Abstract:
:The TNF family molecule RANKL and its receptor RANK are key regulators of bone remodeling, lymph node formation, and mammary gland development during pregnancy. RANKL and RANK are also expressed in the central nervous systems (CNS). However, the functional relevance of RANKL/RANK in the brain was entirely unknown. Recently, our group reported that the RANKL/RANK signaling pathway has an essential role in the central regulation of body temperature via the prostaglandin axis. This review discusses novel aspects of the RANKL/RANK system as key regulators of fever and female basal body temperature in the CNS.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Hanada R,Hanada T,Penninger JMdoi
10.1515/BC.2010.149subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1365-70issue
12eissn
1431-6730issn
1437-4315journal_volume
391pub_type
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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journal_title:Biological chemistry
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doi:10.1515/hsz-2015-0127
更新日期:2015-09-01 00:00:00
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doi:10.1515/hsz-2015-0289
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2001.149
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doi:10.1515/BC.2004.011
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journal_title:Biological chemistry
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更新日期:1997-09-01 00:00:00
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