

pub_type

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