Abstract:
:Parvulins belong to the family of peptidyl-prolyl cis/trans isomerases (PPIases) assisting in protein folding and in regulating the function of a broad variety of proteins in all branches of life. The human representatives Pin1 and Par14/17 are directly involved in processes influencing cellular maintenance and cell fate decisions such as cell-cycle progression, metabolic pathways and ribosome biogenesis. This review on human parvulins summarizes the current knowledge of these enzymes and intends to oppose the well-studied Pin1 to its less well-examined homolog human Par14/17 with respect to structure, catalytic and cellular function.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Matena A,Rehic E,Hönig D,Kamba B,Bayer Pdoi
10.1515/hsz-2017-0137subject
Has Abstractpub_date
2018-01-26 00:00:00pages
101-125issue
2eissn
1431-6730issn
1437-4315pii
/j/bchm.just-accepted/hsz-2017-0137/hsz-2017-0137.journal_volume
399pub_type
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