Abstract:
:The central process for the transfer of the genetic information from the nucleic acid world into the structure of proteins is the ribosomal elongation cycle, where the sequence of codons is translated into the sequence of amino acids. The nascent polypeptide chain is elongated by one amino acid during the reactions of one cycle. Essentially, three models for the elongation cycle have been proposed. The allosteric three-site model and the hybrid-site model describe different aspects of tRNA binding and do not necessarily contradict each other. However, the alpha-epsilon model is not compatible with both models. The three models are evaluated in the light of recent results on the tRNA localization within the ribosome: the tRNAs of the elongating ribosome could be localized by two different techniques, viz. an advanced method of small-angle neutron scattering and cryo-electron microscopy. The best fit with the biochemical and structural data is obtained with the alpha-epsilon model.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Spahn CM,Nierhaus KHdoi
10.1515/bchm.1998.379.7.753subject
Has Abstractpub_date
1998-07-01 00:00:00pages
753-72issue
7eissn
1431-6730issn
1437-4315journal_volume
379pub_type
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