Abstract:
:Angiotensin-converting enzyme (ACE) plays an important role in blood pressure control. ACE also has effects on renal function, reproduction, hematopoiesis, and several aspects of the immune response. ACE 10/10 mice overexpress ACE in monocytic cells; macrophages from ACE 10/10 mice demonstrate increased polarization toward a proinflammatory phenotype. As a result, ACE 10/10 mice have a highly effective immune response following challenge with melanoma, bacterial infection, or Alzheimer disease. As shown in ACE 10/10 mice, enhanced monocytic function greatly contributes to the ability of the immune response to defend against a wide variety of antigenic and non-antigenic challenges.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Bernstein KE,Gonzalez-Villalobos RA,Giani JF,Shah K,Bernstein E,Janjulia T,Koronyo Y,Shi PD,Koronyo-Hamaoui M,Fuchs S,Shen XZdoi
10.1515/hsz-2013-0295subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1173-8issue
10eissn
1431-6730issn
1437-4315pii
/j/bchm.just-accepted/hsz-2013-0295/hsz-2013-0295.journal_volume
395pub_type
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