Structure and function of the human parvulins Pin1 and Par14/17.

Abstract:

:Parvulins belong to the family of peptidyl-prolyl cis/trans isomerases (PPIases) assisting in protein folding and in regulating the function of a broad variety of proteins in all branches of life. The human representatives Pin1 and Par14/17 are directly involved in processes influencing cellular maintenance and cell fate decisions such as cell-cycle progression, metabolic pathways and ribosome biogenesis. This review on human parvulins summarizes the current knowledge of these enzymes and intends to oppose the well-studied Pin1 to its less well-examined homolog human Par14/17 with respect to structure, catalytic and cellular function.

journal_name

Biol Chem

journal_title

Biological chemistry

authors

Matena A,Rehic E,Hönig D,Kamba B,Bayer P

doi

10.1515/hsz-2017-0137

subject

Has Abstract

pub_date

2018-01-26 00:00:00

pages

101-125

issue

2

eissn

1431-6730

issn

1437-4315

pii

/j/bchm.just-accepted/hsz-2017-0137/hsz-2017-0137.

journal_volume

399

pub_type

杂志文章,评审
  • A Scj1p homolog and folding catalysts present in dog pancreas microsomes.

    abstract::Dog pancreas microsomes represent the key components of the established model system for the analysis of protein transport into the mammalian endoplasmic reticulum. More recently, these microsomes were also employed in cell-free systems which address questions related to protein folding and protein degradation in the ...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.1999.149

    authors: Bies C,Guth S,Janoschek K,Nastainczyk W,Volkmer J,Zimmermann R

    更新日期:1999-10-01 00:00:00

  • The FIRE3-mediated sterol response of the FAS promoter requires NF-Y/CBF as a coactivator.

    abstract::The transcription of the fatty acid synthase (FAS) gene is regulated by the sterol status of the cell via cleavage of the sterol regulatory element-binding protein (SREBP). When human HepG2 hepatoma cells were cotransfected with an expression plasmid for mature SREBP-1a together with FAS promoter/reporter constructs s...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2001.136

    authors: Wolf SS,Roder K,Sickinger S,Schweizer M

    更新日期:2001-07-01 00:00:00

  • Ammonia increases nitric oxide, free Zn(2+), and metallothionein mRNA expression in cultured rat astrocytes.

    abstract::Ammonia is a major player in the pathogenesis of hepatic encephalopathy (HE) and affects astrocyte function by triggering a self-amplifying cycle between osmotic and oxidative stress. We recently demonstrated that hypoosmotic astrocyte swelling rapidly stimulates nitric oxide (NO) production and increases intracellula...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2011.199

    authors: Kruczek C,Görg B,Keitel V,Bidmon HJ,Schliess F,Häussinger D

    更新日期:2011-12-01 00:00:00

  • The T-knot motif revisited.

    abstract::The T-knot scaffold, a disulphide-reinforced structural motif shared by several proteins with very different biological functions, has been defined as 'a stretch of the protein chain which comprises two strands of a beta-sheet and three loops, knotted by two disulphides into the shape of the letter T'. In this communi...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.1999.159

    authors: Polticelli F,Pascarella S,Bordo D,Bolognesi M,Ascenzi P

    更新日期:1999-10-01 00:00:00

  • Specific nucleoprotein complexes within adenovirus capsids.

    abstract::Adenoviral DNA was examined within capsids by dimethyl sulfate footprinting. Protein-DNA interactions were visualized through ligation-mediated PCR (LM-PCR). Signals for protein binding were found adjacent to both inverted terminal repeats (ITR). There were no indications of close protein binding at several other loci...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2001.169

    authors: Dobner T,Büchner D,Zeller T,Wolf H,Niller HH

    更新日期:2001-09-01 00:00:00

  • Inorganic nitrite bioactivation and role in physiological signaling and therapeutics.

    abstract::The bioactivation of inorganic nitrite refers to the conversion of otherwise 'inert' nitrite to the diatomic signaling molecule nitric oxide (NO), which plays important roles in human physiology and disease, notably in the regulation of vascular tone and blood flow. While the most well-known sources of NO are the nitr...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2019-0349

    authors: Amdahl MB,DeMartino AW,Gladwin MT

    更新日期:2019-12-18 00:00:00

  • Role of chitinase-like proteins in cancer.

    abstract::Chitinase-like proteins (CLPs) are lectins combining properties of cytokines and growth factors. Human CLPs include YKL-40, YKL-39 and SI-CLP that are secreted by cancer cells, macrophages, neutrophils, synoviocytes, chondrocytes and other cells. The best investigated CLP in cancer is YKL-40. Serum and plasma levels o...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2015-0269

    authors: Kzhyshkowska J,Yin S,Liu T,Riabov V,Mitrofanova I

    更新日期:2016-03-01 00:00:00

  • Sphingomyelin breakdown in T cells: role in activation, effector functions and immunoregulation.

    abstract::Host T cell activation, a key step in obtaining adaptive immunity against pathogens, is initiated by the binding of the T cell receptor to a foreign antigenic peptide presented by the major histocompatibility complex on the surface of an antigen-presenting cell and, consequently, formation of an immunological synapse....

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2014-0282

    authors: Beyersdorf N,Müller N

    更新日期:2015-06-01 00:00:00

  • A structural network associated with the kallikrein-kinin and renin-angiotensin systems.

    abstract::The kallikrein-kinin and renin-angiotensin (KKS-RAS) systems represent two highly regulated proteolytic systems that are involved in several physiological and pathological processes. Although their protein-protein interactions can be studied using experimental approaches, it is difficult to differentiate between direc...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2010.046

    authors: Stoka V,Turk V

    更新日期:2010-04-01 00:00:00

  • Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation.

    abstract::Human inositol phosphate multikinase (IPMK) is a multifunctional protein in cellular signal transduction, namely, a multispecific inositol phosphate kinase, phosphatidylinositol 3-kinase, and a scaffold within the mTOR-raptor complex. To fulfill these nuclear and cytoplasmic functions, intracellular targeting of IPMK ...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2011-0209

    authors: Meyer R,Nalaskowski MM,Ehm P,Schröder C,Naj X,Brehm MA,Mayr GW

    更新日期:2012-03-01 00:00:00

  • Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors.

    abstract::The adipocytokine adiponectin and its receptor (AdipoR) comprise a new receptor-ligand system that is involved in a variety of clinically important morbidities such as obesity, type 2 diabetes and cardiovascular diseases. Adiponectin exerts a multitude of beneficial and tissue specific effects depending on its unique,...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2010.104

    authors: Heiker JT,Kosel D,Beck-Sickinger AG

    更新日期:2010-09-01 00:00:00

  • Cis-regulatory sequences from the first intron of the rat glutamine synthetase gene are involved in hepatocyte specific expression of the enzyme.

    abstract::In order to identify regulatory elements involved in the hepatocyte specific expression of the enzyme glutamine synthetase [GS (E.C. 6.3.1.2)] we analyzed the first intron of the rat GS gene. A sequence analysis detected clusters of potential transcription factor binding sites in regions that are hypersensitive for DN...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/bchm.1997.378.1.11

    authors: Gaunitz F,Gaunitz C,Papke M,Gebhardt R

    更新日期:1997-01-01 00:00:00

  • Domain topology of human Rasal.

    abstract::Rasal is a modular multi-domain protein of the GTPase-activating protein 1 (GAP1) family; its four known members, GAP1m, Rasal, GAP1IP4BP and Capri, have a Ras GTPase-activating domain (RasGAP). This domain supports the intrinsically slow GTPase activity of Ras by actively participating in the catalytic reaction. In t...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2017-0159

    authors: Cuellar J,Valpuesta JM,Wittinghofer A,Sot B

    更新日期:2017-12-20 00:00:00

  • The XPD helicase: XPanDing archaeal XPD structures to get a grip on human DNA repair.

    abstract::Xeroderma pigmentosum complementation group D protein (XPD) is an iron-sulfur cluster containing 5'-3' helicase and, in humans, part of the transcription factor TFIIH. TFIIH is involved in nucleotide excision repair as well as in transcription initiation. Recently, three different groups have reported the structures o...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2010.076

    authors: Wolski SC,Kuper J,Kisker C

    更新日期:2010-07-01 00:00:00

  • DNA-binding specificity of PAR and C/EBP leucine zipper proteins: a single amino acid substitution in the C/EBP DNA-binding domain confers PAR-like specificity to C/EBP.

    abstract::PAR and C/EBP family proteins are liver-enriched basic leucine zipper (bZip) transcription factors that bind similar sites on the promoters of albumin and cholesterol 7 alpha hydroxylase genes. However, C/EBP proteins have a more relaxed binding specificity than PAR proteins, in that they recognize many sites within p...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:

    authors: Falvey E,Marcacci L,Schibler U

    更新日期:1996-12-01 00:00:00

  • Benefits of stable isotope labeling in RNA analysis.

    abstract::RNAs are key players in life as they connect the genetic code (DNA) with all cellular processes dominated by proteins. They contain a variety of chemical modifications and many RNAs fold into complex structures. Here, we review recent progress in the analysis of RNA modification and structure on the basis of stable is...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2018-0447

    authors: Asadi-Atoi P,Barraud P,Tisne C,Kellner S

    更新日期:2019-06-26 00:00:00

  • Reverse action of ribonuclease T1 in frozen aqueous systems.

    abstract::We have studied ribonuclease T1 (EC 3.1-27.3)-catalysed synthesis of guanylyl-(3'-->5')cytidine in frozen aqueous reaction mixtures at -10 degrees C and in solution at 0 degree C in order to investigate whether ribonuclease-catalysed synthetic reactions can take advantage of the yield-increasing effect of freezing as ...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/bchm.1997.378.2.115

    authors: Haensler M,Hahn U,Jakubke HD

    更新日期:1997-02-01 00:00:00

  • Enhancers, enhancers - from their discovery to today's universe of transcription enhancers.

    abstract::Transcriptional enhancers are short (200-1500 base pairs) DNA segments that are able to dramatically boost transcription from the promoter of a target gene. Originally discovered in simian virus 40 (SV40), a small DNA virus, transcription enhancers were soon also found in immunoglobulin genes and other cellular genes ...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2014-0303

    authors: Schaffner W

    更新日期:2015-04-01 00:00:00

  • Expression, subcellular distribution and plasma membrane binding of cathepsin B and gelatinases in bone metastatic tissue.

    abstract::The possible application of proteinase inhibitors in the support of anti-tumor chemotherapy requires profound knowledge of the proteinases involved in malignant processes. Therefore, the occurrence of cathepsins B, D, H, L and S and of gelatinases, urokinase plasminogen activator and stromelysins was studied in biopsi...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/bchm3.1996.377.11.695

    authors: Arkona C,Wiederanders B

    更新日期:1996-11-01 00:00:00

  • GAPDH enhances group II intron splicing in vitro.

    abstract::Group II introns are autocatalytic RNAs which self-splice in vitro. However, in vivo additional protein factors might be involved in the splicing process. We used an affinity chromatography method called 'StreptoTag' to identify group II intron binding proteins from Saccharomyces cerevisiae. This method uses a hybrid ...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2004.076

    authors: Böck-Taferner P,Wank H

    更新日期:2004-07-01 00:00:00

  • Activation of GPR119 by fatty acid agonists augments insulin release from clonal β-cells and isolated pancreatic islets and improves glucose tolerance in mice.

    abstract::G-protein coupled receptor 119 (GPR119) is emerging as a potential target for the treatment of type 2 diabetes with beneficial effects on glucose homeostasis. This study assessed the insulin-secreting properties of various GPR119 agonists and the distribution of GPR119 in pancreatic islets. Endogenous ligands [oleoyle...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2013-0255

    authors: Moran BM,Abdel-Wahab YH,Flatt PR,McKillop AM

    更新日期:2014-04-01 00:00:00

  • Comparative study of the differential cell death protecting effect of various ROS scavengers.

    abstract::Oxidative stress has for a long time been associated with cell death, especially classical necrosis, however, its role in other cell death pathways is less clear. Here, we evaluated in a comparative way, the effect of four different reactive oxygen species (ROS) scavengers, N-acetyl-L-cysteine (NAC), α-tocopherol and ...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2017-0317

    authors: Kavčič N,Pegan K,Vandenabeele P,Turk B

    更新日期:2019-01-28 00:00:00

  • An efficient method for the preparation of long heteroduplex DNA as substrate for mismatch repair by the Escherichia coli MutHLS system.

    abstract::We present a method that allows preparing long DNA containing defined mismatches without the use of gel electrophoretic or chromatographic purification steps. The preparation starts with the synthesis of two PCR products, which are identical except for those positions that will later form the mismatches. One of the PC...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2002.166

    authors: Thomas E,Pingoud A,Friedhoff P

    更新日期:2002-09-01 00:00:00

  • Nitrite, a naturally occurring precursor of nitric oxide that acts like a 'prodrug'.

    abstract::There are enzymatic and non-enzymatic mechanisms that generate NO* from nitrite in blood, stomach, saliva, urine and skin. In blood vessels, nitrite-derived NO* can provide protection via compensatory vasodilation during hypoxia, and in various body fluids it may have antibacterial activity. In the skin, nitrite-deriv...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2006.065

    authors: Suschek CV,Schewe T,Sies H,Kröncke KD

    更新日期:2006-05-01 00:00:00

  • How to get rid of mitochondria: crosstalk and regulation of multiple mitophagy pathways.

    abstract::Mitochondria are indispensable cellular organelles providing ATP and numerous other essential metabolites to ensure cell survival. Reactive oxygen species (ROS), which are formed as side reactions during oxidative phosphorylation or by external agents, induce molecular damage in mitochondrial proteins, lipids/membrane...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2017-0206

    authors: Zimmermann M,Reichert AS

    更新日期:2017-12-20 00:00:00

  • An internally quenched peptide as a new model substrate for rhomboid intramembrane proteases.

    abstract::Rhomboids are ubiquitous intramembrane serine proteases that cleave transmembrane substrates. Their functions include growth factor signaling, mitochondrial homeostasis, and parasite invasion. A recent study revealed that the Escherichia coli rhomboid protease EcGlpG is essential for its extraintestinal pathogenic col...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2018-0255

    authors: Arutyunova E,Jiang Z,Yang J,Kulepa AN,Young HS,Verhelst S,O'Donoghue AJ,Lemieux MJ

    更新日期:2018-11-27 00:00:00

  • Increased local levels of granulocyte colony-stimulating factor are associated with the beneficial effect of pre-elafin (SKALP/trappin-2/WAP3) in experimental emphysema.

    abstract::Few therapeutic options are offered to treat inflammation and alveolar wall destruction in emphysema. The effect of recombinant human pre-elafin, an elastase inhibitor, was evaluated in porcine pancreatic elastase (PPE)-induced emphysema in C57BL/6 mice. In a first protocol, mice received a single instillation of pre-...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2006.114

    authors: Janelle MF,Doucet A,Bouchard D,Bourbonnais Y,Tremblay GM

    更新日期:2006-07-01 00:00:00

  • Pressure- and temperature-induced unfolding studies: thermodynamics of core hydrophobicity and packing of ribonuclease A.

    abstract::In this work we demonstrate that heat and pressure induce only slightly different energetic changes in the unfolded state of RNase A. Using pressure and temperature as denaturants on a significant number of variants, and by determining the free energy of unfolding at different temperatures, we estimated the stability ...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2006.038

    authors: Font J,Benito A,Torrent J,Lange R,Ribó M,Vilanova M

    更新日期:2006-03-01 00:00:00

  • A role for the metalloprotease invadolysin in insulin signaling and adipogenesis.

    abstract::Invadolysin is a novel metalloprotease conserved amongst metazoans that is essential for life in Drosophila. We previously showed that invadolysin was essential for the cell cycle and cell migration, linking to metabolism through a role in lipid storage and interaction with mitochondrial proteins. In this study we dem...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2016-0226

    authors: Chang CW,Abhinav K,Di Cara F,Panagakou I,Vass S,Heck MM

    更新日期:2017-03-01 00:00:00

  • Chaperone-assisted degradation: multiple paths to destruction.

    abstract::Molecular chaperones are well known as facilitators of protein folding and assembly. However, in recent years multiple chaperone-assisted degradation pathways have also emerged, including CAP (chaperone-assisted proteasomal degradation), CASA (chaperone-assisted selective autophagy), and CMA (chaperone-mediated autoph...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2010.058

    authors: Kettern N,Dreiseidler M,Tawo R,Höhfeld J

    更新日期:2010-05-01 00:00:00