Abstract:
BACKGROUND:The genetic basis of complex diseases like ischemic stroke probably consists of several predisposing risk factors, such as genes involved in inflammation and thrombotic pathways. On this basis the aim of our study was to evaluate the role of SNPs (single nucleotide polymorphisms) of some pro-inflammatory/anti-inflammatory and coagulation/fibrinolytic genes in patients with acute ischemic stroke. METHODS:The study population consisted of 144 consecutive Caucasian adult patients who were hospitalized in the Internal Medicine Department at the University of Palermo between November 2006 and January 2008, and who met inclusion criteria. The cases were patients admitted with a diagnosis of acute ischemic stroke, and age-matched (± 3 years) control subjects: patients admitted to our Internal Medicine Department for any cause other than acute cardiovascular and cerebrovascular events and for routine checkup examinations. Molecular analysis of alleles at the -308 nucleotide (-308G/A) of TNF-α gene, -1082/-819 haplotypes of IL-10 gene, IL-1RN exon 2 VNR polymorphism, alleles at the -174 nucleotide (-174G/C) of IL-6 gene, PAI-1675 5G/4G polymorphism, alleles at the -7351 nucleotide (-7351C/T) of tPA gene was undertaken in both patient groups. RESULTS:We analyzed 96 subjects with acute ischemic stroke and 48 control subjects. We observed a significantly higher frequency of IL-10 1082 AA genotype in stroke patients with a significant risk trend. We also reported a higher frequency in stroke subjects with a significant risk trend of the TPA 7351-CT genotype and of IL-1RN-VNTR 86 bp 2/2 genotype. Moreover, we observed a significant relationship with TOAST subtype only with regard to CC TPA genotype and 1/1 IL-1 VNTR 86 bp and lacunar strokes. CONCLUSIONS:Ischemic stroke is a common multifactor disease, which is affected by a number of genetic mutations and environmental factors. Our findings showing a relationship between pro-inflammatory/anti-inflammatory and thrombotic/fibrinolytic genes SNPs and ischemic stroke may contribute to delineate a possible stroke risk profile in subjects with cerebrovascular risk factors.
journal_name
Cytokinejournal_title
Cytokineauthors
Tuttolomondo A,Di Raimondo D,Forte GI,Casuccio A,Vaccarino L,Scola L,Pecoraro R,Serio A,Clemente G,Arnao V,Palmeri M,Misiano G,Lio D,Pinto A,Licata Gdoi
10.1016/j.cyto.2012.02.012subject
Has Abstractpub_date
2012-06-01 00:00:00pages
398-405issue
3eissn
1043-4666issn
1096-0023pii
S1043-4666(12)00064-6journal_volume
58pub_type
杂志文章相关文献
CYTOKINE文献大全abstract::The present study was aimed at defining the activity of human and mouse monocyte chemotactic protein-1 (MCP-1) on homologous and heterologous mononuclear phagocytes. Human natural and recombinant MCP-1 and mouse natural MCP-1/JE were tested as chemoattractants on human blood monocytes and mouse peritoneal macrophages....
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90004-3
更新日期:1994-01-01 00:00:00
abstract::The regulation of local L-tryptophan concentrations by tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO) induced by various stimuli such as interferon-γ (IFN-γ) is one of the key mechanisms in antimicrobial effect. Recently, IDO is also focused on an immunosuppressive mechanism shared by several different...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.04.022
更新日期:2012-08-01 00:00:00
abstract::Cardiotrophin-1 (CT-1) is a recently discovered cytokine that was isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. In this study, the effects of chronic administration of CT-1 to mice (0.5 or 2 microg by intraperitoneal injection, twice a day for 14 days) were determined. A dose-dependent ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0123
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:Current orthopedic therapies, aimed solely at symptomatic control, are unable to restore the cytokine imbalance that produces the hallmark clinical profile of osteoarthritis. While a myriad of chemical factors in the cytokine network stimulate local joint inflammation and pain, Interleukin 1 (IL-1) is widely ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2016.03.008
更新日期:2016-05-01 00:00:00
abstract::This study was conducted to compare the secretion of TGF-beta isoforms by human ovarian carcinoma (OVCA) cell lines (n=12) and human peritoneal mesothelial cells (HPMC;n=6) and to examine the regulation of their production by inflammatory cytokines. TGF-beta isoforms were furthermore analysed in OVCA-associated asciti...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0632
更新日期:2000-07-01 00:00:00
abstract::Asthma and type I diabetes are major causes of chronic illness in childhood which, according to the current paradigm, have mutually antagonistic immunopathologies. Nonetheless, the disorders appear to preferably coexist both on population and individual levels. To assess whether children with asthma and type I diabete...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.04.015
更新日期:2006-05-01 00:00:00
abstract::Our aim was to explore the putative beneficial effects of low-to-moderate intensity exercise training program in patients with irritable bowel syndrome (IBS). This study evaluated the changes in blood oxidative stress status, inflammatory biomarkers and IBS severity symptoms following 24 weeks of moderate aerobic exer...
journal_title:Cytokine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cyto.2017.12.016
更新日期:2018-02-01 00:00:00
abstract::The gene for C10, a member of the beta-chemokine family of cytokines, contains a novel second exon encoding a 16 amino acid sequence which is inserted into the amino-terminal region of the protein. We propose a model of C10 structure in which the sequence encoded by the second exon is located on the surface of the pro...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0060
更新日期:1996-06-01 00:00:00
abstract::The self-renewal capacity of germline derived stem cells (GSCs) makes them an ideal source for research and use in clinics. Despite the presence of active gene network similarities between embryonic stem cells (ESCs) and GSCs, there are unanswered questions regarding the roles of evolutionary conserved genes in GSCs. ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.02.021
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:We had previously reported metabolic abnormalities in TNF-treated weight-gaining (WG) rats, associated with increased soluble and membrane TNF receptors. OBJECTIVE:On the basis of these findings, we hypothesized that stabilization of TNF in circulation in WG animals by these receptors augmented the action o...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(03)00105-4
更新日期:2003-06-21 00:00:00
abstract::IL-12p70 is a proinflammatory cytokine secreted by dendritic cells, monocytes and macrophages. It plays a crucial role in cell-mediated immunity by inducing proliferation of T cell and natural killer cells, and enhancing their cytotoxic activity. In adaptive immune response, it acts on naive T cells to differentiate i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.03.021
更新日期:2013-06-01 00:00:00
abstract::Interleukin 6 (IL-6) stimulates fibrinogen (Fg) gene expression both in vivo and in vitro; while interleukin 1 (IL-1) paradoxically stimulates in vivo, yet inhibits in vitro, Fg synthesis. The naturally occurring interleukin 1 receptor antagonist (IL-1ra) and passive immunization with anti-IL-6 antiserum were used to ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90035-4
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVES:To determine the relationship of serum resistin concentrations to biochemical determinants of bone metabolism, comorbidity and outcomes in patients with hip fracture (HF). METHODS:In 256 consecutive patients (mean age 81.9±7.8 years; 71.1% women) serum levels of resistin (determined by ELISA), biochemical p...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.06.023
更新日期:2011-11-01 00:00:00
abstract::Elevated levels of the cytokine IL-13 has been found to be associated with autoimmune diseases, including Sjögren's Syndrome. However, whether IL-13 plays a causative role in disease development is not known and cannot be easily studied in humans. Our previous work has shown that levels of IL-13 are elevated in Id3 kn...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.06.009
更新日期:2014-10-01 00:00:00
abstract:AIMS:This study investigates the relationships between matrix metalloproteinases, inflammations mediators and type 2 diabetes mellitus in Tunisians metabolic syndrome (Mets) patients. METHODS:The study has included 239 MetS patients and 247 controls. Mets was defined according to the NCEP-ATPIII report. Mets patients ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2016.07.009
更新日期:2016-10-01 00:00:00
abstract:RATIONALE:Inflammation exacerbates a number of deleterious effects on the heart, most notable being left ventricular dysfunction (LVD). A promoter polymorphism of the NFKB1 gene (encodes p50 subunit) results in lower protein levels of NFkB p50 subunits, which in its dimmer (p50) form has anti-inflammatory effects. The ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.12.020
更新日期:2013-03-01 00:00:00
abstract::We have recently reported the identification of four novel members of the interleukin-1 (IL-1) family which we designated as IL-1 homologue 1-4 (IL-1H1-4). These proteins exhibit significant sequence homology to other members of the IL-1 family. Of these homologues, only IL-1H4 (renamed IL-1F7b) was predicted to conta...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.0873
更新日期:2002-04-21 00:00:00
abstract::Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the presence of autoantibodies to normal components of the hemidesmosome (BPAg1 and BPAg2). Histology of skin lesions demonstrate a subepidermal vesicle and a predominantly eosinophilic dermal cellular infiltrate. Interleukin 5 (IL-5) pl...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0791
更新日期:2001-01-07 00:00:00
abstract::The authors have shown previously that in addition to its survival effects on neurons and glia, ciliary neurotrophic factor (CNTF) induced potent cachectic effects and acute phase proteins when present in the peripheral circulation at concentrations of < or = 10 ng/ml. These effects did not depend upon the induction o...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0104
更新日期:1996-10-01 00:00:00
abstract::Patients admitted to a medical intensive care unit (ICU) are characterized by an activated immune system and exhibit a high mortality rate irrespective of the underlying cause of admission. Interleukin (IL)-33 has been shown to be protective in experimental sepsis models and it has been demonstrated that circulating l...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1016/j.cyto.2017.09.017
更新日期:2018-03-01 00:00:00
abstract::Fetal liver is the main site of haematopoiesis during mid-gestation. The adult liver still provides a favourable environment for extramedullary haematopoiesis. Nevertheless, regulation of liver haematopoiesis by cell-cell contacts or by cytokines remains poorly understood. Recently, we have shown that rat liver epithe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0639
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVES:Vascular endothelial cell growth factor (VEGF) plays an important role in the biology of gynecological cancer, usually linked with aggressive tumour behaviour and a poor postoperative outcome. Yet, its role in benign breast/gynecological conditions is less clear. METHODS:Serum VEGF was analysed in a series ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.12.007
更新日期:2011-03-01 00:00:00
abstract::The activation of STAT1 and STAT3 in response to SEB was analyzed in spleen of Balb/c mice. The intraperitoneal injection of the superantigen SEB activated STAT1 and STAT3 in spleen. Activated STAT1 almost completely disappeared in 24 h even though activated STAT3 was present for more than 48 h after SEB injection. Cy...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2003.09.006
更新日期:2004-01-07 00:00:00
abstract::Invariant Natural Killer T (iNKT) cells represent a population of innate T lymphocytes which act as 'first-responders' to infection. While they have long been considered a versatile cell, capable of secretion of multiple cytokines upon activation, recent evidence now indicates that distinct lineages of iNKT cells with...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2014.12.005
更新日期:2015-04-01 00:00:00
abstract::Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal disease characterized by overwhelming inflammation response and multiple organ damage. Most of the clinical and laboratory manifestations of HLH are thought to be related to hypercytokinemia and organ infiltration with lymphocytes and histiocytes. The aim...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2016.05.022
更新日期:2016-09-01 00:00:00
abstract::Given the known anti-tumorigenic properties of IFNγ, its effect on glioma cell survival was investigated. Though IFNγ had no effect on glioma cell viability, it induced cell cycle arrest. This was accompanied by increased expression of p53 and retinoic acid inducible gene (RIG-I). While RIG-I had no effect on glioma c...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.10.009
更新日期:2017-01-01 00:00:00
abstract::In a previous work we demonstrated that monoclonal antibody (mAb) 8C2 recognized a human granulocyte-colony stimulating factor (hG-CSF) region left unmasked after binding to placenta receptors, whereas mAb 6E3 defined a receptor-buried epitope. Herein we examined the role of these antigenic regions on the proliferativ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(03)00099-1
更新日期:2003-04-01 00:00:00
abstract::Human interferon regulatory factor 7 (IRF7) plays an important role in the innate antiviral immune response. To date, the characteristics and functions of waterfowl IRF7 have not been clarified. This study reports the cDNA sequence, tissue distribution, and antiviral function of duck IRF7. The duck IRF7 gene has a 153...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.06.001
更新日期:2019-01-01 00:00:00
abstract::Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α bu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.11.010
更新日期:2014-02-01 00:00:00
abstract::The gene for ISG12 (originally designated p27) was isolated as an oestrogen-induced gene. The authors undertook a comprehensive study using quantitative RT-PCR, in which we delineate the regulation of ISG12 by seven different cytokines including interferons and poly(I). poly(C) in seven human cell lines of different o...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0549
更新日期:2000-03-01 00:00:00