Abstract:
:The average amount of cholesterol in the whole animal equals approximately 2100 mg/kg body weight, and 15% and 23% of this sterol in the mouse and human, respectively, is found in the central nervous system. There is no detectable uptake across the blood-brain barrier of cholesterol carried in lipoproteins in the plasma, even in the newborn. However, high rates of de novo cholesterol synthesis in the glia and neurons provide the sterol necessary for early brain development. Once a stable brain size is achieved in the adult, cholesterol synthesis continues, albeit at a much lower rate, and this synthesis is just balanced by the excretion of an equal amount of sterol, either as 24(S)-hydroxycholesterol or, presumably, as cholesterol itself.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Dietschy JMdoi
10.1515/BC.2009.035subject
Has Abstractpub_date
2009-04-01 00:00:00pages
287-93issue
4eissn
1431-6730issn
1437-4315pii
10.1515/BC.2009.035journal_volume
390pub_type
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