Abstract:
:The kallikrein-related peptidase (KLK) gene family of 15 serine proteases encodes many proteins, including prostate specific antigen (PSA or KLK3), that are well described and/or are potential biomarkers for hormone-related cancers. Variant mRNA transcripts produced by alternative splicing, polyadenylation or AUG sites, or intron retention have been found for each of the KLK genes. The predicted protein for many of these alternative transcripts is different from that of the classical kallikrein-related peptidases and would not be an active serine protease. The majority of these novel protein isoforms have not been studied in vivo. The possible function(s) of the variant transcripts/protein isoforms and potential roles that they may play in hormone-related cancers are still unknown and are the focus of this short review.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Tan OL,Whitbread AK,Clements JA,Dong Ydoi
10.1515/BC.2006.088subject
Has Abstractpub_date
2006-06-01 00:00:00pages
697-705issue
6eissn
1431-6730issn
1437-4315journal_volume
387pub_type
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