Abstract:
:Major advances have been made during the last decade in our understanding of adrenal steroid hormone biosynthesis. Two key players in these pathways are the human mitochondrial cytochrome P450 enzymes CYP11B1 and CYP11B2, which catalyze the final steps in the biosynthesis of cortisol and aldosterone. Using data from mutations found in patients suffering from steroid hormone-related diseases, from mutagenesis studies and from the construction of three-dimensional models of these enzymes, structural information could be deduced that provide a clue to the stereo- and regiospecific steroid hydroxylation reactions carried out by these enzymes. In this review, we summarize the current knowledge on the physiological function and the biochemistry of these enzymes. Furthermore, the pharmacological and toxicological importance of these steroid hydroxylases, the means for the identification of their potential inhibitors and possible biotechnological applications are discussed.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Bureik M,Lisurek M,Bernhardt Rdoi
10.1515/BC.2002.174keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
1537-51issue
10eissn
1431-6730issn
1437-4315journal_volume
383pub_type
杂志文章,评审abstract::Rhomboids are ubiquitous intramembrane serine proteases that cleave transmembrane substrates. Their functions include growth factor signaling, mitochondrial homeostasis, and parasite invasion. A recent study revealed that the Escherichia coli rhomboid protease EcGlpG is essential for its extraintestinal pathogenic col...
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pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
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更新日期:2000-03-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2000.120
更新日期:2000-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Biological chemistry
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更新日期:1998-02-01 00:00:00
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更新日期:1997-11-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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更新日期:1998-07-01 00:00:00
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