Abstract:
:The physiological function of the GPI-anchored ectoenzyme aminopeptidase P (APP) is still elusive. Most researchers suppose that this enzyme inactivates biologically active peptides like bradykinin, neuropeptide tyrosine (NPY) and others (Vanhoof et al., 1995). We demonstrate by immunohistology with a specific antibody raised in rabbits and measurement of enzymatic activity in suspensions and of confluent monolayers on microscopic coverslips ('monolayer kinetics') that APP is a cell surface enzyme (ectoenzyme) of endothelial and lymphoid cells.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Lasch J,Moschner S,Sann H,Zellmer S,Koelsch Rdoi
10.1515/bchm.1998.379.6.705subject
Has Abstractpub_date
1998-06-01 00:00:00pages
705-9issue
6eissn
1431-6730issn
1437-4315journal_volume
379pub_type
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