IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells.

abstract：:One of the control mechanisms of cathepsin B biosynthesis and trafficking operates through alternative splicing of pre-mRNA. An mRNA lacking exon 2 is more efficiently translated than that containing all exons, and may be responsible for elevated biosynthesis and enzyme routing to the extracellular space, with critica...

journal_title：Biological chemistry

authors： Baici A,Müntener K,Willimann A,Zwicky R

更新日期：2006-08-01 00:00:00

abstract：:The average amount of cholesterol in the whole animal equals approximately 2100 mg/kg body weight, and 15% and 23% of this sterol in the mouse and human, respectively, is found in the central nervous system. There is no detectable uptake across the blood-brain barrier of cholesterol carried in lipoproteins in the plas...

journal_title：Biological chemistry

authors： Dietschy JM

更新日期：2009-04-01 00:00:00

abstract：:Small RNAs such as microRNAs (miRNAs), short interfering RNAs (siRNAs) or Piwi-interacting RNAs (piRNAs) are important regulators of gene expression in various organisms. Small RNAs bind to a member of the Argonaute protein family and are incorporated into larger structures that mediate diverse gene silencing events. ...

journal_title：Biological chemistry

authors： Dueck A,Meister G

更新日期：2014-06-01 00:00:00

abstract：:The bioactivation of inorganic nitrite refers to the conversion of otherwise 'inert' nitrite to the diatomic signaling molecule nitric oxide (NO), which plays important roles in human physiology and disease, notably in the regulation of vascular tone and blood flow. While the most well-known sources of NO are the nitr...

journal_title：Biological chemistry

authors： Amdahl MB,DeMartino AW,Gladwin MT

更新日期：2019-12-18 00:00:00

abstract：:Two members of the nuclear receptor superfamily, EcR (ecdysteroid receptor protein) and Usp (Ultraspiracle), heterodimerize to form a functional receptor for the steroid hormone 20-hydroxyecdysone and thus enable it to coordinate morphogenetic events during insect metamorphosis. N-terminally His-tagged Usp was overexp...

journal_title：Biological chemistry

authors： Rymarczyk G,Grad I,Rusek A,Oświecimska-Rusin K,Niedziela-Majka A,Kochman M,Ozyhar A

更新日期：2003-01-01 00:00:00

abstract：:The ligand-activated aryl hydrocarbon receptor (AHR) is known to modulate many genes in a highly cell-specific manner, either directly or indirectly via secondary effects. In contrast, little is known about the effects of AHR deficiency on gene expression balance. We compared the transcriptome of CD4 T cells from AHR-...

journal_title：Biological chemistry

authors： Frericks M,Temchura VV,Majora M,Stutte S,Esser C

更新日期：2006-09-01 00:00:00

abstract：:We have previously described Kunitz-type serine proteinase inhibitors purified from Bauhinia seeds. Human plasma kallikrein shows different susceptibility to those inhibitors. In this communication, we describe the interaction of human plasma kallikrein with fluorogenic and non-fluorogenic peptides based on the Bauhin...

journal_title：Biological chemistry

authors： Oliva ML,Santomauro-Vaz EM,Andrade SA,Juliano MA,Pott VJ,Sampaio MU,Sampaio CA

更新日期：2001-01-01 00:00:00

abstract：:The regulation of eukaryotic gene expression is a complicated process involving the interaction of a large number of transacting factors with specific cis-regulatory elements. DNA methylation plays a role in this scheme by acting in cis to modulate protein-DNA interactions. Several lines of evidence indicate that meth...

journal_title：Biological chemistry

authors： Bergman Y,Mostoslavsky R

更新日期：1998-04-01 00:00:00

abstract：:The bifunctional protein DCoH (dimerization cofactor of HNF-1) is a transcriptional coactivator of homeodomain proteins and a cytoplasmic enzyme. Here we report on the isolation, nucleotide sequence and genomic structure of the chicken and rat DCoH genes. They have an unusual first exon coding for a single amino acid....

journal_title：Biological chemistry

authors： Bossow S,Riepl S,Igo-Kemenes T

更新日期：1998-11-01 00:00:00

abstract：:Understanding the molecular mechanisms behind extreme temperature stability is of relevance for the protein folding problem and for designing proteins for industrial and medical applications. A powerful approach for understanding the structural basis of thermostability is the comparison of high resolution structures o...

journal_title：Biological chemistry

authors： Macedo-Ribeiro S,Darimont B,Sterner R

更新日期：1997-03-01 00:00:00

abstract：:Proteomic identification of protease cleavage site specificity (PICS) is a recent proteomic approach for the easy mapping of protease subsite preferences that determines both the prime- and non-prime side specificity concurrently. Here we greatly facilitate user access by providing an automated and simple web-based da...

journal_title：Biological chemistry

authors： Schilling O,auf dem Keller U,Overall CM

更新日期：2011-11-01 00:00:00

abstract：:To exploit the B-lymphocyte antigen-CD20 binding capacity of the Ibritumomab tiuxetan (IBTN) monoclonal antibody (mAb) for imaging, the over-expression of B cells in non-Hodgkin's lymphoma (NHL) (a myeloproliferative disorder of the lymphatic system) was investigated. In the current investigation, we present the label...

journal_title：Biological chemistry

authors： Shah SQ,Khan AU,Khan MR

更新日期：2012-01-01 00:00:00

abstract：:Early diagnostics at the preclinical stage of Alzheimer's disease is of utmost importance for drug development in clinical trials and prognostic guidance. Since soluble Aβ oligomers are considered to play a crucial role in the disease pathogenesis, several methods aim to quantify Aβ oligomers in body fluids such as ce...

journal_title：Biological chemistry

authors： Kravchenko K,Kulawik A,Hülsemann M,Kühbach K,Zafiu C,Herrmann Y,Linnartz C,Peters L,Bujnicki T,Willbold J,Bannach O,Willbold D

更新日期：2017-04-01 00:00:00

abstract：:Magnesium cation (Mg2+) is the most abundant divalent cation in living cells, where it is required for various intracellular functions. In chloroplasts and cyanobacteria, established photosynthetic model systems, Mg2+ is the central ion in chlorophylls, and Mg2+ flux across the thylakoid membrane is required for count...

journal_title：Biological chemistry

authors： Pohland AC,Schneider D

更新日期：2019-09-25 00:00:00

abstract：:The central process for the transfer of the genetic information from the nucleic acid world into the structure of proteins is the ribosomal elongation cycle, where the sequence of codons is translated into the sequence of amino acids. The nascent polypeptide chain is elongated by one amino acid during the reactions of...

journal_title：Biological chemistry

authors： Spahn CM,Nierhaus KH

更新日期：1998-07-01 00:00:00

abstract：:DEAD-box proteins disrupt or remodel RNA and protein/RNA complexes at the expense of ATP. The catalytic core is composed of two flexibly connected RecA-like domains. The N-terminal domain contains most of the motifs involved in nucleotide binding and serves as a minimalistic model for helicase/nucleotide interactions....

journal_title：Biological chemistry

authors： Strohmeier J,Hertel I,Diederichsen U,Rudolph MG,Klostermeier D

更新日期：2011-04-01 00:00:00

abstract：:DHX36 is a member of the DExD/H box helicase family, which comprises a large number of proteins involved in various cellular functions. Recently, the function of DHX36 in the regulation of G-quadruplexes (G4s) was demonstrated. G4s are alternative nucleic acid structures, which influence many cellular pathways on a tr...

journal_title：Biological chemistry

authors： Schult P,Paeschke K

更新日期：2020-10-01 00:00:00

abstract：:The infectivity and pathogenicity of influenza virus are primarily determined by host cellular trypsin-type processing proteases which cleave the viral membrane fusion glycoprotein hemagglutinin (HA). Therefore the distribution of the processing protease is a major determinant of the infectious organ tropism. The comm...

journal_title：Biological chemistry

authors： Yao D,Chen Y,Kuwajima M,Shiota M,Kido H

更新日期：2004-06-01 00:00:00

abstract：:TNF-alpha is a major pro-inflammatory cytokine that regulates further cytokine induction, especially of IL-1 and IL-6, in many human diseases including cancer, inflammation and immune disorders. In a search for new inhibitors of inducible TNF-alpha promoter activity and expression, cultures of the imperfect fungus Tri...

journal_title：Biological chemistry

authors： Rether J,Serwe A,Anke T,Erkel G

更新日期：2007-06-01 00:00:00

abstract：:Mutations of the p53 gene may alter the specific regulatory domains of the protein. We examined the conserved domains III, IV and V by SSCP using PCR primers covering exons 5, 6, 7 and 8 from hairy cell leukemia (HCL), polyps, colorectal and gastric carcinomas. A low rate of p53 mutations was detected in HCL and polyp...

journal_title：Biological chemistry

authors： Marcsek ZL,König EA

更新日期：1998-04-01 00:00:00

abstract：:Disulfide bonds play a critical role in a variety of structural and mechanistic processes associated with proteins inside the cells and in the extracellular environment. The thioredoxin family of proteins like thioredoxin (Trx), glutaredoxin (Grx) and protein disulfide isomerase, are involved in the formation, transfe...

journal_title：Biological chemistry

authors： Sousa SF,Neves RPP,Waheed SO,Fernandes PA,Ramos MJ

更新日期：2019-04-24 00:00:00

abstract：:Major advances have been made during the last decade in our understanding of adrenal steroid hormone biosynthesis. Two key players in these pathways are the human mitochondrial cytochrome P450 enzymes CYP11B1 and CYP11B2, which catalyze the final steps in the biosynthesis of cortisol and aldosterone. Using data from m...

journal_title：Biological chemistry

authors： Bureik M,Lisurek M,Bernhardt R

更新日期：2002-10-01 00:00:00

abstract：:Maintenance of cellular redox control is pivotal for normal cellular functions and cell fate decisions including cell death. Among the key cellular redox systems in mammals, the glutathione peroxidase (GPX) family of proteins is the largest conferring multifaceted functions and affecting virtually all cellular process...

journal_title：Biological chemistry

authors： Buday K,Conrad M

更新日期：2020-10-22 00:00:00

abstract：:Bradykinin causes vascular relaxations through release of endothelial relaxing factors including prostacyclin, nitric oxide (NO) and epoxyeicosatrienoic acids (EETs). Bradykinin is metabolized by angiotensin converting enzyme (ACE) and ACE inhibition enhances bradykinin relaxations. Our goal was to characterize the ro...

journal_title：Biological chemistry

authors： Gauthier KM,Cepura CJ,Campbell WB

更新日期：2013-09-01 00:00:00

abstract：:The kallikrein-kinin and renin-angiotensin (KKS-RAS) systems represent two highly regulated proteolytic systems that are involved in several physiological and pathological processes. Although their protein-protein interactions can be studied using experimental approaches, it is difficult to differentiate between direc...

journal_title：Biological chemistry

authors： Stoka V,Turk V

更新日期：2010-04-01 00:00:00

abstract：:Disruption of the plasma membrane poses deadly threat to eukaryotic cells and survival requires a rapid membrane repair system. Recent evidence reveal various plasma membrane repair mechanisms, which are required for cells to cope with membrane lesions including membrane fusion and replacement strategies, remodeling o...

journal_title：Biological chemistry

authors： Boye TL,Nylandsted J

更新日期：2016-10-01 00:00:00

abstract：:Mammalian apolipoproteinB (apoB) RNA editing is a site-specific deamination reaction that mediates the C to U conversion responsible for apoB48 production in the mammalian small intestine. This process is not detected in chicken apoB RNA. Mammalian apoB RNA editing is mediated by a multicomponent enzyme complex that i...

journal_title：Biological chemistry

authors： Anant S,Yu H,Davidson NO

更新日期：1998-08-01 00:00:00

abstract：:A FAD and [4Fe-4S]cluster-containing enzyme from Clostridium aminobutyricum catalyses the reversible dehydration of 4-hydroxybutyryl-CoA to crotonyl-CoA which involves the cleavage of an unactivated C-H bond at the beta-carbon. Transient oxidation of the substrate to an enoxy radical by FAD might facilitate the remova...

journal_title：Biological chemistry

authors： Cinkaya I,Buckel W,Medina M,Gomez-Moreno C,Cammack R

更新日期：1997-08-01 00:00:00

abstract：:Kallikrein-related peptidases (KLKs) are a family of serine proteases that were shown to be useful cancer biomarkers. KLKs have been shown to be dysregulated in prostate cancer (PCa). microRNAs (miRNAs) are short RNA nucleotides that negatively regulate gene expression and have been reportedly dysregulated in PCa. We ...

journal_title：Biological chemistry

authors： White NM,Youssef YM,Fendler A,Stephan C,Jung K,Yousef GM

更新日期：2012-04-01 00:00:00

abstract：:Hypoxia-inducible transcription factor (HIF), an αβ dimer, is the key inducer of hypoxia-responsive genes that operate both during normal development and pathological processes in association with decreased oxygen availability. The products of HIF target genes function in, e.g., hematopoiesis, angiogenesis, iron trans...

journal_title：Biological chemistry

authors： Myllyharju J,Koivunen P

更新日期：2013-04-01 00:00:00